Professor Joseph Lynch

Professor

Queensland Brain Institute

Affiliate Research Fellow

Institute for Molecular Bioscience
j.lynch@uq.edu.au
+61 7 334 66375

Overview

Joe Lynch completed a BSc majoring in Physics at the University of Melbourne. He then moved to the University of NSW to undertake a Masters of Biomedical Engineering and then a Ph.D. in Physiology with Peter Barry. His postdoctoral studies were undertaken in Germany, France and at the Garvan Institute of Medical Research in Sydney. He moved to University of QLD in 1996 as a Senior Lecturer in the School of Biomedical Sciences, was awarded an NHMRC Senior Research Fellowship in 2004 (renewed in 2009). He relocated to the QBI in October 2007.

Research Interests

  • neurotransmission in the central nervous system
    The major research interest in the laboratory concerns the molecular structure and function of the structurally-related glycine and GABAA receptor chloride channels that mediate inhibitory neurotransmission in the central nervous system. The GABAA receptor is an important target for neuroactive drugs and the glycine receptor has recently emerged as a drug target for inflammatory pain. We try to understand the mechanisms by which these receptors open and close, their structure and their molecular pharmacology. His laboratory is also interested in identifying novel compounds active at these receptors as leads for therapeutic development and as pharmacological tools for basic research. A more complete description of our current research interests is given at http://www.qbi.uq.edu.au//?page=160882 . Experimental approaches include molecular biology, protein chemistry, manual and automated patch-clamp electrophysiology, fluorescence imaging, automated high throughput fluorescence-based screening, voltage-clamp fluorescence.

Qualifications

  • PhD, University of New South Wales
  • Master of Biomedical Engineering, University of New South Wales
  • Bachelor of Science, University of Melbourne

Publications

View all Publications

Supervision

View all Supervision

Publications

Book Chapter

  • Lynch, Joseph W., Zhang, Yan, Talwar, Sahil and Estrada-Mondragon, Argel (2017). Glycine receptor drug discovery. In Ion channels downunder (pp. 225-253) Cambridge, MA United States: Academic Press. doi:10.1016/bs.apha.2017.01.003

  • Lynch, J. W. and Barry, P. (2007). Ligand-gated ion channels: permeation and activation. In S. H. Chung, O. S. Anderson and V. Krishnamurthy (Ed.), Biological Membrane Ion Channels (pp. 335-368) New York: Springer.

  • Hawthorne, R. L. and Lynch, J W (2006). The molecular pharmacology of the glycine receptor. In H.R. Arias (Ed.), Biological and Biophysical Aspects of Ligand-Gated Ion Channel Receptor Superfamilies (pp. 227-240) Kerala, India: Research Signpost.

Journal Article

Conference Publication

Grants (Administered at UQ)

PhD and MPhil Supervision

Current Supervision

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Principal Advisor

    Other advisors:

Completed Supervision