Professor Matt Trau

Senior Group Leader

Australian Institute for Bioengineering and Nanotechnology

Professorial Research Fellow

School of Chemistry and Molecular Biosciences
Faculty of Science
m.trau@uq.edu.au
+61 7 334 64173

Overview

Professor Matt Trau is currently a Professor of Chemistry at The University of Queensland (UQ); and is also Deputy Director and co-founder of the Australian Institute for Bioengineering and Nanotechnology. Since graduating from the University of Sydney (BSc Hons I, University Medal) and the University of Melbourne (PhD in Physical Chemistry, 1993), he has held positions in industry and academia across the globe. These include a Fulbright Research Fellowship at Princeton University, USA; and a research scientist at Dow Chemical and ICI Pty Ltd. Professor Trau has been a Visiting Professor at two of the largest Cancer Research Centres in the world: The Dana Farber Cancer Research Institute, Harvard Medical School, Boston (2000); and the Fred Hutchinson Cancer Research Centre, Seattle (2008). Professor Trau is internationally recognised for his innovative and cross-disciplinary research at the interface between chemistry, nanotechnology, biology and medicine. He has co-authored more than 170 refereed publications, many of which appear in the highest impact journals in his field, e.g., eigth Science and Nature family publications. His major awards and honours include an ARC Federation Fellowship (one of the most prestigious scientific fellowships in Australia), a Fulbright Research Fellowship to the USA; a Queensland Young Tall Poppy Award; a UQ Foundation/Vice Chancellor’s Research Excellence Award; a Paul Harris Fellowship; and a Pink Circle Award for breast cancer research excellence.

Research Impacts

Research

Nanoscience, Nanotechnology, Molecular diagnostics.

Leadership of major multi-disciplinary international programs

Professor Trau has raised more than $22 million in competitive national and international grant funding in the past 10 years. In the last five years, Professor Trau has initiated and led several large international programs that involve close collaboration between leading nanotechnologists, molecular biologists, geneticists and commercial researchers - with the goal of creating cutting edge diagnostics. These include a $4 million National and International Research Alliances Program (NIRAP) grant from the Queensland government ("International Partnership for preventative and Personalised Medicine)"; and two consecutive $5 million multidisciplinary collaborative grants from the National Breast Cancer Foundation (NBCF): "Novel strategies for Prediction and Control of Advanced Breast Cancer via Nanoscaled Epigenetic-Based Biosensors", 2008-2013; and "Enabling Clinical Epigenetic Diagnostics: The Next Generation of Personalized Breast Cancer Care", 2013-2018. These grants involve research collaborations with some of the highest calibre scientists in the world, e.g., Dr Lee Hartwell (2001 Nobel Laureate) from Seattle was a co-chief investigator on the NIRAP grant, and each of the NBCF grants include leading geneticists, pathologists and oncologists from across Australia and around the world. In the past five years, he has been a consultant for a range of national and international companies such as Merck, Digene, Beckman Coulter, Panbio and A.I. Scientific, as well as being the founder and Director of Nanomics BioSystems Pty Ltd (a spinoff company from his laboratory).

Major plenary lectures and international conferences

Since 2003, Professor Trau has presented more than 60 invited plenary/keynote lectures at major international conferences spanning the disciplines of Chemistry, Nanotechnology, Chemical Engineering, Cancer and Diagnostics. Recent examples include: the 4th International NanoBio Conference, (Seattle) 2012; the 14th International Colloid & Surface Science Conference, (Japan) 2012; "Cancer Nanotechnology" Gordon Research Conference, (USA) 2011; the WA Cancer Conference 2011; Sydney Cancer Conference, 2010. In the past 10 years, Professor Trau has played the role of conference convenor, chair, co-chair and symposium chair for 10 major international conferences. Recent examples include: immediate past chair of the 1st International Conference on BioNano Innovation, (Brisbane) 2012; co-chair of the 5th International NanoBio Conference scheduled for Brisbane in 2014.

Qualifications

  • PhD, University of Melbourne
  • Bachelor of Science (Hons), The University of Sydney

Publications

View all Publications

Supervision

  • Doctor Philosophy

  • Doctor Philosophy

  • Doctor Philosophy

View all Supervision

Publications

Book

Book Chapter

  • Lane, Rebecca E., Korbie, Darren, Trau, Matt and Hill, Michelle M. (2017). Purification protocols for extracellular vesicles. In Winston Patrick Kuo and Shidong Jia (Ed.), Extracellular vesicles: methods and protocols (pp. 111-130) New York, United States: Humana Press. doi:10.1007/978-1-4939-7253-1_10

  • Wee, Eugene J. H., Shiddiky, Muhammad J. A. and Trau, Matt (2013). Detecting DNA methylation for cancer diagnostics and prognostics. In Muhammad J. A. Shiddiky, Eugene J. H. Wee, Sakandar Rauf and Matt Trau (Ed.), Microfluidics, nanotechnology and disease biomarkers for personalized medicine applications (pp. 117-132) New York, NY, United States: Nova Publishers.

  • Battersby, B. J., Chen, A., Kozak, D. and Trau, M. (2012). Biosensors for disease biomarker detection. In Seamus Higson (Ed.), Biosensors for medical applications (pp. 191-216) Oxford, United Kingdom: Woodhead Publishing. doi:10.1016/B978-1-84569-935-2.50007-3

  • Pattemore, J. A., Trau, M. and Henry, R. J. (2008). Nanotechnology : the future of cost-effective plant genotyping. In R. J. Henry (Ed.), Plant genotyping II : SNP technology (pp. 133-153) Wallingford, United Kingdom: CABI Publishing. doi:10.1079/9781845933821.0133

  • Battersby, Bronwyn J., Grondahl, Lisbeth, Lawrie, Gwendolyn A. and Trau, Matt (2004). Colloids for encoding chemical libraries: Applications in biological screening. In F. Caruso (Ed.), Colloids and Colloid Assemblies (pp. 507-560) Weinheim: Wiley VCH.

Journal Article

Conference Publication

  • Koo, K., Wee, E., Mainwaring, P., Wang, Y. and Trau, M. (2016). Towards precision medicine: A cancer molecular subtyping nano-strategy for RNA biomarkers in tumor and urine. In: 28th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, Munich Germany, (S33-S33). November 29 - December 2 2016.

  • Wee, Eugene J. H., Koo, Kevin M., Mainwaring, Paul N. and Trau, Mattias (2015). Towards rapid and cost-effective point-of-care detection of TMPRSS2:ERG fusion transcripts in urine via a novel methodology. In: 2015 ASCO Annual Meeting Abstracts. Annual Meeting of the American Society of Clinical Oncology (ASCO), Chicago, IL United States, (). 29 May-02 June 2015.

  • Vaidyanathan, Ramanathan, van Leeuwen, Lara Michelle, Rauf, Sakandar, Shiddiky, Muhammad J. A and Trau, Matt (2014). A Multiplex Device Based on Tunable Nanoshear Forces for Highly Specific Detection of Multiple Protein Biomarkers. In: Proceedings of the 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS). 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, San Antonio, TX United States, (1972-1974). 26-30 October 2014.

  • Shiddiky, Muhammad J, Vaidyanathan, Ramanathan, Naghibosadat, Maedeh, Rauf, Sakandar, Korbie, Darren, Carrascosa, Laura G and Trau, Matt (2014). Detecting Exosomes Specifically: a Microfluidic Approach Based on Alternating Current Electrohydrodynamic Induced Nanoshearing. In: Proceedings of the 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS). 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, San Antonio, TX United States, (674-676). 26-30 October 2014.

  • Shiddiky, Muhammad J, Sina, Abu Ali Ibn, Carracosa, Laura G, Palanisamy, Ramkumar, Rauf, Sakandar and Trau, Matt (2014). Methylsorb: A Simple Method for Quantifying DNA Methylation Using DNA-gold Affinity Interactions. In: ICECE 2014, 8th International Conference on Electrical and Computer Engineering. 8th International Conference on Electrical and Computer Engineering, Dhaka, Bangladesh, (17-20). 20-22 December 2014. doi:10.1109/ICECE.2014.7027002

  • Trau, Matt (2014). Tunable Nano-Shearing: Some New Ideas for Capturing Ctcs and Rare Molecules From Blood. In: Special Issue: COSA's 41st Annual Scientific Meeting. Joining Forces - Accelerating Progress. COSA's 41st Annual Scientific Meeting. Joining Forces - Accelerating Progress, Melbourne, VIC Australia, (99-99). 2-4 December 2014. doi:10.1111/ajco.12304

  • Shiddiky, Muhammad J. A., Vaidyanathan, Ramanathan, Rauf, Sakandar, Tay, Zhikai and Trau, Matt (2013). Tuneable "nanoshearing": an innovative mechanism for the accurate and specific capture of rare cancer cells. In: Roland Zengerle, The 17th International Conference on Miniaturised Systems for Chemistry and Life Sciences: μTAS 2013. Proceedings. μTAS 2013: The 17th International Conference on Miniaturised Systems for Chemistry and Life Sciences (MicroTAS 2013), Freiburg, Germany, (26-28). 27-31 October, 2013.

  • Noohom, Wadcharawadee, Jack, Kevin S., Martin, Darren J. and Trau, Matt (2009). Understanding and control of mechanical properties of HA/PHBV nanocomposites for bone applications. In: Proceedings of the 8th World Biomaterials Congress. 8th World Biomaterials Conference, Amsterdam, Netherlands, (). 28 May- 1 June, 2008.

  • Corrie, S. R., Lawrie, G. A., Battersby, B. J., Ford, K., Ruhmann, A., Koehler, K., Sabath, D. E. and Trau, M. (2007). Quantitative data analysis methods for bead-based DNA hybridization assays using generic flow cytometry platforms. In: James L. Madara, Journal of Molecular Diagnostics: Association for Molecular Pathology 2007 Annual Meeting Abstracts. Association for Molecular Pathology 2007 Annual Meeting, The Hyatt Regency Century Plaza Hotel, Los Angeles, California, (699-699). 7-10 November, 2007.

  • Wu, A. C., Grondahl, L., Jack, K. S., Trau, M. and Cassady, A. I. (2006). Minimization of pro-inflammatory responses of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) for use in bone tissue engineering. In: 28th Australasian Polymer Symposium & Australian Society for Biomaterials. 28th Australasian Polymer Symposium & Australian Society for Biomat, Rotorua, (Abstract). 5-9th February, 2006.

  • Corrie, Simon, Lawrie, Gwen, Battersby, Bronwyn and Trau, Matt (2006). Organosilica particles for DNA screening applications. In: 2006 International Conference on Nanoscience and Nanotechnology. Proceedings. ICONN 2006: International Conference On Nanoscience and Nanotechnology, Brisbane, QLD, Australia, (190-193). 3-7 July, 2006. doi:10.1109/ICONN.2006.340599

  • Grondahl, L, Keen, I, Raggatt, L, Chandler-Temple, A. F., Cool, S M and Trau, M (2006). Tailoring poly(3-hydroxybutyrate-co-3-hydroxyvalerate) for bone tissue engineering. In: 28th Australasian Polymer Symposium & Aust Society for Biomaterials. 28th Australasian Polymer Symposium & Aust Society for Biomat, Rotorua, (Abstract). 5-9 Feb, 2006.

  • Keen, I., Raggatt, L., Cool, S. M., Nurcombe, V., Fredericks, P., Trau, M. and Grondahl, L. (2005). Response of osteoblast cells to the surface properties of Poly(3-hydroxybutyrate-co-hydroxyvalerate) PHBV. In: 2nd ARC Centre For Functional Nanomaterials Annual Conference. 2nd ARC Centre For Functional Nanomaterials Annual Conference, Maroochydore, (Seminar). Nov, 2005.

  • Grondahl, L., Lutton, C. J., Kenny, B., Cool, S. M., Cassady, A.I. and Trau, M. (2004). Development and in vitro testing of a biodegradable bone scaffold. In: 7th World Biomaterials Congress. 7th World Biomaterials Congress, Sydney, (Abstract). May, 2004.

  • Kumarasuriyar, A., Jackson, R., Grondahl, L., Trau, M., Nurcombe, V. and Cool, S. M. (2004). In vitro analysis of a bioactive, biodegradable material for bone repair. In: 7th World Biomaterials Congress. 7th World Biomaterials Congress, Sydney, (Poster). May, 2004.

  • Keen, I., Grondahl, L., Raggatt, L., Fredericks, P.M., Nurcombe, V., Trau, M. and Cool, S. M. (2004). Influence of solvent on the surface properties of PHBV solvent cast films. In: 27th Australasian Polymer Symposium. 27th Australasian Polymer Symposium, Adelaide, (Abstract). Nov, 2004.

  • Keen, I., Grondahl, L., Cool, S. M., Nurcombe, V. and Trau, M. (2004). Surface modification of PHBV for bone tissue engineering. In: 7th World Biomaterials Congress. 7th World Biomaterials Congress, Sydney, (Abstract). May, 2004.

  • Grondahl, L., Chandler-Temple, A. F., Luong-Van, E. K., Riding, A. S., Kumarasuriyar, A., Kenny, B., Cool, S. M., Nurcombe, V., Whittaker, A. K., Cassady, I.A. and Trau, M. (2003). Biodegradable polyester materials: Uses in bone regeneration. In: 26th Australian Polymer Conference. 26th Australian Polymer Conference, Noosa, (Abstract). July, 2003.

  • Chandler-Temple, A. F., Grondahl, L., Trau, M., Cool, S. M. and Nurcombe, V. (2003). Surface modification for PHBV for enhanced biocompatibility. In: 13th Annual Conference of Australian Society for Biomaterials. 13th Annual Conference of Australian Society for Biomaterials, Brisbane, (Poster). March, 2003.

  • Lawrie, G. A., Battersby, B. J., Grondahl, L., Tam, T., Lorentzen, M. and Trau, M. (2003). To stick or not to stick: Surface modification of colloidal nanoparticles to control interparticle associations. In: 11th International Conference on Surface and Colloid Science. 11th International Conference on Surface & Colloid Science, Brazil, (Abstract). September, 2003.

  • Trau, M., Saville, D. A. and Aksay, I. A. (1996). Field-induced two- and three-dimensional colloidal crystals. In: 1995 MRS Fall Meeting & Exhibit, Boston, MA, USA, (153-153). 27 November-1 December, 1995.

Edited Outputs

Grants (Administered at UQ)

PhD and MPhil Supervision

Current Supervision

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Joint Principal Advisor

Completed Supervision