I am a Research Fellow at the Institute for Molecular Bioscience at the University of Queensland, specialising in systems immunology, data mining, and artificial intelligence. I have made significant contributions to vaccine and biomarker discovery and to defining the molecular basis of host-pathogen immunity.
My academic background includes a Diploma in Physics from La Sapienza University in Italy (2005) and a Ph.D. in Molecular Pathogenesis and Immunology from the University of Perugia, Italy (2011). I have received training from several leading institutions, including Imperial College, LSHTM, the University of Oxford, the Wellcome Trust Sanger Institute, and QIMR Berghofer, where I developed a solid foundation in the analysis of multi-omics data. My work has led to the identification of several malaria vaccine candidates currently under evaluation in pre-clinical trials in a project funded by the National Foundation for Medical Research and Innovation. I recently received an NIH RO1 grant alongside PI Doolan to develop the first T cell-exclusive malaria vaccine.
My current research interests can be divided into five general themes:
1)System-based genomic approaches to inform the rational design of vaccines against complex human pathogens
2) Defining the molecular basis of immune heterogeneity between individuals using a system-based approach
2)Biomarker discovery for EBV-related cancers
3)Epigenetics and host immunity
4)Application of advanced data mining techniques in medical genomics
Journal Article: Evaluating the stability of host-reference gene expression and simultaneously quantifying parasite burden and host immune responses in murine malaria
Browne, Daniel J., Kelly, Ashton M., Brady, Jamie, Proietti, Carla, Sarathkumara, Yomani D., Pattinson, David J. and Doolan, Denise L. (2023). Evaluating the stability of host-reference gene expression and simultaneously quantifying parasite burden and host immune responses in murine malaria. Scientific Reports, 13 (1) 21071, 1-11. doi: 10.1038/s41598-023-48066-9
Journal Article: Comparative analysis of the humoral immune response to the EBV proteome across EBV-related malignancies
Argirion, Ilona, Pfeiffer, Ruth M., Proietti, Carla, Coghill, Anna E., Yu, Kelly J., Middeldorp, Jaap M., Sarathkumara, Yomani D., Hsu, Wan-Lun, Chien, Yin-Chu, Lou, Pei-Jen, Wang, Cheng-Ping, Rothman, Nathaniel, Lan, Qing, Chen, Chien-Jen, Mbulaiteye, Sam M., Jarrett, Ruth F., Glimelius, Ingrid, Smedby, Karin E., Hjalgrim, Henrik, Hildesheim, Allan, Doolan, Denise L. and Liu, Zhiwei (2023). Comparative analysis of the humoral immune response to the EBV proteome across EBV-related malignancies. Cancer Epidemiology, Biomarkers and Prevention, 32 (5), OF1-OF10. doi: 10.1158/1055-9965.epi-22-0452
Journal Article: Characterizing and correcting immune dysfunction in non-tuberculous mycobacterial disease
Ratnatunga, Champa N., Tungatt, Katie, Proietti, Carla, Halstrom, Sam, Holt, Michael R., Lutzky, Viviana P., Price, Patricia, Doolan, Denise L., Bell, Scott C., Field, Matt A., Kupz, Andreas, Thomson, Rachel M. and Miles, John J. (2022). Characterizing and correcting immune dysfunction in non-tuberculous mycobacterial disease. Frontiers in Immunology, 13 1047781, 1-20. doi: 10.3389/fimmu.2022.1047781
Effective Multiple Sclerosis diagnosis based on EBV proteome screening
(2024–2026) MS Research Australia Project Grant
UNDERSTANDING THE LINK BETWEEN EBV AND MULTIPLE SCLEROSIS
An opportunity exists for a PhD position in molecular immunology, where cutting-edge technologies will be applied to understand the molecular basis of the link between EBV and Multiple Sclerosis. Epstein-Barr virus (EBV) is the top identified causative agent of Multiple Sclerosis, but how this occurs is not known. This project aims to apply an innovative approach using proteome-wide screening of EBV to identify the subset of EBV proteins from the complete EBV proteome that triggers MS. It will compare responses in individuals with different stages of MS and apply sophisticated computational analytics to identify specific EBV proteins that predict MS disease. This EBV signature of MS could be translated into a clinic-friendly point-of-care test. If successful, this project could revolutionize the diagnosis and management of MS, providing patients with a quicker and more accurate diagnosis and enhanced quality of life.
Subject areas: Immunology, Molecular immunology, Systems biology, Multiple Sclerosis, Autoimmunity, EBV
Eligibility: Entry: Bachelor degree with Honours Class I (or equivalent via outstanding record of professional or research achievements) Experience/Background: laboratory-based experience in immunology, host-pathogen interactions, immune regulation and infectious diseases; excellent computer, communication, and organisational skills are required.
Supervisors:
Professor Denise Doolan & Dr Carla Proietti
MOLECULAR IMMUNOLOGY OF MALARIA
An opportunity exists for a PhD position in the molecular immunology of malaria. The focus of this project will be to apply cutting-edge technologies to understand the molecular basis of protective immunity to malaria. It will take advantage of controlled human infection models and as well as animal models to explore the mechanisms underlying protective immunity to malaria and immune responsiveness. Using a range of interdisciplinary approaches, including immune profiling, transcriptomics, proteomics, and small molecule characterization, the project aims to define the critical cells and signalling pathways required for protective immunity against malaria. It is anticipated that this research will have broad application to a wide range of infectious and chronic diseases, with important implications for vaccination.
Subject areas: Immunology, Molecular immunology, Systems biology, Vaccinology, Malaria
Eligibility: Entry: Bachelor degree with Honours Class I (or equivalent via outstanding record of professional or research achievements) Experience/Background: laboratory-based experience in immunology, host-pathogen interactions, immune regulation and infectious diseases; excellent computer, communication, and organisational skills are required.
Supervisors:
Professor Denise Doolan (IMB) & Dr Carla Proietti (IMB)
SYSTEMS IMMUNOLOGY AND MULTI-OMICS APPROACHES TO UNDERSTAND PROTECTIVE IMMUNITY TO HUMAN MALARIA
This PhD project aims to develop and apply computational approaches that integrate systems biology and molecular immunology to understand host-pathogen immunity and predict immune control of malaria. The project will utilise systems-based immunology and multi-omics approaches to profile the host immune response in controlled infection models of malaria at molecular, cellular, transcriptome and proteome-wide scale.
The overall aim will be to develop and apply omics-based technologies and computational tools, including network theory and machine learning, to integrate multiple high-dimensional datasets and reveal novel insights into host-pathogen immunity and predict immune responsiveness and parasite control. Modelling of large-scale existing datasets, including those generated by single-cell RNA-sequencing technologies, may also be a feature of this project. The opportunity to identify new knowledge and integrate this with experimental data produced by our laboratory will be instrumental to extending the impact of these bioinformatics analyses. This project will provide an opportunity to be at the forefront in cutting-edge technologies and advances in computational analysis of integrated high-dimensional omic data.
Methodologies: Bioinformatics, Machine Learning, Immunology, Systems Immunology, Systems Biology, Genomics/Proteomics/Transcriptomics, Molecular and Cell Biology, Statistics
Eligibility: Entry: BSc Honours Class I (or equivalent via outstanding record of professional or research achievements) Experience/Background: Experience with programming languages, mathematics, statistics and/or background in immunology and molecular sciences, with an interest in integrating the fields of immunology and bioinformatics.
Excellent computer, communication, and organisational skills are required. Forward thinking, innovation and creativity are encouraged.
Supervisors:
Professor Denise Doolan (IMB) & Dr Carla Proietti (IMB)
Associate Professor Jessica Mar (AIBN)
Browne, Daniel J., Kelly, Ashton M., Brady, Jamie, Proietti, Carla, Sarathkumara, Yomani D., Pattinson, David J. and Doolan, Denise L. (2023). Evaluating the stability of host-reference gene expression and simultaneously quantifying parasite burden and host immune responses in murine malaria. Scientific Reports, 13 (1) 21071, 1-11. doi: 10.1038/s41598-023-48066-9
Argirion, Ilona, Pfeiffer, Ruth M., Proietti, Carla, Coghill, Anna E., Yu, Kelly J., Middeldorp, Jaap M., Sarathkumara, Yomani D., Hsu, Wan-Lun, Chien, Yin-Chu, Lou, Pei-Jen, Wang, Cheng-Ping, Rothman, Nathaniel, Lan, Qing, Chen, Chien-Jen, Mbulaiteye, Sam M., Jarrett, Ruth F., Glimelius, Ingrid, Smedby, Karin E., Hjalgrim, Henrik, Hildesheim, Allan, Doolan, Denise L. and Liu, Zhiwei (2023). Comparative analysis of the humoral immune response to the EBV proteome across EBV-related malignancies. Cancer Epidemiology, Biomarkers and Prevention, 32 (5), OF1-OF10. doi: 10.1158/1055-9965.epi-22-0452
Characterizing and correcting immune dysfunction in non-tuberculous mycobacterial disease
Ratnatunga, Champa N., Tungatt, Katie, Proietti, Carla, Halstrom, Sam, Holt, Michael R., Lutzky, Viviana P., Price, Patricia, Doolan, Denise L., Bell, Scott C., Field, Matt A., Kupz, Andreas, Thomson, Rachel M. and Miles, John J. (2022). Characterizing and correcting immune dysfunction in non-tuberculous mycobacterial disease. Frontiers in Immunology, 13 1047781, 1-20. doi: 10.3389/fimmu.2022.1047781
Sarathkumara, Yomani D., Browne, Daniel J., Kelly, Ashton M., Pattinson, David J., Rush, Catherine M., Warner, Jeffrey, Proietti, Carla and Doolan, Denise L. (2022). The effect of tropical temperatures on the quality of RNA extracted from stabilized whole-blood samples. International Journal of Molecular Sciences, 23 (18) 10609, 1-15. doi: 10.3390/ijms231810609
Identifying Epstein-Barr virus peptide sequences associated with differential IgG antibody response
Coghill, Anna E., Fang, Jianwen, Liu, Zhiwei, Chen, Chien-Jen, Jarrett, Ruth F., Hjalgrim, Henrik, Proietti, Carla, Yu, Kelly J., Hsu, Wan-Lun, Lou, Pei-Jen, Wang, Chen-Ping, Zhao, Yingdong, Doolan, Denise L. and Hildesheim, Allan (2022). Identifying Epstein-Barr virus peptide sequences associated with differential IgG antibody response. International Journal of Infectious Diseases, 114, 65-71. doi: 10.1016/j.ijid.2021.10.054
Characterization of the humoral immune response to the EBV proteome in extranodal NK/T-cell lymphoma
Liu, Zhiwei, Sarathkumara, Yomani D., Chan, John K. C., Kwong, Yok-Lam, Lam, Tai Hing, Ip, Dennis Kai Ming, Chiu, Brian C. -H., Xu, Jun, Su, Yu-Chieh, Proietti, Carla, Cooper, Martha M., Yu, Kelly J., Bassig, Bryan, Liang, Raymond, Hu, Wei, Ji, Bu-Tian, Coghill, Anna E., Pfeiffer, Ruth M., Hildesheim, Allan, Rothman, Nathaniel, Doolan, Denise L. and Lan, Qing (2021). Characterization of the humoral immune response to the EBV proteome in extranodal NK/T-cell lymphoma. Scientific Reports, 11 (1) 23664, 1-8. doi: 10.1038/s41598-021-02788-w
Pearson, Mark S., Tedla, Bemnet A., Mekonnen, Gebeyaw G., Proietti, Carla, Becker, Luke, Nakajima, Rie, Jasinskas, Al, Doolan, Denise L., Amoah, Abena S., Knopp, Stefanie, Rollinson, David, Ali, Said M., Kabole, Fatma, Hokke, Cornelis H., Adegnika, Akim A., Field, Matt A., van Dam, Govert, Corstjens, Paul L. A. M., Mduluza, Takafira, Mutapi, Francisca, Oeuvray, Claude, Greco, Beatrice, Chaiyadet, Sujittra, Laha, Thewarach, Cai, Pengfei, McManus, Donald P., Bottazzi, Maria Elena, Felgner, Philip L., Sotillo, Javier and Loukas, Alex (2021). Immunomics-guided discovery of serum and urine antibodies for diagnosing urogenital schistosomiasis: a biomarker identification study. The Lancet Microbe, 2 (11), E617-E626. doi: 10.1016/s2666-5247(21)00150-6
Loiseau, Claire, Traore, Boubacar, Ongoiba, Aissata, Kayentao, Kassoum, Doumbo, Safiatou, Doumtabe, Didier, de Sousa, Karina P., Brady, Jamie L., Proietti, Carla, Crompton, Peter D. and Doolan, Denise L. (2021). Memory CD8+ T cell compartment associated with delayed onset of Plasmodium falciparum infection and better parasite control in sickle-cell trait children. Clinical and Translational Immunology, 10 (3) e1265, 1-12. doi: 10.1002/cti2.1265
Evaluation of the antibody response to the EBV proteome in EBV-associated classical Hodgkin lymphoma
Liu, Zhiwei, Jarrett, Ruth F, Hjalgrim, Henrik, Proietti, Carla, Chang, Ellen T., Smedby, Karin E., Yu, Kelly J., Lake, Annette, Troy, Sally, McAulay, Karen A., Pfeiffer, Ruth M., Adami, Hans-Olov, Glimelius, Bengt, Melbye, Mads, Hildesheim, Allan, Doolan, Denise L. and Coghill, Anna E. (2020). Evaluation of the antibody response to the EBV proteome in EBV-associated classical Hodgkin lymphoma. International Journal of Cancer, 147 (3), 608-618. doi: 10.1002/ijc.32741
Coghill, Anna E., Pfeiffer, Ruth M., Proietti, Carla, Hsu, Wan-Lun, Chien, Yin-Chu, Lekieffre, Lea, Krause, Lutz, Teng, Andy, Pablo, Jocelyn, Yu, Kelly J., Lou, Pei-Jen, Wang, Cheng-Ping, Liu, Zhiwei, Chen, Chien-Jen, Middeldorp, Jaap, Mulvenna, Jason, Bethony, Jeff, Hildesheim, Allan and Doolan, Denise L. (2020). Erratum: Correction: Identification of a Novel, EBV-based Antibody Risk Stratification Signature for Early Detection of Nasopharyngeal Carcinoma in Taiwan (Clinical cancer research : an official journal of the American Association for Cancer Research (2018) 24 6 (1305-1314)). Clinical Cancer Research, 26 (13), 3496-3496. doi: 10.1158/1078-0432.CCR-20-1828
Development and validation of serological markers for detecting recent Plasmodium vivax infection
Longley, Rhea J., White, Michael T., Takashima, Eizo, Brewster, Jessica, Morita, Masayuki, Harbers, Matthias, Obadia, Thomas, Robinson, Leanne J., Matsuura, Fumie, Liu, Zoe S. J., Li-Wai-Suen, Connie S. N., Tham, Wai-Hong, Healer, Julie, Huon, Christele, Chitnis, Chetan E., Nguitragool, Wang, Monteiro, Wuelton, Proietti, Carla, Doolan, Denise L., Siqueira, Andre M., Ding, Xavier C., Gonzalez, Iveth J., Kazura, James, Lacerda, Marcus, Sattabongkot, Jetsumon, Tsuboi, Takafumi and Mueller, Ivo (2020). Development and validation of serological markers for detecting recent Plasmodium vivax infection. Nature Medicine, 26 (5), 741-749+. doi: 10.1038/s41591-020-0841-4
Simon, Julia, Liu, Zhiwei, Brenner, Nicole, Yu, Kelly J., Hsu, Wan-Lun, Wang, Cheng-Ping, Chien, Yin-Chu, Coghill, Anna E., Chen, Chien-Jen, Butt, Julia, Proietti, Carla, Doolan, Denise L., Hildesheim, Allan and Waterboer, Tim (2020). Validation of an Epstein-Barr virus antibody risk stratification signature for nasopharyngeal carcinoma by use of multiplex serology. Journal of Clinical Microbiology, 58 (5) e00077-20, 1-9. doi: 10.1128/JCM.00077-20
Loiseau, Claire, Doumbo, Ogobara K., Traore, Boubacar, Brady, Jamie L., Proietti, Carla, Sousa, Karina P., Crompton, Peter D. and Doolan, Denise L. (2020). A novel population of memory‐activated natural killer cells associated with low parasitaemia in Plasmodium falciparum ‐exposed sickle‐cell trait children. Clinical and Translational Immunology, 9 (4) e1125, e1125. doi: 10.1002/cti2.1125
Proietti, Carla, Krause, Lutz, Trieu, Angela, Dodoo, Daniel, Gyan, Ben, Koram, Kwadwo A., Rogers, William O., Richie, Thomas L., Crompton, Peter D., Felgner, Philip L. and Doolan, Denise L. (2020). Immune signature against Plasmodium falciparum antigens predicts clinical immunity in distinct malaria endemic communities. Molecular and Cellular Proteomics, 19 (1), 101-113. doi: 10.1074/mcp.RA118.001256
Coghill, Anna E., Proietti, Carla, Liu, Zhiwei, Krause, Lutz, Bethony, Jeff, Prokunina-Olsson, Ludmila, Obajemu, Adeola, Nkrumah, Francis, Biggar, Robert J., Bhatia, Kishor, Hildesheim, Allan, Doolan, Denise L. and Mbulaiteye, Sam M. (2020). The association between the comprehensive Epstein–Barr virus serologic profile and endemic Burkitt lymphoma. Cancer Epidemiology Biomarkers and Prevention, 29 (1), 57-62. doi: 10.1158/1055-9965.EPI-19-0551
Tessema, Sofonias K., Nakajima, Rie, Jasinskas, Algis, Monk, Stephanie L., Lekieffre, Lea, Lin, Enmoore, Kiniboro, Benson, Proietti, Carla, Siba, Peter, Felgner, Philip L., Doolan, Denise L., Mueller, Ivo and Barry, Alyssa E. (2019). Protective immunity against severe malaria in children is associated with a limited repertoire of antibodies to conserved PfEMP1 variants. Cell Host & Microbe, 26 (5), 579-590+. doi: 10.1016/j.chom.2019.10.012
Subissi, Lorenzo, Kanoi, Bernard N., Balikagala, Betty, Egwang, Thomas G., Oguike, Mary, Verra, Federica, Proietti, Carla, Bousema, Teun, Drakeley, Chris J. and Sepulveda, Nuno (2019). Plasmodium malariae and Plasmodium ovale infections and their association with common red blood cell polymorphisms in a highly endemic area of Uganda. Transactions of the Royal Society of Tropical Medicine and Hygiene, 113 (7), 370-378. doi: 10.1093/trstmh/trz015
Liu, Zhiwei, Coghill, Anna E., Pfeiffer, Ruth M., Proietti, Carla, Hsu, Wan-Lun, Chien, Yin-Chu, Lekieffre, Lea, Krause, Lutz, Yu, Kelly J., Lou, Pei-Jen, Wang, Cheng-Ping, Mulvenna, Jason, Middeldorp, Jaap M., Bethony, Jeff, Chen, Chien-Jen, Doolan, Denise L. and Hildesheim, Allan (2018). Patterns of interindividual variability in the antibody repertoire targeting proteins across the Epstein-Barr virus proteome. The Journal of Infectious Diseases, 217 (12), 1923-1931. doi: 10.1093/infdis/jiy122
Coghill, Anna E., Pfeiffer, Ruth M., Proietti, Carla, Hsu, Wan-Lun, Chien, Yin-Chu, Lekieffre, Lea, Krause, Lutz, Teng, Andy, Pablo, Jocelyn, Yu, Kelly J., Lou, Pei-Jen, Wang, Cheng-Ping, Liu, Zhiwei, Chen, Chien-Jen, Middeldorp, Jaap, Mulvenna, Jason, Bethony, Jeff, Hildesheim, Allan and Doolan, Denise L. (2018). Identification of a Novel, EBV-based antibody risk stratification signature for early detection of nasopharyngeal carcinoma in Taiwan. Clinical Cancer Research, 24 (6), 1305-1314. doi: 10.1158/1078-0432.CCR-17-1929
Calypso: a user-friendly web-server for mining and visualizing microbiome-environment interactions
Zakrzewski, Martha, Proietti, Carla, Ellis, Jonathan J., Hasan, Shihab, Brion, Marie-Jo, Berger, Bernard and Krause, Lutz (2017). Calypso: a user-friendly web-server for mining and visualizing microbiome-environment interactions. Bioinformatics, 33 (5), 782-783. doi: 10.1093/bioinformatics/btw725
Proietti, Carla, Zakrzewski, Martha, Watkins, Thomas S., Berger, Bernard, Hasan, Shihab, Ratnatunga, Champa N., Brion, Marie-Jo, Crompton, Peter D., Miles, John J., Doolan, Denise L. and Krause, Lutz (2016). Mining, visualizing and comparing multidimensional biomolecular data using the Genomics Data Miner (GMine) web-server. Scientific Reports, 6 (1) 38178. doi: 10.1038/srep38178
The case for a rational genome-based vaccine against malaria
Proietti, Carla and Doolan, Denise L. (2015). The case for a rational genome-based vaccine against malaria. Frontiers in Microbiology, 5 (DEC) 741, 1-19. doi: 10.3389/fmicb.2014.00741
Genome-based vaccine design: The promise for malaria and other infectious diseases
Doolan, Denise L., Apte, Simon H. and Proietti, Carla (2014). Genome-based vaccine design: The promise for malaria and other infectious diseases. International Journal for Parasitology, 44 (12), 901-913. doi: 10.1016/j.ijpara.2014.07.010
Proietti, C., Verra, F., Bretscher, M. T., Stone, W., Kanoi, B. N., Balikagala, B., Egwang, T. G., Corran, P., Ronca, R., Arca, B., Riley, E. M., Crisanti, A., Drakeley, C. and Bousema, T. (2013). Influence of infection on malaria-specific antibody dynamics in a cohort exposed to intense malaria transmission in northern Uganda. Parasite Immunology, 35 (5-6), 164-173. doi: 10.1111/pim.12031
Continuing intense malaria transmission in northern Uganda
Proietti, Carla, Pettinato, Davide D., Kanoi, Bernard N., Ntege, Edward, Crisanti, Andrea, Riley, Eleanor M., Egwang, Thomas G., Drakeley, Chris and Bousema, Teun (2011). Continuing intense malaria transmission in northern Uganda. American Journal of Tropical Medicine and Hygiene, 84 (5), 830-837. doi: 10.4269/ajtmh.2011.10-0498
Di Cristina, Manlio, Marocco, Daniela, Galizi, Roberto, Proietti, Carla, Spaccapelo, Roberta and Crisanti, Andrea (2008). Temporal and spatial distribution of Toxoplasma gondii differentiation into bradyzoites and tissue cyst formation in vivo. Infection and Immunity, 76 (8), 3491-3501. doi: 10.1128/IAI.00254-08
Rachini, Anna, Pietrella, Donatella, Lupo, Patrizia, Torosantucci, Antonella, Chiani, Paola, Bromuro, Carla, Proietti, Carla, Bistoni, Francesco, Cassone, Antonio and Vecchiarelli, Anna (2007). An anti-β-glucan monoclonal antibody inhibits growth and capsule formation of Cryptococcus neofonnans in vitro and exerts therapeutic, anticryptococcal activity in vivo. Infection and Immunity, 75 (11), 5085-5094. doi: 10.1128/IAI.00278-07
Bonincontro, Adalberto, La Mesa, Camillo, Proietti, Carla and Risuleo, Gianfranco (2007). A biophysical investigation on the binding and controlled DNA release in a cetyltrimethylammonium bromide-sodium octyl sulfate cat-anionic vesicle system. Biomacromolecules, 8 (6), 1824-1829. doi: 10.1021/bm0612079
Dissecting T cell or antibody immunodominance in a complex host-pathogen system
Proietti, Carla, Krause, Lutz, Roddick, Joanne, Trieu, Angela and Doolan, Denise L. (2012). Dissecting T cell or antibody immunodominance in a complex host-pathogen system. Challenges in Malaria Research, Basel, Switzerland, 10-12 October 2012. London, United Kingdom: BioMed Central. doi: 10.1186/1475-2875-11-s1-o23
Effective Multiple Sclerosis diagnosis based on EBV proteome screening
(2024–2026) MS Research Australia Project Grant
Note for students: The possible research projects listed on this page may not be comprehensive or up to date. Always feel free to contact the staff for more information, and also with your own research ideas.
UNDERSTANDING THE LINK BETWEEN EBV AND MULTIPLE SCLEROSIS
An opportunity exists for a PhD position in molecular immunology, where cutting-edge technologies will be applied to understand the molecular basis of the link between EBV and Multiple Sclerosis. Epstein-Barr virus (EBV) is the top identified causative agent of Multiple Sclerosis, but how this occurs is not known. This project aims to apply an innovative approach using proteome-wide screening of EBV to identify the subset of EBV proteins from the complete EBV proteome that triggers MS. It will compare responses in individuals with different stages of MS and apply sophisticated computational analytics to identify specific EBV proteins that predict MS disease. This EBV signature of MS could be translated into a clinic-friendly point-of-care test. If successful, this project could revolutionize the diagnosis and management of MS, providing patients with a quicker and more accurate diagnosis and enhanced quality of life.
Subject areas: Immunology, Molecular immunology, Systems biology, Multiple Sclerosis, Autoimmunity, EBV
Eligibility: Entry: Bachelor degree with Honours Class I (or equivalent via outstanding record of professional or research achievements) Experience/Background: laboratory-based experience in immunology, host-pathogen interactions, immune regulation and infectious diseases; excellent computer, communication, and organisational skills are required.
Supervisors:
Professor Denise Doolan & Dr Carla Proietti
MOLECULAR IMMUNOLOGY OF MALARIA
An opportunity exists for a PhD position in the molecular immunology of malaria. The focus of this project will be to apply cutting-edge technologies to understand the molecular basis of protective immunity to malaria. It will take advantage of controlled human infection models and as well as animal models to explore the mechanisms underlying protective immunity to malaria and immune responsiveness. Using a range of interdisciplinary approaches, including immune profiling, transcriptomics, proteomics, and small molecule characterization, the project aims to define the critical cells and signalling pathways required for protective immunity against malaria. It is anticipated that this research will have broad application to a wide range of infectious and chronic diseases, with important implications for vaccination.
Subject areas: Immunology, Molecular immunology, Systems biology, Vaccinology, Malaria
Eligibility: Entry: Bachelor degree with Honours Class I (or equivalent via outstanding record of professional or research achievements) Experience/Background: laboratory-based experience in immunology, host-pathogen interactions, immune regulation and infectious diseases; excellent computer, communication, and organisational skills are required.
Supervisors:
Professor Denise Doolan (IMB) & Dr Carla Proietti (IMB)
SYSTEMS IMMUNOLOGY AND MULTI-OMICS APPROACHES TO UNDERSTAND PROTECTIVE IMMUNITY TO HUMAN MALARIA
This PhD project aims to develop and apply computational approaches that integrate systems biology and molecular immunology to understand host-pathogen immunity and predict immune control of malaria. The project will utilise systems-based immunology and multi-omics approaches to profile the host immune response in controlled infection models of malaria at molecular, cellular, transcriptome and proteome-wide scale.
The overall aim will be to develop and apply omics-based technologies and computational tools, including network theory and machine learning, to integrate multiple high-dimensional datasets and reveal novel insights into host-pathogen immunity and predict immune responsiveness and parasite control. Modelling of large-scale existing datasets, including those generated by single-cell RNA-sequencing technologies, may also be a feature of this project. The opportunity to identify new knowledge and integrate this with experimental data produced by our laboratory will be instrumental to extending the impact of these bioinformatics analyses. This project will provide an opportunity to be at the forefront in cutting-edge technologies and advances in computational analysis of integrated high-dimensional omic data.
Methodologies: Bioinformatics, Machine Learning, Immunology, Systems Immunology, Systems Biology, Genomics/Proteomics/Transcriptomics, Molecular and Cell Biology, Statistics
Eligibility: Entry: BSc Honours Class I (or equivalent via outstanding record of professional or research achievements) Experience/Background: Experience with programming languages, mathematics, statistics and/or background in immunology and molecular sciences, with an interest in integrating the fields of immunology and bioinformatics.
Excellent computer, communication, and organisational skills are required. Forward thinking, innovation and creativity are encouraged.
Supervisors:
Professor Denise Doolan (IMB) & Dr Carla Proietti (IMB)
Associate Professor Jessica Mar (AIBN)