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Professor Steven Lane

ATH - Professor

Royal Brisbane Clinical Unit
Faculty of Medicine
s.lane@uq.edu.au

Overview

Publications

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Publications

Journal Article

  • Autophagy prevents graft failure during murine Graft versus Host Disease

    Lineburg, Katie E, Leveque-El Mouttie, Lucie, Hunter, Christopher R., Le Texier, Laeitia, McGirr, Crystal, Teal, Bianca, Blazar, Bruce R., Lane, Steven W, Hill, Geoffrey R, Levesque, Jean-Pierre and MacDonald, Kelli P.A. (2024). Autophagy prevents graft failure during murine Graft versus Host Disease. Blood Advances. doi: 10.1182/bloodadvances.2023010972

  • <i>Trp53</i>-Loss in Hematopoietic Stem Cells Drives the Evolutionary Process of Leukemic Transformation in a <i>Jak2</i> V617F-Driven Myeloproliferative Neoplasms Mouse Model

    Zhang, Ranran, Janardhanan, Yashaswini, Haldar, Rohit, Cooper, Leanne, Jaquelin, Sebastien, Straube, Jasmin, Bywater, Megan and Lane, Steven W (2023). Trp53-Loss in Hematopoietic Stem Cells Drives the Evolutionary Process of Leukemic Transformation in a Jak2 V617F-Driven Myeloproliferative Neoplasms Mouse Model. Blood, 142 (Supplement 1), 4522-4522. doi: 10.1182/blood-2023-188150

  • Clearing the way for new therapies in clonal hematopoiesis

    Ling, Victoria Y. and Lane, Steven W. (2023). Clearing the way for new therapies in clonal hematopoiesis. Blood Advances, 7 (22), 7151-7152. doi: 10.1182/bloodadvances.2023011728

  • Cytokine and Mutation Profiling Reveal Patterns of Complete Remission Rates with Lenzilumab Combination Therapy in Chronic Myelomonocytic Leukemia

    Kutyna, Monika, Kamel, Maha M, Ross, David M., Yong, Agnes S. M., Fong, Chun Yew, Thompson-Peach, Chloe, Lane, Steven W., Yeung, David T, Hughes, Timothy P, Hiwase, Devendra and Thomas, Daniel (2023). Cytokine and Mutation Profiling Reveal Patterns of Complete Remission Rates with Lenzilumab Combination Therapy in Chronic Myelomonocytic Leukemia. Blood, 142 (Supplement 1), 1852-1852. doi: 10.1182/blood-2023-179706

  • Early Generation Telomerase Deficient Mice to Investigate Clonal Hematopoiesis in Aging

    Bruedigam, Claudia, Porter, Amy H, Straube, Jasmin, Cheng, Guidan, Heidel, Florian H and Lane, Steven W (2023). Early Generation Telomerase Deficient Mice to Investigate Clonal Hematopoiesis in Aging. Blood, 142 (Supplement 1), 5598-5598. doi: 10.1182/blood-2023-191246

  • Excellent Early and Major Molecular Responses Observed with Asciminib Treatment for CP-CML: Results from the ALLG CML13 Ascend-CML Study

    Yeung, David T, Shanmuganathan, Naranie, Reynolds, John, Branford, Susan, Walia, Mannu, Yong, Agnes S. M., Shortt, Jake, Burbury, Kate, Chee, Lynette C.Y., Viiala, Nick, Cunningham, Ilona, Ross, David M., D'Souza, Alwyn Bernard, Wright, Matthew P.F., Harrup, Rosemary Anne, Forsyth, Cecily, Filshie, Robin, Browett, Peter J., Lane, Steven W., Grove, Carolyn, Grigg, Andrew P, Hughes, Timothy P and ALLG, on Behalf Of The (2023). Excellent Early and Major Molecular Responses Observed with Asciminib Treatment for CP-CML: Results from the ALLG CML13 Ascend-CML Study. Blood, 142 (Supplement 1), 865-865. doi: 10.1182/blood-2023-172583

  • Lenzilumab in Addition to Azacitidine Improves Complete Response Rates in Chronic Myelomonocytic Leukemia

    Hiwase, Devendra, Ross, David M., Lane, Steven W., Thompson-Peach, Chloe, Fong, Chun Yew, Yong, Agnes S. M., Yeung, David T, Hughes, Timothy P and Thomas, Daniel (2023). Lenzilumab in Addition to Azacitidine Improves Complete Response Rates in Chronic Myelomonocytic Leukemia. Blood, 142 (Supplement 1), 1847-1847. doi: 10.1182/blood-2023-179688

  • Suppression of <i>KRAS</i> and <i>CBL</i> Mutations and Hematological Improvement By Lenzilumab and Azacitidine Treatment in Proliferative Chronic Myelomonocytic Leukemia

    Kamel, Maha M, Kutyna, Monika, Ross, David M., Lane, Steven W., Thompson-Peach, Chloe, Fong, Chun Yew, Yong, Agnes S. M., Yeung, David T, Hughes, Timothy P, Hiwase, Devendra and Thomas, Daniel (2023). Suppression of KRAS and CBL Mutations and Hematological Improvement By Lenzilumab and Azacitidine Treatment in Proliferative Chronic Myelomonocytic Leukemia. Blood, 142 (Supplement 1), 3223-3223. doi: 10.1182/blood-2023-188340

  • Imetelstat-mediated alterations in fatty acid metabolism to induce ferroptosis as a therapeutic strategy for acute myeloid leukemia

    Bruedigam, Claudia, Porter, Amy H., Song, Axia, Vroeg in de Wei, Gerjanne, Stoll, Thomas, Straube, Jasmin, Cooper, Leanne, Cheng, Guidan, Kahl, Vivian F. S., Sobinoff, Alexander P., Ling, Victoria Y., Jebaraj, Billy Michael Chelliah, Janardhanan, Yashaswini, Haldar, Rohit, Bray, Laura J., Bullinger, Lars, Heidel, Florian H., Kennedy, Glen A., Hill, Michelle M., Pickett, Hilda A., Abdel-Wahab, Omar, Hartel, Gunter and Lane, Steven W. (2023). Imetelstat-mediated alterations in fatty acid metabolism to induce ferroptosis as a therapeutic strategy for acute myeloid leukemia. Nature Cancer, 5 (1), 47-65. doi: 10.1038/s43018-023-00653-5

  • Genome-wide Transcription Factor binding maps reveal cell-specific changes in the regulatory architecture of human HSPC

    Subramanian, Shruthi, Thoms, Julie A I, Huang, Yizhou, Cornejo Paramo, Carina Paola, Koch, Forrest Charles, Jacquelin, Sebastien, Shen, Sylvie, Song, Emma, Joshi, Swapna, Brownlee, Christopher Peter, Woll, Petter S., Chacon-Fajardo, Diego, Beck, Dominik, Curtis, David J, Yehson, Kenneth, Antonenas, Vicki, O'Brien, Tracey, Trickett, Annette, Powell, Jason A., Lewis, Ian D, Pitson, Stuart M, Gandhi, Maher K., Lane, Steven W, Vafaee, Fatemeh, Wong, Emily, Gottgens, Berthold, Rokny, Hamid, Wong, Jason Wing Hon and Pimanda, John E (2023). Genome-wide Transcription Factor binding maps reveal cell-specific changes in the regulatory architecture of human HSPC. Blood Journal, 142 (17), 1448-1462. doi: 10.1182/blood.2023021120

  • Cell fate determinant Llgl1 is required for propagation of acute myeloid leukemia

    Eifert, Theresa, Hsu, Chen-Jen, Becker, Alicia L., Graessle, Sarah, Horne, Arik, Bemmann, Franziska, Zhang, Qirui, Heuser, Michael, Vasioukhin, Valeri, Scholl, Sebastian, Hochhaus, Andreas, Siegerist, Florian, Endlich, Nicole, Bullinger, Lars, Lane, Steven W., Haas, Simon, Schnoeder, Tina M. and Heidel, Florian H. (2023). Cell fate determinant Llgl1 is required for propagation of acute myeloid leukemia. Leukemia, 37 (10), 2027-2035. doi: 10.1038/s41375-023-02005-9

  • The TRIM31-paradox: an unexpected benefit for leukemia stem cells

    Straube, Jasmin and Lane, Steven W. (2023). The TRIM31-paradox: an unexpected benefit for leukemia stem cells. Haematologica, 108 (8), 1982-1983. doi: 10.3324/haematol.2022.282622

  • Characteristics and outcomes of patients with acute promyelocytic leukemia and extreme hyperleukocytosis at presentation

    Iland, Harry J, Russell, Nigel H., Dillon, Richard, Schuh, Andre C., Tedjaseputra, Aditya, Wei, Andrew H., Khwaja, Asim, Knapper, Steven, Lane, Steven W, Reynolds, John, McMullin, Mary Frances Frances, Martin, Annalise Maria, Tan, Peter, Taussig, David Christopher C, Wong, Anny, Taper, John M, Fraga, Christina, Kelly, Richard, Tawana, Kiran, Mehta, Priyanka, Mina, Alain, Altman, Jessica K., Mølle, Ingolf, Tauro, Sudhir and Tholouli, Eleni (2023). Characteristics and outcomes of patients with acute promyelocytic leukemia and extreme hyperleukocytosis at presentation. Blood Advances, 7 (11), 2580-2585. doi: 10.1182/bloodadvances.2022007126

  • Shelter from the cytokine storm in myelofibrosis

    Lane, Steven W. (2023). Shelter from the cytokine storm in myelofibrosis. Blood, 141 (20), 2415-2416. doi: 10.1182/blood.2023019779

  • Oncogenic drivers dictate immune control of acute myeloid leukemia

    Austin, Rebecca J., Straube, Jasmin, Halder, Rohit, Janardhanan, Yashaswini, Bruedigam, Claudia, Witkowski, Matthew, Cooper, Leanne, Porter, Amy, Braun, Matthias, Souza-Fonseca-Guimaraes, Fernando, Minnie, Simone A., Cooper, Emily, Jacquelin, Sebastien, Song, Axia, Bald, Tobias, Nakamura, Kyohei, Hill, Geoffrey R., Aifantis, Iannis, Lane, Steven W. and Bywater, Megan J. (2023). Oncogenic drivers dictate immune control of acute myeloid leukemia. Nature Communications, 14 (1) 2155, 1-14. doi: 10.1038/s41467-023-37592-9

  • Cre recombinase expression cooperates with homozygous FLT3 internal tandem duplication knockin mouse model to induce acute myeloid leukemia

    Straube, Jasmin, Eifert, Theresa, Vu, Therese, Janardhanan, Yashaswini, Haldar, Rohit, von Eyss, Björn, Cooper, Leanne, Bruedigam, Claudia, Ling, Victoria Y., Cooper, Emily, Patch, Ann-Marie, Bullinger, Lars, Schnoeder, Tina M., Bywater, Megan, Heidel, Florian H. and Lane, Steven W. (2023). Cre recombinase expression cooperates with homozygous FLT3 internal tandem duplication knockin mouse model to induce acute myeloid leukemia. Leukemia, 37 (4), 741-750. doi: 10.1038/s41375-023-01832-0

  • Real world molecular characterisation and clonal evolution of acute myeloid leukaemia reveals therapeutic opportunities and challenges

    Nelles, Ricky, Seymour, Louise, Richmond, Joshua and Lane, Steven (2023). Real world molecular characterisation and clonal evolution of acute myeloid leukaemia reveals therapeutic opportunities and challenges. Pathology, 55 (1), 64-70. doi: 10.1016/j.pathol.2022.07.019

  • t(15;17) in acute promyelocytic leukemia

    Ling, Victoria Y. and Lane, Steven W. (2023). t(15;17) in acute promyelocytic leukemia. Haematologica, 108 (2), 295-296. doi: 10.3324/haematol.2022.282577

  • 2012 – IMMUNOPROTEASOME FUNCTION MAINTAINS ONCOGENIC GENE EXPRESSION IN KMT2A-COMPLEX DRIVEN LEUKEMIA

    Heidel, Florian, Tubio-Santamaria, Nuria, Jayavelu, Ashok Kumar, Schnoeder, Tina, Eifert, Theresa, Hsu, Chen-Jen, Perner, Florian, Zhang, Qirui, Wenge, Daniela, Hansen, Fynn, jyotsana, Nidhi, Lane, Steven, von Eyss, Björn, Deshpande, Aniruddha, Kühn, Michael, Schwaller, Jürg, Ebstein, Frederic, Krüger, Elke, Hochhaus, Andreas, Heuser, Michael, Ori, alessandro, Mann, Matthias and Armstrong, Scott (2023). 2012 – IMMUNOPROTEASOME FUNCTION MAINTAINS ONCOGENIC GENE EXPRESSION IN KMT2A-COMPLEX DRIVEN LEUKEMIA. Experimental Hematology, 124, S42. doi: 10.1016/j.exphem.2023.06.049

  • Targeting cell cycle and apoptosis to overcome chemotherapy resistance in acute myeloid leukemia

    Ling, Victoria Y., Straube, Jasmin, Godfrey, William, Haldar, Rohit, Janardhanan, Yashaswini, Cooper, Leanne, Bruedigam, Claudia, Cooper, Emily, Tavakoli Shirazi, Paniz, Jacquelin, Sebastien, Tey, Siok-Keen, Baell, Jonathan, Huang, Fei, Jin, Jianwen, Zhao, Yichao, Bullinger, Lars, Bywater, Megan J. and Lane, Steven W. (2023). Targeting cell cycle and apoptosis to overcome chemotherapy resistance in acute myeloid leukemia. Leukemia, 37 (1), 143-153. doi: 10.1038/s41375-022-01755-2

  • Depletion of exhausted alloreactive T cells enables targeting of stem-like memory T cells to generate tumor-specific immunity

    Minnie, Simone A., Waltner, Olivia G., Ensbey, Kathleen S., Nemychenkov, Nicole S., Schmidt, Christine R., Bhise, Shruti S., Legg, Samuel R. W., Campoy, Gabriela, Samson, Luke D., Kuns, Rachel D., Zhou, Ting, Huck, John D., Vuckovic, Slavica, Zamora, Danniel, Yeh, Albert, Spencer, Andrew, Koyama, Motoko, Markey, Kate A., Lane, Steven W., Boeckh, Michael, Ring, Aaron M., Furlan, Scott N. and Hill, Geoffrey R. (2022). Depletion of exhausted alloreactive T cells enables targeting of stem-like memory T cells to generate tumor-specific immunity. Science Immunology, 7 (76) eabo3420, 1-18. doi: 10.1126/sciimmunol.abo3420

  • Paving the way to improve therapy for Myeloproliferative Neoplasms

    Bywater, Megan and Lane, Steven W. (2022). Paving the way to improve therapy for Myeloproliferative Neoplasms. Nature Communications, 13 (1) 5025. doi: 10.1038/s41467-022-32694-2

  • Epigenetic activation of Plasmacytoid DCs drives IFNAR-dependent therapeutic differentiation of AML

    Salmon, Jessica M., Todorovski, Izabela, Stanley, Kym L., Bruedigam, Claudia, Kearney, Conor J., Martelotto, Luciano G., Rossello, Fernando, Semple, Timothy, Arnau, Gisela Mir, Zethoven, Magnus, Bots, Michael, Bjelosevic, Stefan, Cluse, Leonie A., Fraser, Peter J., Litalien, Veronique, Vidacs, Eva, McArthur, Kate, Matthews, Antony Y., Gressier, Elise, De Weerd, Nicole A., Lichte, Jens, Kelly, Madison J., Hogg, Simon J., Hertzog, Paul J., Kats, Lev M., Vervoort, Stephin J., De Carvalho, Daniel D., Scheu, Stefanie, Bedoui, Sammy ... Johnstone, Ricky W. (2022). Epigenetic activation of Plasmacytoid DCs drives IFNAR-dependent therapeutic differentiation of AML. Cancer Discovery, 12 (6), 1560-1579. doi: 10.1158/2159-8290.CD-20-1145

  • Panel-based gene testing in myelodysplastic/myeloproliferative neoplasm overlap syndromes: Australasian Leukaemia and Lymphoma Group (ALLG) consensus statement

    Enjeti, Anoop K., Agarwal, Rishu, Blombery, Piers, Chee, Lynette, Chua, Chong Chyn, Grigg, Andrew, Hamad, Nada, Iland, Harry, Lane, Steven, Perkins, Andrew, Singhal, Deepak, Tate, Courtney, Tiong, Ing Soo and Ross, David M. (2022). Panel-based gene testing in myelodysplastic/myeloproliferative neoplasm overlap syndromes: Australasian Leukaemia and Lymphoma Group (ALLG) consensus statement. Pathology, 54 (4), 389-398. doi: 10.1016/j.pathol.2022.03.002

  • Better the cure you know: why patients with AML ≥60 years of age should be offered early allogeneic stem cell transplantation

    Tey, Siok-Keen and Lane, Steven W (2022). Better the cure you know: why patients with AML ≥60 years of age should be offered early allogeneic stem cell transplantation. Blood Advances, 6 (5), 1619-1622. doi: 10.1182/bloodadvances.2021004829

  • PLCG1 is required for AML1-ETO leukemia stem cell self-renewal

    Schnoeder, Tina M., Schwarzer, Adrian, Jayavelu, Ashok Kumar, Hsu, Chen-Jen, Kirkpatrick, Joanna, Döhner, Konstanze, Perner, Florian, Eifert, Theresa, Huber, Nicolas, Arreba-Tutusaus, Patricia, Dolnik, Anna, Assi, Salam A, Nafria, Monica, Jiang, Lu, Dai, Yu-Ting, Chen, Zhu, Chen, Sai-Juan, Kellaway, Sophie G., Ptasinska, Anetta, Ng, Elizabeth S., Stanley, Edouard G., Elefanty, Andrew G., Buschbeck, Marcus, Bierhoff, Holger, Brodt, Steffen, Matziolis, Georg, Fischer, Klaus-Dieter, Hochhaus, Andreas, Chen, Chun-Wei ... Heidel, Florian (2022). PLCG1 is required for AML1-ETO leukemia stem cell self-renewal. Blood, 139 (7), 1080-1097. doi: 10.1182/blood.2021012778

  • Optimizing DNA hypomethylating therapy in acute myeloid leukemia and myelodysplastic syndromes

    Straube, Jasmin, Lane, Steven W. and Vu, Therese (2021). Optimizing DNA hypomethylating therapy in acute myeloid leukemia and myelodysplastic syndromes. BioEssays, 43 (10) 2100125, 1-14. doi: 10.1002/bies.202100125

  • Expression of CD49f defines subsets of human regulatory T cells with divergent transcriptional landscape and function that correlate with ulcerative colitis disease activity

    Weerakoon, Harshi, Straube, Jasmin, Lineburg, Katie, Cooper, Leanne, Lane, Steven, Smith, Corey, Alabbas, Saleh, Begun, Jakob, Miles, John J., Hill, Michelle M. and Lepletier, Ailin (2021). Expression of CD49f defines subsets of human regulatory T cells with divergent transcriptional landscape and function that correlate with ulcerative colitis disease activity. Clinical and Translational Immunology, 10 (9) e1334, e1334. doi: 10.1002/cti2.1334

  • Intact TP-53 function is essential for sustaining durable responses to BH3-mimetic drugs in leukemias

    Thijssen, Rachel, Diepstraten, Sarah T., Moujalled, Donia, Chew, Edward, Flensburg, Christoffer, Shi, Melissa X., Dengler, Michael A., Litalien, Veronique, MacRaild, Sarah, Chen, Maoshan, Anstee, Natasha S., Reljić, Boris, Gabriel, Sarah S., Djajawi, Tirta M., Riffkin, Chris D., Aubrey, Brandon J., Chang, Catherine, Tai, Lin, Xu, Zhen, Morley, Thomas, Pomilio, Giovanna, Bruedigam, Claudia, Kallies, Axel, Stroud, David A., Bajel, Ashish, Kluck, Ruth M., Lane, Steven W., Schoumacher, Marie, Banquet, Sébastien ... Wei, Andrew H. (2021). Intact TP-53 function is essential for sustaining durable responses to BH3-mimetic drugs in leukemias. Blood, 137 (20), 2721-2735. doi: 10.1182/blood.2020010167

  • IFN-λ therapy prevents severe gastrointestinal graft-versus-host disease

    Henden, Andrea S., Koyama, Motoko, Robb, Renee J., Forero, Adriana, Kuns, Rachel D., Chang, Karshing, Ensbey, Kathleen S., Varelias, Antiopi, Kazakoff, Stephen H., Waddell, Nicole, Clouston, Andrew D., Giri, Rabina, Begun, Jakob, Blazar, Bruce R., Degli-Esposti, Mariapia A., Kotenko, Sergei V., Lane, Steven W., Bowerman, Kate L., Savan, Ram, Hugenholtz, Philip, Gartlan, Kate H. and Hill, Geoffrey R. (2021). IFN-λ therapy prevents severe gastrointestinal graft-versus-host disease. Blood, 138 (8), 722-737. doi: 10.1182/blood.2020006375

  • Myeloid somatic mutation panel testing in myeloproliferative neoplasms

    Ross, David M., Thomson, Candice, Hamad, Nada, Lane, Steven W., Manos, Kate, Grigg, Andrew P., Guo, Belinda, Erber, Wendy N., Scott, Ashleigh, Viiala, Nick, Chee, Lynette, Latimer, Maya, Tate, Courtney, Grove, Carolyn, Perkins, Andrew C. and Blombery, Piers (2021). Myeloid somatic mutation panel testing in myeloproliferative neoplasms. Pathology, 53 (3), 339-348. doi: 10.1016/j.pathol.2021.01.003

  • A knockout combination for MPN stem cells

    Bywater, Megan and Lane, Steven W. (2021). A knockout combination for MPN stem cells. Journal of Experimental Medicine, 218 (2) e20201884. doi: 10.1084/JEM.20201884

  • Intravascular large B-cell lymphoma presenting with extensive pulmonary embolism

    Wong, Philip, Chambers, Daniel, Godbolt, David and Lane, Steven W. (2021). Intravascular large B-cell lymphoma presenting with extensive pulmonary embolism. British Journal of Haematology, 192 (4), 677-677. doi: 10.1111/bjh.17182

  • Splicing factor YBX1 mediates persistence of JAK2-mutated neoplasms

    Jayavelu, Ashok Kumar, Schnöder, Tina M., Perner, Florian, Herzog, Carolin, Meiler, Arno, Krishnamoorthy, Gurumoorthy, Huber, Nicolas, Mohr, Juliane, Edelmann-Stephan, Bärbel, Austin, Rebecca, Brandt, Sabine, Palandri, Francesca, Schröder, Nicolas, Isermann, Berend, Edlich, Frank, Sinha, Amit U., Ungelenk, Martin, Hübner, Christian A., Zeiser, Robert, Rahmig, Susann, Waskow, Claudia, Coldham, Iain, Ernst, Thomas, Hochhaus, Andreas, Jilg, Stefanie, Jost, Philipp J., Mullally, Ann, Bullinger, Lars, Mertens, Peter R. ... Heidel, Florian H. (2020). Splicing factor YBX1 mediates persistence of JAK2-mutated neoplasms. Nature, 588 (7836), 157-163. doi: 10.1038/s41586-020-2968-3

  • Murine models of myelofibrosis

    Jacquelin, Sebastien, Kramer, Frederike, Mullally, Ann and Lane, Steven W. (2020). Murine models of myelofibrosis. Cancers, 12 (9) 2381, 1-22. doi: 10.3390/cancers12092381

  • MPN: The Molecular Drivers of Disease Initiation, Progression and Transformation and their Effect on Treatment

    Grabek, Julian, Straube, Jasmin, Bywater, Megan and Lane, Steven W. (2020). MPN: The Molecular Drivers of Disease Initiation, Progression and Transformation and their Effect on Treatment. Cells, 9 (8) 1912. doi: 10.3390/cells9081901

  • Hematopoietic stem and progenitor cell-restricted Cdx2 expression induces transformation to myelodysplasia and acute leukemia

    Vu, Therese, Straube, Jasmin, Porter, Amy H., Bywater, Megan, Song, Axia, Ling, Victoria, Cooper, Leanne, Pali, Gabor, Bruedigam, Claudia, Jacquelin, Sebastien, Green, Joanne, Magor, Graham, Perkins, Andrew, Chalk, Alistair M., Walkley, Carl R., Heidel, Florian H., Mukhopadhyay, Pamela, Cloonan, Nicole, Gröschel, Stefan, Mallm, Jan-Philipp, Fröhling, Stefan, Scholl, Claudia and Lane, Steven W. (2020). Hematopoietic stem and progenitor cell-restricted Cdx2 expression induces transformation to myelodysplasia and acute leukemia. Nature Communications, 11 (1) 3021, 3021. doi: 10.1038/s41467-020-16840-2

  • Managing haematology and oncology patients during the COVID-19 pandemic: interim consensus guidance

    Weinkove, Robert, McQuilten, Zoe K, Adler, Jonathan, Agar, Meera R, Blyth, Emily, Cheng, Allen C, Conyers, Rachel, Haeusler, Gabrielle M, Hardie, Claire, Jackson, Christopher, Lane, Steven W, Middlemiss, Tom, Mollee, Peter, Mulligan, Stephen P, Ritchie, David, Ruka, Myra, Solomon, Benjamin, Szer, Jeffrey, Thursky, Karin A, Wood, Erica M, Worth, Leon J, Yong, Michelle K, Slavin, Monica A and Teh, Benjamin W (2020). Managing haematology and oncology patients during the COVID-19 pandemic: interim consensus guidance. Medical Journal of Australia, 212 (10) mja2.50607, 481-489. doi: 10.5694/mja2.50607

  • Type I interferons suppress anti-parasitic immunity and can be targeted to improve treatment of visceral leishmaniasis

    Kumar, Rajiv, Bunn, Patrick T., Singh, Siddharth Sankar, Ng, Susanna S., Montes de Oca, Marcela, De Labastida Rivera, Fabian, Chauhan, Shashi Bhushan, Singh, Neetu, Faleiro, Rebecca J., Edwards, Chelsea L., Frame, Teija C.M., Sheel, Meru, Austin, Rebecca J., Lane, Steven W., Bald, Tobias, Smyth, Mark J., Hill, Geoffrey.R., Best, Shannon E., Haque, Ashraful, Corvino, Dillon, Waddell, Nic, Koufariotis, Lambross, Mukhopadhay, Pamela, Rai, Madhukar, Chakravarty, Jaya, Singh, Om Prakash, Sacks, David, Nylen, Susanne, Uzonna, Jude ... Engwerda, Christian R. (2020). Type I interferons suppress anti-parasitic immunity and can be targeted to improve treatment of visceral leishmaniasis. Cell Reports, 30 (8), 2512-2525.e9. doi: 10.1016/j.celrep.2020.01.099

  • Mapping functional susceptibilities in AML

    Lane, Steven and Henden, Andrea (2020). Mapping functional susceptibilities in AML. The Hematologist, 17 (1). doi: 10.1182/hem.v17.1.10162

  • Transcriptome dynamics of CD4+ T cells during malaria maps gradual transit from effector to memory

    Soon, Megan S. F., Lee, Hyun Jae, Engel, Jessica A., Straube, Jasmin, Thomas, Bryce S., Pernold, Clara P. S., Clarke, Lachlan S., Laohamonthonkul, Pawat, Haldar, Rohit N., Williams, Cameron G., Lansink, Lianne I. M., Moreira, Marcela L., Bramhall, Michael, Koufariotis, Lambros T., Wood, Scott, Chen, Xi, James, Kylie R., Lönnberg, Tapio, Lane, Steven W., Belz, Gabrielle T., Engwerda, Christian R., Khoury, David S., Davenport, Miles P., Svensson, Valentine, Teichmann, Sarah A. and Haque, Ashraful (2020). Transcriptome dynamics of CD4+ T cells during malaria maps gradual transit from effector to memory. Nature Immunology, 21 (12), 1597-1610. doi: 10.1038/s41590-020-0800-8

  • Distinct effects of ruxolitinib and interferon-alpha on murine JAK2V617F myeloproliferative neoplasm hematopoietic stem cell populations

    Austin, Rebecca J., Straube, Jasmin, Bruedigam, Claudia, Pali, Gabor, Jacquelin, Sebastien, Vu, Therese, Green, Joanne, Gräsel, Julius, Lansink, Lianne, Cooper, Leanne, Lee, Shin-Jye, Chen, Nien-Tsu, Lee, Chung-Wei, Haque, Ashraful, Heidel, Florian H., D’Andrea, Richard, Hill, Geoff R., Mullally, Ann, Milsom, Michael D., Bywater, Megan and Lane, Steven W. (2019). Distinct effects of ruxolitinib and interferon-alpha on murine JAK2V617F myeloproliferative neoplasm hematopoietic stem cell populations. Leukemia, 34 (4), 1075-1089. doi: 10.1038/s41375-019-0638-y

  • Inflammation in del(20q): a MST opportunity?

    Lane, Steven W. (2019). Inflammation in del(20q): a MST opportunity?. Blood, 134 (20), 1685-1686. doi: 10.1182/blood.2019003028

  • Acute promyelocytic leukaemia with marked symptomatic hyperleucocytosis: images in haematology

    Yuan, Yin, Mediwake, Heshani, Bokhari, Syed W., Holley, Anthony and Lane, Steven W. (2019). Acute promyelocytic leukaemia with marked symptomatic hyperleucocytosis: images in haematology. British Journal of Haematology, 186 (5), 649-649. doi: 10.1111/bjh.16016

  • Recommendations for the use of pegylated interferon-α in the treatment of classical myeloproliferative neoplasms

    Forsyth, Cecily J., Chan, Wai-Hoong, Grigg, Andrew P., Cook, Nathalie C., Lane, Steven W., Burbury, Kate L., Perkins, Andrew C. and Ross, David M. (2019). Recommendations for the use of pegylated interferon-α in the treatment of classical myeloproliferative neoplasms. Internal Medicine Journal, 49 (8), 948-954. doi: 10.1111/imj.14154

  • Jak2V617F and Dnmt3a loss cooperate to induce myelofibrosis through activated enhancer-driven inflammation

    Jacquelin, Sebastien, Straube, Jasmin, Cooper, Leanne, Vu, Therese, Song, Axia, Bywater, Megan, Baxter, Eva, Heidecker, Matthew, Wackrow, Brad, Porter, Amy, Ling, Victoria, Green, Joanne, Austin, Rebecca, Kazakoff, Stephen, Waddell, Nicola, Hesson, Luke B., Pimanda, John E., Stegelmann, Frank, Bullinger, Lars, Döhner, Konstanze, Rampal, Raajit K., Heckl, Dirk, Hill, Geoffrey R. and Lane, Steven W. (2018). Jak2V617F and Dnmt3a loss cooperate to induce myelofibrosis through activated enhancer-driven inflammation. Blood, 132 (26), blood-2018. doi: 10.1182/blood-2018-04-846220

  • CD155 loss enhances tumor suppression via combined host and tumor-intrinsic mechanisms

    Li, Xian-Yang, Das, Indrajit, Lepletier, Ailin, Addala, Venkateswar, Bald, Tobias, Stannard, Kimberley, Barkauskas, Deborah, Liu, Jing, Aguilera, Amelia Roman, Takeda, Kazuyoshi, Braun, Matthias, Nakamura, Kyohei, Jacquelin, Sebastien, Lane, Steven W., Teng, Michele W.l., Dougall, William C. and Smyth, Mark J. (2018). CD155 loss enhances tumor suppression via combined host and tumor-intrinsic mechanisms. Journal of Clinical Investigation, 128 (6), 2613-2625. doi: 10.1172/JCI98769

  • Recipient mucosal-associated invariant T cells control graft-versus-host-disease within the colon

    Varelias, Antiopi, Bunting, Mark, Ormerod, Kate, Koyama, Motoko, Olver, Stuart, Straube, Jasmin, Kuns, Rachel, Robb, Renee, Henden, Andrea, Cooper, Leanne, Lachner, Nancy, Gartlan, Kate, Lantz, Olivier J., Kjer-Nielsen, Lars, Mak, Jeffrey, Fairlie, David, Clouston, Andrew, McCluskey, James, Rossjohn, Jamie, Lane, Steven, Hugenholtz, Phil and Hill, Geoff (2018). Recipient mucosal-associated invariant T cells control graft-versus-host-disease within the colon. The Journal of Immunology, 200 (1_Supplement), 55.15-55.15. doi: 10.4049/jimmunol.200.supp.55.15

  • Recipient mucosal-associated invariant T cells control GVHD within the colon

    Varelias, Antiopi, Bunting, Mark D., Ormerod, Kate L., Koyama, Motoko, Olver, Stuart D., Straube, Jasmin, Kuns, Rachel D., Robb, Renee J., Henden, Andrea S., Cooper, Leanne, Lachner, Nancy, Gartlan, Kate H., Lantz, Olivier, Kjer-Nielsen, Lars, Mak, Jeffrey Y. W., Fairlie, David P., Clouston, Andrew D., McCluskey, James, Rossjohn, Jamie, Lane, Steven W., Hugenholtz, Philip and Hill, Geoffrey R. (2018). Recipient mucosal-associated invariant T cells control GVHD within the colon. Journal of Clinical Investigation, 128 (5), 1919-1936. doi: 10.1172/JCI91646

  • Conventional dendritic cells are required for the cross-presentation of leukemia-specific antigen in a model of AML relapse post-BMT

    Markey, Kate A., Gartlan, Kate H., Kuns, Rachel D., Lane, Steven W. and Hill, Geoffrey R. (2018). Conventional dendritic cells are required for the cross-presentation of leukemia-specific antigen in a model of AML relapse post-BMT. Bone Marrow Transplantation, 53 (6), 800-803. doi: 10.1038/s41409-018-0148-y

  • The impact of age, NPM1, and FLT3 allelic ratio in patients with acute myeloid leukemia

    Straube, Jasmin, Ling, Victoria Y, Hill, Geoffrey R and Lane, Steven W (2018). The impact of age, NPM1, and FLT3 allelic ratio in patients with acute myeloid leukemia. Blood, 131 (10), 1148-1153. doi: 10.1182/blood-2017-09-807438

  • Oncogenic JAK2causes PD-L1 expression, mediating immune escape in myeloproliferative neoplasms

    Prestipino, Alessandro, Emhardt, Alica J., Aumann, Konrad, O'Sullivan, David, Gorantla, Sivahari P., Duquesne, Sandra, Melchinger, Wolfgang, Braun, Lukas, Vuckovic, Slavica, Boerries, Melanie, Busch, Hauke, Halbach, Sebastian, Pennisi, Sandra, Poggio, Teresa, Apostolova, Petya, Veratti, Pia, Hettich, Michael, Niedermann, Gabriele, Bartholomä, Mark, Shoumariyeh, Khalid, Jutzi, Jonas S., Wehrle, Julius, Dierks, Christine, Becker, Heiko, Schmitt-Graeff, Annette, Follo, Marie, Pfeifer, Dietmar, Rohr, Jan, Fuchs, Sebastian ... Zeiser, Robert (2018). Oncogenic JAK2causes PD-L1 expression, mediating immune escape in myeloproliferative neoplasms. Science Translational Medicine, 10 (429) eaam7729, eaam7729. doi: 10.1126/scitranslmed.aam7729

  • IFN regulatory factor 3 balances Th1 and T follicular helper immunity during nonlethal blood-stage Plasmodium infection

    James, Kylie R., Soon, Megan S. F., Sebina, Ismail, Fernandez-Ruiz, Daniel, Davey, Gayle, Liligeto, Urijah N., Nair, Arya Sheela, Fogg, Lily G., Edwards, Chelsea L., Best, Shannon E., Lansink, Lianne I. M., Schroder, Kate, Wilson, Jane A. C., Austin, Rebecca, Suhrbier, Andreas, Lane, Steven W., Hill, Geoffrey R., Engwerda, Christian R., Heath, William R. and Haque, Ashraful (2018). IFN regulatory factor 3 balances Th1 and T follicular helper immunity during nonlethal blood-stage Plasmodium infection. Journal of Immunology, 200 (4), 1443-1456. doi: 10.4049/jimmunol.1700782

  • Flt-3L expansion of recipient CD8α+ dendritic cells deletes alloreactive donor T cells and represents an alternative to post-transplant cyclophosphamide for the prevention of GVHD

    Markey, Kate A., Kuns, Rachel D., Browne, Daniel J., Gartlan, Kate H., Robb, Renee J., Martins, J. Paulo, Henden, Andrea S., Minnie, Simone A., Cheong, Melody, Koyama, Motoko, Smyth, Mark J., Steptoe, Raymond J., Belz, Gabrielle, Brocker, Thomas, Degli-Esposti, Mariapia A., Lane, Steven W. and Hill, Geoffrey R. (2018). Flt-3L expansion of recipient CD8α+ dendritic cells deletes alloreactive donor T cells and represents an alternative to post-transplant cyclophosphamide for the prevention of GVHD. Clinical Cancer Research, 24 (7), 1604-1616. doi: 10.1158/1078-0432.CCR-17-2148

  • Differential effects on gene transcription and hematopoietic differentiation correlate with GATA2 mutant disease phenotypes

    Chong, C. -E., Venugopal, P., Stokes, P. H., Lee, Y. K., Brautigan, P. J., Yeung, D. T. O., Babic, M., Engler, G. A., Lane, S. W., Klingler-Hoffmann, M., Matthews, J. M., D'Andrea, R. J., Brown, A. L., Hahn, C. N. and Scott, H. S. (2018). Differential effects on gene transcription and hematopoietic differentiation correlate with GATA2 mutant disease phenotypes. Leukemia, 32 (1), 194-202. doi: 10.1038/leu.2017.196

  • Clinical and molecular categorization of progressive, adult-onset cutaneous mastocytosis

    Tate, Courtney, Tang, Fiona, Lane, Steven W. and Seymour, Louise (2017). Clinical and molecular categorization of progressive, adult-onset cutaneous mastocytosis. JAAD Case Reports, 4 (1), 30-32. doi: 10.1016/j.jdcr.2017.09.038

  • Acute myeloid leukemia stem cell function is preserved in the absence of autophagy

    Porter, Amy H., Leveque-El Mouttie, Lucie, Vu, Therese, Bruedigam, Claudia, Sutton, Joanne, Jacquelin, Sebastien, Hill, Geoffrey R., MacDonald, Kelli P. A. and Lane, Steven W. (2017). Acute myeloid leukemia stem cell function is preserved in the absence of autophagy. Haematologica, 102 (9), E344-E347. doi: 10.3324/haematol.2017.166389

  • Hacking the stem cell niche

    Lane, Steven W. and Heidel, Florian H. (2017). Hacking the stem cell niche. Blood, 129 (22), 2951-2952. doi: 10.1182/blood-2017-04-777789

  • Ssb1 and Ssb2 cooperate to regulate mouse hematopoietic stem and progenitor cells by resolving replicative stress

    Shi, Wei, Vu, Therese, Boucher, Didier, Biernacka, Anna, Nde, Jules, Pandita, Raj K., Straube, Jasmin, Boyle, Glen M., Al-Ejeh, Fares, Nag, Purba, Jeffery, Jessie, Harris, Janelle L., Bain, Amanda L., Grzelak, Marta, Skrzypczak, Magdalena, Mitra, Abhishek, Dojer, Norbert, Crosetto, Nicola, Cloonan, Nicole, Becherel, Olivier J., Finnie, John, Skaar, Jeffrey R., Walkley, Carl R., Pandita, Tej K., Rowicka, Maga, Ginalski, Krzysztof, Lane, Steven W. and Khanna, Kum Kum (2017). Ssb1 and Ssb2 cooperate to regulate mouse hematopoietic stem and progenitor cells by resolving replicative stress. Blood, 129 (18), 2479-2492. doi: 10.1182/blood-2016-06-725093

  • Global prevalence of carbapenem resistance in neutropenic patients and association with mortality and carbapenem use: systematic review and meta-analysis

    Righi, Elda, Peri, Anna Maria, Harris, Patrick N. A., Wailan, Alexander M., Liborio, Mariana, Lane, Steven W. and Paterson, David L. (2017). Global prevalence of carbapenem resistance in neutropenic patients and association with mortality and carbapenem use: systematic review and meta-analysis. Journal of Antimicrobial Chemotherapy, 72 (3), 668-677. doi: 10.1093/jac/dkw459

  • GVHD prevents NK-cell-dependent leukemia and virus-specific innate immunity

    Bunting, Mark D., Varelias, Antiopi, Souza-Fonseca-Guimaraes, Fernando, Schuster, Iona S., Lineburg, Katie E., Kuns, Rachel D., Fleming, Peter, Locke, Kelly R., Huntington, Nicholas D., Blazar, Bruce R., Lane, Steven W., Tey, Siok-Keen, MacDonald, Kelli P. A., Smyth, Mark J., Degli-Esposti, Mariapia A. and Hill, Geoffrey R. (2017). GVHD prevents NK-cell-dependent leukemia and virus-specific innate immunity. Blood, 129 (5), 630-642. doi: 10.1182/blood-2016-08-734020

  • An unhealthy diet: making sense of a fatty niche for leukemia stem cells

    Jacquelin, Sebastien, Dishington, Emma J. and Lane, Steven W. (2016). An unhealthy diet: making sense of a fatty niche for leukemia stem cells. Translational Cancer Research, 5 (S4), S878-S881. doi: 10.21037/tcr.2016.10.43

  • Harnessing the immune system in acute myeloid leukaemia

    Austin, Rebecca, Smyth, Mark J. and Lane, Steven W. (2016). Harnessing the immune system in acute myeloid leukaemia. Critical Reviews in Oncology/Hematology, 103, 62-77. doi: 10.1016/j.critrevonc.2016.04.020

  • Telomerase in hematologic malignancies

    Bruedigam, Claudia and Lane, Steven W. (2016). Telomerase in hematologic malignancies. Current Opinion in Hematology, 23 (4), 346-353. doi: 10.1097/MOH.0000000000000252

  • Analysis of telomerase target gene expression effects from murine models in patient cohorts by homology translation and random survival forest modeling

    Bagger, Frederik Otzen, Bruedigam, Claudia and Lane, Steven W. (2016). Analysis of telomerase target gene expression effects from murine models in patient cohorts by homology translation and random survival forest modeling. Genomics Data, 7, 275-280. doi: 10.1016/j.gdata.2016.01.014

  • Jak2V617F driven myeloproliferative neoplasm occurs independently of interleukin-3 receptor beta common signalling

    Vu, Therese, Austin, Rebecca, Kuhn, Catherine Paine, Bruedigam, Claudia, Song, Axia, Guignes, Solene, Jacquelin, Sebastien, Ramshaw, Hayley S., Hill, Geoffrey R., Lopez, Angel F. and Lane, Steven W. (2016). Jak2V617F driven myeloproliferative neoplasm occurs independently of interleukin-3 receptor beta common signalling. Haematologica, 101 (3), E77-E80. doi: 10.3324/haematol.2015.136705

  • Increased risk of melanoma in patients with chronic lymphocytic leukaemia: systematic review and meta-analysis of cohort studies

    Olsen, Catherine M., Lane, Steven W. and Green, Adèle C. (2015). Increased risk of melanoma in patients with chronic lymphocytic leukaemia: systematic review and meta-analysis of cohort studies. Melanoma Research, 26 (2), 188-194. doi: 10.1097/CMR.0000000000000219

  • BET inhibitor resistance emerges from leukaemia stem cells

    Fong, Chun Yew, Gilan, Omer, Lam, Enid Y.N., Rubin, Alan F., Ftouni, Sarah, Tyler, Dean, Stanley, Kym, Sinha, Devbarna, Yeh, Paul, Morison, Jessica, Giotopoulos, George, Lugo, Dave, Jeffrey, Philip, Lee, Stanley Chun-Wei, Carpenter, Christopher, Gregory, Richard, Ramsay, Robert G., Lane, Steven W., Abdel-Wahab, Omar, Kouzarides, Tony, Johnstone, Ricky W., Dawson, Sarah-Jane, Huntly, Brian J.P., Prinjha, Rab K., Papenfuss, Anthony T. and Dawson, Mark A. (2015). BET inhibitor resistance emerges from leukaemia stem cells. Nature, 525 (7570), 538-542. doi: 10.1038/nature14888

  • Tc17 cells are a proinflammatory, plastic lineage of pathogenic CD8<sup>+</sup> T cells that induce GVHD without antileukemic effects

    Gartlan, Kate H., Markey, Kate A., Varelias, Antiopi, Bunting, Mark D., Koyama, Motoko, Kuns, Rachel D., Raffelt, Neil C., Olver, Stuart D., Lineburg, Katie E., Cheong, Melody, Teal, Bianca E., Lor, Mary, Comerford, Iain, Teng, Michele W. L., Smyth, Mark J., McCluskey, James, Rossjohn, Jamie, Stockinger, Brigitta, Boyle, Glen M., Lane, Steven W., Clouston, Andrew D., McColl, Shaun R., MacDonald, Kelli P. A. and Hill, Geoffrey R. (2015). Tc17 cells are a proinflammatory, plastic lineage of pathogenic CD8+ T cells that induce GVHD without antileukemic effects. Blood, 126 (13), 1609-1620. doi: 10.1182/blood-2015-01-622662

  • Ssb2/Nabp1 is dispensable for thymic maturation, male fertility, and DNA repair in mice

    Boucher, Didier, Vu, Therese, Bain, Amanda L., Tagliaro-Jahns, Marina, Shi, Wei, Lane, Steven W. and Khanna, Kum Kum (2015). Ssb2/Nabp1 is dispensable for thymic maturation, male fertility, and DNA repair in mice. FASEB Journal, 29 (8), 3326-3334. doi: 10.1096/fj.14-269944

  • EphA2 Is a Therapy Target in EphA2-Positive Leukemias but Is Not Essential for Normal Hematopoiesis or Leukemia.

    Charmsaz, Sara, Beckett, Kirrilee, Smith, Fiona M., Bruedigam, Claudia, Moore, Andrew S., Al-Ejeh, Fares, Lane, Steven W. and Boyd, Andrew W. (2015). EphA2 Is a Therapy Target in EphA2-Positive Leukemias but Is Not Essential for Normal Hematopoiesis or Leukemia.. PLoS One, 10 (6) e0130692, e0130692-e0130692. doi: 10.1371/journal.pone.0130692

  • Autophagy is required for stem cell mobilization by G-CSF

    Leveque-El Mouttie, Lucie, Vu, Therese, Lineburg, Katie E., Kuns, Rachel D., Bagger, Frederik O., Teal, Bianca E., Lor, Mary, Boyle, Glen M., Bruedigam, Claudia, Mintern, Justine D., Hill, Geoffrey R., MacDonald, Kelli P. A. and Lane, Steven W. (2015). Autophagy is required for stem cell mobilization by G-CSF. Blood, 125 (19), 2933-2936. doi: 10.1182/blood-2014-03-562660

  • Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells

    Walter, Dagmar, Lier, Amelie, Geiselhart, Anja, Thalheimer, Frederic B., Huntscha, Sina, Sobotta, Mirko C., Moehrle, Bettina, Brocks, David, Bayindir, Irem, Kaschutnig, Paul, Muedder, Katja, Klein, Corinna, Jauch, Anna, Schroeder, Timm, Geiger, Hartmut, Dick, Tobias, Holland-Letz, Tim, Schmezer, Peter, Lane, Steven W., Rieger, Michael A., Essers, Marieke A. G., Williams, David A., Trumpp, Andreas and Milsom, Michael D. (2015). Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells. Nature, 520 (7548), 549-552. doi: 10.1038/nature14131

  • A critical role for murine transferrin receptor 2 in erythropoiesis during iron restriction

    Wallace, Daniel F., Secondes, Eriza S., Rishi, Gautam, Ostini, Lesa, McDonald, Cameron J., Lane, Steven W., Vu, Therese, Hooper, John D., Velasco, Gloria, Ramsay, Andrew J., Lopez-Otin, Carlos and Subramaniam, V. Nathan (2015). A critical role for murine transferrin receptor 2 in erythropoiesis during iron restriction. British Journal of Haematology, 168 (6), 891-901. doi: 10.1111/bjh.13225

  • Telomerase inhibition effectively targets mouse and human AML stem cells and delays relapse following chemotherapy

    Bruedigam, C., Bagger, F.O., Heidel, F.H., Paine, Kuhn C., Guignes, S., Song, A., Austin, R., Vu, T., Lee, E., Riyat, S., Moore, A.S., Lock, R.B., Bullinger, L., Hill, G.R., Armstrong, S.A., Williams, D.A. and Lane, S.W. (2014). Telomerase inhibition effectively targets mouse and human AML stem cells and delays relapse following chemotherapy. Cell Stem Cell, 15 (6), 775-790. doi: 10.1016/j.stem.2014.11.010

  • Hit the spleen, JAK!

    Lane, Steven W. and Mullally, Ann (2014). Hit the spleen, JAK!. Blood, 124 (19), 2898-2900. doi: 10.1182/blood-2014-09-600635

  • Modulating the stem cell niche for tissue regeneration

    Lane, Steven W., Williams, David A. and Watt, Fiona M. (2014). Modulating the stem cell niche for tissue regeneration. Nature Biotechnology, 32 (8), 795-803. doi: 10.1038/nbt.2978

  • Sorafenib priming may augment salvage chemotherapy in relapsed and refractory FLT3-ITD-positive acute myeloid leukemia

    Cummins, K. D., Jane, S. M., Ninkovic, S., Bazargan, A., Filshie, R., Sutrave, G., Hertzberg, M., Scott, A., Lane, S., Yannakou, C. K., Ritchie, D., D'Rozario, J., Black, J., Bavishi, K. and Wei, A. (2014). Sorafenib priming may augment salvage chemotherapy in relapsed and refractory FLT3-ITD-positive acute myeloid leukemia. Blood Cancer Journal, 4 (e237) e237, 1-2. doi: 10.1038/bcj.2014.59

  • The Apcmin mouse has altered hematopoietic stem cell function and provides a model for MPD/MDS

    Lane, S. W., Sykes, S. M., Al-Shahrour, F., Shterental, S., Paktinat, M., Lo Celso, C., Jesneck, J. L., Ebert, B. L., Williams, D. A. and Gilliland, D. Gary (2014). The Apcmin mouse has altered hematopoietic stem cell function and provides a model for MPD/MDS. Blood, 123 (2), 301-301. doi: 10.1182/blood-2013-11-540047

  • The cell fate determinant Llgl1 influences HSC fitness and prognosis in AML

    Heidel, Florian H., Bullinger, Lars, Arreba-Tutusaus, Patricia, Wang, Zhu, Gaebel, Julia, Hirt, Carsten, Niederwieser, Dietger, Lane, Steven W., Doehner, Konstanze, Vasioukhin, Valera, Fischer, Thomas and Armstrong, Scott A. (2013). The cell fate determinant Llgl1 influences HSC fitness and prognosis in AML. Journal of Experimental Medicine, 210 (1), 15-22. doi: 10.1084/jem.20120596

  • Induced regulatory T cells promote tolerance when stabilized by rapamycin and IL-2 in vivo

    Zhang, Ping, Tey, Siok-Keen, Koyama, Motoko, Kuns, Rachel D., Olver, Stuart D., Lineburg, Katie E., Lor, Mary, Teal, Bianca E., Raffelt, Neil C., Raju, Jyothy, Leveque, Lucie, Markey, Kate A., Varelias, Antiopi, Clouston, Andrew D., Lane, Steven W., Macdonald, Kelli P. A. and Hill, Geoffrey R. (2013). Induced regulatory T cells promote tolerance when stabilized by rapamycin and IL-2 in vivo. Journal of Immunology, 191 (10), 5291-5303. doi: 10.4049/jimmunol.1301181

  • Deciphering hematopoietic stem cells in their niches: a critical appraisal of genetic models, lineage tracing, and imaging strategies

    Joseph, Chacko, Quach, Julie M., Walkley, Carl R., Lane, Steven W., Lo Celso, Cristina and Purton, Louise E. (2013). Deciphering hematopoietic stem cells in their niches: a critical appraisal of genetic models, lineage tracing, and imaging strategies. Cell Stem Cell, 13 (5), 520-533. doi: 10.1016/j.stem.2013.10.010

  • Depletion of Jak2V617F myeloproliferative neoplasm-propagating stem cells by interferon-alpha in a murine model of polycythemia vera

    Mullally, Ann, Bruedigam, Claudia, Poveromo, Luke, Heidel, Florian H., Purdon, Amy, Vu, Therese, Austin, Rebecca, Heckl, Dirk, Breyfogle, Lawrence J., Kuhn, Catherine Paine, Kalaitzidis, Demetrios, Armstrong, Scott A., Williams, David A., Hill, Geoff R., Ebert, Benjamin L. and Lane, Steven W. (2013). Depletion of Jak2V617F myeloproliferative neoplasm-propagating stem cells by interferon-alpha in a murine model of polycythemia vera. Blood, 121 (18), 3692-3702. doi: 10.1182/blood-2012-05-432989

  • Jak2V617F myeloproliferative neoplasm stem cells and interferon-alpha

    Lane, Steven W. and Mullally, Ann (2013). Jak2V617F myeloproliferative neoplasm stem cells and interferon-alpha. Oncotarget, 4 (4), 500-501. doi: 10.18632/oncotarget.986

  • The Rac GTPase effector p21-activated kinase is essential for hematopoietic stem/progenitor cell migration and engraftment

    Dorrance, Adrienne M., De Vita, Serena, Radu, Maria, Reddy, Pavankumar N. G., McGuinness, Meaghan K., Harris, Chad E., Mathieu, Ronald, Lane, Steven W., Kosoff, Rachelle, Milsom, Michael D., Chernoff, Jonathan and Williams, David A. (2013). The Rac GTPase effector p21-activated kinase is essential for hematopoietic stem/progenitor cell migration and engraftment. Blood, 121 (13), 2474-2482. doi: 10.1182/blood-2012-10-460709

  • Tolerance induction with gene-modified stem cells and immune-preserving conditioning in primed mice: restricting antigen to differentiated antigen-presenting cells permits efficacy

    Coleman, Miranda A., Bridge, Jennifer A., Lane, Steven W., Dixon, Chantelle M., Hill, Geoffrey R., Wells, James W., Thomas, Ranjeny and Steptoe, Raymond J. (2013). Tolerance induction with gene-modified stem cells and immune-preserving conditioning in primed mice: restricting antigen to differentiated antigen-presenting cells permits efficacy. Blood, 121 (6), 1049-1058. doi: 10.1182/blood-2012-06-434100

  • CDX2-driven leukemogenesis involves KLF4 repression and deregulated PPARγ signaling

    Faber, Katrin, Bullinger, Lars, Ragu, Christine, Garding, Angela, Mertens, Daniel, Miller, Christina, Martin, Daniela, Walcher, Daniel, Doehner, Konstanze, Doehner, Hartmut, Claus, Rainer, Plass, Christoph, Sykes, Stephen M., Lane, Steven W., Scholl, Claudia and Froehling, Stefan (2013). CDX2-driven leukemogenesis involves KLF4 repression and deregulated PPARγ signaling. Journal of Clinical Investigation, 123 (1), 299-314. doi: 10.1172/JCI64745

  • Myeloproliferative Neoplasm Animal Models

    Mullally, Ann, Lane, Steven W., Brumme, Kristina and Ebert, Benjamin L. (2012). Myeloproliferative Neoplasm Animal Models. Hematology/Oncology Clinics of North America, 26 (5), 1065-1081. doi: 10.1016/j.hoc.2012.07.007

  • mTOR complex 1 plays critical roles in hematopoiesis and pten-loss-evoked leukemogenesis

    Kalaitzidis, Demetrios, Sykes, Stephen M., Wang, Zhu, Punt, Natalie, Tang, Yuefeng, Ragu, Christine, Sinha, Amit U., Lane, Steven W., Souza, Amanda L., Clish, Clary B., Anastasiou, Dimitrios, Gilliland, D. Gary, Scadden, David T., Guertin, David A. and Armstrong, Scott A. (2012). mTOR complex 1 plays critical roles in hematopoiesis and pten-loss-evoked leukemogenesis. Cell Stem Cell, 11 (3), 429-439. doi: 10.1016/j.stem.2012.06.009

  • Distinct roles for long-term hematopoietic stem cells and erythroid precursor cells in a murine model of Jak2V617F-mediated polycythemia vera

    Mullally, Ann, Poveromo, Luke, Schneider, Rebekka K., Al-Shahrour, Fatima, Lane, Steven W. and Ebert, Benjamin L. (2012). Distinct roles for long-term hematopoietic stem cells and erythroid precursor cells in a murine model of Jak2V617F-mediated polycythemia vera. Blood, 120 (1), 166-172. doi: 10.1182/blood-2012-01-402396

  • Valproic acid combined with cytosine arabinoside in elderly patients with acute myeloid leukemia has in vitro but limited clinical activity

    Lane, Steven, Gill, Devinder, McMillan, Nigel A. J., Saunders, Nicholas, Murphy, Rachel, Spurr, Terrence, Keane, Colm, Fan, Helen Mar and Mollee, Peter (2012). Valproic acid combined with cytosine arabinoside in elderly patients with acute myeloid leukemia has in vitro but limited clinical activity. Leukemia & Lymphoma, 53 (6), 1077-1083. doi: 10.3109/10428194.2011.642302

  • Genetic and pharmacologic inhibition of beta-catenin targets imatinib-resistant leukemia stem cells in CML

    Heidel, Florian H., Bullinger, Lars, Feng, Zhaohui, Wang, Zhu, Neff, Tobias A., Stein, Lauren, Kalaitzidis, Demetrios, Lane, Steve W. and Armstrong, Scott A. (2012). Genetic and pharmacologic inhibition of beta-catenin targets imatinib-resistant leukemia stem cells in CML. Cell Stem Cell, 10 (4), 412-424. doi: 10.1016/j.stem.2012.02.017

  • WT1 expression as a marker of minimal residual disease predicts outcome in acute myeloid leukemia when measured post-consolidation

    Gray, James X., McMillen, Lyle, Mollee, Peter, Paul, Sanjoy, Lane, Steven, Bird, Robert, Gill, Devinder, Saal, Russell and Marlton, Paula (2012). WT1 expression as a marker of minimal residual disease predicts outcome in acute myeloid leukemia when measured post-consolidation. Leukemia Research, 36 (4), 453-458. doi: 10.1016/j.leukres.2011.09.005

  • Rac signaling in osteoblastic cells is required for normal bone development but is dispensable for hematopoietic development

    Lane, Steven W., De Vita, Serena, Alexander, Kylie A., Karaman, Ruchan, Milsom, Michael D., Dorrance, Adrienne M., Purdon, Amy, Louis, Leeann, Bouxsein, Mary L. and Williams, David A. (2012). Rac signaling in osteoblastic cells is required for normal bone development but is dispensable for hematopoietic development. Blood, 119 (3), 736-744. doi: 10.1182/blood-2011-07-368753

  • Bad to the bone

    Lane, Steven W. (2012). Bad to the bone. Blood, 119 (2), 323-325. doi: 10.1182/blood-2011-10-383901

  • Construction and Crystal Structure of Recombinant STNV Capsids

    Lane, Stephen W., Dennis, Caitriona A., Lane, Claire L., Trinh, Chi H., Rizkallah, Pierre J., Stockley, Peter G. and Phillips, Simon E. V. (2011). Construction and Crystal Structure of Recombinant STNV Capsids. Journal of Molecular Biology, 413 (1), 41-50. doi: 10.1016/j.jmb.2011.07.062

  • Degenerate RNA packaging signals in the genome of satellite tobacco necrosis virus: Implications for the assembly of a T = 1 capsid

    Bunka, David H. J., Lane, Stephen W., Lane, Claire L., Dykeman, Eric C., Ford, Robert J., Barker, Amy M., Twarock, Reidun, Phillips, Simon E. V. and Stockley, Peter G. (2011). Degenerate RNA packaging signals in the genome of satellite tobacco necrosis virus: Implications for the assembly of a T = 1 capsid. Journal of Molecular Biology, 413 (1), 51-65. doi: 10.1016/j.jmb.2011.07.063

  • AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias

    Sykes, Stephen M., Lane, Steven W., Bullinger, Lars, Kalaitzidis, Demetrios, Yusuf, Rushdia, Saez, Borja, Ferraro, Francesca, Mercier, Francois, Singh, Harshabad, Brumme, Kristina M., Acharya, Sanket S., Schoell, Claudia, Tothova, Zuzana, Attar, Eyal C., Froehling, Stefan, DePinho, Ronald A., Armstrong, Scott A., Gilliland, D. Gary and Scadden, David T. (2011). AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias. Cell, 146 (5), 697-708. doi: 10.1016/j.cell.2011.07.032

  • Differential niche and Wnt requirements during acute myeloid leukemia progression

    Lane, Steven W., Wang, Yingzi J., Lo Celso, Cristina, Ragu, Christine, Bullinger, Lars, Sykes, Stephen M., Ferraro, Francesca, Shterental, Sebastian, Lin, Charles P., Gilliland, D. Gary, Scadden, David T., Armstrong, Scott A. and Williams, David A. (2011). Differential niche and Wnt requirements during acute myeloid leukemia progression. Blood, 118 (10), 2849-2856. doi: 10.1182/blood-2011-03-345165

  • CNS Relapse in Acute Promyeloctyic Leukemia

    Housman, Elizabeth, Chang, Priscilla, Lane, Steven W., Blinder, Russell, Galinsky, Ilene, Kesari, Santosh, Ho, Vincent T., Stone, Richard M. and Mullally, Ann (2010). CNS Relapse in Acute Promyeloctyic Leukemia. Journal of Clinical Oncology, 28 (24), E409-E411. doi: 10.1200/JCO.2009.27.1577

  • Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia

    Kharas, Michael G., Lengner, Christopher J., Al-Shahrour, Fatima, Bullinger, Lars, Ball, Brian, Zaidi, Samir, Morgan, Kelly, Tam, Winnie, Paktinat, Mahnaz, Okabe, Rachel, Gozo, Maricel, Einhorn, William, Lane, Steven W., Scholl, Claudia, Froehling, Stefan, Fleming, Mark, Ebert, Benjamin L., Gilliland, D. Gary, Jaenisch, Rudolf and Daley, George Q. (2010). Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia. Nature Medicine, 16 (8), 903-908. doi: 10.1038/nm.2187

  • Physiological Jak2V617F expression causes a lethal myeloproliferative neoplasm with differential effects on hematopoietis stem and progenitor cells

    Mullally, Ann, Lane, Steven W., Ball, Brian, Megerdichian, Christine, Okabe, Rachel, Al-Shahrour, Fatima, Paktinat, Mahnaz, Haydu, J. Erika, Housman, Elizabeth, Lord, Allegra M., Wernig, Gerlinde, Kharas, Michael G., Mercher, Thomas, Kutok, Jeffery L., Gilliland, D. Gary and Ebert, Benjamin L. (2010). Physiological Jak2V617F expression causes a lethal myeloproliferative neoplasm with differential effects on hematopoietis stem and progenitor cells. Cancer Cell, 17 (6), 584-596. doi: 10.1016/j.ccr.2010.05.015

  • The Apcmin mouse has altered hematopoietic stem cell function and provides a model for MPD/MDS

    Lane, Steven W., Sykes, Stephen M., Al-Shahrour, Fatima, Shterental, Sebastian, Paktinat, Mahnaz, Lo Celso, Cristina, Jesneck, Jonathan L., Ebert, Benjamin L., Williams, David A. and Gilliland, D. Gary (2010). The Apcmin mouse has altered hematopoietic stem cell function and provides a model for MPD/MDS. Blood, 115 (17), 3489-3497. doi: 10.1182/blood-2009-11-251728

  • Leukemia stem cells

    Lane, Steven W. and Gilliland, D. Gary (2010). Leukemia stem cells. Seminars in Cancer Biology, 20 (2), 71-76. doi: 10.1016/j.semcancer.2009.12.001

  • Characterization of the bone marrow immunofluorescence test in childhood autoimmune neutropenia

    Lane, S. W., Hassell, P., Kennedy, G. A., Fung, Y. L. and Williams, B. A. (2009). Characterization of the bone marrow immunofluorescence test in childhood autoimmune neutropenia. International Journal of Laboratory Hematology, 31 (5), 567-571. doi: 10.1111/j.1751-553X.2008.01084.x

  • The leukemic stem cell niche: Current concepts and therapeutic opportunities

    Lane, Steven W., Scadden, David T. and Gilliland, D. Gary (2009). The leukemic stem cell niche: Current concepts and therapeutic opportunities. Blood, 114 (6), 1150-1157. doi: 10.1182/blood-2009-01-202606

  • Prolonged haematological toxicity from the hyper-CVAD regimen: Manifestations, frequency, and natural history in a cohort of 125 consecutive patients

    Gill, Saar, Lane, Steven, Crawford, Julie, Cull, Gavin, Joske, David, Joske, David, Marlton, Paula, Mollee, Peter, Prince, Miles and Seymour, John (2008). Prolonged haematological toxicity from the hyper-CVAD regimen: Manifestations, frequency, and natural history in a cohort of 125 consecutive patients. Annals of Hematology, 87 (9), 727-734. doi: 10.1007/s00277-008-0488-6

  • A 1 log rise in RQ-PCR transcript levels defines molecular relapse in core binding factor accute myeloid leukemia and predicts subsequent morphologic relapse

    Lane, Steven, Saal, Russell, Mollee, Peter, Jones, Mark, Grigg, Andrew, Taylor, Kerry, Seymour, John, Kennedy, Glen, Williams, Bronwyn, Grimmett, Karen, Griffiths, Vanessa, Gill, Devinder, Hourigan, Matthew and Marlton, Paula (2008). A 1 log rise in RQ-PCR transcript levels defines molecular relapse in core binding factor accute myeloid leukemia and predicts subsequent morphologic relapse. Leukemia & Lymphoma, 49 (3), 517-523. doi: 10.1080/10428190701817266

  • Palifermin-induced Acanthosis Nigricans

    Lane, S. W., Manoharan, S. and Mollee, P. N. (2007). Palifermin-induced Acanthosis Nigricans. Internal Medicine Journal, 37 (6), 417-418. doi: 10.1111/j.1445-5994.2007.01340.x

  • Increased Mortality with FLA Compared with ADE Chemotherapy in High-risk AML (Letter to the Editor)

    Lane, Steven W., Marlton, Paula and Mollee, Peter N. (2006). Increased Mortality with FLA Compared with ADE Chemotherapy in High-risk AML (Letter to the Editor). Blood, 108 (12), 3950-3951. doi: 10.1182/blood-2006-06-032680

  • Safety and efficacy of pegfilgrastim compared to granulocyte colony stimulating factor (G-CSF)supporting a dose-intensive, rapidly cycling anti-metabolite containing chemotherapy regimen (Hyper-CVAD) for lymphoid malignancy

    Lane, Steven W., Crawford, Julie, Kenealy, Melita, Cull, Gavin, Seymour, John F., Prince, H. Miles, Marlton, Paula, Gill, Devinder ‌ and Mollee, Peter‌ N. (2006). Safety and efficacy of pegfilgrastim compared to granulocyte colony stimulating factor (G-CSF)supporting a dose-intensive, rapidly cycling anti-metabolite containing chemotherapy regimen (Hyper-CVAD) for lymphoid malignancy. Leukemia and Lymphoma, 47 (9), 1813-1817. doi: 10.1080/10428190600632832

  • Hereditary fibrinogen A alpha-chain amyloidosis

    Lane, S. W., Goodman, H. J., Francis, L., Bofinger, A. M. and Mollee, P. N. (2006). Hereditary fibrinogen A alpha-chain amyloidosis. Pathology, 38 (4), 380-382. doi: 10.1080/00313020600820823

  • Role of VAD in the initial treatment of multiple myeloma

    Lane, Steven W., Gill, Devinder, Mollee, Peter N. and Rajkumar, S. Vincent (2005). Role of VAD in the initial treatment of multiple myeloma. Blood, 106 (10), 3674-3675. doi: 10.1182/blood-2005-07-2610

  • Intestinal Pseudo-Obstruction Complicating Multiple Sclerosis

    Lane, S. W. and Pender, M. P. (2005). Intestinal Pseudo-Obstruction Complicating Multiple Sclerosis. Internal Medicine Journal, 35 (3), 191-192. doi: 10.1111/j.1445-5994.2004.00753.x

Conference Publication

PhD and MPhil Supervision

Current Supervision

  • CRISPR-Cas9 approaches to model Myeloproliferative Neoplasms in vivo.

    Doctor Philosophy — Principal Advisor

  • Genomic drivers of progression of MPN to AML

    Doctor Philosophy — Principal Advisor

  • Targeting the Cancer-Immune Crosstalk in Acute Myeloid Leukaemia

    Doctor Philosophy — Associate Advisor

Completed Supervision

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