Dr Jenifer Pendiuk Goncalves

Postdoctoral Research Fellow

Australian Institute for Bioengineering and Nanotechnology

Overview

I am an enthusiastic Biologist, with MSc and PhD in Cell and Molecular Biology. I have experience leading different projects on biomedical research, from skin wound healing to cancer, from natural products to nanomedicine tools. My most ambitious goal is to contribute for overcoming the cancer therapy-related challenge of avoiding the severe adverse effects caused by toxic drugs on healthy tissues, seeking to obtain the maximum efficiency of diverse therapeutic systems in the absence of toxicity. On one side, I investigate the power of oncology nanomedicine, by discovering/designing simple, relatively low cost and efficient nanoparticles that could either have intrinsic antitumor action or specifically deliver drugs into tumor sites in a controlled manner. On the other side, I look for molecules found in nature (plants, fungi, animals) that can either directly fight tumors or stimulate the immune system to do so. Nowadays, I focus my investigation on the role of extracellular vesicles and their specific molecular components that can interact with the tumor microenvironment, in order to explore them and develop nanomedicine devices for cancer diagnosis and therapy. The diversity of scientific subjects that I experienced so far during my academic formation (from chemistry to biomedicine) thought me that all life processes are somehow connected. That is why I believe in all science fields working together in a multidisciplinary effort to understand the mechanisms behind life and to find creative solutions for overcoming diseases.

Publications

  • Stafim da Cunha, Regiane, Gregório, Paulo Cézar, Maciel, Rayana Ariane Pereira, Favretto, Giane, Franco, Célia Regina Cavichiolo, Gonçalves, Jenifer Pendiuk, de Azevedo, Marina Luise Viola, Pecoits-Filho, Roberto and Stinghen, Andréa Emilia Marques (2022). Uremic toxins activate CREB/ATF1 in endothelial cells related to chronic kidney disease. Biochemical Pharmacology, 198 114984, 114984. doi: 10.1016/j.bcp.2022.114984

  • Gonçalves, Jenifer P., da Cruz, Anderson F., Nunes, Ábner M., Meneghetti, Mario R., de Barros, Heloise R., Borges, Beatriz S., de Medeiros, Lia C.A.S., Soares, Maurilio J., dos Santos, Mayara P., Grassi, Marco T., Rossi, Gustavo R., Bellan, Daniel L., Biscaia, Stellee M.P., Cristal, Aline M., Buzzo, João L.A., Ribeiro, Yasmin C., Acco, Alexandra, Cardoso, Mateus B., Simas, Fernanda F., Trindade, Edvaldo S., Riegel-Vidotti, Izabel C. and de Oliveira, Carolina C. (2021). Biocompatible gum arabic-gold nanorod composite as an effective therapy for mistreated melanomas. International Journal of Biological Macromolecules, 185, 551-561. doi: 10.1016/j.ijbiomac.2021.06.172

  • Ventura, Ana Clara Sans Salomão Brunow, de Paula, Thalita, Gonçalves, Jenifer Pendiuk, Soley, Bruna da Silva, Cretella, Ananda Beatriz Munhoz, Otuki, Michel Fleith and Cabrini, Daniela Almeida (2021). The oil from Moringa oleifera seeds accelerates chronic skin wound healing. Phytomedicine Plus, 1 (3) 100099, 100099. doi: 10.1016/j.phyplu.2021.100099

View all Publications

Publications

Journal Article

  • Stafim da Cunha, Regiane, Gregório, Paulo Cézar, Maciel, Rayana Ariane Pereira, Favretto, Giane, Franco, Célia Regina Cavichiolo, Gonçalves, Jenifer Pendiuk, de Azevedo, Marina Luise Viola, Pecoits-Filho, Roberto and Stinghen, Andréa Emilia Marques (2022). Uremic toxins activate CREB/ATF1 in endothelial cells related to chronic kidney disease. Biochemical Pharmacology, 198 114984, 114984. doi: 10.1016/j.bcp.2022.114984

  • Gonçalves, Jenifer P., da Cruz, Anderson F., Nunes, Ábner M., Meneghetti, Mario R., de Barros, Heloise R., Borges, Beatriz S., de Medeiros, Lia C.A.S., Soares, Maurilio J., dos Santos, Mayara P., Grassi, Marco T., Rossi, Gustavo R., Bellan, Daniel L., Biscaia, Stellee M.P., Cristal, Aline M., Buzzo, João L.A., Ribeiro, Yasmin C., Acco, Alexandra, Cardoso, Mateus B., Simas, Fernanda F., Trindade, Edvaldo S., Riegel-Vidotti, Izabel C. and de Oliveira, Carolina C. (2021). Biocompatible gum arabic-gold nanorod composite as an effective therapy for mistreated melanomas. International Journal of Biological Macromolecules, 185, 551-561. doi: 10.1016/j.ijbiomac.2021.06.172

  • Ventura, Ana Clara Sans Salomão Brunow, de Paula, Thalita, Gonçalves, Jenifer Pendiuk, Soley, Bruna da Silva, Cretella, Ananda Beatriz Munhoz, Otuki, Michel Fleith and Cabrini, Daniela Almeida (2021). The oil from Moringa oleifera seeds accelerates chronic skin wound healing. Phytomedicine Plus, 1 (3) 100099, 100099. doi: 10.1016/j.phyplu.2021.100099

  • Gonçalves, Jenifer Pendiuk, de Oliveira, Carolina Camargo, da Silva Trindade, Edvaldo, Riegel-Vidotti, Izabel Cristina, Vidotti, Marcio and Simas, Fernanda Fogagnoli (2021). In vitro biocompatibility screening of a colloidal gum Arabic-polyaniline conducting nanocomposite. International Journal of Biological Macromolecules, 173, 109-117. doi: 10.1016/j.ijbiomac.2021.01.101

  • Bellan, D.L., Biscaia, S.M.P., Rossi, G.R., Cristal, A.M., Gonçalves, J.P., Oliveira, C.C., Simas, F.F., Sabry, D.A., Rocha, H.A.O., Franco, C.R.C., Chammas, R., Gillies, R.J. and Trindade, E.S. (2020). Green does not always mean go: a sulfated galactan from Codium isthmocladum green seaweed reduces melanoma metastasis through direct regulation of malignancy features. Carbohydrate Polymers, 250 116869, 116869. doi: 10.1016/j.carbpol.2020.116869

  • Pendiuk Gonçalves, Jenifer, Fraga da Cruz, Anderson, Ribeiro de Barros, Heloise, Santana Borges, Beatriz, Almeida Soares de Medeiros, Lia Carolina, Soares, Maurilio José, Padovan dos Santos, Mayara, Grassi, Marco Tadeu, Chandra, Anil, del Mercato, Loretta Laureana, Rodrigues Rossi, Gustavo, da Silva Trindade, Edvaldo, Riegel-Vidotti, Izabel Cristina and Camargo de Oliveira, Carolina (2020). Beyond gold nanoparticles cytotoxicity: potential to impair metastasis hallmarks. European Journal of Pharmaceutics and Biopharmaceutics, 157, 221-232. doi: 10.1016/j.ejpb.2020.10.019

  • Rossi, Gustavo R., Gonçalves, Jenifer P., McCulloch, Timothy, Delconte, Rebecca B., Hennessy, Robert J., Huntington, Nicholas D., Trindade, Edvaldo S. and Souza-Fonseca-Guimaraes, Fernando (2020). The antitumor effect of heparin is not mediated by direct NK cell activation. Journal of Clinical Medicine, 9 (8) 2666, 2666-11. doi: 10.3390/jcm9082666

  • Seraphim, Patricia M., Leal, Ermelindo C., Moura, João, Gonçalves, Pedro, Gonçalves, Jenifer P. and Carvalho, Eugénia (2020). Lack of lymphocytes impairs macrophage polarization and angiogenesis in diabetic wound healing. Life Sciences, 254 117813, 117813. doi: 10.1016/j.lfs.2020.117813

  • Bellan, D. L., Mazepa, E., Biscaia, S. M. P., Gonçalves, J. P., Oliveira, C. C., Rossi, G. R., Ferreira, L. G., Noseda, M. D., Trindade, E. S., Duarte, M. E. R. and Franco, C. R. C. (2020). Non-cytotoxic sulfated heterorhamnan from Gayralia brasiliensis green seaweed reduces driver features of melanoma metastatic progression. Marine Biotechnology, 22 (2), 194-206. doi: 10.1007/s10126-020-09944-9

  • Teruya, Rúbia Eri, Gonçalves, Jenifer Pendiuk, de Oliveira, Carolina Camargo and Marino, Cláudia Eliana Bruno (2019). Zirconia activation by ultraviolet irradiation and O2 plasma to obtain hydrophilic surface for implantology. Materials Research Express, 6 (8) 085414. doi: 10.1088/2053-1591/ab26c5

  • Gonçalves, Jenifer Pendiuk, Potrich, Francine Bittencourt, Dos Santos, Maria Luiza Ferreira, Gagosian, Viviana Stephanie Costa, Rossi, Gustavo Rodrigues, Thiago, Jacomasso, Mendes, Aline, Nader, Helena Bonciani, Winnischofer, Sheila Maria Brochado, Trindade, Edvaldo S. and De Oliveira, Carolina Camargo (2019). In vitro attenuation of classic metastatic melanoma-related features by highly diluted natural complexes: molecular and functional analyses. International Journal of Oncology, 55 (3), 721-732. doi: 10.3892/ijo.2019.4846

  • Leme, Daniela Morais, Sehr, Andrea, Grummt, Tamara, Gonçalves, Jenifer Pendiuk, Jacomasso, Thiago, Winnischofer, Sheila Maria Brochado, Potrich, Francine Bittencourt, Oliveira, Carolina Camargo de, Trindade, Edvaldo da Silva and de Oliveira, Danielle Palma (2018). In vitro characterization of cutaneous immunotoxicity of immortalized human keratinocytes (HaCaT) exposed to reactive and disperse textile dyes. Journal of Toxicology and Environmental Health Part A: Current Issues, 81 (13), 589-603. doi: 10.1080/15287394.2018.1464981

  • Biscaia, S. M.P., Carbonero, E. R., Bellan, D. L., Borges, B. S., Costa, C. R., Rossi, G. R., Gonçalves, J. P., Melo, C. M., Lívero, F. A.R., Ruthes, A. C., Zotz, R., Silva, E. V., Oliveira, C. C., Acco, A., Nader, H. B., Chammas, R., Iacomini, M., Franco, C. R.C. and Trindade, E. S. (2017). Safe therapeutics of murine melanoma model using a novel antineoplasic, the partially methylated mannogalactan from Pleurotus eryngii. Carbohydrate Polymers, 178, 95-104. doi: 10.1016/j.carbpol.2017.08.117

  • de Oliveira, Carolina C., Abud, Ana P. R., de Oliveira, Simone M., de SF Guimarães, Fernando, de Andrade, Lucas F., Di Bernardi, Raffaello P., de O Coletto, Ediely L., Kuczera, Diogo, Da Lozzo, Eneida J., Gonçalves, Jenifer P., da S Trindade, Edvaldo and de F Buchi, Dorly (2011). Developments on drug discovery and on new therapeutics: highly diluted tinctures act as biological response modifiers. BMC Complementary and Alternative Medicine, 11 (1) 101. doi: 10.1186/1472-6882-11-101