Klejch, Tomáš, Keough, Dianne T., Chavchich, Marina, Travis, Jye, Skácel, Jan, Pohl, Radek, Janeba, Zlatko, Edstein, Michael D., Avery, Vicky M., Guddat, Luke W. and Hocková, Dana (2019) Sulfide, sulfoxide and sulfone bridged acyclic nucleoside phosphonates as inhibitors of the Plasmodium falciparum and human 6-oxopurine phosphoribosyltransferases: synthesis and evaluation. European Journal of Medicinal Chemistry, 183 111667. doi:10.1016/j.ejmech.2019.111667
Journal Article: Mycobacterial dynamin-like protein IniA mediates membrane fission
Wang, Manfu, Guo, Xiangyang, Yang, Xiuna, Zhang, Bing, Ren, Jie, Liu, Aijun, Ran, Yajun, Yan, Bing, Chen, Fang, Guddat, Luke W., Hu, Junjie, Li, Jun and Rao, Zihe (2019) Mycobacterial dynamin-like protein IniA mediates membrane fission. Nature Communications, 10 1: 3906. doi:10.1038/s41467-019-11860-z
Journal Article: Synthesis, evaluation and structural investigations of potent purple acid phosphatase inhibitors as drug leads for osteoporosis
Feder, Daniel, Kan, Meng-Wei, Hussein, Waleed M., Guddat, Luke W., Schenk, Gerhard and McGeary, Ross P. (2019) Synthesis, evaluation and structural investigations of potent purple acid phosphatase inhibitors as drug leads for osteoporosis. European Journal of Medicinal Chemistry, 111611. doi:10.1016/j.ejmech.2019.111611
(2019–2020) Australian Nuclear Science and Technology Organisation
(2018–2020) NHMRC Project Grant
Ketol-acid reductoisomerase: An important antituberculosis drug target
(2018–2020) NHMRC Project Grant
Discovery of new antimalarial drugs
Doctor Philosophy
New Antimicrobial Drug Targets
Doctor Philosophy
Structure, mechanism and inhibition of plant and fungal acetohydroxyacid synthases
(2018) Doctor Philosophy
Snake venom nerve growth factors
Lavin, Martin F., Earl, Stephen, Birrell, Geoff, St. Pierre, Liam, Guddat, Luke W., John de Jersey and Masci, Paul (2009). Snake venom nerve growth factors. In Stephen P Mackessy (Ed.), Handbook of Venoms and Toxins of Reptiles 1st ed. (pp. 377-392) United States of America: CRC Press, Taylor & Francis Group.
Structure and properties of acetohydroxyacid synthase
Duggleby, R.G., Guddat, L. W. and Pang, S. S. (2004). Structure and properties of acetohydroxyacid synthase. In F. Jordan and M. S. Patel (Ed.), Thiamine. Catalytic Mechanisms 1st ed. (pp. 251-274) USA: Marcel Dekker.
Guddat, Luke and Martin, Jennifer Louise (1997). Structure of DsbA. In Guidebook to molecular chaperones and protein-folding catalysts (pp. x-xx) Oxford (U.K.): Oxford Universit Press.
Klejch, Tomáš, Keough, Dianne T., Chavchich, Marina, Travis, Jye, Skácel, Jan, Pohl, Radek, Janeba, Zlatko, Edstein, Michael D., Avery, Vicky M., Guddat, Luke W. and Hocková, Dana (2019) Sulfide, sulfoxide and sulfone bridged acyclic nucleoside phosphonates as inhibitors of the Plasmodium falciparum and human 6-oxopurine phosphoribosyltransferases: synthesis and evaluation. European Journal of Medicinal Chemistry, 183 111667. doi:10.1016/j.ejmech.2019.111667
Mycobacterial dynamin-like protein IniA mediates membrane fission
Wang, Manfu, Guo, Xiangyang, Yang, Xiuna, Zhang, Bing, Ren, Jie, Liu, Aijun, Ran, Yajun, Yan, Bing, Chen, Fang, Guddat, Luke W., Hu, Junjie, Li, Jun and Rao, Zihe (2019) Mycobacterial dynamin-like protein IniA mediates membrane fission. Nature Communications, 10 1: 3906. doi:10.1038/s41467-019-11860-z
Feder, Daniel, Kan, Meng-Wei, Hussein, Waleed M., Guddat, Luke W., Schenk, Gerhard and McGeary, Ross P. (2019) Synthesis, evaluation and structural investigations of potent purple acid phosphatase inhibitors as drug leads for osteoporosis. European Journal of Medicinal Chemistry, 111611. doi:10.1016/j.ejmech.2019.111611
Terán, David, Doleželová, Eva, Keough, Dianne T., Hocková, Dana, Zíková, Alena and Guddat, Luke W. (2019) Crystal structures of Trypanosoma brucei hypoxanthine – guanine – xanthine phosphoribosyltransferase in complex with IMP , GMP and XMP. The FEBS Journal, . doi:10.1111/febs.14987
The binding mode of an ADP analogue to a metallohydrolase mimics the likely transition state
Feder, Daniel, Gahan, Lawrence R., McGeary, Ross P., Guddat, Luke W. and Schenk, Gerhard (2019) The binding mode of an ADP analogue to a metallohydrolase mimics the likely transition state. ChemBioChem, 20 12: 1536-1540. doi:10.1002/cbic.201900077
Wu, Bin, Yu, Qi, Zheng, Shan, Pedroso, Marcelo Monteiro, Guddat, Luke W., He, Bingfang and Schenk, Gerhard (2019) Relative catalytic efficiencies and transcript levels of three D‐ and two L‐lactate dehydrogenases for optically pure D‐lactate production in Sporolactobacillus inulinus. MicrobiologyOpen, 8 5: e00704. doi:10.1002/mbo3.704
Krishna, Vagolu Siva, Zheng, Shan, Rekha, Estharla Madhu, Guddat, Luke W. and Sriram, Dharmarajan (2019) Discovery and evaluation of novel Mycobacterium tuberculosis ketol-acid reductoisomerase inhibitors as therapeutic drug leads. Journal of Computer-Aided Molecular Design, 33 3: 357-366. doi:10.1007/s10822-019-00184-1
Synthesis of the seco-limonoid BCD ring system identifies a Hsp90 chaperon machinery (p23) inhibitor
Pinkerton, David M., Chow, Sharon, Eisa, Nada H., Kainth, Kashish, Vanden Berg, Timothy J., Burns, Jed M., Guddat, Luke W., Savage, G. Paul, Chadli, Ahmed and Williams, Craig M. (2019) Synthesis of the seco-limonoid BCD ring system identifies a Hsp90 chaperon machinery (p23) inhibitor. Chemistry - A European Journal, 25 6: 1451-1455. doi:10.1002/chem.201805420
Crystal structures of membrane transporter MmpL3, an Anti-TB drug target
Zhang, Bing, Li, Jun, Yang, Xiaolin, Wu, Lijie, Zhang, Jia, Yang, Yang, Zhao, Yao, Zhang, Lu, Yang, Xiuna, Yang, Xiaobao, Cheng, Xi, Liu, Zhijie, Jiang, Biao, Jiang, Hualiang, Guddat, Luke W., Yang, Haitao and Rao, Zihe (2019) Crystal structures of membrane transporter MmpL3, an Anti-TB drug target. Cell, 176 3: 636-648.e13. doi:10.1016/j.cell.2019.01.003
Structural insights into substrate recognition by the type VII secretion system
Wang, Shuhui, Zhou, Kaixuan, Yang, Xiaolin, Zhang, Bing, Zhao, Yao, Xiao, Yu, Yang, Xiuna, Yang, Haitao, Guddat, Luke W., Li, Jun and Rao, Zihe (2019) Structural insights into substrate recognition by the type VII secretion system. Protein and Cell, . doi:10.1007/s13238-019-00671-z
Synthesis and evaluation of novel purple acid phosphatase inhibitors
Hussein, Waleed M., Feder, Daniel, Schenk, Gerhard, Guddat, Luke W. and McGeary, Ross P. (2019) Synthesis and evaluation of novel purple acid phosphatase inhibitors. MedChemComm, 10 1: 61-71. doi:10.1039/c8md00491a
An electron transfer path connects subunits of a mycobacterial respiratory supercomplex
Gong, Hongri, Li, Jun, Xu, Ao, Tang, Yanting, Ji, Wenxin, Gao, Ruogu, Wang, Shuhui, Yu, Lu, Tian, Changlin, Li, Jingwen, Yen, Hsin-Yung, Lam, Sin Man, Shui, Guanghou, Yang, Xiuna, Sun, Yuna, Li, Xuemei, Jia, Minze, Yang, Cheng, Jiang, Biao, Lou, Zhiyong, Robinson, Carol V., Wong, Luet-Lok, Guddat, Luke W., Sun, Fei, Wang, Quan and Rao, Zihe (2018) An electron transfer path connects subunits of a mycobacterial respiratory supercomplex. Science, 362 6418: . doi:10.1126/science.aat8923
Eng, Wai Soon, Rejman, Dominik, Pohl, Radek, West, Nicholas P., Woods, Kyra, Naesens, Lieve M.J., Keough, Dianne T. and Guddat, Luke W. (2018) Pyrrolidine nucleoside bisphosphonates as antituberculosis agents targeting hypoxanthine-guanine phosphoribosyltransferase. European Journal of Medicinal Chemistry, 159 10-22. doi:10.1016/j.ejmech.2018.09.039
Engineering highly functional thermostable proteins using ancestral sequence reconstruction
Gumulya, Yosephin, Baek, Jong-Min, Wun, Shun-Jie, Thomson, Raine E. S., Harris, Kurt L., Hunter, Dominic J. B., Behrendorff, James B. Y. H., Kulig, Justyna, Zheng, Shan, Wu, Xueming, Wu, Bin, Stok, Jeanette E., De Voss, James J., Schenk, Gerhard, Jurva, Ulrik, Andersson, Shalini, Isin, Emre M., Bodén, Mikael, Guddat, Luke and Gillam, Elizabeth M. J. (2018) Engineering highly functional thermostable proteins using ancestral sequence reconstruction. Nature Catalysis, 1 11: 878-888. doi:10.1038/s41929-018-0159-5
Garcia, Mario D., Chua, Sheena M. H., Low, Yu-Shang, Lee, Yu-Ting, Agnew-Francis, Kylie, Wang, Jian-Guo, Nouwens, Amanda, Lonhienne, Thierry, Williams, Craig M., Fraser, James A. and Guddat, Luke W. (2018) Commercial AHAS-inhibiting herbicides are promising drug leads for the treatment of human fungal pathogenic infections. Proceedings of the National Academy of Sciences of the United States of America, 115 41: E9649-E9658. doi:10.1073/pnas.1809422115
Klejch, Tomáš, Pohl, Radek, Janeba, Zlatko, Sun, Minghan, Keough, Dianne T., Guddat, Luke W. and Hocková, Dana (2018) Acyclic nucleoside phosphonates with unnatural nucleobases, favipiravir and allopurinol, designed as potential inhibitors of the human and Plasmodium falciparum 6-oxopurine phosphoribosyltransferases. Tetrahedron, 74 40: 5886-5897. doi:10.1016/j.tet.2018.08.014
Purple acid phosphatase inhibitors as leads for osteoporosis chemotherapeutics
Hussein, Waleed M., Feder, Daniel, Schenk, Gerhard, Guddat, Luke W. and McGeary, Ross P. (2018) Purple acid phosphatase inhibitors as leads for osteoporosis chemotherapeutics. European Journal of Medicinal Chemistry, 157 462-479. doi:10.1016/j.ejmech.2018.08.004
Doleželová, Eva, Terán, David, Gahura, Ondřej, Kotrbová, Zuzana, Procházková, Michaela, Keough, Dianne, Špaček, Petr, Hocková, Dana, Guddat, Luke and Zíková, Alena (2018) Evaluation of the Trypanosoma brucei 6-oxopurine salvage pathway as a potential target for drug discovery. PLoS Neglected Tropical Diseases, 12 2: 1-28. doi:10.1371/journal.pntd.0006301
Wu, Bin, Zheng, Shan, Pedroso, Marcelo Monteiro, Guddat, Luke W., Chang, Siyuan, He, Bingfang and Schenk, Gerhard (2018) Processivity and enzymatic mechanism of a multifunctional family 5 endoglucanase from Bacillus subtilis BS-5 with potential applications in the saccharification of cellulosic substrates. Biotechnology for Biofuels, 11 1: 1-15. doi:10.1186/s13068-018-1022-2
Structural insights into the mechanism of inhibition of AHAS by herbicides
Lonhienne, Thierry, Garcia, Mario D., Pierens, Gregory, Mobli, Mehdi, Nouwens, Amanda and Guddat, Luke W. (2018) Structural insights into the mechanism of inhibition of AHAS by herbicides. Proceedings of the National Academy of Sciences of the United States of America, 115 9: E1945-E1954. doi:10.1073/pnas.1714392115
Zhang, Qingqing, Liu, Huijuan, Liu, Xiang, Jiang, Dunquan, Zhang, Bingjie, Tian, Hongliang, Yang, Cheng, Guddat, Luke W., Yang, Haitao, Mi, Kaixia and Rao, Zihe (2018) Discovery of the first macrolide antibiotic binding protein in Mycobacterium tuberculosis: a new antibiotic resistance drug target. Protein and Cell, 1-5. doi:10.1007/s13238-017-0502-7
Patel, Khushboo M., Teran, David, Zheng, Shan, Kandale, Ajit, Garcia, Mario, Lv, You, Schembri, Mark A., McGeary, Ross P., Schenk, Gerhard and Guddat, Luke W. (2017) Crystal structures of Staphylococcus aureus ketol-acid reductoisomerase in complex with two transition state analogues that have biocidal activity. Chemistry- A European Journal, 23 72: 18289-18295. doi:10.1002/chem.201704481
Lonhienne, Thierry, Garcia, Mario D., Noble, Chris, Harmer, Jeffrey, Fraser, James A., Williams, Craig M. and Guddat, Luke W. (2017) High Resolution Crystal Structures of the Acetohydroxyacid Synthase-Pyruvate Complex Provide New Insights into Its Catalytic Mechanism. Chemistryselect, 2 36: 11981-11988. doi:10.1002/slct.201702128
Patel, Khushboo, Teran, David, Zheng, Shan, Kandale, Ajit, Garcia, Mario, Lv, You, Schembri, Mark A, McGeary, Ross P, Schenk, Gerhard and Guddat, Luke William (2017) Crystal structures of Staphylococcus aureus ketol-acid reductoisomerase in complex with two transition state analogs that have biocidal activity. Chemistry (Weinheim an der Bergstrasse, Germany), 23 72: 18289-18295. doi:10.1002/chem.201704481
Keough, Dianne T., Rejman, Dominik, Pohl, Radek, Zborníková, Eva, Hocková, Dana, Croll, Tristan, Edstein, Michael D., Birrell, Geoff W., Chavchich, Marina, Naesens, Lieve M. J., Pierens, Gregory K., Brereton, Ian M. and Guddat, Luke W. (2017) Design of Plasmodium vivax Hypoxanthine-Guanine Phosphoribosyltransferase Inhibitors as Potential Antimalarial Therapeutics. ACS Chemical Biology, 13 1: 82-90. doi:10.1021/acschembio.7b00916
Hohagen, Hendrik, Schwarz, Dominik, Schenk, Gerhard, Guddat, Luke W., Schieder, Doris, Carsten, Jörg and Sieber, Volker (2017) Deacidification of grass silage press juice by continuous production of acetoin from its lactate via an immobilized enzymatic reaction cascade. Bioresource Technology, 245 Pt A: 1084-1092. doi:10.1016/j.biortech.2017.08.203
Yan, Qiaoling, Jiang, Dunquan, Qian, Lanfang, Zhang, Qingqing, Zhang, Wei, Zhou, Weihong, Mi, Kaixia, Guddat, Luke, Yang, Haitao and Rao, Zihe (2017) Structural insight into the activation of PknI kinase from M. tuberculosis via dimerization of the extracellular sensor domain. Structure, 25 8: 1286-1294. doi:10.1016/j.str.2017.06.010
Kaiser, Martin Maxmilian, Baszczynski, Ondrej, Hockova, Dana, Postova-Slavetinska, Lenka, Dracinsky, Martin, Keough, Dianne T., Guddat, Luke W. and Janeba, Zlatko (2017) Acyclic nucleoside phosphonates containing 9-deazahypoxanthine and a five-membered heterocycle as selective inhibitors of plasmodial 6-oxopurine phosphoribosyltransferases. ChemMedChem, 12 14: 1133-1141. doi:10.1002/cmdc.201700293
High resolution crystal structure of a fluoride-inhibited organophosphate-degrading metallohydrolase
Selleck, Christopher , Guddat, Luke W., Ollis, David L., Schenk, Gerhard and Pedroso, Marcelo Monteiro (2017) High resolution crystal structure of a fluoride-inhibited organophosphate-degrading metallohydrolase. Journal of Inorganic Biochemistry, 177 287-290. doi:10.1016/j.jinorgbio.2017.06.013
Spacek, Petr, Keough, Dianne T., Chavchich, Marina, Dracinsky, Martin, Janeba, Zlatko, Naesens, Lieve, Edstein, Michael D., Guddat, Luke W. and Hockova, Dana (2017) Synthesis and evaluation of symmetric acyclic nucleoside bisphosphonates as inhibitors of the Plasmodium falciparum, Plasmodium vivax and human 6-oxopurine phosphoribosyltransferases and the antimalarial activity of their prodrugs. Bioorganic & Medicinal Chemistry, 25 15: 4008-4030. doi:10.1016/j.bmc.2017.05.048
Crystal structure of plant acetohydroxyacid synthase, the target for several commercial herbicides
Garcia, Mario Daniel, Wang, Jian-Guo, Lonhienne, Thierry and Guddat, Luke William (2017) Crystal structure of plant acetohydroxyacid synthase, the target for several commercial herbicides. The FEBS Journal, 284 13: 2037-2051. doi:10.1111/febs.14102
Oligomeric state of hypoxanthine-guanine phosphoribosyltransferase from Mycobacterium tuberculosis
Eng, Wai Soon, Keough, Dianne T., Hockova, Dana, Winzor, Donald J. and Guddat, Luke W. (2017) Oligomeric state of hypoxanthine-guanine phosphoribosyltransferase from Mycobacterium tuberculosis. Biochimie, 135 6-14. doi:10.1016/j.biochi.2016.12.020
Lonhienne, Thierry, Garcia, Mario D. and Guddat, Luke W. (2017) The role of a FAD cofactor in the regulation of acetohydroxyacid synthase by redox signaling molecules. Journal of Biological Chemistry, 292 12: 5101-5109. doi:10.1074/jbc.M116.773242
Selleck, Christopher, Clayton, Daniel, Gahan, Lawrence R., Mitic, Nataša, McGeary, Ross P., Pedroso, Marcelo Monteiro, Guddat, Luke W. and Schenk, Gerhard (2017) Visualization of the reaction trajectory and transition state in a hydrolytic reaction catalyzed by a metalloenzyme. Chemistry: A European Journal, 23 20: 4778-4781. doi:10.1002/chem.201700866
Lukáč, Miloš, Hocková, Dana, Keough, Dianne T., Guddat, Luke W. and Janeba, Zlatko (2017) Novel nucleotide analogues bearing (1H-1,2,3-triazol-4-yl)phosphonic acid moiety as inhibitors of Plasmodium and human 6-oxopurine phosphoribosyltransferases. Tetrahedron, 73 6: 692-702. doi:10.1016/j.tet.2016.12.046
Lonhienne, Thierry, Garcia, Mario D., Fraser, James A., Williams, Craig M. and Guddat, Luke W. (2017) The 2.0 Å X-ray structure for yeast acetohydroxyacid synthase provides new insights into its cofactor and quaternary structure requirements. PLoS One, 12 2: e0171443.1-e0171443.13. doi:10.1371/journal.pone.0171443
Comprehensive understanding of acetohydroxyacid synthase inhibition by different herbicide families
Garcia, Mario D., Nouwens, Amanda, Lonhienne, Thierry G. and Guddat, Luke W. (2017) Comprehensive understanding of acetohydroxyacid synthase inhibition by different herbicide families. Proceedings of the National Academy of Sciences, 114 7: E1091-E1100. doi:10.1073/pnas.1616142114
Špaček, Petr, Keough, Dianne T., Chavchich, Marina, Dračínský, Martin, Janeba, Zlatko, Naesens, Lieve, Edstein, Michael D., Guddat, Luke W. and Hocková, Dana (2017) Synthesis and Evaluation of Asymmetric Acyclic Nucleoside Bisphosphonates as Inhibitors of Plasmodium falciparum and Human Hypoxanthine-Guanine-(Xanthine) Phosphoribosyltransferase. Journal of Medicinal Chemistry, 60 17: 7539-7554. doi:10.1021/acs.jmedchem.7b00926
AIM-1: an antibiotic-degrading metallohydrolase that displays mechanistic flexibility
Selleck, Christopher, Larrabee James A., Harmer, Jeffrey, Guddat, Luke W., Mitić, Natasa, Helweh, Waleed, Ollis, David L., Craig, Whitney R., Tierney, David L., Monteiro Pedroso, Marcelo and Schenk, Gerhard (2016) AIM-1: an antibiotic-degrading metallohydrolase that displays mechanistic flexibility. Chemistry, 22 49: 17704-17714. doi:10.1002/chem.201602762
Eng, Wai Soon, Hocková, Dana, Špaček, Petr, Baszczyňski, Ondřej, Janeba, Zlatko, Naesens, Lieve, Keough, Dianne T. and Guddat, Luke W. (2016) Crystal structures of acyclic nucleoside phosphonates in complex with Escherichia coli hypoxanthine phosphoribosyltransferase. ChemistrySelect, 1 19: 6267-6276. doi:10.1002/slct.201601679
Teran, David, Hockova, Dana, Cesnek, Micha, Zikova, Alena, Naesens, Lieve, Keough, Dianne T. and Guddat, Luke W. (2016) Crystal structures and inhibition of Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase. Scientific Reports, 6 . doi:10.1038/srep35894
New strategies to combat tuberculosis
Schenk, Gerhard and Guddat, Luke W. (2016) New strategies to combat tuberculosis. Australasian Biotechnology, 26 3: 52-53.
Metal ions play an essential catalytic role in the mechanism of ketol-acid reductoisomerase
Tadrowski, Sonya, Pedroso, Marcelo M., Sieber, Volker, Larrabee, James A., Guddat, Luke W. and Schenk, Gerhard (2016) Metal ions play an essential catalytic role in the mechanism of ketol-acid reductoisomerase. Chemistry, 22 22: 7427-7436. doi:10.1002/chem.201600620
Du, Qianyun Sharon, Trabi, Manuela, Richards, Renee Stirling, Mirtschin, Peter, Madaras, Frank, Nouwens, Amanda, Zhao, Kong-Nan, De Jersey, John, Lavin, Martin F., Guddat, Luke W. and Masci, Paul P. (2016) Characterization and structural analysis of a potent anticoagulant phospholipase A2 from Pseudechis australis snake venom. Toxicon, 111 37-49. doi:10.1016/j.toxicon.2015.12.017
Commercial herbicides can trigger the oxidative inactivation of acetohydroxyacid synthase
Lonhienne, Thierry, Nouwens, Amanda, Williams, Craig M., Fraser, James A., Lee, Yu-Ting, West, Nicholas P. and Guddat, Luke W. (2016) Commercial herbicides can trigger the oxidative inactivation of acetohydroxyacid synthase. Angewandte Chemie, 128 13: 4319-4323. doi:10.1002/ange.201511985
You, Lv, Kandale, Ajit, Wun, Shun Jie, McGeary, Ross P., Williams, Simon J., Kobe, Bostjan, Sieber, Volker, Schembri, Mark A., Schenk, Gerhard and Guddat, Luke W. (2016) Crystal structure of Mycobacterium tuberculosis ketol-acid reductoisomerase at 1.0 Å resolution: A potential target for anti-tuberculosis drug discovery. Febs Journal, 283 7: 1184-1196. doi:10.1111/febs.13672
Commercial Herbicides Can Trigger the Oxidative Inactivation of Acetohydroxyacid Synthase
Lonhienne, Thierry, Nouwens, Amanda, Williams, Craig M., Fraser, James A., Lee, Yu-Ting, West, Nicholas P. and Guddat, Luke W. (2016) Commercial Herbicides Can Trigger the Oxidative Inactivation of Acetohydroxyacid Synthase. Angewandte Chemie - International Edition, 55 13: 4247-4251. doi:10.1002/anie.201511985
Martin M. Kaiser, Dana Hocková, Wang, Tzu-Hsuan, Martin Dračínský, Lenka Poštová-Slavětínská, Eliška Procházková, Michael D. Edstein, Marina Chavchich, Keough, Dianne T, Guddat, Luke W and Zlatko Janeba (2015) Synthesis and Evaluation of Novel Acyclic Nucleoside Phosphonates as Inhibitors of Plasmodium falciparum and Human 6-Oxopurine Phosphoribosyltransferases. ChemMedChem, 10 10: 1707-1723. doi:10.1002/cmdc.201500322
Hockova, Dana, Janeba, Zlatko, Naesens, Lieve, Edstein, Michael D., Chavchich, Marina, Keough, Dianne T. and Guddat, Luke W. (2015) Antimalarial activity of prodrugs of N-branched acyclic nucleoside phosphonate inhibitors of 6-oxopurine phosphoribosyltransferases. Bioorganic and Medicinal Chemistry, 23 17: 5502-5510. doi:10.1016/j.bmc.2015.07.038
Eng, Wai Soon, Hockova, Dana, Spacek, Petr, Janeba, Zlatko, West, Nicholas P., Woods, Kyra, Naesens, Lieve M. J., Keough, Dianne T. and Guddat, Luke W. (2015) First crystal structures of mycobacterium tuberculosis 6-oxopurine phosphoribosyltransferase: complexes with GMP and pyrophosphate and with acyclic nucleoside phosphonates ehose prodrugs have antituberculosis activity. Journal of Medicinal Chemistry, 58 11: 4822-4838. doi:10.1021/acs.jmedchem.5b00611
Pohl, Radek, Slavetinska, Lenka Postova, Eng, Wai Soon, Keough, Dianne T., Guddat, Luke W. and Rejman, Dominik (2015) Synthesis, conformational studies, and biological properties of phosphonomethoxyethyl derivatives of nucleobases with a locked conformation via a pyrrolidine ring. Organic and Biomolecular Chemistry, 13 16: 4693-4705. doi:10.1039/c5ob00097a
Keough, Dianne T., Hockova, Dana, Janeba, Zlatko, Wang, Tzu-Hsuan, Naesens, Lieve, Edstein, Michael D., Chavchich, Marina and Guddat, Luke W. (2015) Aza-acyclic nucleoside phosphonates containing a second phosphonate group as inhibitors of the human, Plasmodium falciparum and vivax 6-oxopurine phosphoribosyltransferases and their prodrugs as antimalarial agents. Journal of Medicinal Chemistry, 58 2: 827-846. doi:10.1021/jm501416t
McGeary, Ross P., Schenk, Gerhard and Guddat, Luke W. (2014) The applications of binuclear metallohydrolases in medicine: recent advances in the design and development of novel drug leads for purple acid phosphatases, metallo-beta-lactamases and arginases. European Journal of Medicinal Chemistry, 76 132-144. doi:10.1016/j.ejmech.2014.02.008
Pedroso, Marcelo M., Ely, Fernanda, Lonhienne, Thierry, Gahan, Lawrence R., Ollis, David L., Guddat, Luke W. and Schenk, Gerhard (2014) Determination of the catalytic activity of binuclear metallohydrolases using isothermal titration calorimetry. Journal of Biological Inorganic Chemistry, 19 3: 389-398. doi:10.1007/s00775-013-1079-0
International Year of Crystallography
Batten, Stuart R., Kobe, Bostjan and Guddat, Luke (2014) International Year of Crystallography. Australian Journal of Chemistry, 67 12: 1718-1719. doi:10.1071/CH14557
Naesens, Lieve, Guddat, Luke W., Keough, Dianne T., van Kuilenburg, André B. P., Meijer, Judith, Vande Voorde, Johan and Balzarini, Jan (2013) Role of human hypoxanthine guanine phosphoribosyltransferase in activation of the antiviral agent T-705 (favipiravir). Molecular Pharmacology, 84 4: 615-629. doi:10.1124/mol.113.087247
Keough, Dianne T., Hocková, Dana, Rejman, Dominik, Spaček, Petr, Vrbková, Silvie, Krečmerová, Marcela, Eng, Wai Soon, Jans, Harmen, West, Nicholas P., Naesens, Lieve M. J., de Jersey, John and Guddat, Luke W. (2013) Inhibition of the Escherichia coli 6-oxopurine phosphoribosyltransferases by nucleoside phosphonates: potential for new antibacterial agents. Journal of Medicinal Chemistry, 56 17: 6967-6984. doi:10.1021/jm400779n
Baszczynski, Ondrej, Hockova, Dana, Janeba, Zlatko, Holy, Antonin, Jansa, Petr, Dracinsky, Martin, Keough, Dianne T. and Guddat, Luke W. (2013) The effect of novel [3-fluoro-(2-phosphonoethoxy)propyl]purines on the inhibition of Plasmodium falciparum, Plasmodium vivax and human hypoxanthine-guanine-(xanthine) phosphoribosyltransferases. European Journal of Medicinal Chemistry, 67 81-89. doi:10.1016/j.ejmech.2013.06.032
Acetohydroxyacid synthase: A target for antimicrobial drug discovery
Pue, Nason and Guddat, Luke W. (2013) Acetohydroxyacid synthase: A target for antimicrobial drug discovery. Current Pharmaceutical Design, 19 1-17.
Keough, Dianne T., Špaček, Petr, Hocková, Dana, Tichý, Tomáš, Vrbková, Silvie, Slavětínská, Lenka, Janeba, Zlatko, Naesens, Lieve, Edstein, Michael D., Chavchich, Marina, Wang, Tzu-Hsuan, de Jersey, John and Guddat, Luke W. (2013) Acyclic nucleoside phosphonates containing a second phosphonate group are potent inhibitors of 6-oxopurine phosphoribosyltransferases and have antimalarial activity. Journal of Medicinal Chemistry, 56 6: 2513-2526. doi:10.1021/jm301893b
Lee, Yu-Ting, Cui, Chang-Jun, Chow, Eve W. L., Pue, Nason, Lonhienne, Thierry, Wang, Jian-Guo, Fraser, James A. and Guddat, Luke W. (2013) Sulfonylureas have antifungal activity and are potent inhibitors of Candida albicans acetohydroxyacid synthase. Journal of Medicinal Chemistry, 56 1: 210-219. doi:10.1021/jm301501k
Millers, Emma-Karin I., Johnson, Lambro A., Birrell, Geoff W., Masci, Paul P., Lavin, Martin F., de Jersey, John and Guddat, Luke W. (2013) The structure of human microplasmin in complex with textilinin-1, an aprotinin-like inhibitor from the Australian brown snake. PLoS One, 8 1: e54104.1-e54104.12. doi:10.1371/journal.pone.0054104
Feder, Daniel, Hussein, Waleed M., Clayton, Daniel J., Kan, Meng-Wei, Schenk, Gerhard, McGeary, Ross P. and Guddat, Luke W. (2012) Identification of purple acid phosphatase inhibitors by fragment-based screening: promising new leads for osteoporosis therapeutics. Chemical Biology and Drug Design, 80 5: 665-674. doi:10.1111/cbdd.12001
Wong, Sze-Ho, Lonhienne, Thierry G. A., Winzor, Donald J., Schenk, Gerhard and Guddat, Luke W. (2012) Bacterial and plant ketol-acid reductoisomerases have different mechanisms of induced fit during the catalytic cycle. Journal of Molecular Biology, 424 3-4: 168-179. doi:10.1016/j.jmb.2012.09.018
Binuclear metallohydrolases: Complex mechanistic strategies for a simple chemical reaction
Schenk, Gerhard, Mitić, Nataša, Gahan, Lawrence R., Ollis, David L., McGeary, Ross P. and Guddat, Luke W. (2012) Binuclear metallohydrolases: Complex mechanistic strategies for a simple chemical reaction. Accounts of Chemical Research, 45 9: 1593-1603. doi:10.1021/ar300067g
Liu, Ligong, Li, Caiping, Cochran, Siska, Feder, Daniel, Guddat, Luke W. and Ferro, Vito (2012) A focused sulfated glycoconjugate Ugi library for probing heparan sulfate-binding angiogenic growth factors. Bioorganic & Medicinal Chemistry Letters, 22 19: 6190-6194. doi:10.1016/j.bmcl.2012.08.001
Hockova, Dana, Keough, Dianne T., Janeba, Zlatko, Wang, Tzu-Hsuan, de Jersey, John and Guddat, Luke W. (2012) Synthesis of novel N-branched acyclic nucleoside phosphonates as potent and selective inhibitors of human, plasmodium falciparum and plasmodium vivax 6-oxopurine phosphoribosyltransferases. Journal of Medicinal Chemistry, 55 13: 6209-6223. doi:10.1021/jm300662d
Penicillin inhibitors of purple acid phosphatase
Faridoon, Hussein, Waleed M., Islam, Nazar Ul, Guddat, Luke W., Schenk, Gerhard and McGeary, Ross P. (2012) Penicillin inhibitors of purple acid phosphatase. Bioorganic and Medicinal Chemistry Letters, 22 7: 2555-2559. doi:10.1016/j.bmcl.2012.01.123
The structure-activity relationship in herbicidal monosubstituted sulfonylureas
Li, Zheng-Ming, Ma, Yi, Guddat, Luke, Cheng, Pei-Quan, Wang, Jian-Guo, Pangi, Siew S., Dong, Yu-Hui, Lai, Cheng-Ming, Wang, Ling-Xiu, Jia, Guo-Feng, Li, Yong-Hong, Wang, Su-Hua, Liu, Jie, Zhao, Wei-Guang and Wang, Bao Lei (2012) The structure-activity relationship in herbicidal monosubstituted sulfonylureas. Pest Management Science, 68 4: 618-628. doi:10.1002/ps.2305
Krecmerova, Marcela, Dracinsky, Martin, Hockova, Dana, Holy, Antonín, Keough, Dianne T. and Guddat, Luke W. (2012) Synthesis of purine N-9-[2-hydroxy-3-O-(phosphonomethoxy)propyl] derivatives and their side-chain modified analogs as potential antimalarial agents. Bioorganic and Medicinal Chemistry, 20 3: 1222-1230. doi:10.1016/j.bmc.2011.12.034
Phosphate-bound structure of an organophosphate-degrading enzyme from Agrobacterium radiobacter
Ely, Fernanda, Pedroso, Marcelo M., Gahan, Lawrence R., Ollis, David L., Guddat, Luke W. and Schenk, Gerhard (2012) Phosphate-bound structure of an organophosphate-degrading enzyme from Agrobacterium radiobacter. Journal of Inorganic Biochemistry, 106 1: 19-22. doi:10.1016/j.jinorgbio.2011.09.015
Cesnek, Michael, Hockova, Dana, Holy, Antonín, Dracinsky, Martin, Baszczynski, Ondřej, de Jersey, John, Keough, Dianne T. and Guddat, Luke W. (2011) Synthesis of 9-phosphonoalkyl and 9-phosphonoalkoxyalkyl purines: Evaluation of their ability to act as inhibitors of Plasmodium falciparum, Plasmodium vivax and human hypoxanthine-guanine-(xanthine) phosphoribosyltransferases. Bioorganic and Medicinal Chemistry, 20 2: 1076-1089. doi:10.1016/j.bmc.2011.11.034
Wang, Jianguo, Tan, Haizhong, Li, Yonghong, Ma, Yi, Li, Zhengming and Guddat, Luke W. (2011) Chemical synthesis, in vitro acetohydroxyacid synthase (AHAS) inhibition, herbicidal activity, and computational studies of isatin derivatives. Journal of Agricultural and Food Chemistry, 59 18: 9892-9900. doi:10.1021/jf2021607
6-Oxopurine phosphoribosyltransferase: A target for the development of antimalarial drugs
de Jersey, John, Holý, Antonín, Hocková, Dana, Naesens, Lieve, Keough, Dianne T. and Guddat, Luke W. (2011) 6-Oxopurine phosphoribosyltransferase: A target for the development of antimalarial drugs. Current Topics in Medicinal Chemistry, 11 16: 2085-2102. doi:10.2174/156802611796575911
Drug targets for the treatment of protozoan parasitic diseases
Guddat, L (2011) Drug targets for the treatment of protozoan parasitic diseases. Current Topics in Medicinal Chemistry, 11 16: 2010-2011.
Keough, Dianne T., Hockova, Daná, Krečmerová, Marcela, Česnek, Michal, Holý, Antonín, Naesens, Lieve, Brereton, Ian M., Winzor, Donald J., de Jersey, John and Guddat, Luke W. (2010) Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase: A target for anti-malarial chemotherapy. Molecular and Biochemical Parasitology, 173 2: 165-169. doi:10.1016/j.molbiopara.2010.05.018
Ely, Fernanda, Hadler, Kieran S., Gahan, Lawrence R., Guddat, Luke W., Ollis, David L. and Schenk, Gerhard (2010) The organophosphate-degrading enzyme from Agrobacterium radiobacter displays mechanistic flexibility for catalysis. Biochemical Journal, 432 3: 565-573. doi:10.1042/BJ20101054
Hockova, Dana, Holy, Antonín, Masojidkova, Milena, Keough, Dianne T., de Jersey, John and Guddat, Luke W. (2009) Synthesis of branched 9-[2-(2-phosphonoethoxy)ethyl]purines as a new class of acyclic nucleoside phosphonates which inhibit Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase. Bioorganic & Medicinal Chemistry, 17 17: 6218-6232. doi:10.1016/j.bmc.2009.07.044
Keough, Dianne T., Hockova, Dana, Holy, Antonin, Naesens, Lieve M. J., Skinner-Adams, Tina S., de Jersey, John and Guddat, Luke W. (2009) Inhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: A new class of antimalarial therapeutics. Journal of Medicinal Chemistry, 52 14: 4391-4399. doi:10.1021/jm900267n
Millers, Emma-Karin K., Trabi, Manuela, Masci, Paul P., Lavin, Martin F., de Jersey, John and Guddat, Luke W. (2009) Crystal structure of textilinin-1, a Kunitz-type serine protease inhibitor from the venom of the Australian common brown snake (Pseudonaja textilis). FEBS Journal, 276 11: 3163-3175. doi:10.1111/j.1742-4658.2009.07034.x
Leung, Eleanor W. W. and Guddat, Luke W. (2009) Conformational changes in a plant ketol-acid reductoisomerase upon Mg2+ and NADPH binding as revealed by two crystal structures. Journal of Molecular Biology, 389 1: 167-182. doi:10.1016/j.jmb.2009.04.012
Wang, Jian-Guo, Lee, Patrick K.-M., Dong, Yu-Hui, Pang, Siew Siew, Duggleby, Ronald G., Li, Zheng-Ming and Guddat, Luke W. (2009) Crystal structures of two novel sulfonylurea herbicides in complex with Arabidopsis thaliana acetohydroxyacid synthase. FEBS Journal, 276 5: 1282-1290. doi:10.1111/j.1742-4658.2009.06863.x
Inhibition of purple acid phosphatase with alpha-alkoxynaphthylmethylphosphonic acids
McGeary, Ross P., Vella, Peter, Mak, Jeffery Y. W., Guddat, Luke W. and Schenk, Gerhard (2009) Inhibition of purple acid phosphatase with alpha-alkoxynaphthylmethylphosphonic acids. Bioorganic & Medicinal Chemistry Letters, 19 1: 163-166. doi:10.1016/j.bmcl.2008.10.125
Hadler, K., Tanifum, E.A., Yip, S.H.-C., Mitic, N., Guddat, L.W., Jackson, C.J., Gahan, L.R., Nguyen, K., Carr, P.D., Ollis, D.L., Hengge, A.C., Larrabee, J.A. and Schenk, G. (2008) Substrate-promoted formation of a catalytically competent binuclear center and regulation of reactivity in a glycerophosphodiesterase from Enterobacter aerogenes. Journal of the American Chemical Society, 130 43: 14129-14138. doi:10.1021/ja803346w
Hadler, K.ieran S., Huber, Thomas, Cassady, A. Ian, Weber, Jane, Robinson, Jodie, Burrows, Allan, Kelly, Gregory, Guddat, Luke W., Hume, David A., Schenk, Gerhard and Flanagan, Jack U. (2008) Identification of a non-purple tartrate-resistant acid phosphatase: An evolutionary link to Ser/Thr protein phosphatases?. BMC Research Notes, 1 1-8. doi:10.1186/1756-0500-1-78
Schenk, Gerhard, Elliott, Tristan W., Leung, Eleanor, Carrington, Lyle E., Mitic, Natasa, Gahan, Lawrence R. and Guddat, Luke W. (2008) Crystal structures of a purple acid phosphatase, representing different steps of this enzyme's catalytic cycle. BMC Structural Biology, 8 6: 1-13. doi:10.1186/1472-6807-8-6
Structure and mechanism of inhibition of plant acetohydroxyacid synthase
Duggleby, R.G., McCourt, J.A. and Guddat, Luke W. (2008) Structure and mechanism of inhibition of plant acetohydroxyacid synthase. Plant Physiology and Biochemistry, 2008 46: 309-324. doi:10.1016/j.plaphy.2007.12.004
Plant collagenase: Unique collagenolytic activity of cysteine proteases from ginger
Kim, M., Hamilton, S. E., Guddat, L. W. and Overall, C. M. (2007) Plant collagenase: Unique collagenolytic activity of cysteine proteases from ginger. Biochimica Et Biophysica Acta General Subjects, 1770 12: 1627-1635. doi:10.1016/j.bbagen.2007.08.003
Structure, function and diversity of plant purple acid phosphatases
Leung, Eleanor W. W., Teixeira, Marina, Guddat, Luke W., Mitić, Natasa and Schenk, Gerhard (2007) Structure, function and diversity of plant purple acid phosphatases. Current Topics in Plant Biology, 8 21-31.
Keough, Dianne T., Skinner-Adams, Tina, Jones, Malcolm K., Ng, Ai-Lin., Brereton, Ian M., Guddat, Luke W. and de Jersey, John (2006) Lead compounds for antimalarial chemotherapy: Purine base analogs discriminate between human and P-falciparum 6-oxopurine phosphoribosyltransferases. Journal of Medicinal Chemistry, 49 25: 7479-7486. doi:10.1021/jm061012j
Zheng, Yuan-Zhi, Guddat, Luke, Farlow, Anthony and de Jersey, John (2006) Structure-function relationships in human hypoxanthine-guanine phosphoribosyltransferase (HGPRT) by random mutagenesis. Chemical Research in Chinese Universities, 22 2: 251-252. doi:10.1016/S1005-9040(06)60090-1
Millers, E. K. I., Masci, P. P., Lavin, M. F., de Jersey, J. and Guddat, L. W. (2006) Crystallization and preliminary X-ray analysis of a Kunitz-type inhibitor, textilinin-1 from Pseudonaja textilis textilis. Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 62 Pt 7: 642-645. doi:10.1107/S1744309106019099
Herbicide-binding Sites Revealed in the Structure of Plant Acetohydroxyacid Synthase
McCourt, J. A., Pang, S. S., King-Scott, J., Guddat, L. W. and Duggleby, R. G. (2006) Herbicide-binding Sites Revealed in the Structure of Plant Acetohydroxyacid Synthase. Proceedings of The National Academy of Sciences of The United States of America, 103 3: 569-573. doi:10.1073/pnas.0508701103
Identification and molecular modeling of a novel, plant-like, human purple acid phosphatase
Flanagan, J. U., Cassady, A. I., Schenk, G., Guddat, L. W. and Hume, D. A. (2006) Identification and molecular modeling of a novel, plant-like, human purple acid phosphatase. Gene, 377 1: 12-20. doi:10.1016/j.gene.2006.02.031
Inhibition studies of purple acid phosphatases: Implications for the catalytic mechanism
Elliott, T. W., Mitic, N., Gahan, L. R., Guddat, L. W. and Schenk, G. (2006) Inhibition studies of purple acid phosphatases: Implications for the catalytic mechanism. Journal of the Brazilian Chemical Society, 17 8: 1558-1565. doi:10.1590/S0103-50532006000800011
Mammalian-like purple acid phosphatases in plants
De Jersey, J., Zheng, Yuan-Zhi, Fan, H. K., Schenk, G., Guddat, L. and Hamilton, S. (2006) Mammalian-like purple acid phosphatases in plants. Chemical Research In Chinese Universities, 22 2: 263-264. doi:10.1016/S1005-9040(06)60093-7
The Catalytic Mechanisms of Binuclear Metallohydrolases
Mitic, Natasa, Smith, Sarah J., Neves, Ademir, Guddat, Luke W., Gahan, Lawrence R. and Schenk, Gerhard (2006) The Catalytic Mechanisms of Binuclear Metallohydrolases. Chemical Reviews, 106 8: 3338-3363. doi:10.1021/cr050318f
Tyagi, R., Duquerroy, S., Navaza, J., Guddat, L. W. and Duggleby, R. G. (2005) The crystal structure of a bacterial Class II ketol-acid reductolsomerase: Domain conservation and evolution. Protein Science, 14 12: 3089-3100. doi:10.1110/ps.051791305
Structure-activity relationships for a new family of sulfonylurea herbicides
Wang, Jian-Guo, Li, Zheng-Ming, Ma, Zheng-Ming, Wang, Bao-Lei, Jiang, Lin, Pang, Siew Siew, Lee, Yu-Ting, Guddat, Luke W. and Duggleby, Ronald G. (2005) Structure-activity relationships for a new family of sulfonylurea herbicides. Journal of Computer-aided Molecular Design, 19 11: 801-820. doi:10.1007/s10822-005-9028-9
Aspartic proteases of Plasmodium falciparum as the target of HIV-1 protease inhibitors - Reply
Skinner-Adams, Tina S., Guddat, Luke W., Gardiner, Donald L., McCarthy, James S. and Andrews, Katherine T. (2005) Aspartic proteases of Plasmodium falciparum as the target of HIV-1 protease inhibitors - Reply. Journal of Infectious Diseases, 191 8: 1382-1383. doi:10.1086/428782
Savarino, Andrea, Cauda, Roberto, Cassone, Antonio, Skinner-Adams, Tina S., Guddat, Luke W., Gardiner, Donald L., McCarthy, J. James S. and Andrews, Katherine T. (2005) Aspartic proteases of Plasmodium falciparum as the target of HIV-1 protease inhibitors [3] (multiple letters). Journal of Infectious Diseases, 191 8: 1381-1383. doi:10.1086/428781
Elucidating the specificity of binding of sulfonylurea herbicides to acetohydroxyacid synthase
McCourt, J. A., Pang, S. S., Guddat, L. W. and Duggleby, R. G. (2005) Elucidating the specificity of binding of sulfonylurea herbicides to acetohydroxyacid synthase. Biochemistry, 44 7: 2330-2338. doi:10.1021/bi047980a
Schenk, G., Gahan, L. R., Carrington, L. E., Mitic, N., Valizadeh, M., Hamilton, S. E., de Jersey, J. and Guddat, L. W. (2005) Phosphate forms an unusual tripodal complex with the Fe-Mn center of sweet potato purple acid phosphatase. Proceedings of The National Academy of Sciences of The United States of America, 102 2: 273-278. doi:10.1073/pnas.0407239102
Tyagi, Rajiv, Lee, Yu-Ting, Guddat, Luke W. and Duggleby, Ronald G. (2005) Probing the mechanism of the bifunctional enzyme ketol-acid reductoisomerase by site-directed mutagenesis of the active site. Febs Journal, 272 2: 593-602. doi:10.1111/j.1742-4658.2004.04506.x
Keough, Dianne T., Brereton, Ian M., De Jersey, John and Guddat, Luke W. (2005) The crystal structure of free human hypoxanthineguanine phosphoribosyltransferase reveals extensive conformational plasticity throughout the catalytic cycle. Journal of Molecular Biology, 351 1: 170-181. doi:10.1016/j.jmb.2005.05.061
Phosphotyrosyl peptides and analogues as substrates and inhibitors of purple acid phosphatases
Valizadeh, Mohsen, Schenk, Gerhard, Nash, Kevin, Oddie, Geoff W., Guddat, Luke W., Hume, David A., de Jersey, John, Burke, Terrence R. and Hamilton, Susan (2004) Phosphotyrosyl peptides and analogues as substrates and inhibitors of purple acid phosphatases. Archives of Biochemistry And Biophysics, 424 2: 154-162. doi:10.1016/j.abb.2004.01.008
Pang, S. S., Guddat, L. W. and Duggleby, R. G. (2004) Crystallization of Arabidopsis thaliana acetohydroxyacid synthase in complex with the sulfonylurea herbicide chlorimuron ethyl. Acta Crystallographica Section D: Biological Crystallography, 60 1: 153-155. doi:10.1107/S0907444903025423
Facile crystallization of Escherichia coli ketol-acid reductoisomerase
McCourt, J. A., Tyagi, R., Guddat, L. W., Biou, V. and Duggleby, R. G. (2004) Facile crystallization of Escherichia coli ketol-acid reductoisomerase. Acta Crystallographica Section D: Biological Crystallography, 60 8: 1432-1434. doi:10.1107/S0907444904012247
Pang, S. S., Duggleby, R. G., Schowen, R. L. and Guddat, L. W. (2004) The crystal structures of Klebsiella pneumoniae acetolactate synthase with enzyme-bound cofactor and with an unusual intermediate. Journal of Biological Chemistry, 279 3: 2242-2253. doi:10.1074/jbc.M304038200
Molecular basis of sulfonylurea herbicide inhibition of acetohydroxyacid synthase
Pang, S. S., Guddat, L. W. and Duggleby, R. G. (2003) Molecular basis of sulfonylurea herbicide inhibition of acetohydroxyacid synthase. Journal of Biological Chemistry, 278 9: 7639-7644. doi:10.1074/jbc.M211648200
Duggleby, Ronald G., Pang, Siew Siew, Yu, Hongqi and Guddat, Luke W. (2003) Systematic characterization of mutations in yeast acetohydroxyacid synthase: Interpretation of herbicide-resistance data. European Journal of Biochemistry, 270 13: 2895-2904. doi:10.1046/j.1432-1033.2003.03671.x
Crystal structure of yeast acetohydroxyacid synthase: A target for herbicidal inhibitors
Pang, S. S., Duggleby, R. G. and Guddat, L. W. (2002) Crystal structure of yeast acetohydroxyacid synthase: A target for herbicidal inhibitors. Journal of Molecular Biology, 317 2: 249-262. doi:10.1006/jmbi.2001.5419
Guddat, L. W., Vos, S., Martin, J. L., Keough, D. T. and De Jersey, J. (2002) Crystal structures of free, IMP-, and GMP-bound Escherichia coli hypoxanthine phosphoribosyltransferase. Protein Science, 11 7: 1626-1638. doi:10.1110/ps.0201002
Crystallization of the FAD-independent acetolactate synthase of Klebsiella pneumoniae
Pang, S. S., Guddat, L. W. and Duggleby, R.G. (2002) Crystallization of the FAD-independent acetolactate synthase of Klebsiella pneumoniae. Acta Crystallographica Section D - Biological Crystallography, D58 7: 1237-1239. doi:10.1107/S0907444902008132
Edeling, M. A., Guddat, L. W., Fabianek, R. A., Thony-Meyer, L. and Martin, J. L. (2002) Structure of CcmG/DsbE at 1.14 angstrom resolution: High-fidelity reducing activity in an indiscriminately oxidizing environment. Structure, 10 7: 973-979. doi:10.1016/S0969-2126(02)00794-3
Three-dimensional structure of an immunoglobulin light-chain dimer with amyloidogenic properties
Bourne, P. C., Ramsland, P. A., Shan, L., Fan, Z. C., DeWitt, C. R., Shultz, B. B., Terzyan, S. S., Moomaw, C. R., Slaughter, C. A., Guddat, L. W. and Edmundson, A. B. (2002) Three-dimensional structure of an immunoglobulin light-chain dimer with amyloidogenic properties. Acta Crystallographica Section D: Biological Crystallography, 58 5: 815-823. doi:10.1107/S0907444902004183
Crystallization and preliminary diffraction studies of native and selenomethionine CcmG (CycY, DsbE)
Edeling, M. A., Guddat, L. W., Fabianek, R. A., Halliday, J. A., Jones, A., Thony-Meyer, L. and Martin, J. L. (2001) Crystallization and preliminary diffraction studies of native and selenomethionine CcmG (CycY, DsbE). Acta Crystallographica Section D-Biological Crystallography, D57 9: 1293-1295. doi:10.1107/S0907444901009982
Crystallization of the catalytic subunit of Saccharomyces cerevisiae acetohydroyacid synthase
Pang, S. S., Guddat, L. W. and Duggleby, R.G. (2001) Crystallization of the catalytic subunit of Saccharomyces cerevisiae acetohydroyacid synthase. Acta Crystallographica Section D: Biological Crystallography, 57 9: 1321-1323. doi:10.1107/S0907444901011635
Structure, function and regulation of tartrate-resistant acid phosphatase
Oddie, G. W., Schenk, G., Angel, N. Z., Walsh, N., Guddat, L. W., deJersey, J., Cassady, A. I., Hamilton, S. E. and Hume, D. A. (2000) Structure, function and regulation of tartrate-resistant acid phosphatase. Bone, 27 5: 575-584. doi:10.1016/S8756-3282(00)00368-9
Guddat, Luke W., Shan, Lin, Broomell, Christopher, Ramsland, Paul A., Fan, Zhao-Chang, Anchin, Jerry M., Linthicum, D. Scott and Edmundson, Allen B. (2000) The three-dimensional structure of a complex of a murine Fab (NC10.14) with a potent sweetener (NC174): An illustration of structural diversity in antigen recognition by immunoglobulins. Journal of Molecular Biology, 302 4: 853-872. doi:10.1006/jmbi.2000.4083
Identification of mammalian-like purple acid phosphatases in a wide range of plants
Schenk, G., Ge, Y., Guddat, L., Carrington, L. E., Hume, D. A., Hamilton, S. E. and deJersey, J. (2000) Identification of mammalian-like purple acid phosphatases in a wide range of plants. Gene, 250 1-2: 117-125. doi:10.1016/S0378-1119(00)00186-4
Schenk, G., Carrington, L., Hamilton, S. E., De Jersey, J. and Guddat, L. W. (1999) Crystallization and preliminary X-ray diffraction data for a purple acid phosphastase from sweet potato. Acta Crystallographica Section D: Biological Crystallography, 55 12: 2051-2052. doi:10.1107/S0907444999012597
Fan, Zhao-Chang, Shan, Lin, Goldsteen, Benjamin Z., Guddat, Luke W., Thakur, Archana, Landolfi, Nicholas F., Co, Man Sung, Vasquez, Maximiliano, Queen, Cary, Ramsland, Paul A. and Edmundson, Allen B. (1999) Comparison of the three-dimensional structures of a humanized and a chimeric Fab of an anti-γ-interferon antibody. Journal of Molecular Recognition, 12 1: 19-32. doi:10.1002/(SICI)1099-1352(199901/02)12:1<19::AID-JMR445>3.0.CO;2-Y
Crystal structure of mammalian purple acid phosphatase
Guddat, L. W., McAlpine, A. S., Hume, D. A., Hamilton, S. E., De Jersey, J. and Martin, J. L. (1999) Crystal structure of mammalian purple acid phosphatase. Structure With Folding & Design, 7 7: 757-767. doi:10.1016/S0969-2126(99)80100-2
Crystallization and preliminary X-ray diffraction studies of mammalian purple acid phosphatase
Guddat, L. W., McAlpine, A. S., Hume, D. A., De Jersey, J., Hamilton, S. E. and Martin, J. L. (1999) Crystallization and preliminary X-ray diffraction studies of mammalian purple acid phosphatase. Acta Crystallographica Section D: Biological Crystallography, 55 8: 1462-1464. doi:10.1107/S0907444999006241
Guddat, LW, Bardwell, JCA and Martin, JL (1998) Crystal structures of reduced and oxidized DsbA: investigation of domain motion and thiolate stabilization. Structure, 6 6: 757-767. doi:10.1016/S0969-2126(98)00077-X
Three-dimensional structure of a human Fab with high affinity for tetanus toxoid
Faber, Catherine, Shan, Lin, Fan, Zhao-Chang, Guddat, Luke W., Furebring, Christina, Ohlin, Mats, Borrebaeck, Carl A.K. and Edmundson, Allen B. (1998) Three-dimensional structure of a human Fab with high affinity for tetanus toxoid. Immunotechnology, 3 4: 253-270. doi:10.1016/S1380-2933(97)10003-3
Guddat, LW, Bardwell, JCA, Glockshuber, R, HuberWunderlich, M, Zander, T and Martin, JL (1997) Structural analysis of three His32 mutants of DsbA: Support for an electrostatic role of His32 in DsbA stability. Protein Science, 6 9: 1893-1900. doi:10.1002/pro.5560060910
Guddat, LW, Bardwell, JCA, Zander, T and Martin, JL (1997) The uncharged surface features surrounding the active site of Escherichia coli DsbA are conserved and are implicated in peptide binding. Protein Science, 6 6: 1148-1156. doi:10.1002/pro.5560060603
Three-dimensional structure of the alpha-conotoxin GI at 1.2 angstrom resolution
Guddat, LW, Martin, JL, Shan, L, Edmundson, AB and Gray, WR (1996) Three-dimensional structure of the alpha-conotoxin GI at 1.2 angstrom resolution. Biochemistry, 35 35: 11329-11335. doi:10.1021/bi960820h
Hu, Shu-Hong, Gehrmann, John, Guddat, Luke W., Alewood, Paul F., Craik, David J. and Martin, Jennifer L. (1996) The 1.1 angstrom crystal structure of the neuronal acetylcholine receptor antagonist, alpha-conotoxin PnIA from Conus pennaceus. Structure, 4 4: 417-423. doi:10.1016/S0969-2126(96)00047-0
Edmundson, Allen B., Shan, Lin, Fan, Zhao-Chang, Guddat, Luke W., Hanson, B. Leif and Andersen, Kim N. (1996) Crystallographic analysis of antigen-antibody complexes: End-on insertion of ligands in antibodies - CDR3 loops as arbiters. Methods: A Companion to Methods in Enzymology, 9 3: 542-558. doi:10.1006/meth.1996.0062
Intramolecular signaling upon complexation
Guddat, L. W., Shan, L., Fan, Z. C., Andersen, K. N., Linthicum, , Rosauer, R., Linthicum, D. S. and Edmundson, A. B. (1995) Intramolecular signaling upon complexation. FASEB Journal, 9 1: 101-106.
Local and transmitted conformational changes on complexation of an anti-sweetener Fab
Guddat, Luke W., Shan, Lin, Anchin, Jerry M., Linthicum, D. Scott and Edmundson, Allen B. (1994) Local and transmitted conformational changes on complexation of an anti-sweetener Fab. Journal of Molecular Biology, 236 1: 247-274. doi:10.1006/jmbi.1994.1133
Herron, J. N., Terry, A. H., Johnston, S., He, X. M., Guddat, L. W., Voss, E. W. and Edmundson, A. B. (1994) High resolution structures of the 4–4-20 Fab-fluorescein complex in two solvent systems: effects of solvent on structure and antigen-binding affinity. Biophysical Journal, 67 6: 2167-2183. doi:10.1016/S0006-3495(94)80738-6
Structural aspects of conformational changes in ligand binding by antibody fragments
Edmundson, A. B., Guddat, L. W., Shan, L., Fan, Z. c. and Hanson, B. L. (1994) Structural aspects of conformational changes in ligand binding by antibody fragments. Research in Immunology, 145 1: 56-61. doi:10.1016/S0923-2494(94)80045-6
Crystal Structures of Intact IgG Antibodies
Edmundson, Allen B., Guddat, Luke W. and Andersen, Kim N. (1993) Crystal Structures of Intact IgG Antibodies. ImmunoMethods, 3 3: 197-210. doi:10.1006/immu.1993.1054
Crystallization of an Fv fragment from a human IgM cryoglobulin by a microseeding technique
Shan, L., Guddat, L. W., Raison, R. L. and Edmundson, A. B. (1993) Crystallization of an Fv fragment from a human IgM cryoglobulin by a microseeding technique. Journal of Crystal Growth, 126 2-3: 229-244. doi:10.1016/0022-0248(93)90030-Z
Principles and pitfalls in designing site‐directed peptide ligands
Edmundson, A. B., Harris, D. L., Fan, Z. ‐C, Guddat, L. W., Schley, B. T., Hanson, B. L., Tribbick, G. and Geysen, H. M. (1993) Principles and pitfalls in designing site‐directed peptide ligands. Proteins: Structure, Function, and Bioinformatics, 16 3: 246-267. doi:10.1002/prot.340160304
Three-dimensional structure of a human immunoglobulin with a hinge deletion
Guddat, L. W., Herron, J. N. and Edmundson, A. B. (1993) Three-dimensional structure of a human immunoglobulin with a hinge deletion. Proceedings of the National Academy of Sciences of the United States of America, 90 9: 4271-4275. doi:10.1073/pnas.90.9.4271
Three-dimensional structure of an Fv from a human IgM immunoglobulin
Fan, Zhao-chang, Shan, Lin, Guddat, Luke W., He, Xiao-min, Gray, William R., Raison, Robert L. and Edmundson, Allen B. (1992) Three-dimensional structure of an Fv from a human IgM immunoglobulin. Journal of Molecular Biology, 228 1: 188-207. doi:10.1016/0022-2836(92)90500-J
Deacon, G. B., Gatehouse, B. M., Guddat, L. W. and Ney, S. C. (1989) Difunctionalization of primary aromatic amines with ethylene; synthesis of μ-arylnitrilobis(ethane-2,1-diyl)dimercury(II) complexes. Crystal structure of 2,4,6-Me3C6H2N-(CH2CH2HgCl)2 . Journal of Organometallic Chemistry, 375 1: . doi:10.1016/0022-328X(89)85095-8
Orbell, John D., Guddat, Luke W., Machin, Ken J. and Isaacs, Neil W. (1988) The effect of fast protein liquid chromatography (FPLC) cationic exchange purification on the crystallization of a monoclonal Fab fragment. Analytical Biochemistry, 170 2: 390-392. doi:10.1016/0003-2697(88)90649-5
CRYSTAL STRUCTURE OF Ba//3V//4O//1//3
Gatehouse, B. M., Guddat, L. W. and Roth, R. S. (1987) CRYSTAL STRUCTURE OF Ba//3V//4O//1//3. CHEMTECH, 17 8: 390-395.
The crystal structure of Ba3V4O13
Gatehouse, B. M., Guddat, L. W. and Roth, R. S. (1987) The crystal structure of Ba3V4O13. Journal of Solid State Chemistry, 71 2: 390-395. doi:10.1016/0022-4596(87)90247-7
Fallon, G. D., Gatehouse, B. M. and Guddat, L. (1986) Crystal structures of some niobium and tantalum oxides. IX. K3Nb7O19: A new potassium niobium oxide tunnel structure. Journal of Solid State Chemistry, 61 2: 181-187. doi:10.1016/0022-4596(86)90020-4
Guddat, L. W., Cowan, S. W., Machin, K. J., Isaacs, N. W. and Cotton, R. G H (1985) Crystallization and preliminary crystallographic data of the fab fragment of an anti-phenylalanine hydroxylase monoclonal antibody. Journal of Molecular Biology, 186 2: 479-480. doi:10.1016/0022-2836(85)90121-4
Ketol-acid-reductoisomerase, an emerging target for herbicides and novel antimicrobial agents
Schenk, Gerhard and Guddat, Luke W. (2017). Ketol-acid-reductoisomerase, an emerging target for herbicides and novel antimicrobial agents. In: 18th International Conference on Biological Inorganic Chemistry (ICBIC), Florianopolis Brazil, (S219-S219). 31 July - 4 August 2017.
Inhibition studies of purple acid phosphatases: Implications for the catalytic mechanism
Elliott, Tristan W., Mitić, Nataša, Gahan, Lawrence R., Guddat, Luke W. and Schenk, Gerhard (2006). Inhibition studies of purple acid phosphatases: Implications for the catalytic mechanism. In: , , (1558-1565). . doi:10.1590/S0103-50532006000800011
Duggleby, R.G., McCourt, J. A. and Guddat, L. W. (2005). 3D structure of the overlapping sulfonylurea and imidazolinone herbicide binding sites in acetohydroxyacid synthase. In: 9th Int Congress on Amino Acids & Proteins. 9th Int Congress on Amino Acids & Proteins, Vienna, (Abstract). 8-12 Aug, 2005.
Crystal structure of Escherichia coli ketol-acid reductoisomerase
Duggleby, R.G., Tyagi, R., Duquerroy, S., Navaza, J. and Guddat, L. W. (2005). Crystal structure of Escherichia coli ketol-acid reductoisomerase. In: East Coast Protein Meeting. East Coast Protein Meeting, Coffs Harbour, (Abstract). 24-26 June, 2005.
Crystal structure of textilinin-1
Millers, E. I., Masci, P., Lavin, M. F., De Jersey, J. and Guddat, L. W. (2005). Crystal structure of textilinin-1. In: East Coast Protein Meeting. East Coast Protein Meeting, Coffs Harbour, (Abstract). 24-26 June, 2005.
Elucidation of the binding site for five sulfonylurea herbicides in Arabidopsis thaliana
McCourt, J. A., Pang, S. S., King-Scott, J., Guddat, L. W. and Duggleby, R.G. (2005). Elucidation of the binding site for five sulfonylurea herbicides in Arabidopsis thaliana. In: 30th Annual Lorne Conference on Protein Structure and Function. 30th Annual Lorne Conference on Protein Structure and Function, Lorne, (Abstract). 6-11 Feb, 2005.
McCourt, J. A., Pang, S. S., King-Scott, J., Guddat, L. W. and Duggleby, R.G. (2005). Overlapping sulfonylurea and imidazolinone herbicide binding sites in Arabidopsis thaliana acetohydroxyacid synthase. In: East Coast Protein Meeting. East Coast Protein Meeting, Coffs Harbour, (Abstract). 24-26 June, 2005.
Schenk, G., Carrington, L., Valizadeh, M., De Jersey, J., Hamilton, S. E. and Guddat, L.W. (2003). Crystal structure and mechanism of a purple acid phosphatase from sweet potato: an enzyme with a novel Fe-Mn binuclear metal centre. In: International Conference on Biological Inorganic Chemistry. International Conference on Biological Inorganic Chemistry, Cairns, (Abstract). 19-23 July, 2003.
Molecular basis of sulfonylurea herbicide inhibition of acetohydroxyacid synthase
Pang, S. S., Guddat, L. W. and Duggleby, R.G. (2003). Molecular basis of sulfonylurea herbicide inhibition of acetohydroxyacid synthase. In: East Coast Protein Meeting 2003. East Coast Protein Meeting, Coffs Harbour, (Poster). 27-29 June, 2003.
Duggleby, R.G., Pang, S. S., Schowen, R. L. and Guddat, L. W. (2003). The crystal structures of Klebsiella pneumoniae acetolactate synthase with enzyme-bound cofactor and with an unusual intermediate. In: East Coast Protein Meeting. East Coast Protein Meeting, Coffs Harbour, ((Abstract)). 27-29 June, 2003.
Keough, D. T., Dulley, G., Guddat, L. W., Naesens, L. and De Jersey, J. (2002). Substrate analogues discriminate between human and Plasmodium falciparum 6-oxopurine phosphoribosyltransferases. In: ComBio 2002. ComBio 2002, Sydney, ((Poster)). 29 September - 3 October, 2002.
Yeast acetohydroxyacid synthase. Crystal structure of an enzyme containing non-catalytic FAD
Pang, S. S., Guddat, L. W. and Duggleby, R.G. (2002). Yeast acetohydroxyacid synthase. Crystal structure of an enzyme containing non-catalytic FAD. In: 14th International Symposium on Flavins and Flavoproteins. 14th Int Symposium on Flavins and Flavoproteins, Cambridge, UK, ((Abstract)). 14-18 July, 2002.
Landsberg, M., Guddat, L. W., Hawkins, B. L. and Smith, R. W. (2001). Structural analysis of the hnRNP A proteins: Understanding the interaction between hnRNP A2 and the A2RE trafficking element. In: Australian Society for Biochemistry & Molecular Biology Conference. ASBMB, Canberra, (). 31 Sept-4 Oct, 2001.
Schenk, G., Boutchard, C., Noble, C. J., Moubaraki, B., Murray, K. S., Hanson, G. R., De Jersey, J., Hamilton, S. E., Guddat, L. W. and Carrington, L. (2000). Sweet potato purple acid phosphatase: first example of a strongly antiferromagnetically coupled Fe-Mn binuclear centre in a protein. In: 5th European Biological Inorganic Chemistry Conference. EUROBIC-5, Toulouse, France, (Schenk-G). 17-20 July 2000.
Crystal structure of mammalian purple acid phosphatase: An enzyme with a binuclear metal centre
Guddat, L. W., McAlpine, A. S., Hume, D. A., Hamilton, S. E, De Jersey, J. and Martin, J. L. (1999). Crystal structure of mammalian purple acid phosphatase: An enzyme with a binuclear metal centre. In: Combined Conference Abstracts: 43rd Annual ASBMB, 18th Annual ANZSCDB and 39th Annual ASPP. ComBio 99, Conrad Jupiters, Gold Coast, (Sym-05-01). 27-30 September, 1999.
Crystallisation of a mammalian purple acid phosphatase
Hamilton, S. E., Guddat, L. W., McAlpine, A. S., Hume, D. A., De Jersey, J. and Martin, J. L. (1999). Crystallisation of a mammalian purple acid phosphatase. In: 24th Annual Lorne Conference on Protein Structure and Function. 24th Annual Lorne Conference on Protein Structure and Functin, Erskine House, Lorne, Vic., (C10). 7-11 February, 1999.
Planrtpurple acid phosphatases: Novel forms of the enzyme
Schenk, G., Carrington, L., Guddat, L. W., De Jersey, J. and Hamilton, S. E. (1999). Planrtpurple acid phosphatases: Novel forms of the enzyme. In: Combined Conference Abstracts: 43rd Annual ASBMB, 18th Annual ANZSCDB and 39th Annual ASPP. ComBio 99, Conrad Jupiters, Gold Coast, (Pos-Mon-80). 27-30 September, 1999.
Dulley, G., Ng, A., Qi, J., Guddat, L. W., Keough, D. T. and De Jersey, J. (1999). Plasmodium Falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase as a chemotherapeutic target: Comparison of the human and parasite enzymes. In: Combined Conference Abstracts: 43rd Annual ASBMB, 18th Annual ANZSCDB and 39th Annual ASPP. ComBio 99, Conrad Jupiter, Gold Coast, (Pos-Wed-83). 27-30 September, 1999.
(2019–2020) Australian Nuclear Science and Technology Organisation
(2018–2020) NHMRC Project Grant
Ketol-acid reductoisomerase: An important antituberculosis drug target
(2018–2020) NHMRC Project Grant
(2018–2019) Australian Nuclear Science and Technology Organisation
Herbicide Discovery for Australian WONS Based on Developments in the Bioisostere Concept
(2017–2020) Commonwealth Department of Social Services
Integrative blood coagulation research core facility
(2016) UQ Major Equipment and Infrastructure
Acetohydroxyacid synthase: A new drug target for human fungal pathogens
(2015–2018) NHMRC Project Grant
An integrated approach to combat antibiotic resistance
(2015–2018) NHMRC Project Grant
(2015–2017) Australian National University
(2015) UQ Major Equipment and Infrastructure
An Integrated Study of Acyclic Nucleoside Phosphonates as Antimalarial Drugs
(2012–2015) NHMRC Project Grant
(2012–2013) UQ Major Equipment and Infrastructure
Rational structure based drug design
(2012) Australian Synchrotron Access Program
Rational structure based drug design.
(2012) Australian Synchrotron Access Program
Targeting acetohydroxyacid synthase to discover new antifungal agents
(2011–2014) NHMRC Project Grant
Auto-iTC200 microcalorimeter for high-throughput molecular interaction analyses
(2011) UQ Major Equipment and Infrastructure
Rational Structure Based Drug Design
(2011) Australian Synchrotron Access Program
Rational structure based drug design
(2011) Australian Synchrotron Access Program
Rational sturcture based drug design
(2011) Australian Synchrotron Access Program
Structure and inhibition of enzymes that are drug or herbicide targets
(2011) Australian Synchrotron Access Program
Structure and inhibition of enzymes that are drug or herbicide targets
(2011) Australian Synchrotron Access Program
An integrated high -throughput fluorescence imaging facility
(2010) UQ Major Equipment and Infrastructure
(2009–2012) NHMRC Project Grant
Structure-based design of anti-osteoporotic drug leads: an integrated approach
(2009–2011) ARC Discovery Projects
Pre-clinical evaluation of snake venom proteins with therapeutic potential
(2008–2011) ARC Linkage Projects
Biosynthesis of Branched-Chain Amino Acids: A Target for the Discovery of New Herbicides
(2008) UQ External Support Enabling Grant
An Integrated Approach Towards Development of Highly Specific Chemotherapeutics
(2005–2007) ARC Discovery Projects
(2004–2007) ARC Linkage Projects
Structure and inhibition of acetohydroxyacid synthase
(2004–2006) ARC Discovery Projects
Virtual Screening In Structure-Based Drug Design For Malaria
(2003–2005) NHMRC Project Grant
AUSTRALIAN SYNCHROTRON RESEARCH PROGRAM - Support to visit BioCARS 1st - 8th December 2003
(2003) Australian Nuclear Science and Technology Organisation
Dynamic Light Scattering Instrument
(2003) NHMRC Equipment Grant
(2002–2004) ARC Discovery Projects
(2002–2003) Australian Nuclear Science and Technology Organisation
(2002) Australian Nuclear Science and Technology Organisation
(2002) Australian Nuclear Science and Technology Organisation
X-ray Crystallography of Acetohydroxyacid Synthase: A Target for Herbicide Inhibition.
(2001–2003) ARC Australian Research Council (Large grants)
Biochemical analysis of proteases from ginger with commercial potential
(2000–2002) ARC Collaborative Grant (SPIRT)
(2000) Australian Nuclear Science and Technology Organisation
(2000) ARC Australian Research Council (Small grants)
Travel grant to visit BioCARS, Advanced Photon Source, USA (20-21 December 1999)
(1999–2000) Australian Nuclear Science and Technology Organisation
Discovery of new antimalarial drugs
Doctor Philosophy — Principal Advisor
New Antimicrobial Drug Targets
Doctor Philosophy — Principal Advisor
Other advisors:
Branched Chain Amino Acid Biosynthesis
Doctor Philosophy — Principal Advisor
Other advisors:
Investigations on branched-chain amino acid biosynthesis
Doctor Philosophy — Principal Advisor
Other advisors:
Acetohydroxyacid synthase and dihydroxyacid dehydratase as an antifungal and herbicidal target
Doctor Philosophy — Principal Advisor
Other advisors:
Acetohydroxyacid synthase AHAS: A new drug target for human fungal pathogens
Doctor Philosophy — Associate Advisor
Other advisors:
Structure, function and inhibition of dihydrogen dehydratase (DHAD), an enzyme of the branched chain amino acid pathway
Doctor Philosophy — Associate Advisor
Other advisors:
Identification of protein sequence elements that confer thermostability in CYP2 family forms.
Doctor Philosophy — Associate Advisor
Other advisors:
Design and Synthesis of Metalloenzyme Inhibitors
Doctor Philosophy — Associate Advisor
Other advisors:
Agmatinase-Like-Protein (ALP): an enzyme that controls essential neurologicals functions in the brain
Doctor Philosophy — Associate Advisor
Other advisors:
Development and characterisation of cytochrome P450 enzyme systems for industrial application
Doctor Philosophy — Associate Advisor
Other advisors:
Structure, mechanism and inhibition of plant and fungal acetohydroxyacid synthases
(2018) Doctor Philosophy — Principal Advisor
Other advisors:
Acyclic nucleoside phosphonates as possible chemotherapeutic agents against parasitic diseases
(2017) Doctor Philosophy — Principal Advisor
Other advisors:
Targeting acetohydroxyacid synthase for the discovery of antifungal and herbicidal agents
(2017) Doctor Philosophy — Principal Advisor
Other advisors:
Bacterial ketol-acid reductoisomerase: structure, catalytic mechanism and thermal stability
(2017) Doctor Philosophy — Principal Advisor
Other advisors:
Inhibition of Bacterial 6-Oxopurine Phosphoribosyltransferase as Potential Antibacterial Target
(2016) Doctor Philosophy — Principal Advisor
Other advisors:
A study of the anticoagulant mechanisms of three biological compounds in vitro and in vivo
(2014) Doctor Philosophy — Principal Advisor
Other advisors:
Functional studies of rice KARI and inhibitor discovery
(2013) Master Philosophy — Principal Advisor
Other advisors:
STRUCTURAL STUDIES OF AUSTRALIAN SNAKE VENOM COMPOUNDS
(2008) Doctor Philosophy — Principal Advisor
Drug Discovery Using Rational Structure-Based Design Approaches
(2019) Doctor Philosophy — Associate Advisor
Other advisors:
IMPROVING OUTCOMES OF BIOCHEMICAL TESTING IN THE PATHOLOGY LABORATORY
(2012) Doctor Philosophy — Associate Advisor
Characterisation of the first bacterial purple acid phosphates from Mycobacterium marinum
(2010) Doctor Philosophy — Associate Advisor
Other advisors:
CRYSTAL STRUCTURE DETERMINATION AND SITE-DIRECTED MUTAGENESIS OF ACTIVE SITE RESIDUES IN ESCHERICHIA COLI KETOL-ACID REDUCTOISOMERASE
(2005) Doctor Philosophy — Associate Advisor