Journal Article: Structure-Function Studies of Polymyxin B Lipononapeptides
Gallardo-Godoy, Alejandra, Hansford, Karl, Muldoon, Craig, Becker, Bernd, Elliott, Alysha, Huang, Johnny, Pelingon, Ruby, Butler, Mark, Blaskovich, Mark and Cooper, Matthew (2019) Structure-Function Studies of Polymyxin B Lipononapeptides. Molecules, 24 3: 553. doi:10.3390/molecules24030553
Journal Article: Detection and investigation of Eagle effect resistance to vancomycin in Clostridium difficile with an ATP-bioluminescence assay
Jarrad, Angie M., Blaskovich, Mark A. T., Prasetyoputri, Anggia, Karoli, Tomislav, Hansford, Karl A. and Cooper, Matthew A. (2018) Detection and investigation of Eagle effect resistance to vancomycin in Clostridium difficile with an ATP-bioluminescence assay. Frontiers in Microbiology, 9 JUL: 1420. doi:10.3389/fmicb.2018.01420
Journal Article: Developments in Glycopeptide Antibiotics
Blaskovich, Mark A. T., Hansford, Karl A., Butler, Mark S., Jia, ZhiGuang, Mark, Alan E. and Cooper, Matthew A. (2018) Developments in Glycopeptide Antibiotics. ACS Infectious Diseases, 4 5: 715-735. doi:10.1021/acsinfecdis.7b00258
Lipopeptide antibiotics for XDR Gram-negative infections
(2018–2020) NHMRC Development Grant
Novel membrane-targeted antibiotics against drug-resistant Gram-positive bacterial infections
(2016–2019) NHMRC Development Grant
Structure-Function Studies of Polymyxin B Lipononapeptides
Gallardo-Godoy, Alejandra, Hansford, Karl, Muldoon, Craig, Becker, Bernd, Elliott, Alysha, Huang, Johnny, Pelingon, Ruby, Butler, Mark, Blaskovich, Mark and Cooper, Matthew (2019) Structure-Function Studies of Polymyxin B Lipononapeptides. Molecules, 24 3: 553. doi:10.3390/molecules24030553
Jarrad, Angie M., Blaskovich, Mark A. T., Prasetyoputri, Anggia, Karoli, Tomislav, Hansford, Karl A. and Cooper, Matthew A. (2018) Detection and investigation of Eagle effect resistance to vancomycin in Clostridium difficile with an ATP-bioluminescence assay. Frontiers in Microbiology, 9 JUL: 1420. doi:10.3389/fmicb.2018.01420
Developments in Glycopeptide Antibiotics
Blaskovich, Mark A. T., Hansford, Karl A., Butler, Mark S., Jia, ZhiGuang, Mark, Alan E. and Cooper, Matthew A. (2018) Developments in Glycopeptide Antibiotics. ACS Infectious Diseases, 4 5: 715-735. doi:10.1021/acsinfecdis.7b00258
Protein-inspired antibiotics active against vancomycin- and daptomycin-resistant bacteria
Blaskovich, Mark A T, Hansford, Karl A., Gong, Yujing, Butler, Mark S., Muldoon, Craig, Huang, Johnny X., Ramu, Soumya, Silva, Alberto B., Cheng, Mu, Kavanagh, Angela M., Ziora, Zyta, Premraj, Rajaratnam, Lindahl, Fredrik, Bradford, Tanya A., Lee, June C., Karoli, Tomislav, Pelingon, Ruby, Edwards, David J., Amado, Maite, Elliott, Alysha G, Phetsang, Wanida, Daud, Noor Huda, Deecke, Johan E, Sidjabat, Hanna E, Ramaologa, Sefetogi, Zuegg, Johannes, Betley, Jason R, Beevers, Andrew P G, Smith, Richard A G, Roberts, Jason A, Paterson, David L. and Cooper, Matthew A. (2018) Protein-inspired antibiotics active against vancomycin- and daptomycin-resistant bacteria. Nature Communications, 9 1: 22. doi:10.1038/s41467-017-02123-w
Investigating the interaction of octapeptin A3 with model bacterial membranes
Han, Mei-Ling, Shen, Hsin-Hui, Hansford, Karl A., Schneider, Elena K., Sivanesan, Sivashangarie, Roberts, Kade D., Thompson, Philip E., Le Brun, Anton P., Zhu, Yan, Sani, Marc-Antoine, Separovic, Frances, Blaskovich, Mark A. T., Baker, Mark A., Moskowitz, Samuel M., Cooper, Matthew A., Li, Jian and Velkov, Tony (2017) Investigating the interaction of octapeptin A3 with model bacterial membranes. ACS Infectious Diseases, 3 8: 606-619. doi:10.1021/acsinfecdis.7b00065
Synthesis of octapeptin C4 and biological profiling against NDM-1 and polymyxin-resistant bacteria
Becker, Bernd, Butler, Mark S., Hansford, Karl A., Gallardo-Godoy, Alejandra, Elliott, Alysha G., Huang, Johnny X., Edwards, David J., Blaskovich, Mark A. T. and Cooper, Matthew A. (2017) Synthesis of octapeptin C4 and biological profiling against NDM-1 and polymyxin-resistant bacteria. Bioorganic and Medicinal Chemistry Letters, 27 11: 2407-2409. doi:10.1016/j.bmcl.2017.04.027
Desselle, Mathilde R., Neale, Ruth, Hansford, Karl A., Zuegg, Johannes, Elliott, Alysha G., Cooper, Matthew A. and Blaskovich, Mark A. T. (2017) Institutional profile: Community for Open Antimicrobial Drug Discovery - crowdsourcing new antibiotics and antifungals. Future Science OA, 3 2: FSO171. doi:10.4155/fsoa-2016-0093
Jarrad, A. M., Debnath, A., Miyamoto, Y., Hansford, K. A., Pelingon, R., Butler, M. S., Bains, T., Karoli, T., Blaskovich, M. A. T., Eckmann, L. and Cooper, M. A. (2016) Nitroimidazole carboxamides as antiparasitic agents targeting Giardia lamblia, Entamoeba histolytica and Trichomonas vaginalis. European Journal of Medicinal Chemistry, 120 353-362. doi:10.1016/j.ejmech.2016.04.064
Chemical philanthropy: a path forward for antibiotic discovery?
Hansford, Karl A., Blaskovich, Mark A. T. and Cooper, Matthew A. (2016) Chemical philanthropy: a path forward for antibiotic discovery?. Future Medicinal Chemistry, 8 9: 925-929. doi:10.4155/fmc-2016-0029
Bi, Sisi, Ranzoni, Andrea, Huang, Johnny X., Hansford, Karl and Cooper, Matthew A. (2015) Affinities and in-plane stress forces between glycopeptide antibiotics and biomimetic bacterial membranes. Sensing and Bio-Sensing Research, 3 24-30. doi:10.1016/j.sbsr.2014.10.003
Glycopeptide antibiotics: back to the future
Butler, Mark S., Hansford, Karl A., Blaskovich, Mark A. T., Halai, Reena and Cooper, Matthew A. (2014) Glycopeptide antibiotics: back to the future. Journal of Antibiotics, 67 9: 631-644. doi:10.1038/ja.2014.111
Anti-cooperative ligand binding and dimerisation in the glycopeptide antibiotic dalbavancin
Cheng, Mu, Ziora, Zyta M., Hansford, Karl A., Blaskovich, Mark A., Butler, Mark S. and Cooper, Matthew A. (2014) Anti-cooperative ligand binding and dimerisation in the glycopeptide antibiotic dalbavancin. Organic and Biomolecular Chemistry, 12 16: 2568-2575. doi:10.1039/c3ob42428f
Tong, Wenyong, Gagnon, Martin, Sprules, Tara, Gilbert, Michael, Chowdhury, Shafinaz, Meerovitch, Karen, Hansford, Karl, Purisima, Enrico O., Blankenship, John W., Cheung, Nai-Kong V., Gehring, Kalle, Lubell, William D. and Saragovi, H. Uri (2010) Small-molecule ligands of GD2 ganglioside, designed from NMR studies, exhibit induced-fit binding and bioactivity. Chemistry and Biology, 17 2: 183-194. doi:10.1016/j.chembiol.2010.01.012
Hansford, Karl A., Guarin, Sergio Andres Perez, Skene, W. G. and Lubell, William D. (2006) Bis(pyrrol-2-yl)arylenes from the tandem bidirectional addition of vinyl grignard reagent to aryl diesters. Organic Chemistry, 37 5: 7996-8000. doi:10.1021/jo0510888
Hansford, Karl A., Zanzarova, Valeria, Dorr, Aurélie and Lubell, William D. (2004) Three-step solution-phase combinatorial access to 1,2-disubstituted and 1,2,5-trisubstituted pyrroles from carboxylic esters. Journal of Combinatorial Chemistry, 6 6: 893-898. doi:10.1021/cc049904x
Kaul, R, Brouillette, Y, Sajjadi, Z, Hansford, Karl and Lubell, W. D. (2004) Selective tert-butyl ester deprotection in the presence of acid labile protecting groups with use of ZnBr2. Journal of Organic Chemistry, 69 18: 6131-6133. doi:10.1021/jo0491206
Hansford, Karl A., Dettwiller, James E. and Lubell, William D. (2004) One-pot synthesis of homoallylic ketones from the addition of vinyl grignard reagent to carboxylic esters. ChemInform, 35 16: 4887-4890. doi:10.1021/ol0359822
Arumugam, Thiruma V., Arnold, Naomi, Proctor, Lavinia M., Newman, Michelle, Reid, Robert C., Hansford, Karl A., Fairlie, David P., Shiels, Ian A. and Taylor, Stephen M. (2003) Comparative protection against rat intestinal reperfusion injury by a new inhibitor of sPLA2, COX-1 and COX-2 selective inhibitors, and an LTC4 receptor antagonist. British Journal of Pharmacology, 140 1: 71-80. doi:10.1038/sj.bjp.0705402
Hansford, Karl A., Reid, Robert C., Clark, Chris I., Tyndall, Joel D. A., Whitehouse, Michael W., Guthrie, Tom, McGeary, Ross P., Schafer, Karl, Martin, Jennifer L. and Fairlie, David P. (2003) D-Tyrosine as a chiral precusor to potent inhibitors of human nonpancreatic secretory phospholipase A(2) (IIa) with antiinflammatory activity. Chembiochem, 4 2-3: 181-185. doi:10.1002/cbic.200390029
Towards the cis-bromination of double bonds
Carman, Raymond M., Derbyshire, Roger P. C., Hansford, Karl A., Kadirvelraj, Renu and Robinson, Ward T. (2001) Towards the cis-bromination of double bonds. Australian Journal of Chemistry, 54 2: 117-126. doi:10.1071/CH01016
Halogenated terpenoids. XXXI * Tribromides from the bromination of various exocyclic olefins
Carman, Raymond M., Hansford, Karl A. and Kennard, Colin H. L. (2000) Halogenated terpenoids. XXXI * Tribromides from the bromination of various exocyclic olefins. Australian Journal of Chemistry, 53 5: 439-442.
Halogenated terpenoids. XXXI tribromides from the bromination of various exocyclic olefins
Carman, R. M., Hansford, K. A. and Kennard, C. H. L. (2000) Halogenated terpenoids. XXXI tribromides from the bromination of various exocyclic olefins. Australian Journal of Chemistry, 53 5: 439-442. doi:10.1071/CH00041
Halogenated Terpenoids. XXIX The 1-Bromo 1-Bromomethyl Cyclohexyl System
Brecknell, Douglas J., Carman, Raymond M., Edwards, Ross A., Hansford, Karl, Karoli, Tomislav and Robinson, Ward T. (1997) Halogenated Terpenoids. XXIX The 1-Bromo 1-Bromomethyl Cyclohexyl System. Australian Journal of Chemistry, 50 7: 689-700. doi:10.1071/C96188
Clark, C. I., Fairlie, D. P., Hansford, K., McGeary, R. P., Reid, R. C. and Stoermer, M. J. (2007). New amino acid derivatives useful for the treatment of inflammatory disease or condition e.g. rheumatic arthritis. .
Lipopeptide antibiotics for XDR Gram-negative infections
(2018–2020) NHMRC Development Grant
Novel membrane-targeted antibiotics against drug-resistant Gram-positive bacterial infections
(2016–2019) NHMRC Development Grant