Associate Professor Vicki Whitehall

Honorary Associate Professor

School of Clinical Medicine
Faculty of Medicine

Overview

Qualifications

  • Doctor of Philosophy, The University of Queensland
  • Bachelor of Science (Hons I), The University of Queensland
  • Bachelor of Science, The University of Queensland

Publications

View all Publications

Supervision

  • Doctor Philosophy

  • Doctor Philosophy

  • Doctor Philosophy

View all Supervision

Publications

Journal Article

  • Liu, Cheng, Bettington, Mark L., Walker, Neal I., Dwine, Joel, Hartel, Gunter F., Leggett, Barbara A. and Whitehall, Vicki L. J. (2018) CpG island methylation in sessile serrated adenomas increases with age, indicating lower risk of malignancy in young patients. Gastroenterology, . doi:10.1053/j.gastro.2018.07.012

  • Bettington, Mark, Rosty, Christophe, Whitehall, Vicki, Leggett, Barbara, McKeone, Diane, Pearson, Sally-Ann and Walker, Neal (2018) A morphological and molecular study of proposed early forms of the traditional serrated adenoma. Histopathology, . doi:10.1111/his.13714

  • Lannagan, Tamsin R. M., Lee, Young K., Wang, Tongtong, Roper, Jatin, Bettington, Mark L., Fennell, Lochlan, Vrbanac, Laura, Jonavicius, Lisa, Somashekar, Roshini, Gieniec, Krystyna, Yang, Miao, Ng, Jia Q, Suzuki, Nobumi, Ichinose, Mari, Wright, Josephine A., Kobayashi, Hiroki, Putoczki, Tracey L., Hayakawa, Yoku, Leedham, Simon J., Abud, Helen E., Yilmaz, Ömer H., Marker, Julie, Klebe, Sonja, Wirapati, Pratyaksha, Mukherjee, Siddhartha, Tejpar, Sabine, Leggett, Barbara A., Whitehall, Vicki L. J., Worthley, Daniel L. and Woods, Susan L. (2018) Genetic editing of colonic organoids provides a molecularly distinct and orthotopic preclinical model of serrated carcinogenesis. Gut, gutjnl-2017. doi:10.1136/gutjnl-2017-315920

  • Bettington, Mark, Brown, Ian, Rosty, Christophe, Walker, Neal, Liu, Cheng, Croese, John, Rahman, Tony, Pearson, Sally-Ann, McKeone, Diane, Leggett, Barbara and Whitehall, Vicki (2018) Sessile serrated adenomas in young patients may have limited risk of malignant progression. Journal of Clinical Gastroenterology, 1. doi:10.1097/MCG.0000000000001014

  • Bond, Catherine E., Liu, Cheng, Kawamata, Futoshi, McKeone, Diane M., Fernando, Winnie, Jamieson, Saara, Pearson, Sally-Ann, Kane, Alexandra, Woods, Susan L., Lannagan, Tamsin R. M., Somashekar, Roshini, Lee, Young, Dumenil, Troy, Hartel, Gunter, Spring, Kevin J., Borowsky, Jennifer, Fennell, Lochlan, Bettington, Mark, Lee, Jason, Worthley, Daniel L., Leggett, Barbara A. and Whitehall, Vicki L. J. (2018) Oncogenic BRAF mutation induces DNA methylation changes in a murine model for human serrated colorectal neoplasia. Epigenetics, 13 1: 40-48. doi:10.1080/15592294.2017.1411446

  • Fennell, Lochlan J., Jamieson, Saara, McKeone, Diane, Corish, Tracie, Rohdmann, Megan, Furner, Tori, Bettington, Mark, Liu, Cheng, Kawamata, Futoshi, Bond, Catherine, Van De Pols, Jolieke, Leggett, Barbara and Whitehall, Vicki (2018) MLH1-93 G/a polymorphism is associated with MLH1 promoter methylation and protein loss in dysplastic sessile serrated adenomas with BRAFV600E mutation. BMC Cancer, 18 1: 1-7. doi:10.1186/s12885-017-3946-5

  • Kawamata, Futoshi, Patch, Ann-Marie, Nones, Katia, Bond, Catherine, McKeone, Diane, Pearson, Sally-Ann, Homma, Shigenori, Liu, Cheng, Fennell, Lochlan, Dumenil, Troy, Hartel, Gunter, Kobayasi, Nozomi, Yokoo, Hideki, Fukai, Moto, Nishihara, Hiroshi, Kamiyama, Toshiya, Burge, Matthew E., Karapetis, Christos S., Taketomi, Akinobu, Leggett, Barbara, Waddell, Nicola and Whitehall, Vicki (2018) Copy number profiles of paired primary and metastatic colorectal cancers. Oncotarget, 9 3: 3394-3405. doi:10.18632/oncotarget.23277

  • Borowsky, Jennifer, Dumenil, Troy, Bettington, Mark, Pearson, Sally-Ann, Bond, Catherine, Fennell, Lochlan, Liu, Cheng, McKeone, Diane, Rosty, Christophe, Brown, Ian, Walker, Neal, Leggett, Barbara and Whitehall, Vicki (2017) The role of APC in WNT pathway activation in serrated neoplasia. Modern Pathology , 31 3: 495-504. doi:10.1038/modpathol.2017.150

  • Liu, Cheng, Walker, Neal I., Leggett, Barbara A., Whitehall, Vicki L. J., Bettington, Mark L. and Rosty, Christophe (2017) Sessile serrated adenomas with dysplasia: morphological patterns and correlations with MLH1 immunohistochemistry. Modern Pathology, 30 12: 1728-1738. doi:10.1038/modpathol.2017.92

  • Fennell, Lochlan J. , Clendenning, Mark, McKeone, Diane M. , Jamieson, Saara H., Balachandran, Samanthy, Borowsky, Jennifer, Liu, John, Kawamata, Futoshi, Bond, Catherine E., Rosty, Christophe, Burge, Matthew E., Buchanan, Daniel D., Leggett, Barbara A.  and Whitehall, Vicki L. J. (2017) RNF43 is mutated less frequently in Lynch Syndrome compared with sporadic microsatellite unstable colorectal cancers. Familial Cancer, 17 1: 1-7. doi:10.1007/s10689-017-0003-0

  • Liu, Cheng, Mckeone, Diane M., Walker, Neal I., Bettington, Mark L., Leggett, Barbara A. and Whitehall, Vicki L. J. (2017) GNAS mutations are present in colorectal traditional serrated adenomas, serrated tubulovillous adenomas and serrated adenocarcinomas with adverse prognostic features. Histopathology, 70 7: 1079-1088. doi:10.1111/his.13180

  • Scarpa, Aldo, Chang, David K., Nones, Katia, Corbo, Vincenzo, Patch, Ann-Marie, Bailey, Peter, Lawlor, Rita T., Johns, Amber L., Miller, David K., Mafficini, Andrea, Rusev, Borislav, Scardoni, Maria, Antonello, Davide, Barbi, Stefano, Sikora, Katarzyna O., Cingarlini, Sara, Vicentini, Caterina, McKay, Skye, Quinn, Michael C.J., Bruxner, Timothy J.C., Christ, Angelika N., Harliwong, Ivon, Idrisoglu, Senel, McLean, Suzanne, Nourse, Craig, Nourbakhsh, Ehsan, Wilson, Peter J., Anderson, Matthew J., Fink, J. Lynn, Newell, Felicity, Waddell, Nick, Holmes, Oliver, Kazakoff, Stephen H., Leonard, Conrad, Wood, Scott, Xu, Qinying, Nagaraj, Shivashankar Hiriyur, Amato, Eliana, Dalai, Irene, Bersani, Samantha, Cataldo, Ivana, Dei Tos, Angelo P., Capelli, Paola, Davì, Maria Vittoria, Landoni, Luca, Malpaga, Anna, Miotto, Marco, Whitehall, Vicki L.J., Leggett, Barbara A., Harris, Janelle L., Harris, Jonathan, Jones, Marc D., Humphris, Jeremy, Chantrill, Lorraine A., Chin, Venessa, Nagrial, Adnan M., Pajic, Marina, Scarlett, Christopher J., Pinho, Andreia, Rooman, Ilse, Toon, Christopher, Wu, Jianmin, Pinese, Mark, Cowley, Mark, Barbour, Andrew, Mawson, Amanda, Humphrey, Emily S., Colvin, Emily K., Chou, Angela, Lovell, Jessica A., Jamieson, Nigel B., Duthie, Fraser, Gingras, Marie-Claude, Fisher, William E., Dagg, Rebecca A., Lau, Loretta M.S., Lee, Michael, Pickett, Hilda A., Reddel, Roger R., Samra, Jaswinder S., Kench, James G., Merrett, Neil D., Epari, Krishna, Nguyen, Nam Q., Zeps, Nikolajs, Falconi, Massimo, Simbolo, Michele, Butturini, Giovanni, Van Buren, George, Partelli, Stefano, Fassan, Matteo, Khanna, Kum Kum, Gill, Anthony J., Wheeler, David A., Gibbs, Richard A., Musgrove, Elizabeth A., Bassi, Claudio, Tortora, Giampaolo, Pederzoli, Paolo, Pearson, John V., Waddell, Nicola, Biankin, Andrew V. and Grimmond, Sean M. (2017) Whole-genome landscape of pancreatic neuroendocrine tumours. Nature, 543 7643: 65-71. doi:10.1038/nature21063

  • Bettington, Mark, Walker, Neal, Rahman, Tony, Vandeleur, Ann, Whitehall, Vicki, Leggett, Barbara and Croese, John (2017) High prevalence of sessile serrated adenomas in contemporary outpatient colonoscopy practice. Internal Medicine Journal, 47 3: 318-323. doi:10.1111/imj.13329

  • Bettington, Mark, Walker, Neal, Rosty, Christophe, Brown, Ian, Clouston, Andrew, McKeone, Diane, Pearson, Sally-Ann, Leggett, Barbara and Whitehall, Vicki (2016) Clinicopathological and molecular features of sessile serrated adenomas with dysplasia or carcinoma. Gut, 66 1: 97-106. doi:10.1136/gutjnl-2015-310456

  • Bond, Catherine E., McKeone, Diane M., Kalimutho, Murugan, Bettington, Mark L., Pearson, Sally-Ann, Dumenil, Troy D., Wockner, Leesa F., Burge, Matthew, Leggett, Barbara A. and Whitehall, Vicki L. J. (2016) RNF43 and ZNRF3 are commonly altered in serrated pathway colorectal tumorigenesis. Oncotarget, 7 43: 70589-70600. doi:10.18632/oncotarget.12130

  • Bettington, Mark L., Walker, Neal I., Rosty, Christophe, Brown, Ian S., Clouston, Andrew D., McKeone, Diane M., Pearson, Sally Ann, Klein, Kerenaftali, Leggett, Barbara A. and Whitehall, Vicki L. (2015) A clinicopathological and molecular analysis of 200 traditional serrated adenomas. Modern Pathology, 28 3: 414-427. doi:10.1038/modpathol.2014.122

  • Bond, Catherine E., Bettington, Mark L., Pearson, Sally-Ann, McKeone, Diane M., Leggett, Barbara A. and Whitehall, Vicki (2015) Methylation and expression of the tumour suppressor, PRDM5, in colorectal cancer and polyp subgroups. BMC Cancer, 15 1: 20. doi:10.1186/s12885-015-1011-9

  • Bettington, Mark, Walker, Neal, Rosty, Christophe, Brown, Ian, Clouston, Andrew, Mckeone, Diane, Pearson, Sally-Ann, Klein, Kerenaftali, Leggett, Barbara and Whitehall, Vicki (2015) Serrated tubulovillous adenoma of the large intestine. Histopathology, 68 4: 578-587. doi:10.1111/his.12788

  • Whitehall, V. L. J., Dumenil, T. D., McKeone, D. M., Bond, C. E., Bettington, M. L., Buttenshaw, R. L., Bowdler, L., Montgomery, G. W., Wockner, L. F. and Leggett, B. A. (2014) Isocitrate dehydrogenase 1 R132C mutation occurs exclusively in microsatellite stable colorectal cancers with the CpG island methylator phenotype. Epigenetics, 9 11: 1454-1460. doi:10.4161/15592294.2014.971624

  • Dumenil, Troy D., Wockner, Leesa F., Bettington, Mark, Mckeone, Diane M., Klein, Kerenaftali, Bowdler, Lisa M., Montgomery, Grant W., Leggett, Barbara A. and Whitehall, Vicki L. J. (2014) Genome-wide DNA methylation analysis of formalin-fixed paraffin embedded colorectal cancer tissue. Genes Chromosomes and Cancer, 53 7: 537-548. doi:10.1002/gcc.22164

  • Bond, Catherine E., Nancarrow, Derek J., Wockner, Leesa F., Wallace, Leanne, Montgomery, Grant W., Leggett, Barbara A. and Whitehall, Vicki L. J. (2014) Microsatellite stable colorectal cancers stratified by the BRAF V600E mutation show distinct patterns of chromosomal instability. Plos One, 9 3: . doi:10.1371/journal.pone.0091739

  • Bettington, Mark, Walker, Neal, Rosty, Christophe, Brown, Ian, Clouston, Andrew, Wockner, Leesa, Whitehall, Vicki and Leggett, Barbara (2014) Critical appraisal of the diagnosis of the sessile serrated adenoma. American Journal of Surgical Pathology, 38 2: 158-166. doi:10.1097/PAS.0000000000000103

  • Day, Fiona L., Jorissen, Robert N., Lipton, Lara, Mouradov, Dmitri, Sakthianandeswaren, Anuratha, Christie, Michael, Li, Shan, Tsui, Cary, Tie, Jeannie, Desai, Jayesh, Xu, Zheng-Zhou, Molloy, Peter, Whitehall, Vicki, Leggett, Barbara A., Jones, Ian T., McLaughlin, Stephen, Ward, Robyn L., Hawkins, Nicholas J., Ruszkiewicz, Andrew R., Moore, James, Busam, Dana, Zhao, Qi, Strausberg, Robert L., Gibbs, Peter and Sieber, Oliver M. (2013) PIK3CA and PTEN gene and exon mutation-specific clinicopathologic and molecular associations in Colorectal cancer. Clinical Cancer Research, 19 12: 3285-3296. doi:10.1158/1078-0432.CCR-12-3614

  • Rosty, Christophe, Hewett, David G., Brown, Ian S., Leggett, Barbara A. and Whitehall, Vicki L. J. (2013) Serrated polyps of the large intestine: current understanding of diagnosis, pathogenesis, and clinical management. Journal of Gastroenterology, 48 3: 287-302. doi:10.1007/s00535-012-0720-y

  • Bond, Catherine E., Umapathy, Aarti, Buttenshaw, Ron L., Wockner, Leesa, Leggett, Barbara A. and Whitehall, Vicki L. J. (2012) Chromosomal instability in BRAF mutant, microsatellite stable colorectal cancers. Plos One, 7 10: e47483.1-e47483.9. doi:10.1371/journal.pone.0047483

  • Whitehall, Vicki and Leggett, Barbara (2011) Microsatellite instability: Detection and management in sporadic colorectal cancer. Journal of Gastroenterology and Hepatology, 26 12: 1697-1699. doi:10.1111/j.1440-1746.2011.06932.x

  • Walker, R. Griff, Landmann, Juergen K., Hewett, David G., Worthley, Daniel L., Buttenshaw, Ron L., Knight, Ngaire, Webb, Penny M., Whiteman, David C., Whitehall, Vicki L. and Leggett, Barbara A. (2010) Hyperplastic Polyposis syndrome is associated with cigarette smoking, which may be a modifiable risk factor. The American Journal of Gastroenterology, 105 7: 1642-1647. doi:10.1038/ajg.2009.757

  • Hinoue, Toshinori, Weisenberger, Daniel J., Pan, Fei, Campan, Mihaela, Kim, Myungjin, Young, Joanne, Whitehall, Vicki L., Leggett, Barbara A. and Laird, Peter W. (2009) Analysis of the Association between CIMP and BRAF(V600E) in Colorectal Cancer by DNA Methylation Profiling. PLoS One, 4 12: . doi:10.1371/journal.pone.0008357

  • Loh, K, Chia, J. A., Greco, S., Cozzi, S.J., Buttenshaw, R.L., Bond, C.E., Simms, L.A., Pike, T., Young, J. P., Jass, J.R., Spring, K. J., Leggett, B. A. and Whitehall, V.L.J. (2008) Bone morphogenic protein 3 inactivation is an early and frequent event in colorectal cancer development. Genes, Chromosomes & Cancer, 47 6: 449-460. doi:10.1002/gcc.20552

  • Worthley, D. L., Whitehall, V. L., Spring, K. J. and Leggett. B. A. (2007) Colorectal carcinogenesis: Road maps to cancer. World Journal of Gastroenterology, 13 28: 3784-3791.

  • Chia, June A., Simms, Lisa A., Cozzi, Sarah-Jane, Young, Joanne, Jass, Jeremy R., Walsh, Michael D., Spring, Kevin J., Leggett, Barbara A. and Whitehall, Vicki L. J. (2006) SnoN expression is differently regulated in microsatellite unstable compared with microsatellite stable colorectal cancers. BMC Cancer, 6 252: 1-6. doi:10.1186/1471-2407-6-252

  • Spring, Kevin, Zhao, Zhen Zhen, Karamatic, Rozemary, Walsh, Michael, Whitehall, Vicki, Pike, Tanya, Simms, Lisa, Young, Joanne, James, Michael, Montgomery, Grant, Appleyard, Mark, Hewett, David, Togashi, Kazutomo, Jass, Jeremy and Leggett, Barbara (2006) High prevalence of sessile serrated adenomas with BRAF mutations: A prospective study of patients undergoing colonoscopy. Gastroenterology, 131 5: 1400-1407. doi:10.1053/j.gastro.2006.08.038

  • Young, Joanne, Simms, Lisa A., Barker, Melissa A., Walsh, Michael D., Biden, Kelli G., Buttenshaw, Ron, Whitehall, Vicki L.J., Arnold, Sven, Jackson, Leigh, Kambara, Takeshi, Spring, Kevin J., Jenkins, Mark A., Walker, Graeme J., Hopper, John L., Leggett, Barbara A. and Jass, Jeremy R. (2005) Evidence for BRAF mutation and variable levels of microsatellite instability in a syndrome of familial colorectal cancer. Clinical Gastroenterology and Hepatology, 3 3: 254-263. doi:10.1016/S1542-3565(04)00673-1

  • Kambara, T., Simms, L. A., Whitehall, V. L. J., Spring, K. J., Wynter, C. V. A., Walsh, M. D., Barker, M. A., Arnold, S., McGivern, A., Matsubara, N., Tanaka, N., Higuchi, T., Young, J., Jass, J. R. and Leggett, B. A. (2004) BRAF mutation is associated with DNA methylation in serrated polyps and cancers of the colorectum. Gut, 53 8: 1137-1144. doi:10.1136/gut.2003.037671

  • Kambara, Takeshi, Whitehall, Vicki L. J., Spring, Kevin J., Barker, Melissa A., Arnold, Sven, Wynter, Coral V. A., Matsubara, Nagahide, Tanaka, Noriaki, Young, Joanne P., Leggett, Barbara A. and Jass, Jeremy R. (2004) Role of inherited defects of MYH in the development of sporadic colorectal cancer. Genes, Chromosomes and Cancer, 40 1: 1-9. doi:10.1002/gcc.20011

Conference Publication

PhD and MPhil Supervision

Current Supervision

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Principal Advisor

    Other advisors:

Completed Supervision