The University of Queensland

Developments in Glycopeptide Antibiotics

Blaskovich, Mark A. T., Hansford, Karl A., Butler, Mark S., Jia, ZhiGuang, Mark, Alan E. and Cooper, Matthew A. (2018) Developments in Glycopeptide Antibiotics. ACS Infectious Diseases, . doi:10.1021/acsinfecdis.7b00258

Protein-inspired antibiotics active against vancomycin- and daptomycin-resistant bacteria

Blaskovich, Mark A T, Hansford, Karl A., Gong, Yujing, Butler, Mark S., Muldoon, Craig, Huang, Johnny X., Ramu, Soumya, Silva, Alberto B., Cheng, Mu, Kavanagh, Angela M., Ziora, Zyta, Premraj, Rajaratnam, Lindahl, Fredrik, Bradford, Tanya A., Lee, June C., Karoli, Tomislav, Pelingon, Ruby, Edwards, David J., Amado, Maite, Elliott, Alysha G, Phetsang, Wanida, Daud, Noor Huda, Deecke, Johan E, Sidjabat, Hanna E, Ramaologa, Sefetogi, Zuegg, Johannes, Betley, Jason R, Beevers, Andrew P G, Smith, Richard A G, Roberts, Jason A, Paterson, David L. and Cooper, Matthew A. (2018) Protein-inspired antibiotics active against vancomycin- and daptomycin-resistant bacteria. Nature Communications, 9 1: 22. doi:10.1038/s41467-017-02123-w

Investigating the interaction of octapeptin A3 with model bacterial membranes

Han, Mei-Ling, Shen, Hsin-Hui, Hansford, Karl A., Schneider, Elena K., Sivanesan, Sivashangarie, Roberts, Kade D., Thompson, Philip E., Le Brun, Anton P., Zhu, Yan, Sani, Marc-Antoine, Separovic, Frances, Blaskovich, Mark A. T., Baker, Mark A., Moskowitz, Samuel M., Cooper, Matthew A., Li, Jian and Velkov, Tony (2017) Investigating the interaction of octapeptin A3 with model bacterial membranes. ACS Infectious Diseases, 3 8: 606-619. doi:10.1021/acsinfecdis.7b00065

Synthesis of octapeptin C4 and biological profiling against NDM-1 and polymyxin-resistant bacteria

Becker, Bernd, Butler, Mark S., Hansford, Karl A., Gallardo-Godoy, Alejandra, Elliott, Alysha G., Huang, Johnny X., Edwards, David J., Blaskovich, Mark A. T. and Cooper, Matthew A. (2017) Synthesis of octapeptin C4 and biological profiling against NDM-1 and polymyxin-resistant bacteria. Bioorganic and Medicinal Chemistry Letters, 27 11: 2407-2409. doi:10.1016/j.bmcl.2017.04.027

Institutional profile: Community for Open Antimicrobial Drug Discovery - crowdsourcing new antibiotics and antifungals

Desselle, Mathilde R., Neale, Ruth, Hansford, Karl A., Zuegg, Johannes, Elliott, Alysha G., Cooper, Matthew A. and Blaskovich, Mark A. T. (2017) Institutional profile: Community for Open Antimicrobial Drug Discovery - crowdsourcing new antibiotics and antifungals. Future Science OA, 3 2: . doi:10.4155/fsoa-2016-0093

Nitroimidazole carboxamides as antiparasitic agents targeting Giardia lamblia, Entamoeba histolytica and Trichomonas vaginalis

Jarrad, A. M., Debnath, A., Miyamoto, Y., Hansford, K. A., Pelingon, R., Butler, M. S., Bains, T., Karoli, T., Blaskovich, M. A. T., Eckmann, L. and Cooper, M. A. (2016) Nitroimidazole carboxamides as antiparasitic agents targeting Giardia lamblia, Entamoeba histolytica and Trichomonas vaginalis. European Journal of Medicinal Chemistry, 120 353-362. doi:10.1016/j.ejmech.2016.04.064

Chemical philanthropy: a path forward for antibiotic discovery?

Hansford, Karl A., Blaskovich, Mark A. T. and Cooper, Matthew A. (2016) Chemical philanthropy: a path forward for antibiotic discovery?. Future Medicinal Chemistry, 8 9: 925-929. doi:10.4155/fmc-2016-0029

Affinities and in-plane stress forces between glycopeptide antibiotics and biomimetic bacterial membranes

Bi, Sisi, Ranzoni, Andrea, Huang, Johnny X., Hansford, Karl and Cooper, Matthew A. (2015) Affinities and in-plane stress forces between glycopeptide antibiotics and biomimetic bacterial membranes. Sensing and Bio-Sensing Research, 3 24-30. doi:10.1016/j.sbsr.2014.10.003

Glycopeptide antibiotics: back to the future

Butler, Mark S., Hansford, Karl A., Blaskovich, Mark A. T., Halai, Reena and Cooper, Matthew A. (2014) Glycopeptide antibiotics: back to the future. Journal of Antibiotics, 67 9: 631-644. doi:10.1038/ja.2014.111

Anti-cooperative ligand binding and dimerisation in the glycopeptide antibiotic dalbavancin

Cheng, Mu, Ziora, Zyta M., Hansford, Karl A., Blaskovich, Mark A., Butler, Mark S. and Cooper, Matthew A. (2014) Anti-cooperative ligand binding and dimerisation in the glycopeptide antibiotic dalbavancin. Organic and Biomolecular Chemistry, 12 16: 2568-2575. doi:10.1039/c3ob42428f

Small-molecule ligands of GD2 ganglioside, designed from NMR studies, exhibit induced-fit binding and bioactivity

Tong, Wenyong, Gagnon, Martin, Sprules, Tara, Gilbert, Michael, Chowdhury, Shafinaz, Meerovitch, Karen, Hansford, Karl, Purisima, Enrico O., Blankenship, John W., Cheung, Nai-Kong V., Gehring, Kalle, Lubell, William D. and Saragovi, H. Uri (2010) Small-molecule ligands of GD2 ganglioside, designed from NMR studies, exhibit induced-fit binding and bioactivity. Chemistry and Biology, 17 2: 183-194. doi:10.1016/j.chembiol.2010.01.012

Bis(pyrrol-2-yl)arylenes from the tandem bidirectional addition of vinyl grignard reagent to aryl diesters

Hansford, Karl A., Guarin, Sergio Andres Perez, Skene, W. G. and Lubell, William D. (2006) Bis(pyrrol-2-yl)arylenes from the tandem bidirectional addition of vinyl grignard reagent to aryl diesters. Organic Chemistry, 37 5: 7996-8000. doi:10.1021/jo0510888

Three-step solution-phase combinatorial access to 1,2-disubstituted and 1,2,5-trisubstituted pyrroles from carboxylic esters

Hansford, Karl A., Zanzarova, Valeria, Dorr, Aurélie and Lubell, William D. (2004) Three-step solution-phase combinatorial access to 1,2-disubstituted and 1,2,5-trisubstituted pyrroles from carboxylic esters. Journal of Combinatorial Chemistry, 6 6: 893-898. doi:10.1021/cc049904x

Selective tert-butyl ester deprotection in the presence of acid labile protecting groups with use of ZnBr2

Kaul, R, Brouillette, Y, Sajjadi, Z, Hansford, Karl and Lubell, W. D. (2004) Selective tert-butyl ester deprotection in the presence of acid labile protecting groups with use of ZnBr2. Journal of Organic Chemistry, 69 18: 6131-6133. doi:10.1021/jo0491206

One-pot synthesis of homoallylic ketones from the addition of vinyl grignard reagent to carboxylic esters

Hansford, Karl A., Dettwiller, James E. and Lubell, William D. (2004) One-pot synthesis of homoallylic ketones from the addition of vinyl grignard reagent to carboxylic esters. ChemInform, 35 16: 4887-4890. doi:10.1021/ol0359822

Comparative protection against rat intestinal reperfusion injury by a new inhibitor of sPLA2, COX-1 and COX-2 selective inhibitors, and an LTC4 receptor antagonist

Arumugam, Thiruma V., Arnold, Naomi, Proctor, Lavinia M., Newman, Michelle, Reid, Robert C., Hansford, Karl A., Fairlie, David P., Shiels, Ian A. and Taylor, Stephen M. (2003) Comparative protection against rat intestinal reperfusion injury by a new inhibitor of sPLA2, COX-1 and COX-2 selective inhibitors, and an LTC4 receptor antagonist. British Journal of Pharmacology, 140 1: 71-80. doi:10.1038/sj.bjp.0705402

D-Tyrosine as a chiral precusor to potent inhibitors of human nonpancreatic secretory phospholipase A(2) (IIa) with antiinflammatory activity

Hansford, Karl A., Reid, Robert C., Clark, Chris I., Tyndall, Joel D. A., Whitehouse, Michael W., Guthrie, Tom, McGeary, Ross P., Schafer, Karl, Martin, Jennifer L. and Fairlie, David P. (2003) D-Tyrosine as a chiral precusor to potent inhibitors of human nonpancreatic secretory phospholipase A(2) (IIa) with antiinflammatory activity. Chembiochem, 4 2-3: 181-185. doi:10.1002/cbic.200390029

Towards the cis-bromination of double bonds

Carman, Raymond M., Derbyshire, Roger P. C., Hansford, Karl A., Kadirvelraj, Renu and Robinson, Ward T. (2001) Towards the cis-bromination of double bonds. Australian Journal of Chemistry, 54 2: 117-126. doi:10.1071/CH01016

Halogenated terpenoids. XXXI * Tribromides from the bromination of various exocyclic olefins

Carman, Raymond M., Hansford, Karl A. and Kennard, Colin H. L. (2000) Halogenated terpenoids. XXXI * Tribromides from the bromination of various exocyclic olefins. Australian Journal of Chemistry, 53 5: 439-442.

Halogenated terpenoids. XXXI tribromides from the bromination of various exocyclic olefins

Carman, R. M., Hansford, K. A. and Kennard, C. H. L. (2000) Halogenated terpenoids. XXXI tribromides from the bromination of various exocyclic olefins. Australian Journal of Chemistry, 53 5: 439-442. doi:10.1071/CH00041

Halogenated Terpenoids. XXIX The 1-Bromo 1-Bromomethyl Cyclohexyl System

Brecknell, Douglas J., Carman, Raymond M., Edwards, Ross A., Hansford, Karl, Karoli, Tomislav and Robinson, Ward T. (1997) Halogenated Terpenoids. XXIX The 1-Bromo 1-Bromomethyl Cyclohexyl System. Australian Journal of Chemistry, 50 7: 689-700. doi:10.1071/C96188

New amino acid derivatives useful for the treatment of inflammatory disease or condition e.g. rheumatic arthritis

Clark, C. I., Fairlie, D. P., Hansford, K., McGeary, R. P., Reid, R. C. and Stoermer, M. J. (2007). New amino acid derivatives useful for the treatment of inflammatory disease or condition e.g. rheumatic arthritis. .