Dr Tara Roberts

Honorary Fellow

UQ Centre for Clinical Research
Faculty of Medicine

Overview

Research Interests

  • The role of SMG1 in inflammation and cellular stress responses
  • Rat models of neurodegeneration in Ataxia-Telangiectasia
  • Cellular respones to cytosolic DNA

Qualifications

  • Doctor of Philosophy, The University of Queensland
  • Bachelor of Science (Honours), The University of Queensland

Publications

  • Quek, Hazel, Luff, John, Cheung, KaGeen, Kozlov, Sergei, Gatei, Magtouf, Lee, C. Soon, Bellingham, Mark C., Noakes, Peter G., Lim, Yi Chieh, Barnett, Nigel L., Dingwall, Steven, Wolvetang, Ernst, Mashimo, Tomoji, Roberts, Tara L. and Lavin, Martin F. (2016) Rats with a missense mutation in Atm display neuroinflammation and neurodegeneration subsequent to accumulation of cytosolic DNA following unrepaired DNA damage. Journal of Leukocyte Biology, 101 4: 927-947. doi:10.1189/jlb.4VMA0716-316R

  • Roberts, Tara L., Ho, Uda, Luff, John, Lee, C. Soon, Apte, Simon H., MacDonald, Kelli P. A., Raggatt, Liza-Jane, Pettit, Allison R., Morrow, Carl A., Waters, Michael J., Chen, Phil, Woods, Rick G., Thomas, Gethin P., St. Pierre, Liam, Farah, Camile S., Clarke, Raymond A., Brown, James A. L. and Lavin, Martin F. (2013) Smg1 haploinsufficiency predisposes to tumor formation and inflammation. PNAS: Proceedings of the National Academy of Sciences of the United States of America, 110 4: E285-E294. doi:10.1073/pnas.1215696110

  • Roberts, Tara L., Idris, Adi, Dunn, Jasmyn A., Kelly, Greg M., Burnton, Carol M., Hodgson, Samantha, Hardy, Lani. L., Garceau, Valerie, Sweet, Matthew J., Ross, Ian L., Hume, David A. and Stacey, Katryn J. (2009) HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA. Science, 323 5917: 1057-1060. doi:10.1126/science.1169841

View all Publications

Available Projects

  • SMG1 is a member of the PI-3 kinase like kinase (PIKK) family of proteins which include ATM, DNA-PK and mTOR. Members of this family have well-characterised roles in responses to cellular stress including DNA damage and nutrient deprivation. We recently described a novel role for SMG1 as a tumour suppressor. Decreased SMG1 protein expression led to increased development of cancer, particularly lymphomas and lung adenocarcinomas. SMG1 loss also increased basal inflammation and oxidative damage to tissues prior to tumour development. Current work is focussed on determining the molecular mechanisms by which SMG1 regulates inflammation and cellular stress responses.

View all Available Projects

Publications

Featured Publications

  • Roberts, Tara L., Ho, Uda, Luff, John, Lee, C. Soon, Apte, Simon H., MacDonald, Kelli P. A., Raggatt, Liza-Jane, Pettit, Allison R., Morrow, Carl A., Waters, Michael J., Chen, Phil, Woods, Rick G., Thomas, Gethin P., St. Pierre, Liam, Farah, Camile S., Clarke, Raymond A., Brown, James A. L. and Lavin, Martin F. (2013) Smg1 haploinsufficiency predisposes to tumor formation and inflammation. PNAS: Proceedings of the National Academy of Sciences of the United States of America, 110 4: E285-E294. doi:10.1073/pnas.1215696110

  • Roberts, Tara L., Idris, Adi, Dunn, Jasmyn A., Kelly, Greg M., Burnton, Carol M., Hodgson, Samantha, Hardy, Lani. L., Garceau, Valerie, Sweet, Matthew J., Ross, Ian L., Hume, David A. and Stacey, Katryn J. (2009) HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA. Science, 323 5917: 1057-1060. doi:10.1126/science.1169841

Book Chapter

  • Stacey, Katryn J., Clark, Francis, Young, Greg R. and Roberts, Tara L. (2008). Discrimination of self and non-self DNAs. In Ken J. Ishii and Shizuo Akira (Ed.), Nucleic Acids in Innate Immunity (pp. 85-100) Boca Raton, FL, USA: CRC Press.

Journal Article

Other Outputs

Possible Research Projects

Note for students: The possible research projects listed on this page may not be comprehensive or up to date. Always feel free to contact the staff for more information, and also with your own research ideas.

  • SMG1 is a member of the PI-3 kinase like kinase (PIKK) family of proteins which include ATM, DNA-PK and mTOR. Members of this family have well-characterised roles in responses to cellular stress including DNA damage and nutrient deprivation. We recently described a novel role for SMG1 as a tumour suppressor. Decreased SMG1 protein expression led to increased development of cancer, particularly lymphomas and lung adenocarcinomas. SMG1 loss also increased basal inflammation and oxidative damage to tissues prior to tumour development. Current work is focussed on determining the molecular mechanisms by which SMG1 regulates inflammation and cellular stress responses.