The University of Queensland

Advanced glycation, diabetes, and dementia

Dhananjayan, Karthik, Forbes, Josephine and Münch, Gerald (2018). Advanced glycation, diabetes, and dementia. Type 2 diabetes and dementia. (pp. 169-193) edited by Velandai Srikanth and Zoe Arvanitakis. London, United Kingdom: Academic Press (Elsevier). doi: 10.1016/B978-0-12-809454-9.00009-3

Dietary AGEs in the development and progression of chronic kidney disease

Fotheringham, Amelia K., Gallo, Linda A. and Forbes, Josephine M. (2018). Dietary AGEs in the development and progression of chronic kidney disease. Dietary AGEs and their role in health and disease. (pp. 213-224) edited by Jaime Uribarri. Boca Raton, FI, United States: CRC Press. doi: 10.1201/9781315120041

Role of oxidative stress in diabetic nephropathy

Forbes, Josephine M., Coughlan, Melinda T. and Cooper, Mark E. (2011). Role of oxidative stress in diabetic nephropathy. Advances in Pathogenesis of Diabetic Nephropathy. (pp. 199-218) Nova Science Publishers, Inc..

Glucagon-like peptide-1 receptor signaling modifies the extent of diabetic kidney disease through dampening the receptor for advanced glycation end products–induced inflammation

Sourris, Karly C., Ding, Yi, Maxwell, Scott S., Al-sharea, Annas, Kantharidis, Phillip, Mohan, Muthukumar, Rosado, Carlos J., Penfold, Sally A., Haase, Claus, Xu, Yangsong, Forbes, Josephine M., Crawford, Simon, Ramm, Georg, Harcourt, Brooke E., Jandeleit-Dahm, Karin, Advani, Andrew, Murphy, Andrew J., Timmermann, Daniel B., Karihaloo, Anil, Knudsen, Lotte Bjerre, El-Osta, Assam, Drucker, Daniel J., Cooper, Mark E. and Coughlan, Melinda T. (2023). Glucagon-like peptide-1 receptor signaling modifies the extent of diabetic kidney disease through dampening the receptor for advanced glycation end products–induced inflammation. Kidney International, 105 (1), 132-149. doi: 10.1016/j.kint.2023.09.029

Alpha cell receptor for advanced glycation end products associate with glucagon expression in type 1 diabetes

Leung, Sherman S., Lenchik, Nataliya, Mathews, Clayton, Pugliese, Alberto, McCarthy, Domenica A., Le Bagge, Selena, Ewing, Adam, Harris, Mark, Radford, Kristen J., Borg, Danielle J., Gerling, Ivan and Forbes, Josephine M. (2023). Alpha cell receptor for advanced glycation end products associate with glucagon expression in type 1 diabetes. Scientific Reports, 13 (1) 12948, 1-15. doi: 10.1038/s41598-023-39243-x

RAGE antagonism with azeliragon improves xenograft rejection by T cells in humanized mice

Joshi, Aditi A., Wu, Ying, Deng, Songyan, Preston-Hurlburt, Paula, Forbes, Josephine M. and Herold, Kevan C. (2022). RAGE antagonism with azeliragon improves xenograft rejection by T cells in humanized mice. Clinical Immunology, 245 109165, 1-6. doi: 10.1016/j.clim.2022.109165

Advanced glycation end products and inflammation in type 1 diabetes development

Du, Chenping, Whiddett, Rani O., Buckle, Irina, Chen, Chen, Forbes, Josephine M. and Fotheringham, Amelia K. (2022). Advanced glycation end products and inflammation in type 1 diabetes development. Cells, 11 (21) 3503, 1-18. doi: 10.3390/cells11213503

Hypoxic human proximal tubular epithelial cells undergo ferroptosis and elicit an NLRP3 inflammasome response in CD1c+ dendritic cells

Giuliani, Kurt T. K., Grivei, Anca, Nag, Purba, Wang, Xiangju, Rist, Melissa, Kildey, Katrina, Law, Becker, Ng, Monica S., Wilkinson, Ray, Ungerer, Jacobus, Forbes, Josephine M., Healy, Helen and Kassianos, Andrew J. (2022). Hypoxic human proximal tubular epithelial cells undergo ferroptosis and elicit an NLRP3 inflammasome response in CD1c+ dendritic cells. Cell Death and Disease, 13 (8) 739, 1-13. doi: 10.1038/s41419-022-05191-z

Mitochondrial dysfunction in individuals with diabetic kidney disease: a systematic review

Flemming, Nicole, Pernoud, Laura, Forbes, Josephine and Gallo, Linda (2022). Mitochondrial dysfunction in individuals with diabetic kidney disease: a systematic review. Cells, 11 (16) 2481, 1-24. doi: 10.3390/cells11162481

Advanced glycation end products (AGEs) and chronic kidney disease: does the modern diet AGE the kidney?

Fotheringham, Amelia K., Gallo, Linda A., Borg, Danielle J. and Forbes, Josephine M. (2022). Advanced glycation end products (AGEs) and chronic kidney disease: does the modern diet AGE the kidney?. Nutrients, 14 (13) 2675, 1-28. doi: 10.3390/nu14132675

Soluble RAGE Prevents Type 1 Diabetes Expanding Functional Regulatory T Cells

Leung, Sherman S., Borg, Danielle J., McCarthy, Domenica A., Boursalian, Tamar E., Cracraft, Justen, Zhuang, Aowen, Fotheringham, Amelia K., Flemming, Nicole, Watkins, Thomas, Miles, John J., Groop, Per-Henrik, Scheijen, Jean L., Schalkwijk, Casper G., Steptoe, Raymond J., Radford, Kristen J., Knip, Mikael and Forbes, Josephine M. (2022). Soluble RAGE Prevents Type 1 Diabetes Expanding Functional Regulatory T Cells. Diabetes, 71 (9), 1994-2008. doi: 10.2337/db22-0177

The impact of a modified carbohydrate formula, and its constituents, on glycaemic control and inflammatory markers: a nested mechanistic sub-study

Doola, Ra'eesa, Deane, Adam M., Barrett, Helen L., Okano, Satomi, Tolcher, Debbie M., Gregory, Kye, Coombes, Jeff S., Schalkwijk, Casper, Todd, Alwyn S., Forbes, Josephine M. and Sturgess, David J. (2022). The impact of a modified carbohydrate formula, and its constituents, on glycaemic control and inflammatory markers: a nested mechanistic sub-study. Journal of Human Nutrition and Dietetics, 35 (3), 455-465. doi: 10.1111/jhn.12959

Kidney disease risk factors do not explain impacts of low dietary protein on kidney function and structure

Fotheringham, Amelia K., Solon-Biet, Samantha M., Bielefeldt-Ohmann, Helle, McCarthy, Domenica A., McMahon, Aisling C., Ruohonen, Kari, Li, Isaac, Sullivan, Mitchell A., Whiddett, Rani O., Borg, Danielle J., Cogger, Victoria C., Ballard, William O., Turner, Nigel, Melvin, Richard G., Raubenheimer, David, Le Couteur, David G., Simpson, Stephen J. and Forbes, Josephine M. (2021). Kidney disease risk factors do not explain impacts of low dietary protein on kidney function and structure. iScience, 24 (11) 103308, 103308. doi: 10.1016/j.isci.2021.103308

T cell expression and release of kidney injury molecule-1 in response to glucose variations initiates kidney injury in early diabetes

Forbes, Josephine M., McCarthy, Domenica A., Kassianos, Andrew J., Baskerville, Tracey, Fotheringham, Amelia J., Giuliani, Kurt T. K., Grivei, Anca, Murphy, Andrew J., Flynn, Michelle C., Sullivan, Mitchell A., Chandrashekar, Preeti, Whiddett, Rani, Radford, Kristen J., Flemming, Nicole, Beard, Sam S., D’Silva, Neisha, Nisbet, Janelle, Morton, Adam, Teasdale, Stephanie, Russell, Anthony, Isbel, Nicole, Jones, Timothy, Couper, Jennifer, Healy, Helen, Harris, Mark, Donaghue, Kim, Johnson, David W., Cotterill, Andrew, Barrett, Helen L. and O’Moore-Sullivan, Trisha (2021). T cell expression and release of kidney injury molecule-1 in response to glucose variations initiates kidney injury in early diabetes. Diabetes, 70 (8), 1754-1766. doi: 10.2337/db20-1081

Short duration alagebrium chloride therapy prediabetes does not inhibit progression to autoimmune diabetes in an experimental model

Borg, Danielle J., Faridi, Pouya, Giam, Kai Lin, Reeves, Peta, Fotheringham, Amelia K., McCarthy, Domenica A., Leung, Sherman, Ward, Micheal S., Harcourt, Brooke E., Ayala, Rochelle, Scheijen, Jean L., Briskey, David, Dudek, Nadine L., Schalkwijk, Casper G., Steptoe, Raymond, Purcell, Anthony W. and Forbes, Josephine M. (2021). Short duration alagebrium chloride therapy prediabetes does not inhibit progression to autoimmune diabetes in an experimental model. Metabolites, 11 (7) 426, 1-21. doi: 10.3390/metabo11070426

Advanced glycation end products as predictors of renal function in youth with type 1 diabetes

Forbes, Josephine M., Le Bagge, Selena, Righi, Samuel, Fotheringham, Amelia K., Gallo, Linda A., McCarthy, Domenica A., Leung, Sherman, Baskerville, Tracey, Nisbett, Janelle, Morton, Adam, Teasdale, Stephanie, D'Silva, Neisha, Barrett, Helen, Jones, Timothy, Couper, Jennifer, Donaghue, Kim, Isbel, Nicole, Johnson, David W., Donnellan, Leigh, Deo, Permal, Akison, Lisa K., Moritz, Karen M. and O'Moore-Sullivan, Trisha (2021). Advanced glycation end products as predictors of renal function in youth with type 1 diabetes. Scientific Reports, 11 (1) 9422, 9422. doi: 10.1038/s41598-021-88786-4

Long term high protein diet feeding alters the microbiome and increases intestinal permeability, systemic inflammation and kidney injury in mice

Snelson, Matthew, Clarke, Rachel Elise, Nguyen, Tuong-Vi, Penfold, Sally Anne, Forbes, Josephine Maree, Tan, Sih Min and Coughlan, Melinda Therese (2021). Long term high protein diet feeding alters the microbiome and increases intestinal permeability, systemic inflammation and kidney injury in mice. Molecular Nutrition and Food Research, 65 (8) 2000851, 1-12. doi: 10.1002/mnfr.202000851

Processed foods drive intestinal barrier permeability and microvascular diseases

Snelson, Matthew, Tan, Sih Min, Clarke, Rachel E., De Pasquale, Cassandra, Thallas-Bonke, Vicki, Nguyen, Tuong-Vi, Penfold, Sally A., Harcourt, Brooke E., Sourris, Karly C., Lindblom, Runa S., Ziemann, Mark, Steer, David, El-Osta, Assam, Davies, Michael J., Donnellan, Leigh, Deo, Permal, Kellow, Nicole J., Cooper, Mark E., Woodruff, Trent M., Mackay, Charles R., Forbes, Josephine M. and Coughlan, Melinda T. (2021). Processed foods drive intestinal barrier permeability and microvascular diseases. Science Advances, 7 (14) eabe4841, 1-16. doi: 10.1126/sciadv.abe4841

Impact of dietary carbohydrate type and protein–carbohydrate interaction on metabolic health

Wali, Jibran A., Milner, Annabelle J., Luk, Alison W. S., Pulpitel, Tamara J., Dodgson, Tim, Facey, Harrison J. W., Wahl, Devin, Kebede, Melkam A., Senior, Alistair M., Sullivan, Mitchell A., Brandon, Amanda E., Yau, Belinda, Lockwood, Glen P., Koay, Yen Chin, Ribeiro, Rosilene, Solon-Biet, Samantha M., Bell-Anderson, Kim S., O’Sullivan, John F., Macia, Laurence, Forbes, Josephine M., Cooney, Gregory J., Cogger, Victoria C., Holmes, Andrew, Raubenheimer, David, Le Couteur, David G. and Simpson, Stephen J. (2021). Impact of dietary carbohydrate type and protein–carbohydrate interaction on metabolic health. Nature Metabolism, 3 (6), 810-828. doi: 10.1038/s42255-021-00393-9

The AGE receptor, OST48 drives podocyte foot process effacement and basement membrane expansion (alters structural composition)

Zhuang, Aowen, Yap, Felicia Y. T., Borg, Danielle J., McCarthy, Domenica, Fotheringham, Amelia, Leung, Sherman, Penfold, Sally A., Sourris, Karly C., Coughlan, Melinda T., Schulz, Benjamin L. and Forbes, Josephine M. (2021). The AGE receptor, OST48 drives podocyte foot process effacement and basement membrane expansion (alters structural composition). Endocrinology, Diabetes and Metabolism, 4 (3) e00278, e00278. doi: 10.1002/edm2.278

Going in early: hypoxia as a target for kidney disease prevention in diabetes?

Barrett, Helen L., Donaghue, Kim C. and Forbes, Josephine M. (2020). Going in early: hypoxia as a target for kidney disease prevention in diabetes?. Diabetes, 69 (12), 2578-2580. doi: 10.2337/dbi20-0037

Circulating levels of the soluble receptor for AGE (sRAGE) during escalating oral glucose dosages and corresponding isoglycaemic i.v. glucose infusions in individuals with and without type 2 diabetes

Fotheringham, Amelia K., Bagger, Jonatan I., Borg, Danielle J., McCarthy, Domenica A., Holst, Jens J., Vilsbøll, Tina, Knop, Filip K. and Forbes, Josephine M. (2020). Circulating levels of the soluble receptor for AGE (sRAGE) during escalating oral glucose dosages and corresponding isoglycaemic i.v. glucose infusions in individuals with and without type 2 diabetes. Nutrients, 12 (10) 2928, 2928-12. doi: 10.3390/nu12102928

Transient intermittent hyperglycemia accelerates atherosclerosis by promoting myelopoiesis

Flynn, Michelle C., Kraakman, Michael J., Tikellis, Christos, Lee, Man Ks, Hanssen, Nordin Mj, Kammoun, Helene L., Pickering, Raelene, Dragoljevic, Dragana, Al-Sharea, Annas, Barrett, Tessa J., Hortle, Fiona, Byrne, Frances L., Olzomer, Ellen, McCarthy, Domenica A., Schalkwijk, Casper G., Forbes, Josephine M., Hoehn, Kyle, Makowski, Liza, Lancaster, Graeme I., El-Osta, Assam, Fisher, Edward A., Goldberg, Ira J., Cooper, Mark E., Nagareddy, Prabhakara R., Thomas, Merlin C. and Murphy, Andrew J. (2020). Transient intermittent hyperglycemia accelerates atherosclerosis by promoting myelopoiesis. Circulation Research, 127 (7) CIRCRESAHA.120.316653, 877-892. doi: 10.1161/CIRCRESAHA.120.316653

Prolyl hydroxylase inhibitors: a breath of fresh air for diabetic kidney disease?

Forbes, Josephine M. (2020). Prolyl hydroxylase inhibitors: a breath of fresh air for diabetic kidney disease?. Kidney International, 97 (5), 855-857. doi: 10.1016/j.kint.2020.01.038

Disruption of glycogen utilization markedly improves the efficacy of carboplatin against preclinical models of clear cell ovarian carcinoma

Khan, Tashbib, He, Yaowu, Kryza, Thomas, Harrington, Brittney S., Gunter, Jennifer H., Sullivan, Mitchell A., Cuda, Tahleesa, Rogers, Rebecca, Davies, Claire M., Broomfield, Amy, Gough, Madeline, Wu, Andy C., McGann, Thomas, Weroha, S. John, Haluska, Paul, Forbes, Josephine M., Armes, Jane E., Barry, Sinead C., Coward, Jermaine I., Jagasia, Nisha, Chetty, Naven, Snell, Cameron E., Lourie, Rohan, Perrin, Lewis C. and Hooper, John D. (2020). Disruption of glycogen utilization markedly improves the efficacy of carboplatin against preclinical models of clear cell ovarian carcinoma. Cancers, 12 (4) 869, 869. doi: 10.3390/cancers12040869

Targeting the receptor for advanced glycation end products (RAGE) in type 1 diabetes

Le Bagge, Selena, Fotheringham, Amelia K., Leung, Sherman S. and Forbes, Josephine M. (2020). Targeting the receptor for advanced glycation end products (RAGE) in type 1 diabetes. Medicinal Research Reviews, 40 (4) med.21654, 1200-1219. doi: 10.1002/med.21654

Delineating a role for the mitochondrial permeability transition pore in diabetic kidney disease by targeting cyclophilin D

Lindblom, Runa S. J., Higgins, Gavin C., Nguyen, Tuong-Vi, Arnstein, Maryann, Henstridge, Darren C., Granata, Cesare, Snelson, Matthew, Thallas-Bonke, Vicki, Cooper, Mark E., Forbes, Josephine M. and Coughlan, Melinda T. (2020). Delineating a role for the mitochondrial permeability transition pore in diabetic kidney disease by targeting cyclophilin D. Clinical Science, 134 (2), 239-259. doi: 10.1042/CS20190787

Complement C5a induces renal injury in diabetic kidney disease by disrupting mitochondrial metabolic agility

Tan, Sih Min, Ziemann, Mark, Thallas-Bonke, Vicki, Snelson, Matthew, Kumar, Vinod, Laskowski, Adrienne, Nguyen, Tuong-Vi, Huynh, Kevin, Clarke, Michele V., Libianto, Renata, Baker, Scott T., Skene, Alison, Power, David A., MacIsaac, Richard J., Henstridge, Darren C., Wetsel, Rick A., El-Osta, Assam, Meikle, Peter J., Wilson, Scott G., Forbes, Josephine M., Cooper, Mark E., Ekinci, Elif I., Woodruff, Trent M. and Coughlan, Melinda T. (2019). Complement C5a induces renal injury in diabetic kidney disease by disrupting mitochondrial metabolic agility. Diabetes, 69 (1), 83-98. doi: 10.2337/db19-0043

Development and progression of non-alcoholic fatty liver disease: the role of advanced glycation end products

Fernando, Dinali H., Forbes, Josephine M., Angus, Peter W. and Herath, Chandana B. (2019). Development and progression of non-alcoholic fatty liver disease: the role of advanced glycation end products. International Journal of Molecular Sciences, 20 (20) 5037, 5037. doi: 10.3390/ijms20205037

Genetic characterization of early renal changes in a novel mouse model of diabetic kidney disease

Balmer, Lois A., Whiting, Rhiannon, Rudnicka, Caroline, Gallo, Linda A., Jandeleit, Karin A., Chow, Yan, Chow, Z., Richardson, Kirsty L., Forbes, Josephine M. and Morahan, G. (2019). Genetic characterization of early renal changes in a novel mouse model of diabetic kidney disease. Kidney International, 96 (4), 918-926. doi: 10.1016/j.kint.2019.04.031

Globally elevating the AGE clearance receptor, OST48, does not protect against the development of diabetic kidney disease, despite improving insulin secretion

Zhuang, Aowen, Yap, Felicia Y. T., McCarthy, Domenica, Leung, Chris, Sourris, Karly C., Penfold, Sally A., Thallas-Bonke, Vicki, Coughlan, Melinda T., Schulz, Benjamin L. and Forbes, Josephine M. (2019). Globally elevating the AGE clearance receptor, OST48, does not protect against the development of diabetic kidney disease, despite improving insulin secretion. Scientific Reports, 9 (1) 13664, 13664. doi: 10.1038/s41598-019-50221-0

Glucose and glycogen in the diabetic kidney: heroes or villains?

Sullivan, Mitchell A. and Forbes, Josephine M. (2019). Glucose and glycogen in the diabetic kidney: heroes or villains?. EBioMedicine, 47, 590-597. doi: 10.1016/j.ebiom.2019.07.067

Response to Letter to the Editor: "Advanced Glycation End Products and esRAGE Are Associated With Bone Turnover and Incidence of Hip Fracture in Older Men"

Lamb, Lydia S., Davis, Timothy M E, Forbes, Josephine, Irrgang, Felix, Golledge, Jonathan, Flicker, Leon and Yeap, Bu B. (2019). Response to Letter to the Editor: "Advanced Glycation End Products and esRAGE Are Associated With Bone Turnover and Incidence of Hip Fracture in Older Men". Journal of Clinical Endocrinology and Metabolism, 104 (3), 684-685. doi: 10.1210/jc.2018-02198

The effect of a low carbohydrate formula on glycaemia in critically ill enterally-fed adult patients with hyperglycaemia: a blinded randomised feasibility trial

Doola, Ra'eesa, Deane, Adam M., Tolcher, Debbie M., Presneill, Jeffrey J., Barrett, Helen L., Forbes, Josephine M., Todd, Alwyn S., Okano, Satomi and Sturgess, David J. (2019). The effect of a low carbohydrate formula on glycaemia in critically ill enterally-fed adult patients with hyperglycaemia: a blinded randomised feasibility trial. Clinical Nutrition ESPEN, 31, 80-87. doi: 10.1016/j.clnesp.2019.02.013

Advanced Glycation End Products and esRAGE Are Associated With Bone Turnover and Incidence of Hip Fracture in Older Men

Lamb, Lydia S., Alfonso, Helman, Norman, Paul E., Davis, Timothy M. E., Forbes, Josephine, Müench, Gerald, Irrgang, Felix, Almeida, Osvaldo P., Golledge, Jonathan, Hankey, Graeme J., Flicker, Leon and Yeap, Bu B. (2018). Advanced Glycation End Products and esRAGE Are Associated With Bone Turnover and Incidence of Hip Fracture in Older Men. Journal of Clinical Endocrinology and Metabolism, 103 (11), 4224-4231. doi: 10.1210/jc.2018-00674

RAGE deletion confers renoprotection by reducing responsiveness to transforming growth factor-β and increasing resistance to apoptosis

Hagiwara, Shinji, Sourris, Karly, Ziemann, Mark, Tieqiao, Wu, Mohan, Muthukumar, McClelland, Aaron D, Brennan, Eoin, Forbes, Josephine, Coughlan, Melinda, Harcourt, Brooke, Penfold, Sally, Wang, Bo, Higgins, Gavin, Pickering, Raelene, El-Osta, Assam, Thomas, Merlin C, Cooper, Mark E and Kantharidis, Phillip (2018). RAGE deletion confers renoprotection by reducing responsiveness to transforming growth factor-β and increasing resistance to apoptosis. Diabetes, 67 (5), 960-973. doi: 10.2337/db17-0538

Diabetes-specific formulae versus standard formulae as enteral nutrition to treat hyperglycemia in critically ill patients: protocol for a randomized controlled feasibility trial

Doola, Ra'eesa, Todd, Alwyn S., Forbes, Josephine M., Deane, Adam M., Presneill, Jeffrey J. and Sturgess, David J. (2018). Diabetes-specific formulae versus standard formulae as enteral nutrition to treat hyperglycemia in critically ill patients: protocol for a randomized controlled feasibility trial. JMIR Research Protocols, 7 (4) e90, e90. doi: 10.2196/resprot.9374

Mitochondrial dysfunction and signalling in diabetic kidney disease: oxidative stress and beyond

Flemming, Nicole Bernadette, Gallo, Linda Alba and Forbes, Josephine Maree (2018). Mitochondrial dysfunction and signalling in diabetic kidney disease: oxidative stress and beyond. Seminars in Nephrology, 38 (2), 101-110. doi: 10.1016/j.semnephrol.2018.01.001

Mitochondrial dysfunction in diabetic kidney disease

Forbes, Josephine M. and Thorburn, David R. (2018). Mitochondrial dysfunction in diabetic kidney disease. Nature Reviews. Nephrology, 14 (5), 291-312. doi: 10.1038/nrneph.2018.9

Glycaemic variability and its association with enteral and parenteral nutrition in critically ill ventilated patients

Doola, Ra'eesa, Greer, Ristan M., Hurford, Rod, Flatley, Christopher, Forbes, Josephine M., Todd, Alwyn S., Joyce, Chris J. and Sturgess, David J. (2018). Glycaemic variability and its association with enteral and parenteral nutrition in critically ill ventilated patients. Clinical Nutrition, 38 (4), 1707-1712. doi: 10.1016/j.clnu.2018.08.001

Perinatal exposure to high dietary advanced glycation end products in transgenic NOD8.3 mice leads to pancreatic beta cell dysfunction

Borg, Danielle J., Yap, Felicia Y. T., Keshvari, Sahar, Simmons, David G., Gallo, Linda A., Fotheringham, Amelia K., Zhuang, Aowen, Slattery, Robyn M., Hasnain, Sumaira Z., Coughlan, Melinda T., Kantharidis, Phillip and Forbes, Josephine M. (2017). Perinatal exposure to high dietary advanced glycation end products in transgenic NOD8.3 mice leads to pancreatic beta cell dysfunction. Islets, 10 (1), 10-24. doi: 10.1080/19382014.2017.1405189

Glycation: a new hope in targeting hepatocellular carcinoma?

Leung, Christopher, Angus, Peter W. and Forbes, Josephine M. (2017). Glycation: a new hope in targeting hepatocellular carcinoma?. Translational Cancer Research, 6 (S9), S1491-S1497. doi: 10.21037/tcr.2017.11.06

Targeted mitochondrial therapy using MitoQ shows equivalent renoprotection to angiotensin converting enzyme inhibition but no combined synergy in diabetes

Ward, Micheal S.., Flemming, Nicole B., Gallo, Linda A., Fotheringham, Amelia K., McCarthy, Domenica A., Zhuang, Aowen, Tang, Peter H., Borg, Danielle J., Shaw, Hannah, Harvie, Benjamin, Briskey, David R., Roberts, Llion A., Plan, Manuel R., Murphy, Michael P., Hodson, Mark P. and Forbes, Josephine M. (2017). Targeted mitochondrial therapy using MitoQ shows equivalent renoprotection to angiotensin converting enzyme inhibition but no combined synergy in diabetes. Scientific Reports, 7 (1) 15190, 15190. doi: 10.1038/s41598-017-15589-x

Increased liver AGEs induce hepatic injury mediated through an OST48 pathway

Zhuang, Aowen, Yap, Felicia Y. T., Bruce, Clinton, Leung, Chris, Plan, Manuel R., Sullivan, Mitchell A., Herath, Chandana, McCarthy, Domenica, Sourris, Karly C., Kantharidis, Phillip, Coughlan, Melinda T., Febbraio, Mark A. , Hodson, Mark P., Watt, Matthew J., Angus, Peter, Schulz, Benjamin L. and Forbes, Josephine M. (2017). Increased liver AGEs induce hepatic injury mediated through an OST48 pathway. Scientific Reports, 7 (1) 12292, 12292. doi: 10.1038/s41598-017-12548-4

Vascular complications in diabetes: old messages, new thoughts

Forbes, Josephine M. and Fotheringham, Amelia K. (2017). Vascular complications in diabetes: old messages, new thoughts. Diabetologia, 60 (11), 2129-2138. doi: 10.1007/s00125-017-4360-x

Serum 25-hydroxyvitamin D concentrations are associated with nuclear factor kappa-B activity but not with inflammatory markers in healthy normoglycemic adults

Mousa, Aya, de Courten, Maximilian P. J., Forbes, Josephine and de Courten, Barbora (2017). Serum 25-hydroxyvitamin D concentrations are associated with nuclear factor kappa-B activity but not with inflammatory markers in healthy normoglycemic adults. Journal of Steroid Biochemistry and Molecular Biology, 177, 216-222. doi: 10.1016/j.jsbmb.2017.07.013

Effect of dietary advanced glycation end products on inflammation and cardiovascular risks in healthy overweight adults: a randomised crossover trial

Baye, Estifanos, de Courten, Maximilian P. J., Walker, Karen, Ranasinha, Sanjeeva, Earnest, Arul, Forbes, Josephine M. and de Courten, Barbora (2017). Effect of dietary advanced glycation end products on inflammation and cardiovascular risks in healthy overweight adults: a randomised crossover trial. Scientific Reports, 7 (1) 4123, 4123. doi: 10.1038/s41598-017-04214-6

Disparity in the micronutrient content of diets high or low in advanced glycation end products (AGEs) does not explain changes in insulin sensitivity

Pearce, Karma, Hatzinikolas, Alicia, Moran, Lisa, de Courten, Maximilian P. J., Forbes, Josephine, Scheijen, Jean L. J. M., Schalkwijk, Casper G., Walker, Karen and de Courten, Barbora (2017). Disparity in the micronutrient content of diets high or low in advanced glycation end products (AGEs) does not explain changes in insulin sensitivity. International Journal of Food Sciences and Nutrition, 68 (8), 1-6. doi: 10.1080/09637486.2017.1319468

A drop in the circulating concentrations of soluble receptor for advanced glycation end products is associated with seroconversion to autoantibody positivity but not with subsequent progression to clinical disease in children en route to type 1 diabetes

Salonen, K. M., Ryhanen, S. J., Forbes, J. M., Harkonen, T., Ilonen, J., Simell, O., Veijola, R., Groop, P. -H. and Knip, M. (2017). A drop in the circulating concentrations of soluble receptor for advanced glycation end products is associated with seroconversion to autoantibody positivity but not with subsequent progression to clinical disease in children en route to type 1 diabetes. Diabetes/Metabolism Research and Reviews, 33 (4) e2872, e2872. doi: 10.1002/dmrr.2872

Receptor for advanced glycation end products (RAGE) in type 1 diabetes pathogenesis

Leung, Sherman S., Forbes, Josephine M. and Borg, Danielle J. (2016). Receptor for advanced glycation end products (RAGE) in type 1 diabetes pathogenesis. Current Diabetes Reports, 16 (10) 100, 100. doi: 10.1007/s11892-016-0782-y

Dietary advanced glycation end-products aggravate non-alcoholic fatty liver disease

Leung, Christopher, Herath, Chandana B., Jia, Zhiyuan, Andrikopoulos, Sof, Brown, Bronwyn E., Davies, Michael J., Rivera, Leni R., Furness, John B., Forbes, Josephine M. and Angus, Peter W. (2016). Dietary advanced glycation end-products aggravate non-alcoholic fatty liver disease. World Journal of Gastroenterology, 22 (35), 8026-8040. doi: 10.3748/wjg.v22.i35.8026

Diabetic kidney disease: a role for advanced glycation end-product receptor 1 (AGE-R1)?

Zhuang, Aowen and Forbes, Josephine M. (2016). Diabetic kidney disease: a role for advanced glycation end-product receptor 1 (AGE-R1)?. Glycoconjugate Journal, 33 (4), 645-652. doi: 10.1007/s10719-016-9693-z

Targeting advanced glycation with pharmaceutical agents: where are we now?

Borg, Danielle J. and Forbes, Josephine M. (2016). Targeting advanced glycation with pharmaceutical agents: where are we now?. Glycoconjugate Journal, 33 (4), 653-670. doi: 10.1007/s10719-016-9691-1

Mitochondria-power players in kidney function?

Forbes, Josephine M. (2016). Mitochondria-power players in kidney function?. Trends in Endocrinology and Metabolism, 27 (7), 441-442. doi: 10.1016/j.tem.2016.05.002

Diet low in advanced glycation end products increases insulin sensitivity in healthy overweight individuals: a double-blind, randomized, crossover trial

de Courten, Barbora, de Courten, Maximilian P. J., Soldatos, Georgia, Dougherty, Sonia L., Straznicky, Nora, Schlaich, Markus, Sourris, Karly C., Chand, Vibhasha, Scheijen, Jean L. J. M., Kingwell, Bronwyn A., Cooper, Mark E., Schalkwijk, Casper G., Walker, Karen Z. and Forbes, Josephine M. (2016). Diet low in advanced glycation end products increases insulin sensitivity in healthy overweight individuals: a double-blind, randomized, crossover trial. American Journal of Clinical Nutrition, 103 (6), 1426-1433. doi: 10.3945/ajcn.115.125427

Once daily administration of the SGLT2 inhibitor, empagliflozin, attenuates markers of renal fibrosis without improving albuminuria in diabetic db/db mice

Gallo, Linda A., Ward, Micheal S., Fotheringham, Amelia K., Zhuang, Aowen, Borg, Danielle J., Flemming, Nicole B., Harvie, Ben M., Kinneally, Toni L., Yeh, Shang-Ming, McCarthy, Domenica A., Koepsell, Hermann, Vallon, Volker, Pollock, Carol, Panchapakesan, Usha and Forbes, Josephine M. (2016). Once daily administration of the SGLT2 inhibitor, empagliflozin, attenuates markers of renal fibrosis without improving albuminuria in diabetic db/db mice. Scientific Reports, 6 (1) 26428, 28124. doi: 10.1038/srep26428

Antigen-encoding bone marrow terminates islet-directed memory CD8+ T-cell responses to alleviate islet transplant rejection

Coleman, Miranda A., Jessup, Claire F., Bridge, Jennifer A., Overgaard, Nana H., Penko, Daniella, Walters, Stacey, Borg, Danielle J., Galea, Ryan, Forbes, Josephine M., Thomas, Ranjeny, Coates, Patrick T. C., Grey, Shane T., Wells, James W. and Steptoe, Raymond J. (2016). Antigen-encoding bone marrow terminates islet-directed memory CD8+ T-cell responses to alleviate islet transplant rejection. Diabetes, 65 (5), 1328-1340. doi: 10.2337/db15-1418

Deficiency in apoptosis-inducing factor recapitulates chronic kidney disease via aberrant mitochondrial homeostasis

Coughlan, Melinda T., Higgins, Gavin C., Tuong-Vi Nguyen, Penfold, Sally A., Thallas-Bonke, Vicki, Tan, Sih Mm, Ramm, Georg, Van Bergen, Nicole J., Henstridge, Darren C., Sourris, Karly C., Harcourt, Brooke E., Trounce, Ian A., Robb, Portia M., Laskowski, Adrienne, McGee, Sean L., Genders, Amanda J., Walder, Ken, Drew, Brian G., Gregorevic, Paul, Qian, Hongwei, Thomas, Merlin C., Jerums, George, Macisaac, Richard J., Skene, Alison, Ekinci, Elif I., Wijeyeratne, Xiaonan W., Gallo, Linda A., Heiman-Edelstein, Michal, Ryan, Michael T. ... Forbes, Josephine M. (2016). Deficiency in apoptosis-inducing factor recapitulates chronic kidney disease via aberrant mitochondrial homeostasis. Diabetes, 65 (4), 1085-1098. doi: 10.2337/db15-0864

The SGLT2 Inhibitor, Empagliflozin, Attenuates Some Markers of Renal Fibrosis without Improving Albuminuria in Diabetic <i>Db/Db</i> Mice

Gallo, Linda A, Ward, Micheal S, Fotheringham, Amelia K, Zhuang, Aowen, Koepsell, Hermann, Vallon, Volker, Pollock, Carol, Panchapakesan, Usha and Forbes, Josephine M (2016). The SGLT2 Inhibitor, Empagliflozin, Attenuates Some Markers of Renal Fibrosis without Improving Albuminuria in Diabetic Db/Db Mice. The FASEB Journal, 30 (S1). doi: 10.1096/fasebj.30.1_supplement.740.18

Mapping time-course mitochondrial adaptations in the kidney in experimental diabetes

Coughlan, Melinda T., Nguyen, Tuong-Vi, Penfold, Sally A., Higgins, Gavin C., Thallas-Bonke, Vicki, Tan, Sih Min, Van Bergen, Nicole J., Sourris, Karly C., Harcourt, Brooke E., Thorburn, David R., Trounce, Ian A., Cooper, Mark E. and Forbes, Josephine M. (2016). Mapping time-course mitochondrial adaptations in the kidney in experimental diabetes. Clinical Science, 130 (9), 711-720. doi: 10.1042/CS20150838

Synbiotics easing renal failure by improving gut microbiology (SYNERGY): a randomized trial

Rossi, Megan, Johnson, David W., Morrison, Mark, Pascoe, Elaine M., Coombes, Jeff S., Forbes, Josephine M., Szeto, Cheuk-Chun, McWhinney, Brett C., Ungerer, Jacobus P. J. and Campbell, Katrina L. (2016). Synbiotics easing renal failure by improving gut microbiology (SYNERGY): a randomized trial. Clinical Journal of the American Society of Nephrology, 11 (2), 223-231. doi: 10.2215/CJN.05240515

Tapping into mitochondria to find novel targets for diabetes complications

Fleming, Nicole B., Gallo, Linda, Ward, Micheal S. and Forbes, Josephine M. (2016). Tapping into mitochondria to find novel targets for diabetes complications. Current Drug Targets, 17 (12), 1341-1349. doi: 10.2174/1389450116666150727114410

Abdominal obesity and brain atrophy in type 2 diabetes mellitus

Climie, Rachel E. D., Moran, Chris, Callisaya, Michele, Blizzard, Leigh, Sharman, James E., Venn, Alison, Phan, Thanh G., Beare, Richard, Forbes, Josephine, Blackburn, Nicholas B. and Srikanth, Velandai (2015). Abdominal obesity and brain atrophy in type 2 diabetes mellitus. PloS One, 10 (11) e0142589, e0142589. doi: 10.1371/journal.pone.0142589

Dietary advanced glycation end products consumption as a direct modulator of insulin sensitivity in overweight humans: a study protocol for a double-blind, randomized, two period cross-over trial

de Courten, Barbora, de Courten, Maximilian P. J., Schalkwijk, Casper G., Walker, Karen Z. and Forbes, Josephine (2015). Dietary advanced glycation end products consumption as a direct modulator of insulin sensitivity in overweight humans: a study protocol for a double-blind, randomized, two period cross-over trial. JMIR Research Protocols, 4 (3) e93, e93+. doi: 10.2196/resprot.4552

SaO035: Synbiotic therapy in pre-dialysis: a randomised controlled trial

Rossi, Megan, Johnson, David, Pascoe, Elaine, Coombes, Jeff, Forbes, Josephine, Szeto, Cheuk-Chun, McWhinney, Brett, Ungerer, Jacobus and Campbell, Katrina (2015). SaO035: Synbiotic therapy in pre-dialysis: a randomised controlled trial. Nephrology, Dialysis, Transplantation, 30 (suppl_3), iii38-iii38. doi: 10.1093/ndt/gfv152.02

Decrease in circulating concentrations of soluble receptors for advanced glycation end products at the time of seroconversion to autoantibody positivity in children with prediabetes

Salonen, Kirsi M., Ryhanen, Samppa J., Forbes, Josephine M., Borg, Danielle J., Harkonen, Taina, Ilonen, Jorma, Simell, Olli, Veijola, Riitta, Groop, Per-Henrik and Knip, Mikael (2015). Decrease in circulating concentrations of soluble receptors for advanced glycation end products at the time of seroconversion to autoantibody positivity in children with prediabetes. Diabetes Care, 38 (4), 665-670. doi: 10.2337/dc14-1186

A rapid extraction method for glycogen from formalin-fixed liver

Sullivan, Mitchell A., Li, Shihan, Aroney, Samuel T.N., Deng, Bin, Li, Cheng, Roura, Eugeni, Schulz, Benjamin L., Harcourt, Brooke E., Forbes, Josephine M. and Gilbert, Robert G. (2015). A rapid extraction method for glycogen from formalin-fixed liver. Carbohydrate Polymers, 118, 9-15. doi: 10.1016/j.carbpol.2014.11.005

Contrasting association of circulating sCD14 with insulin sensitivity in non-obese and morbidly obese subjects

de Courten, Barbora, Moreno-Navarrete, Jose Maria, Lyons, Jasmine, Soldatos, Georgia, de Courten, Maximilian, Dougherty, Sonia, Forbes, Josephine and Fernandez-Real, Jose Manuel (2015). Contrasting association of circulating sCD14 with insulin sensitivity in non-obese and morbidly obese subjects. Molecular Nutrition and Food Research, 60 (1), 103-109. doi: 10.1002/mnfr.201500102

Impairment of liver glycogen storage in the db/db animal model of type 2 diabetes: a potential target for future therapeutics?

Sullivan, Mitchell A., Harcourt, Brooke E., Xu, Ping, Forbes, Josephine M. and Gilbert, Robert G. (2015). Impairment of liver glycogen storage in the db/db animal model of type 2 diabetes: a potential target for future therapeutics?. Current Drug Targets, 16 (10), 1088-1093. doi: 10.2174/1389450116666150727123115

Type 2 diabetes, skin autofluorescence, and brain atrophy

Moran, C., Munch, G., Forbes, J.M., Beare, R., Blizzard, L., Venn, A.J., Phan, T.G., Chen, J. and Srikanth, V. (2015). Type 2 diabetes, skin autofluorescence, and brain atrophy. Diabetes, 64 (1), 279-283. doi: 10.2337/db14-0506

Glycemic control in diabetes is restored by therapeutic manipulation of cytokines that regulate beta cell stress

Hasnain, Sumaira Z., Borg, Danielle J., Harcourt, Brooke E., Tong, Hui, Sheng, Yonghua H., Ng, Choa Ping, Das, Indrajit, Wang, Ran, Chen, Alice C.-H., Loudovaris, Thomas, Kay, Thomas W., Thomas, Helen E., Whitehead, Jonathan P., Forbes, Josephine M., Prins, Johannes B. and McGuckin, Michael A. (2014). Glycemic control in diabetes is restored by therapeutic manipulation of cytokines that regulate beta cell stress. Nature Medicine, 20 (12), 1417-1426. doi: 10.1038/nm.3705

Nox‐4 deletion reduces oxidative stress and injury by PKC‐α‐associated mechanisms in diabetic nephropathy

Thallas‐Bonke, Vicki, Jha, Jay C., Gray, Stephen P., Barit, David, Haller, Hermann, Schmidt, Harald H.H.W., Coughlan, Melinda T., Cooper, Mark E., Forbes, Josephine M. and Jandeleit‐Dahm, Karin A.M. (2014). Nox‐4 deletion reduces oxidative stress and injury by PKC‐α‐associated mechanisms in diabetic nephropathy. Physiological Reports, 2 (11) e12192, e12192.1-e12192.13. doi: 10.14814/phy2.12192

Deletion of bone-marrow-derived receptor for AGEs (RAGE) improves renal function in an experimental mouse model of diabetes

Tesch, Greg, Sourris, Karly C., Summers, Shaun A., McCarthy, Domenica, Ward, Micheal S., Borg, Danielle J., Gallo, Linda A., Fotheringham, Amelia K., Pettit, Allison R., Yap, Felicia Y. T., Harcourt, Brooke E., Tan, Adeline L. Y., Kausman, Joshua Y., Nikolic-Paterson, David, Kitching, Arthur R. and Forbes, Josephine M. (2014). Deletion of bone-marrow-derived receptor for AGEs (RAGE) improves renal function in an experimental mouse model of diabetes. Diabetologia, 57 (9), 1977-1985. doi: 10.1007/s00125-014-3291-z

Stress in the kidney is the road to pERdition: is endoplasmic reticulum stress a pathogenic mediator of diabetic nephropathy?

Zhuang, Aowen and Forbes, Josephine M. (2014). Stress in the kidney is the road to pERdition: is endoplasmic reticulum stress a pathogenic mediator of diabetic nephropathy?. Journal of Endocrinology, 222 (3), R97-R111. doi: 10.1530/JOE-13-0517

Ramipril inhibits AGE-RAGE-induced matrix metalloproteinase-2 activation in experimental diabetic nephropathy

Fukami, Kei, Yamagishi, Sho-ichi, Coughlan, Melinda T., Harcourt, Brooke E., Kantharidis, Phillip, Thallas-Bonke, Vicki, Okuda, Seiya, Cooper, Mark E. and Forbes, Josephine M. (2014). Ramipril inhibits AGE-RAGE-induced matrix metalloproteinase-2 activation in experimental diabetic nephropathy. Diabetology and Metabolic Syndrome, 6 (1) 86, 86. doi: 10.1186/1758-5996-6-86

Circulating concentrations of soluble receptor for AGE are associated with age and AGER gene polymorphisms in children with newly diagnosed type 1 diabetes

Salonen, Kirsi M., Ryhanen, Samppa J., Forbes, Josephine M., Harkonen, Taina, Ilonen, Jorma, Laine, Antti-Pekka, Groop, Per-Henrik and Knip, Mikael (2014). Circulating concentrations of soluble receptor for AGE are associated with age and AGER gene polymorphisms in children with newly diagnosed type 1 diabetes. Diabetes Care, 37 (7), 1975-1981. doi: 10.2337/dc13-3049

SYNbiotics Easing Renal failure by improving Gut microbiologY (SYNERGY): a protocol of placebo-controlled randomised cross-over trial

Rossi, Megan, Johnson, David W., Morrison, Mark, Pascoe, Elaine, Coombes, Jeff S., Forbes, Josephine M., McWhinney, Brett C., Ungerer, Jacobus P. J., Dimeski, Goce and Campbell, Katrina L. (2014). SYNbiotics Easing Renal failure by improving Gut microbiologY (SYNERGY): a protocol of placebo-controlled randomised cross-over trial. BMC Nephrology, 15 (1) 106, 106.1-106.10. doi: 10.1186/1471-2369-15-106

Dietary glycotoxins exacerbate progression of experimental fatty liver disease

Leung, Christopher, Herath, Chandana B., Jia, Zhiyuan, Goodwin, Michelle, Mak, Kai Yan, Watt, Matthew J., Forbes, Josephine M. and Angus, Peter W. (2014). Dietary glycotoxins exacerbate progression of experimental fatty liver disease. Journal of Hepatology, 60 (4), 832-838. doi: 10.1016/j.jhep.2013.11.033

Plasma advanced glycation end products (AGEs) and NF-κB activity are independent determinants of diastolic and pulse pressure

Sourris, Karly C., Lyons, Jasmine G., Dougherty, Sonia L., Chand, Vibhasha, Straznicky, Nora E., Schlaich, Markus P., Grima, Mariee T., Cooper, Mark E., Kingwell, Bronwyn A., de Courten, Maximilian P. J., Forbes, Josephine M. and de Courten, Barbora (2014). Plasma advanced glycation end products (AGEs) and NF-κB activity are independent determinants of diastolic and pulse pressure. Clinical Chemistry and Laboratory Medicine, 52 (1), 129-138. doi: 10.1515/cclm-2012-0850

Dietary advanced glycation end products as an environmental contributor to type 1 diabetes

Borg, Danielle J. and Forbes, Josephine M. (2013). Dietary advanced glycation end products as an environmental contributor to type 1 diabetes. IMARS Highlights, 8 (5), 21-22.

Environmental determinants of islet autoimmunity (ENDIA): a pregnancy to early life cohort study in children at-risk of type 1 diabetes

Penno, Megan A. S., Couper, Jennifer J., Craig, Maria E., Colman, Peter G., Rawlinson, William D., Cotterill, Andrew M., Jones, Timothy W., Harrison, Leonard C., ENDIA Study Group and Forbes, Josephine M. (2013). Environmental determinants of islet autoimmunity (ENDIA): a pregnancy to early life cohort study in children at-risk of type 1 diabetes. BMC Pediatrics, 13 (1) 124, 124.1-124.15. doi: 10.1186/1471-2431-13-124

Deficiency in mitochondrial complex I activity due to Ndufs6 gene trap insertion induces renal disease

Forbes, Josephine M., Ke, Bi-Xia, Tuong-Vi Nguyen, Henstridge, Darren C., Penfold, Sally A., Laskowski, Adrienne, Sourris, Karly C., Groschner, Lukas N., Cooper, Mark E., Thorburn, David R. and Coughlan, Melinda T. (2013). Deficiency in mitochondrial complex I activity due to Ndufs6 gene trap insertion induces renal disease. Antioxidants and Redox Signaling, 19 (4), 331-343. doi: 10.1089/ars.2012.4719

Effects of high-density lipoprotein elevation with cholesteryl ester transfer protein inhibition on insulin secretion

Siebel, Andrew L., Natoli, Alaina K., Yap, Felicia Y. T., Carey, Andrew L., Reddy-Luthmoodoo, Medini, Sviridov, Dmitri, Weber, Chek Ing Kiu, Meneses-Lorente, Georgina, Maugeais, Cyrille, Forbes, Josephine M. and Kingwell, Bronwyn A. (2013). Effects of high-density lipoprotein elevation with cholesteryl ester transfer protein inhibition on insulin secretion. Circulation Research, 113 (2), 167-175. doi: 10.1161/CIRCRESAHA.113.300689

Glucose homeostasis can be differentially modulated by varying individual components of a western diet

Forbes, Josephine M., Cowan, Samantha P., Andrikopoulos, Sofianos, Morley, Amy L., Ward, Leigh C., Walker, Karen Z., Cooper, Mark E. and Coughlan, Melinda T. (2013). Glucose homeostasis can be differentially modulated by varying individual components of a western diet. Journal of Nutritional Biochemistry, 24 (7), 1251-1257. doi: 10.1016/j.jnutbio.2012.09.009

Insulin infusion reduces hepatocyte growth factor in lean humans

de Courten, Barbora, de Courten, Maximilian P. J., Dougherty, Sonia, Forbes, Josephine M., Potts, Jenna R. and Considine, Robert V. (2013). Insulin infusion reduces hepatocyte growth factor in lean humans. Metabolism: Clinical and Experimental, 62 (5), 647-650. doi: 10.1016/j.metabol.2012.10.013

Effects of SGLT2 Inhibition in Human Kidney Proximal Tubular Cells-Renoprotection in Diabetic Nephropathy?

Panchapakesan, Usha, Pegg, Kate, Gross, Simon, Komala, Muralikrishna Gangadharan, Mudaliar, Harshini, Forbes, Josephine, Pollock, Carol and Mather, Amanda (2013). Effects of SGLT2 Inhibition in Human Kidney Proximal Tubular Cells-Renoprotection in Diabetic Nephropathy?. PLoS One, 8 (2) e54442, e54442.1-e54442.8. doi: 10.1371/journal.pone.0054442

Advanced glycation end products augment experimental hepatic fibrosis

Goodwin, Michelle, Herath, Chandana, Jia, Zhiyuan, Leung, Chris, Coughlan, Melinda T., Forbes, Josephine and Angus, Peter (2013). Advanced glycation end products augment experimental hepatic fibrosis. Journal of Gastroenterology and Hepatology, 28 (2), 369-376. doi: 10.1111/jgh.12042

Advanced glycation end products (AGEs) are cross-sectionally associated with insulin secretion in healthy subjects

Forbes, Josephine M., Sourris, Karly C., de Courten, Maximilian P. J., Dougherty, Sonia L., Chand, Vibhasha, Lyons, Jasmine G., Bertovic, David, Coughlan, Melinda T., Schlaich, Markus P., Soldatos, Georgia, Cooper, Mark E., Straznicky, Nora E., Kingwell, Bronwyn A. and de Courten, Barbora (2013). Advanced glycation end products (AGEs) are cross-sectionally associated with insulin secretion in healthy subjects. Amino Acids, 46 (2), 321-326. doi: 10.1007/s00726-013-1542-9

Brain atrophy in type 2 diabetes: regional distribution and influence on cognition

Moran, Chris, Phan, Thanh G., Chen, Jian, Blizzard, Leigh, Beare, Richard, Venn, Alison, Munch, Gerald, Wood, Amanda G., Forbes, Josephine, Greenaway, Timothy M., Pearson, Susan and Srikanth, Velandai (2013). Brain atrophy in type 2 diabetes: regional distribution and influence on cognition. Diabetes Care, 36 (12), 4036-4042. doi: 10.2337/dc13-0143

Coming full circle in diabetes mellitus: From complications to initiation

Harcourt, Brooke E., Penfold, Sally A. and Forbes, Josephine M. (2013). Coming full circle in diabetes mellitus: From complications to initiation. Nature Reviews Endocrinology, 9 (2), 113-123. doi: 10.1038/nrendo.2012.236

Mechanisms of diabetic complications

Forbes, Josephine M. and Cooper, Mark E. (2013). Mechanisms of diabetic complications. Physiological Reviews, 93 (1), 137-188. doi: 10.1152/physrev.00045.2011

Methylglyoxal, cognitive function and cerebral atrophy in older people

Srikanth, Velandai, Westcott, Bernadette, Forbes, Josephine, Phan, Thanh G., Beare, Richard, Venn, Alison, Pearson, Sue, Greenaway, Tim, Parameswaran, Venkat and Muench, Gerald (2013). Methylglyoxal, cognitive function and cerebral atrophy in older people. Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 68 (1), 68-73. doi: 10.1093/gerona/gls100

Targeting advanced glycation endproducts and mitochondrial dysfunction in cardiovascular disease

Ward, Micheal S., Fortheringham, Amelia K., Cooper, Mark E . and Forbes, Josephine M. (2013). Targeting advanced glycation endproducts and mitochondrial dysfunction in cardiovascular disease. Current Opinion in Pharmacology, 13 (4), 654-661. doi: 10.1016/j.coph.2013.06.009

Targeting the AGE-RAGE axis improves renal function in the context of a healthy diet low in advanced glycation end-product content.

Thallas-Bonke, Vicki, Coughlan, Melinda T, Tan, Adeline LY, Harcourt, Brooke E, Morgan, Philip E, Davies, Michael J, Bach, Leon A, Cooper, Mark E and Forbes, Josephine M (2013). Targeting the AGE-RAGE axis improves renal function in the context of a healthy diet low in advanced glycation end-product content.. Nephrology (Carlton, Vic.), 18 (1), 47-56. doi: 10.1111/j.1440-1797.2012.01665.x

Erratum: methylglyoxal modification of Na v 1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy (Nature Medicine (2012) 18 (926-933))

Bierhaus, Angelika, Fleming, Thomas, Stoyanov, Stoyan, Leffler, Andreas, Babes, Alexandru, Neacsu, Cristian, Sauer, Susanne K., Eberhardt, Mirjam, Schnölzer, Martina, Lasischka, Felix, Neuhuber, Winfried L., Kichko, Tatjana I., Konrade, Ilze, Elvert, Ralf, Mier, Walter, Pirags, Valdis, Lukic, Ivan K., Morcos, Michael, Dehmer, Thomas, Rabbani, Naila, Thornalley, Paul J., Edelstein, Diane, Nau, Carla, Forbes, Josephine, Humpert, Per M., Schwaninger, Markus, Ziegler, Dan, Stern, David M., Cooper, Mark E. ... Nawroth, Peter P. (2012). Erratum: methylglyoxal modification of Na v 1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy (Nature Medicine (2012) 18 (926-933)). Nature Medicine, 18 (9), 1445-1445. doi: 10.1038/nm0912-1445c

Advanced glycation end-products (AGEs) and functionality of reverse cholesterol transport in patients with type 2 diabetes and in mouse models

Low, H., Hoang, A., Forbes, J., Thomas, M., Lyons, J. G., Nestel, P., Bach, L. A. and Sviridov, D. (2012). Advanced glycation end-products (AGEs) and functionality of reverse cholesterol transport in patients with type 2 diabetes and in mouse models. Diabetologia, 55 (9), 2513-2521. doi: 10.1007/s00125-012-2570-9

Methylglyoxal modification of Na v 1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy

Bierhaus, Angelika, Fleming, Thomas, Stoyanov, Stoyan, Leffler, Andreas, Babes, Alexandru, Neacsu, Cristian, Sauer, Susanne K., Eberhardt, Mirjam, Schnoelzer, Martina, Lasischka, Felix, Neuhuber, Winfried L., Kichko, Tatjana I., Konrade, Ilze, Elvert, Ralf, Mier, Walter, Pirags, Valdis, Lukic, Ivan K., Morcos, Michael, Dehmer, Thomas, Rabbani, Naila, Thornalley, Paul J., Edelstein, Diane, Nau, Carla, Forbes, Josephine, Humpert, Per M., Schwaninger, Markus, Ziegler, Dan, Stern, David M., Cooper, Mark E. ... Nawroth, Peter P. (2012). Methylglyoxal modification of Na v 1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy. Nature Medicine, 18 (6), 926-933. doi: 10.1038/nm.2750

Coenzyme Q10 attenuates diastolic dysfunction, cardiomyocyte hypertrophy and cardiac fibrosis in the db/db mouse model of type 2 diabetes

Huynh, K., Kiriazis, H., Du, X. -J., Love, J. E., Jandeleit-Dahm, K. A., Forbes, J. M., McMullen, J. R. and Ritchie, R. H. (2012). Coenzyme Q10 attenuates diastolic dysfunction, cardiomyocyte hypertrophy and cardiac fibrosis in the db/db mouse model of type 2 diabetes. Diabetologia, 55 (5), 1544-1553. doi: 10.1007/s00125-012-2495-3

Advanced glycation end products as environmental risk factors for the development of type 1 diabetes

Yap, Felicia Y. T., Kantharidis, Phillip, Coughlan, Melinda T., Slattery, Robyn and Forbes, Josephine M. (2012). Advanced glycation end products as environmental risk factors for the development of type 1 diabetes. Current Drug Targets, 13 (4), 526-540. doi: 10.2174/138945012799499758

Glycation in diabetic nephropathy

Forbes, Josephine M. and Cooper, Mark E. (2012). Glycation in diabetic nephropathy. Amino Acids, 42 (4), 1185-1192. doi: 10.1007/s00726-010-0771-4

Ubiquinone (coenzyme Q10) prevents renal mitochondrial dysfunction in an experimental model of type 2 diabetes

Sourris, Karly C., Harcourt, Brooke E., Tang, Peter H., Morley, Amy L., Karina Huynh, Penfold, Sally A., Coughlan, Melinda T., Cooper, Mark E., Tuong-Vi Nguyen, Ritchie, Rebecca H. and Forbes, Josephine M. (2012). Ubiquinone (coenzyme Q10) prevents renal mitochondrial dysfunction in an experimental model of type 2 diabetes. Free Radical Biology and Medicine, 52 (3), 716-723. doi: 10.1016/j.freeradbiomed.2011.11.017

Obesity-induced renal impairment is exacerbated in interleukin-6-knockout mice

Harcourt, Brooke E., Forbes, Josephine M. and Matthews, Vance B. (2012). Obesity-induced renal impairment is exacerbated in interleukin-6-knockout mice. Nephrology, 17 (3), 257-262. doi: 10.1111/j.1440-1797.2011.01547.x

Advanced glycation end products are direct modulators of β-cell function

Coughlan, Melinda T., Yap, Felicia Y. T., Tong, David C. K., Andrikopoulos, Sofianos, Gasser, Anna, Thallas-Bonke, Vicki, Webster, Diane E., Miyazaki, Jun-ichi, Kay, Thomas W., Slattery, Robyn M., Kaye, David M., Drew, Brian G., Kingwell, Bronwyn A., Fourlanos, Spiros, Groop, Per-Henrik, Harrison, Leonard C., Knip, Mikael and Forbes, Josephine M. (2011). Advanced glycation end products are direct modulators of β-cell function. Diabetes, 60 (10), 2523-2532. doi: 10.2337/db10-1033

Advanced glycation urinary protein-bound biomarkers and severity of diabetic nephropathy in man

Coughlan, Melinda T., Patel, Sheila K., Jerums, George, Penfold, Sally A., Nguyen, Tuong-Vi, Sourris, Karly C., Panagiotopoulos, Sianna, Srivastava, Piyush M., Cooper, Mark E., Burrell, Louise M., MacIsaac, Richard J. and Forbes, Josephine M. (2011). Advanced glycation urinary protein-bound biomarkers and severity of diabetic nephropathy in man. American Journal of Nephrology, 34 (4), 347-355. doi: 10.1159/000331064

The advanced glycation end product-lowering agent ALT-711 is a low-affinity inhibitor of thiamine diphosphokinase

Krautwald, Martina, Leech, Dale, Horne, Stacey, Steele, Megan L., Forbes, Josephine, Rahmadi, Anton, Griffith, Renate and Muench, Gerald (2011). The advanced glycation end product-lowering agent ALT-711 is a low-affinity inhibitor of thiamine diphosphokinase. Rejuvenation Research, 14 (4), 383-391. doi: 10.1089/rej.2010.1143

Targeted reduction of advanced glycation improves renal function in obesity

Harcourt, Brooke E., Sourris, Karly C., Coughlan, Melinda T., Walker, Karen Z., Dougherty, Sonia L., Andrikopoulos, Sofianos, Morley, Amy L., Thallas-Bonke, Vicki, Chand, Vibhasha, Penfold, Sally A., de Courten, Maximilian P. J., Thomas, Merlin C., Kingwell, Bronwyn A., Bierhaus, Angelika, Cooper, Mark E., de Courten, Barbora and Forbes, Josephine M. (2011). Targeted reduction of advanced glycation improves renal function in obesity. Kidney International, 80 (2), 190-198. doi: 10.1038/ki.2011.57

Temporal increases in urinary carboxymethyllysine correlate with albuminuria development in diabetes

Coughlan, Melinda T. and Forbes, Josephine M. (2011). Temporal increases in urinary carboxymethyllysine correlate with albuminuria development in diabetes. American Journal of Nephrology, 34 (1), 9-17. doi: 10.1159/000328581

Erratum to: Receptor for advanced glycation end-products (RAGE) provides a link between genetic susceptibility and environmental factors in type 1 diabetes

Forbes, J. M., Söderlund, J., Yap, F. Y. T., Knip, M., Andrikopoulos, S., Ilonen, J., Simell, O., Veijola, R., Sourris, K. C., Coughlan, M. T., Forsblom, C., Slattery, R., Bierhaus, A., Grey, S. T., Wessman, M., Yamamoto, H., Cooper, M. E. and Groop, P.-H. (2011). Erratum to: Receptor for advanced glycation end-products (RAGE) provides a link between genetic susceptibility and environmental factors in type 1 diabetes. Diabetologia, 54 (6), 1586-1587. doi: 10.1007/s00125-011-2145-1

Receptor for advanced glycation end-products (RAGE) provides a link between genetic susceptibility and environmental factors in type 1 diabetes

Forbes, J. M., Soderlund, J., Yap, F. Y. T., Knip, M., Andrikopoulos, S., Ilonen, J., Simell, O., Veijola, R., Sourris, K. C., Coughlan, M. T., Forsblom, C., Slattery, R., Grey, S. T., Wessman, M., Yamamoto, H., Bierhaus, A., Cooper, M. E. and Groop, P.-H. (2011). Receptor for advanced glycation end-products (RAGE) provides a link between genetic susceptibility and environmental factors in type 1 diabetes. Diabetologia, 54 (5), 1032-1042. doi: 10.1007/s00125-011-2058-z

Increased risk of cardiovascular disease in Type 1 diabetes: arterial exposure to remnant lipoproteins leads to enhanced deposition of cholesterol and binding to glycated extracellular matrix proteoglycans

Mangat, R., Su, J. W., Lambert, J. E., Clandinin, M. T., Wang, Y., Uwiera, R. R., Forbes, J. M., Vine, D. F., Cooper, M. E., Mamo, J. C. and Proctor, S. D. (2011). Increased risk of cardiovascular disease in Type 1 diabetes: arterial exposure to remnant lipoproteins leads to enhanced deposition of cholesterol and binding to glycated extracellular matrix proteoglycans. Diabetic Medicine, 28 (1), 61-72. doi: 10.1111/j.1464-5491.2010.03138.x

Receptor for AGEs (RAGE) blockade may exert its renoprotective effects in patients with diabetic nephropathy via induction of the angiotensin II type 2 (AT2) receptor

Sourris, K. C., Morley, A. L., Koitka, A., Samuel, P., Coughlan, M. T., Penfold, S. A., Thomas, M. C., Bierhaus, A., Nawroth, P. P., Yamamoto, H., Allen, T. J., Walther, T., Hussain, T., Cooper, M. E. and Forbes, J. M. (2010). Receptor for AGEs (RAGE) blockade may exert its renoprotective effects in patients with diabetic nephropathy via induction of the angiotensin II type 2 (AT2) receptor. Diabetologia, 53 (11), 2442-2451. doi: 10.1007/s00125-010-1837-2

The relationship between heat shock protein 72 expression in skeletal muscle and insulin sensitivity is dependent on adiposity

Henstridge, Darren C., Forbes, Josephine M., Penfold, Sally A., Formosa, Melissa F., Dougherty, Sonia, Gasser, Anna, de Courten, Maximilian P., Cooper, Mark E., Kingwell, Bronwyn A. and de Courten, Barbora (2010). The relationship between heat shock protein 72 expression in skeletal muscle and insulin sensitivity is dependent on adiposity. Metabolism: Clinical and Experimental, 59 (11), 1556-1561. doi: 10.1016/j.metabol.2010.01.027

The physiological deadlock between AMPK and gluconeogenesis: SOGA, a novel protein, may provide the key

Forbes, Josephine M. (2010). The physiological deadlock between AMPK and gluconeogenesis: SOGA, a novel protein, may provide the key. American Journal of Pathology, 177 (4), 1600-1602. doi: 10.2353/ajpath.2010.100679

The pleiotropic actions of rosuvastatin confer renal benefits in the diabetic Apo-E knockout mouse

Giunti, Sara, Calkin, Anna C., Forbes, Josephine M., Allen, Terri J., Thomas, Merlin C., Cooper, Mark E. and Jandeleit-Dahm, Karin A. (2010). The pleiotropic actions of rosuvastatin confer renal benefits in the diabetic Apo-E knockout mouse. American Journal of Physiology - Renal Physiology, 299 (3), F528-F535. doi: 10.1152/ajprenal.00127.2010

Circulating high-molecular-weight RAGE ligands activate pathways implicated in the development of diabetic nephropathy

Penfold, Sally A., Coughlan, Melinda T., Patel, Sheila K., Srivastava, Piyush M., Sourris, Karly C., Steer, David, Webster, Diane E., Thomas, Merlin C., MacIsaac, Richard J., Jerums, George, Burrell, Louise M., Cooper, Mark E. and Forbes, Josephine M. (2010). Circulating high-molecular-weight RAGE ligands activate pathways implicated in the development of diabetic nephropathy. Kidney International, 78 (3), 287-295. doi: 10.1038/ki.2010.134

Reply

Norman, Paul E., Davis, Wendy A., Coughlan, Melinda T., Forbes, Josephine M., Golledge, Jonathan and Davis, Timothy M. E. (2010). Reply. Journal of Vascular Surgery, 52 (2), 536-536. doi: 10.1016/j.jvs.2010.04.032

Preservation of kidney function with combined inhibition of NADPH oxidase and angiotensin-converting enzyme in diabetic nephropathy

Thallas-Bonke, Vicki, Coughlan, Melinda T., Bach, Leon A., Cooper, Mark E. and Forbes, Josephine M. (2010). Preservation of kidney function with combined inhibition of NADPH oxidase and angiotensin-converting enzyme in diabetic nephropathy. American Journal of Nephrology, 32 (1), 73-82. doi: 10.1159/000314924

Advanced glycation end-products induce vascular dysfunction via resistance to nitric oxide and suppression of endothelial nitric oxide synthase

Soro-Paavonen, Aino, Zhang, Wei-Zeng, Venardos, Kylie, Coughlan, Melinda T., Harris, Emma, Tong, David C. K., Brasacchio, Daniella, Paavonen, Karri, Chin-Dusting, Jaye, Cooper, Mark E., Kaye, David, Thomas, Merlin C. and Forbes, Josephine M. (2010). Advanced glycation end-products induce vascular dysfunction via resistance to nitric oxide and suppression of endothelial nitric oxide synthase. Journal of Hypertension, 28 (4), 780-788. doi: 10.1097/HJH.0b013e328335043e

Errata: Reduction of the accumulation of advanced glycation end products by ACE inhibition in experimental diabetic nephropathy (Diabetes (2002) 51, (3274-3282))

Forbes, J. M., Cooper, M. E., Thallas, V., Burns, W. C., Thomas, M. C., Brammar, G. C., Lee, F., Grant, S. L., Burrell, L. A., Jerums, G. and Osicka, T. M. (2010). Errata: Reduction of the accumulation of advanced glycation end products by ACE inhibition in experimental diabetic nephropathy (Diabetes (2002) 51, (3274-3282)). Diabetes, 59 (4), 1113-1114. doi: 10.2337/db10-er04a

Disparate effects on renal and oxidative parameters following RAGE deletion, AGE accumulation inhibition, or dietary AGE control in experimental diabetic nephropathy

Tan, Adeline L. Y., Sourris, Karly C., Harcourt, Brooke E., Thallas-Bonke, Vicki, Penfold, Sally, Andrikopoulos, Sofianos, Thomas, Merlin C., O'Brien, Richard C., Bierhaus, Angelika, Cooper, Mark E., Forbes, Josephine M. and Coughlan, Melinda T. (2010). Disparate effects on renal and oxidative parameters following RAGE deletion, AGE accumulation inhibition, or dietary AGE control in experimental diabetic nephropathy. American Journal of Physiology - Renal Physiology, 298 (3), F763-F770. doi: 10.1152/ajprenal.00591.2009

Modulation of the cellular expression of circulating advanced glycation end-product receptors in type 2 diabetic nephropathy

Sourris, Karly C., Harcourt, Brooke E., Penfold, Sally A., Yap, Felicia Y. T., Morley, Amy L., Morgan, Philip E., Davies, Michael J., Baker, Scott T., Jerums, George and Forbes, Josephine M. (2010). Modulation of the cellular expression of circulating advanced glycation end-product receptors in type 2 diabetic nephropathy. Experimental Diabetes Research, 2010 (Art No.: 974681) 974681, 1-9. doi: 10.1155/2010/974681

Serum carboxymethyllysine concentrations are reduced in diabetic men with abdominal aortic aneurysms: Health In Men study

Norman, Paul E., Davis, Wendy A., Coughlan, Melinda T., Forbes, Josephine M., Golledge, Jonathan and Davis, Timothy M. E. (2009). Serum carboxymethyllysine concentrations are reduced in diabetic men with abdominal aortic aneurysms: Health In Men study. Journal of Vascular Surgery, 50 (3), 626-631. doi: 10.1016/j.jvs.2009.05.058

c-Jun NH2-terminal kinase activity in subcutaneous adipose tissue but not nuclear factor-κB activity in peripheral blood mononuclear cells is an independent determinant of insulin resistance in healthy individuals

Sourris, Karly C., Lyons, Jasmine G., de Courten, Maximilian P. J., Dougherty, Sonia L., Henstridge, Darren C., Cooper, Mark E., Hage, Michelle, Dart, Anthony, Kingwell, Bronwyn A., Forbes, Josephine M. and de Courten, Barbora (2009). c-Jun NH2-terminal kinase activity in subcutaneous adipose tissue but not nuclear factor-κB activity in peripheral blood mononuclear cells is an independent determinant of insulin resistance in healthy individuals. Diabetes, 58 (6), 1259-1265. doi: 10.2337/db08-1725

High-density lipoprotein modulates glucose metabolism in patients with type 2 diabetes mellitus

Drew, Brian G., Duffy, Stephen J., Formosa, Melissa F., Natoli, Alaina K., Henstridge, Darren C., Penfold, Sally A., Thomas, Walter G., Mukhamedova, Nigora, de Courten, Barbora, Forbes, Josephine M., Yap, Felicia Y., Kaye, David M., van Hall, Gerrit, Febbraio, Mark A., Kemp, Bruce E., Sviridov, Dmitri, Steinberg, Gregory R. and Kingwell, Bronwyn A. (2009). High-density lipoprotein modulates glucose metabolism in patients with type 2 diabetes mellitus. Circulation, 119 (15), 2103-2111. doi: 10.1161/CIRCULATIONAHA.108.843219

The effect of salsalate on insulin action and glucose tolerance in obese non-diabetic patients: results of a randomised double-blind placebo-controlled study

Koska, J., Ortega, E., Bunt, J. C., Gasser, A., Impson, J., Hanson, R. L., Forbes, J., de Courten, B. and Krakoff, J. (2009). The effect of salsalate on insulin action and glucose tolerance in obese non-diabetic patients: results of a randomised double-blind placebo-controlled study. Diabetologia, 52 (3), 385-393. doi: 10.1007/s00125-008-1239-x

A new perspective on therapeutic inhibition of advanced glycation in diabetic microvascular complications: Common downstream endpoints achieved through disparate therapeutic approaches?

Sourris, Karly C., Harcourt, Brooke E. and Forbes, Josephine M. (2009). A new perspective on therapeutic inhibition of advanced glycation in diabetic microvascular complications: Common downstream endpoints achieved through disparate therapeutic approaches?. American Journal of Nephrology, 30 (4), 323-335. doi: 10.1159/000226586

Interactions Between Advanced Glycation End-Products (AGE) and their Receptors in the Development and Progression of Diabetic Nephropathy - are these Receptors Valid Therapeutic Targets

Sourris, Karly C. and Forbes, Josephine M. (2009). Interactions Between Advanced Glycation End-Products (AGE) and their Receptors in the Development and Progression of Diabetic Nephropathy - are these Receptors Valid Therapeutic Targets. Current Drug Targets, 10 (1), 42-50. doi: 10.2174/138945009787122905

Rage-induced cytosolic ROS promote mitochondrial superoxide generation in diabetes

Coughlan, Melinda T., Thorburn, David R., Penfold, Sally A., Laskowski, Adrienne, Harcourt, Brooke E., Sourris, Karly C., Tan, Adeline L. Y., Fukami, Kei, Thallas-Bonke, Vicki, Nawroth, Peter P., Brownlee, Michael, Bierhaus, Angelika, Cooper, Mark E. and Forbes, Josephine M. (2009). Rage-induced cytosolic ROS promote mitochondrial superoxide generation in diabetes. Journal of the American Society of Nephrology, 20 (4), 742-752. doi: 10.1681/ASN.2008050514

Heat shock protein expression in diabetic nephropathy

Barutta, Federica, Pinach, Silvia, Giunti, Sara, Vittone, Ferdinando, Forbes, Josephine M., Chiarle, Roberto, Arnstein, Maryann, Perin, Paolo Cavallo, Camussi, Giovanni, Cooper, Mark E. and Gruden, Gabriella (2008). Heat shock protein expression in diabetic nephropathy. American Journal of Physiology - Renal Physiology, 295 (6), F1817-F1824. doi: 10.1152/ajprenal.90234.2008

Receptor for advanced glycation end products (RAGE) deficiency attenuates the development of atherosclerosis in diabetes

Soro-Paavonen, Aino, Watson, Anna M. D., Li, Jiaze, Paavonen, Karri, Koitka, Audrey, Calkin, Anna C., Barit, David, Coughlan, Melinda T., Drew, Brian G., Lancaster, Graeme I., Thomas, Merlin, Forbes, Josephine M., Nawroth, Peter P., Bierhaus, Angelika, Cooper, Mark E. and Jandeleit-Dahm, Karin A. (2008). Receptor for advanced glycation end products (RAGE) deficiency attenuates the development of atherosclerosis in diabetes. Diabetes, 57 (9), 2461-2469. doi: 10.2337/db07-1808

Cardiac inflammation associated with a Western diet is mediated via activation of RAGE by AGEs

Tikellis, Christos, Thomas, Merlin C., Harcourt, Brooke E., Coughlan, Melinda T., Pete, Josepha, Bialkowski, Katarzyna, Tan, Adeline, Bierhaus, Angelika, Cooper, Mark E. and Forbes, Josephine M. (2008). Cardiac inflammation associated with a Western diet is mediated via activation of RAGE by AGEs. American Journal of Physiology: Endocrinology and Metabolism, 295 (2), E323-E330. doi: 10.1152/ajpendo.00024.2008

Oxidative stress as a major culprit in kidney disease in diabetes

Forbes, Josephine M., Coughlan, Melinda T. and Cooper, Mark E. (2008). Oxidative stress as a major culprit in kidney disease in diabetes. Diabetes, 57 (6), 1446-1454. doi: 10.2337/db08-0057

Response to comment on: Thallas-bonke et al. (2008) inhibition of NADPH oxidase prevents advanced glycation end product-mediated damage in diabetic nephropathy through a protein kinase C-α-dependent pathway:Diabetes 57:460-469, 2008

Thallas-Bonke, Vicki and Forbes, Josephine M. (2008). Response to comment on: Thallas-bonke et al. (2008) inhibition of NADPH oxidase prevents advanced glycation end product-mediated damage in diabetic nephropathy through a protein kinase C-α-dependent pathway:Diabetes 57:460-469, 2008. Diabetes, 57 (6), e14-e14. doi: 10.2337/db08-0406

MKK3 signalling plays an essential role in leukocyte-mediated pancreatic injury in the multiple low-dose streptozotocin model

Fukuda, Kyoichi, Tesch, Greg H., Yap, Felicia Y., Forbes, Josephine M., Flavell, Richard A., Davis, Roger J. and Nikolic-Paterson, David J. (2008). MKK3 signalling plays an essential role in leukocyte-mediated pancreatic injury in the multiple low-dose streptozotocin model. Laboratory Investigation, 88 (4), 398-407. doi: 10.1038/labinvest.2008.10

Inhibition of NADPH oxidase prevents advanced glycation end product-mediated damage in diabetic nephropathy through a protein kinase C-α-dependent pathway

Thallas-Bonke, Vicki, Thorpe, Suzanne R., Coughlan, Melinda T., Fukami, Kei, Yap, Felicia Y. T., Sourris, Karly C., Penfold, Sally A., Bach, Leon A., Cooper, Mark E. and Forbes, Josephine M. (2008). Inhibition of NADPH oxidase prevents advanced glycation end product-mediated damage in diabetic nephropathy through a protein kinase C-α-dependent pathway. Diabetes, 57 (2), 460-469. doi: 10.2337/db07-1119

Advanced glycation: implications in tissue damage and disease

Gasser, Anna and Forbes, Josephine M. (2008). Advanced glycation: implications in tissue damage and disease. Protein and Peptide Letters, 15 (4), 385-391. doi: 10.2174/092986608784246515

Advanced glycation of apolipoprotein A-I impairs its anti-atherogenic properties

Hoang, A., Murphy, A. J., Coughlan, M. T., Thomas, M. C., Forbes, J. M., O'Brien, R., Cooper, M. E., Chin-Dusting, J. P. F. and Sviridov, D. (2007). Advanced glycation of apolipoprotein A-I impairs its anti-atherogenic properties. Diabetologia, 50 (8), 1770-1779. doi: 10.1007/s00125-007-0718-9

Combination therapy with the advanced glycation end product cross-link breaker, alagebrium, and angiotensin converting enzyme inhibitors in diabetes: synergy or redundancy?

Coughlan, Melinda T., Thallas-Bonke, Vicki, Pete, Josefa, Long, David M., Gasser, Anna, Tong, David C. K., Arnstein, Maryann, Thorpe, Suzanne R., Cooper, Mark E. and Forbes, Josephine M. (2007). Combination therapy with the advanced glycation end product cross-link breaker, alagebrium, and angiotensin converting enzyme inhibitors in diabetes: synergy or redundancy?. Endocrinology, 148 (2), 886-895. doi: 10.1210/en.2006-1300

AGE, RAGE, and ROS in diabetic nephropathy

Ton, Adeline L. Y., Forbes, Josephine M. and Cooper, Mark E. (2007). AGE, RAGE, and ROS in diabetic nephropathy. Seminars in Nephrology, 27 (2), 130-143. doi: 10.1016/j.semnephrol.2007.01.006

Renal microvascular injury in diabetes: RAGE and redox signaling

Coughlan, Melinda T., Cooper, Mark E. and Forbes, Josephine M. (2007). Renal microvascular injury in diabetes: RAGE and redox signaling. Antioxidants and Redox Signaling, 9 (3), 331-342. doi: 10.1089/ars.2006.1469

Diabetic nephropathy: where hemodynamics meets metabolism

Forbes, J. M., Fukami, K. and Cooper, M. E. (2007). Diabetic nephropathy: where hemodynamics meets metabolism. Experimental and Clinical Endocrinology and Diabetes, 115 (2), 69-84. doi: 10.1055/s-2007-949721

Connective tissue growth factor plays an important role in advanced glycation end product-induced tubular epithelial-to-mesenchymal transition: implications for diabetic renal disease

Burns, Wendy C., Twigg, Stephen M., Forbes, Josephine M., Pete, Josefa, Tikellis, Christos, Thallas-Bonke, Vicki, Thomas, Merlin C., Cooper, Mark E. and Kantharidis, Phillip (2006). Connective tissue growth factor plays an important role in advanced glycation end product-induced tubular epithelial-to-mesenchymal transition: implications for diabetic renal disease. Journal of the American Society of Nephrology, 17 (9), 2484-2494. doi: 10.1681/ASN.2006050525

A developmental nephron deficit in rats is associated with increased susceptibility to a secondary renal injury due to advanced glycation end-products

Zimanyi, M. A., Denton, K. M., Forbes, J. M., Thallas-Bonke, V., Thomas, M. C., Poon, F. and Black, M. J. (2006). A developmental nephron deficit in rats is associated with increased susceptibility to a secondary renal injury due to advanced glycation end-products. Diabetologia, 49 (4), 801-810. doi: 10.1007/s00125-006-0175-x

Erratum: Advanced glycation end product intervention reduce diabetes-accelerated atherosclerosis (Diabetes (2005) 53, (1813-1823))

Forbes, J. M., Yee, L. T.L., Thallas, V., Lassila, M., Candido, R., Jandeleit-Dahm, K. A., Thomas, M. C., Burns, W. C., Deemer, E. K., Thorpe, S. R., Cooper, M. E. and Allen, T. J. (2006). Erratum: Advanced glycation end product intervention reduce diabetes-accelerated atherosclerosis (Diabetes (2005) 53, (1813-1823)). Diabetes, 55 (3)

Novel therapeutics for diabetic micro- and macrovascular complications

Soro-Paavonen, A. and Forbes, J. M. (2006). Novel therapeutics for diabetic micro- and macrovascular complications. Current Medicinal Chemistry, 13 (15), 1777-1788. doi: 10.2174/092986706777452515

Interactions between renin angiotensin system and advanced glycation in the kidney

Thomas, Merlin C., Tikellis, Christos, Burns, Wendy M., Bialkowski, Katarzyna, Cao, Zemin, Coughlan, Melinda T., Jandeleit-Dahm, Karen, Cooper, Mark E. and Forbes, Josephine M. (2005). Interactions between renin angiotensin system and advanced glycation in the kidney. Journal of the American Society of Nephrology, 16 (10), 2976-2984. doi: 10.1681/ASN.2005010013

Rosiglitazone attenuates atherosclerosis in a model of insulin insufficiency independent of its metabolic effects

Calkin, Anna C., Forbes, Josephine M., Smith, Craig M., Lassila, Markus, Cooper, Mark E., Jandeleit-Dahm, Karin A. and Allen, Terri J. (2005). Rosiglitazone attenuates atherosclerosis in a model of insulin insufficiency independent of its metabolic effects. Arteriosclerosis, Thrombosis, and Vascular Biology, 25 (9), 1903-1909. doi: 10.1161/01.ATV.0000177813.99577.6b

High glucose-induced impairment in insulin secretion is associated with reduction in islet glucokinase in a mouse model of susceptibility to islet dysfunction

Kooptiwut, Suwattanee, Kebede, Melkam, Zraika, Sakeneh, Visinoni, Sherley, Aston-Mourney, Kathryn, Favaloro, Jenny, Tikellis, Chris, Thomas, Merlin C., Forbes, Josephine M., Cooper, Mark E., Dunlop, Marjorie, Proietto, Joseph and Andrikopoulos, Sofianos (2005). High glucose-induced impairment in insulin secretion is associated with reduction in islet glucokinase in a mouse model of susceptibility to islet dysfunction. Journal of Molecular Endocrinology, 35 (1), 39-48. doi: 10.1677/jme.1.01720

Modulation of soluble receptor for advanced glycation end products by angiotensin-converting enzyme-1 inhibition in diabetic nephropathy

Forbes, Josephine M., Thorpe, Suzanne R., Thallas-Bonke, Vicki, Pete, Josefa, Thomas, Merlin C., Deemer, Elizabeth R., Bassal, Sahar, El-Osta, Assam, Long, David M., Panagiotopoulos, Sianna, Jerums, George, Osicka, Tanya M. and Cooper, Mark E. (2005). Modulation of soluble receptor for advanced glycation end products by angiotensin-converting enzyme-1 inhibition in diabetic nephropathy. Journal of the American Society of Nephrology, 16 (8), 2363-2372. doi: 10.1681/ASN.2005010062

Agents in development for the treatment of diabetic nephropathy

Fukami, Kei, Cooper, Mark and Forbes, Josephine M. (2005). Agents in development for the treatment of diabetic nephropathy. Expert Opinion On Investigational Drugs, 14 (3), 279-294. doi: 10.1517/13543784.14.3.279

Interactions between the renin angiotensin system and advanced glycation in diabetic nephropathy

Thomas, M. C., Forbes, J. M. and Cooper, M. E. (2005). Interactions between the renin angiotensin system and advanced glycation in diabetic nephropathy. Annals of the New York Academy of Sciences, 1043 (1), 927-927. doi: 10.1196/annals.1333.141

Temporal renal expression of angiogenic growth factors and their receptors in experimental diabetes: role of the renin-angiotensin system

Rizkalla, Bishoy, Forbes, Josephine M., Cao, Zemin, Boner, Geoffrey and Cooper, Mark E. (2005). Temporal renal expression of angiogenic growth factors and their receptors in experimental diabetes: role of the renin-angiotensin system. Journal of Hypertension, 23 (1), 153-164. doi: 10.1097/00004872-200501000-00026

Attenuation of extracellular matrix accumulation in diabetic nephropathy by the advanced glycation end product cross-link breaker ALT-711 via a protein kinase C-α - dependent pathway

Thallas-Bonke, Vicki, Lindschau, Carsten, Rizkalla, Bishoy, Bach, Leon A., Boner, Geoffrey, Meier, Matthias, Haller, Hermann, Cooper, Mark E. and Forbes, Josephine M. (2004). Attenuation of extracellular matrix accumulation in diabetic nephropathy by the advanced glycation end product cross-link breaker ALT-711 via a protein kinase C-α - dependent pathway. Diabetes, 53 (11), 2921-2930. doi: 10.2337/diabetes.53.11.2921

The effects of valsartan on the accumulation of circulating and renal advanced glycation end products in experimental diabetes

Forbes, Josephine M., Thomas, Merlin C., Thorpe, Suzanne R., Alderson, Nathan L. and Cooper, Mark E. (2004). The effects of valsartan on the accumulation of circulating and renal advanced glycation end products in experimental diabetes. Kidney International, Supplement, 66 (S92), S105-S107. doi: 10.1111/j.1523-1755.2004.09225.x

The role of advanced glycation in reduced organic cation transport associated with experimental diabetes

Thomas, Merlin C., Tikellis, Christos, Kantharidis, Phillip, Burns, Wendy C., Cooper, Mark E. and Forbes, Josephine M. (2004). The role of advanced glycation in reduced organic cation transport associated with experimental diabetes. Journal of Pharmacology and Experimental Therapeutics, 311 (2), 456-466. doi: 10.1124/jpet.104.070672

Accelerated nephropathy in diabetic apolipoprotein E-knockout mouse: role of advanced glycation end products

Lassila, Markus, Seah, Kwee K., Allen, Terri J., Thallas, Vicki, Thomas, Merlin C., Candido, Riccardo, Burns, Wendy C., Forbes, Josephine M., Calkin, Anna C., Cooper, Mark E. and Jandeleit-Dahm, Karin A. M. (2004). Accelerated nephropathy in diabetic apolipoprotein E-knockout mouse: role of advanced glycation end products. Journal of the American Society of Nephrology, 15 (8), 2125-2138. doi: 10.1097/01.ASN.0000133025.23732.46

Interactions between angiotensin II and NF-κB-dependent pathways in modulating macrophage infiltration in experimental diabetic nephropathy

Lee, Fiona T. H., Cao, Zemin, Long, David M., Panagiotopoulos, Sianna, Jerums, George, Cooper, Mark E. and Forbes, Josephine M. (2004). Interactions between angiotensin II and NF-κB-dependent pathways in modulating macrophage infiltration in experimental diabetic nephropathy. Journal of the American Society of Nephrology, 15 (8), 2139-2151. doi: 10.1097/01.ASN.0000135055.61833.A8

Advanced glycation end product-interventions reduce diabetes-accelerated atherosclerosis

Forbes, Josephine M., Yee, Louis Teo Loon, Thallas, Vicki, Lassila, Markus, Candido, Riccardo, Jandeleit-Dahm, Karin A., Thomas, Merlin C., Burns, Wendy C., Deemer, Elizabeth K., Thorpe, Susan M., Cooper, Mark E. and Allen, Terri J. (2004). Advanced glycation end product-interventions reduce diabetes-accelerated atherosclerosis. Diabetes, 53 (7), 1813-1823. doi: 10.2337/diabetes.53.7.1813

Early vitamin E supplementation attenuates diabetes-associated vascular dysfunction and the rise in protein kinase C-beta in mesenteric artery and ameliorates wall stiffness in femoral artery of Wistar rats

Wigg, SJ, Tare, M, Forbes, J, Cooper, ME, Thomas, MC, Coleman, HA, Parkington, HC and O'Brien, RC (2004). Early vitamin E supplementation attenuates diabetes-associated vascular dysfunction and the rise in protein kinase C-beta in mesenteric artery and ameliorates wall stiffness in femoral artery of Wistar rats. Diabetologia, 47 (6), 1038-1046. doi: 10.1007/s00125-004-1411-x

Advanced glycation: how are we progressing to combat this web of sugar anomalies in diabetic nephropathy

Forbes, Josephine M., Thallas-Bonke, Vicki, Cooper, Mark E. and Thomas, Merlin C. (2004). Advanced glycation: how are we progressing to combat this web of sugar anomalies in diabetic nephropathy. Current Pharmaceutical Design, 10 (27), 3361-3372. doi: 10.2174/1381612043383151

Identification of angiotensin converting enzyme 2 in the rodent retina

Tikellis, C., Johnston, C. I., Forbes, J. M., Burns, W., Thomas, M. C., Lew, R. A., Yarski, M., Smith, A. I. and Cooper, M. E. (2004). Identification of angiotensin converting enzyme 2 in the rodent retina. Current Eye Research, 29 (6), 419-427. doi: 10.1080/02713680490517944

Superior renoprotective effects of combination therapy with ACE and AGE inhibition in the diabetic spontaneously hypertensive rat

Davis, B. J., Forbes, J. M., Thomas, M. C., Jerums, G., Burns, W. C., Kawachi, H., Allen, T. J. and Cooper, M. E. (2004). Superior renoprotective effects of combination therapy with ACE and AGE inhibition in the diabetic spontaneously hypertensive rat. Diabetologia, 47 (1), 89-97. doi: 10.1007/s00125-003-1256-8

Additive effects of hypertension and diabetes on renal cortical expression of PKC-α and -ε and α-tubulin but not PKC-β1 and -β2

Osicka, Tanya M., Russo, Leileata M., Qiu, Mei-Lan, Brammar, Gail C., Thallas, Vicki, Forbes, Josephine M., Comper, Wayne D. and Jerums, George (2003). Additive effects of hypertension and diabetes on renal cortical expression of PKC-α and -ε and α-tubulin but not PKC-β1 and -β2. Journal of Hypertension, 21 (12), 2399-2407. doi: 10.1097/00004872-200312000-00029

Increased renal vascular endothelial growth factor and angiopoietins by angiotensin II infusion is mediated by both AT1 and AT2 receptors

Rizkalla, Bizhoy, Forbes, Josephine M., Cooper, Mark E. and Cao, Zemin (2003). Increased renal vascular endothelial growth factor and angiopoietins by angiotensin II infusion is mediated by both AT1 and AT2 receptors. Journal of the American Society of Nephrology, 14 (12), 3061-3071. doi: 10.1097/01.ASN.0000099374.58607.C9

Evolving concepts in advanced glycation, diabetic nephropathy, and diabetic vascular disease

Jerums, George, Panagiotopoulos, Sianna, Forbes, Josephine, Osicka, Tanya and Cooper, Mark (2003). Evolving concepts in advanced glycation, diabetic nephropathy, and diabetic vascular disease. Archives of Biochemistry And Biophysics, 419 (1), 55-62. doi: 10.1016/j.abb.2003.08.017

Ramipril prevents microtubular changes in proximal tubules from streptozotocin diabetic rats

Osicka, Tanya M., Forbes, Josephine M., Thallas, Vicki, Brammar, Gail C., Jerums, George and Comper, Wayne D. (2003). Ramipril prevents microtubular changes in proximal tubules from streptozotocin diabetic rats. Nephrology, 8 (4), 205-211. doi: 10.1046/j.1440-1797.2003.00159.x

Role of advanced glycation end products in diabetic nephropathy

Forbes, Josephine M., Cooper, Mark E., Oldfield, Matthew D. and Thomas, Merlin C. (2003). Role of advanced glycation end products in diabetic nephropathy. Journal of the American Society of Nephrology, 14 (suppl 3), S254-S258. doi: 10.1097/01.ASN.0000077413.41276.17

Reduced tubular cation transport in diabetes: prevented by ACE inhibition

Thomas, Merlin C., Tikellis, Chris, Burns, Wendy C., Thallas, Vicki, Forbes, Josephine M., Cao, Zemin, Osicka, Tanya M., Russo, Leileata M., Jerums, George, Ghabrial, Hany, Cooper, Mark E. and Kantharidis, Phillip (2003). Reduced tubular cation transport in diabetes: prevented by ACE inhibition. Kidney International, 63 (6), 2152-2161. doi: 10.1046/j.1523-1755.2003.00006.x

A breaker of advanced glycation end products attenuates diabetes-induced myocardial structural changes

Candido, Riccardo, Forbes, Josephine M., Thomas, Merlin C., Thallas, Vicki, Dean, Rachael G., Burns, Wendy C., Tikellis, Christos, Ritchie, Rebecca H., Twigg, Stephen M., Cooper, Mark E. and Burrell, Louise M. (2003). A breaker of advanced glycation end products attenuates diabetes-induced myocardial structural changes. Circulation Research, 92 (7), 785-792. doi: 10.1161/01.RES.0000065620.39919.20

Characterization of renal angiotensin - converting enzyme 2 in diabetic nephropathy

Tikellis, Christos, Johnston, Colin I., Forbes, Josephine M., Burns, Wendy C., Burrell, Louise M., Risvanis, John and Cooper, Mark E. (2003). Characterization of renal angiotensin - converting enzyme 2 in diabetic nephropathy. Hypertension, 41 (3), 392-397. doi: 10.1161/01.HYP.0000060689.38912.CB

Reversible angiotensin II-mediated albuminuria in rat kidneys is dynamically associated with cytoskeletal organization

Clavant, Steven P., Forbes, Josephine M., Thallas, Vicki, Osicka, Tanya M., Jerums, George and Comper, Wayne D. (2003). Reversible angiotensin II-mediated albuminuria in rat kidneys is dynamically associated with cytoskeletal organization. Nephron, 93 (2), 51-60. doi: 10.1159/000068528

The breakdown of preexisting advanced glycation end products is associated with reduced renal fibrosis in experimental diabetes

Forbes, Josephine M, Thallas, Vicki, Thomas, Merlin C, Founds, Hank W, Burns, Wendy C, Jerums, George and Cooper, Mark E (2003). The breakdown of preexisting advanced glycation end products is associated with reduced renal fibrosis in experimental diabetes. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 17 (12), 1762-1764.

Erratum: Reduction of the accumulation of advanced glycation end products by ACE inhibition in experimental diabetic nephropathy (Diabetes (2000) 51 (3274-3282))

Forbes, J. M., Cooper, M. E., Thallas, V., Burns, W. C., Thomas, M. C., Brammar, G. C., Lee, F., Grant, S. L., Burrell, L. A., Jerums, G. and Osicka, T. M. (2002). Erratum: Reduction of the accumulation of advanced glycation end products by ACE inhibition in experimental diabetic nephropathy (Diabetes (2000) 51 (3274-3282)). Diabetes, 51 (12)

Renal connective tissue growth factor induction in experimental diabetes is prevented by aminoguanidine

Twigg, Stephen M., Cao, Zemin, McLennan, Sue V., Burns, Wendy C., Brammar, Gail, Forbes, Josephine M. and Cooper, Mark E. (2002). Renal connective tissue growth factor induction in experimental diabetes is prevented by aminoguanidine. Endocrinology, 143 (12), 4907-4915. doi: 10.1210/en.2002-220619

Reduction of the accumulation of advanced glycation end products by ACE inhibition in experimental diabetic nephropathy

Forbes, Josephine M., Cooper, Mark E., Thallas, Vicki, Burns, Wendy C., Thomas, Merlin C., Brammar, Gail C., Lee, Fiona, Grant, Sharon L., Burrell, Louise M., Jerums, George and Osicka, Tanya M. (2002). Reduction of the accumulation of advanced glycation end products by ACE inhibition in experimental diabetic nephropathy. Diabetes, 51 (11), 3274-3282. doi: 10.2337/diabetes.51.11.3274

Modulation of nephrin in the diabetic kidney: association with systemic hypertension and increasing albuminuria

Forbes, Josephine M., Bonnet, Fabrice, Russo, Leileata M., Burns, Wendy C., Cao, Zemin, Candido, Riccardo, Kawachi, Hiroshi, Allen, Terri J., Cooper, Mark E., Jerums, George and Osicka, Tanya M. (2002). Modulation of nephrin in the diabetic kidney: association with systemic hypertension and increasing albuminuria. Journal of Hypertension, 20 (5), 985-992. doi: 10.1097/00004872-200205000-00034

Advanced glycation end products cause epithelial-myofibroblast transdifferentiation via the receptor for advanced glycation end products (RAGE)

Oldfield, MD, Bach, LA, Forbes, JM, Nikolic-Paterson, D, McRobert, A, Thallas, V, Atkins, RC, Osicka, T, Jerums, G and Cooper, ME (2001). Advanced glycation end products cause epithelial-myofibroblast transdifferentiation via the receptor for advanced glycation end products (RAGE). Journal of Clinical Investigation, 108 (12), 1853-1863. doi: 10.1172/jci11951

Simultaneous blockade of endothelin A and B receptors in ischemic acute renal failure is detrimental to long-term kidney function

Forbes, Josephine Maree, Hewitson, Timothy David, Becker, Gavin James and Jones, Colin Lindsay (2001). Simultaneous blockade of endothelin A and B receptors in ischemic acute renal failure is detrimental to long-term kidney function. Kidney International, 59 (4), 1333-1341. doi: 10.1046/j.1523-1755.2001.0590041333.x

Endothelin and endothelin A/B receptors are increased after ischaemic acute renal failure

Forbes, JM, Jandeleit-Dahm, K, Allen, TJ, Hewitson, TD, Becker, GJ and Jones, CL (2001). Endothelin and endothelin A/B receptors are increased after ischaemic acute renal failure. Experimental Nephrology, 9 (5), 309-316.

Renoprotective effects of a novel inhibitor of advanced glycation

Forbes, J. M., Soulis, T., Thallas, V., Panagiotopoulos, S., Long, D. M., Vasan, S., Wagle, D., Jerums, G. and Cooper, M. E. (2001). Renoprotective effects of a novel inhibitor of advanced glycation. Diabetologia, 44 (1), 108-114. doi: 10.1007/s001250051587

Ischemic acute renal failure: long-term histology of cell and matrix changes in the rat

Forbes, Josephine M., Hewitson, Timothy D., Becker, Gavin J. and Jones, Colin L. (2000). Ischemic acute renal failure: long-term histology of cell and matrix changes in the rat. Kidney International, 57 (6), 2375-2385. doi: 10.1046/j.1523-1755.2000.00097.x

Angiotensin type 2 receptor is expressed in the adult rat kidney and promotes cellular proliferation and apoptosis

Cao, ZM, Kelly, DJ, Cox, A, Casley, D, Forbes, JM, Martinello, P, Dean, R, Gilbert, RE and Cooper, ME (2000). Angiotensin type 2 receptor is expressed in the adult rat kidney and promotes cellular proliferation and apoptosis. Kidney International, 58 (6), 2437-2451. doi: 10.1046/j.1523-1755.2000.00427.x

The cross-link breaker, N-phenacylthiazolium bromide prevents vascular advanced glycation end-product accumulation

Cooper, ME, Thallas, V, Forbes, J, Scalbert, E, Sastra, S, Darby, I and Soulis, T (2000). The cross-link breaker, N-phenacylthiazolium bromide prevents vascular advanced glycation end-product accumulation. Diabetologia, 43 (5), 660-664. doi: 10.1007/s001250051355

Macrophage and myofibroblast involvement in ischemic acute renal failure is attenuated by endothelin receptor antagonists

Forbes, Josephine M., Leaker, Brian, Hewitson, Tim D., Becker, Gavin J. and Jones, Colin L. (1999). Macrophage and myofibroblast involvement in ischemic acute renal failure is attenuated by endothelin receptor antagonists. Kidney International, 55 (1), 198-208. doi: 10.1046/j.1523-1755.1999.00253.x

Tissue Inhibitor of the Metalloproteinases and Renal Extracellular-Matrix Accumulation

Jones, CL, Fecondo, J, Kelynack, K, Forbes, J, Walker, R and Becker, G (1995). Tissue Inhibitor of the Metalloproteinases and Renal Extracellular-Matrix Accumulation. Experimental Nephrology, 3 (2), 80-86.

Hypoxia and interleukin (IL)-1β synergistically induce cellular senescence in human proximal tubular epithelial cells (PTEC)

Kassianos, Andrew J., Giuliani, Kurt, Nag, Purba, Hong, Seokchan, Wang, Xiangju, Johnston, Rebecca L., Adams, Benjamin, Grivei, Anca, Ho, Kenneth, Ng, Monica, Waddell, Nicola, Forbes, Josephine M., Healy, Helen and Kassianos, Andrew J. (2023). Hypoxia and interleukin (IL)-1β synergistically induce cellular senescence in human proximal tubular epithelial cells (PTEC). 58th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology (ANZSN), Christchurch, New Zealand, 4-6 September 2023. Richmond, VIC, Australia: John Wiley & Sons. doi: 10.1111/nep.14216

Youth with type 1 diabetes at higher risk of developing diabetic kidney disease have alterations in their urine and plasma metabolomic and mitochondrial dna profiles

Sullivan, Mitchell, Pham, Uyen, McCarthy, Domenica, Flemming, Nicole, Fotheringham, Amelia, Chandrashekar, Preeti, Whiddett, Rani, Buckle, Irina, Summers, Kim, Hodson, Mark, de Silva, Neisha, Nisbet, Janelle, Morton, Adam, Teasedale, Stephanie, Doomun, Sheik, de Souza, David, Isbel, Nicole, Jones, Timothy, Couper, Jennifer, Coughlan, Melinda, Johnson, David, O'Moore-Sullivan, Trisha, Barret, Helen, Marcovecchio, M. Loredana, Donaghue, Kim and Forbes, Josephine (2023). Youth with type 1 diabetes at higher risk of developing diabetic kidney disease have alterations in their urine and plasma metabolomic and mitochondrial dna profiles. 58th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology (ANZSN), Christchurch, New Zealand, 4-6 September 2023. Richmond, VIC Australia: John Wiley & Sons.

Mitochondrial dysfunction aligns with risk for diabetic kidney disease in youth with type 1 diabetes

Sullivan, Mitchell, McCarthy, Domenica, Flemming, Nicole, Chandrashekar, Preeti, Hodson, Mark, Fotheringham, Amelia, Whiddett, Rani, De Silva, Neisha, Nisbet, Jinelle, Morton, Adam, Teasdale, Stephanie, Isbel, Nicole, Jones, Timothy, Couper, Jennier, Thorburn, David, Johnson, David, Cotterill, Andrew, Barrett, Helen, O'Moore-Sullivan, Trisha, Donaghue, Kim and Forbes, Josephine (2022). Mitochondrial dysfunction aligns with risk for diabetic kidney disease in youth with type 1 diabetes. 57th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology (ANZSN), Sydney, NSW, Australia, 17–19 October 2022. Richmond, VIC, Australia: John Wiley & Sons.

Complement C5a induces renal injury in diabetic kidney disease via mitochondrial reprogramming

Coughlan, M. T., Tan, S., Ziemann, M., Snelson, M., El-Osta, A., MacIsaac, R. J., Meikle, P. J., Forbes, J. M., Cooper, M. E., Ekinci, E. I. and Woodruff, T. M. (2019). Complement C5a induces renal injury in diabetic kidney disease via mitochondrial reprogramming. 55th Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Barcelona Spain, 16-20 September 2019. Heidelberg, Germany: Springer.

Exploring AGE and sRAGE regulation in response to oral and intravenous glucose loads in individuals with recently diagnosed type 2 diabetes

Fotheringham, A. K., Bagger, J. I., Borg, D. J., McCarthy, D., Vilsboll, T., Knop, F. K. and Forbes, J. M. (2019). Exploring AGE and sRAGE regulation in response to oral and intravenous glucose loads in individuals with recently diagnosed type 2 diabetes. 55th Annual Meeting of the European Association for the Study of Diabetes (EASD), Barcelona, Spain, 16-20 September 2019 . New York, NY, United States: Springer.

GLYCOGEN IN THE DIABETIC KIDNEY: THE HERO OR THE VILLAIN?

Sullivan, M. A., Wang, Z., Li, I., Milton, L., Mccarthy, D., Harcourt, B. E., Penfold, S. and Forbes, J. M. (2018). GLYCOGEN IN THE DIABETIC KIDNEY: THE HERO OR THE VILLAIN?. HOBOKEN: WILEY.

Circulating advanced glycation end products and their endogenous secretory receptor are associated with bone turnover markers and with incidence of hip fracture in older men

Lamb, Lydia, Alfonso, Helman, Norman, Paul E., Davis, Timothy M. E., Forbes, Josephine, Muench, Gerald and Yeap, Bu B. (2018). Circulating advanced glycation end products and their endogenous secretory receptor are associated with bone turnover markers and with incidence of hip fracture in older men. Joint Annual Scientific Meetings of Endocrine-Society-of-Australia (ESA) and Society-for-Reproductive-Biology (SRB), Perth Australia, Aug 27-30, 2017. HOBOKEN: WILEY.

Nutrition support and glycaemic variability in critically ill patients

Doola, R., Hurford, R., Flatley, C., Greer, R. M., Forbes, J. M., Todd, A. S., Joyce, C. J. and Sturgess, D. J. (2018). Nutrition support and glycaemic variability in critically ill patients. 40th ESPEN Congress, Madrid, Spain, 1-4 September 2018. Amsterdam, Netherlands: Elsevier BV. doi: 10.1016/j.clnu.2018.06.1623

The role of GLUT4 in the kidney proximal tubule in blood glucose control and kidney function

Gallo, L. A., Gandhi, M. R., Abel, E. D., Rubera, I., Tauc, M. and Forbes, J. M. (2017). The role of GLUT4 in the kidney proximal tubule in blood glucose control and kidney function. 53rd Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Lisbon Portugal, Sep 11-15, 2017. NEW YORK: SPRINGER.

Using the Geometric Framework to Explore the Longitudinal Effects of Dietary Macronutrient Consumption On Markers of Kidney Aging

Fotheringham, A. K., Solon-Biet, S. M., Mcmahon, A. C., Ballard, W. O., Ruohonen, K., Borg, D. J., Raubenheimer, D., Le Couteur, D. G., Simpson, S. J. and Forbes, J. M. (2017). Using the Geometric Framework to Explore the Longitudinal Effects of Dietary Macronutrient Consumption On Markers of Kidney Aging. HOBOKEN: WILEY.

Mitochondrial dysfunction defines a population of young people with type 1 diabetes at risk of kidney disease

Forbes, J. M., Flemming, N. B., Mccarthy, D. A., Boot, K., De Silva, N., Gallo, L. A., Nisbett, J., Morton, A., Teasdale, S., Thorburn, D. R., Russell, A., Isbel, N., Johnson, D., Morahan, G., Jones, T., Couper, J., Donaghue, K., Hodson, M. P. and O'Moore-Sullivan, T. (2017). Mitochondrial dysfunction defines a population of young people with type 1 diabetes at risk of kidney disease. 53rd Annual Meeting of the European Association for the Study of Diabetes (EASD), Lisbon, Portugal, 11-15 September 2017. Richmond, VIC, Australia: Wiley-Blackwell Publishing Asia.

Mitochondrial dysfunction defines a population of young people with type 1 diabetes at risk of kidney disease

Forbes, J. M., Flemming, N., McCarthy, D., Boot, K., D'Silva, N., Gallo, L., Thorburn, D. R., Russell, A., Johnson, D., Morahan, G., Jones, T., Couper, J., Donaghue, K., Hodson, M. and O'Moore-Sullivan, T. (2017). Mitochondrial dysfunction defines a population of young people with type 1 diabetes at risk of kidney disease. 53rd Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Lisbon Portugal, 11-15 September 2017. New York NY United States: Springer.

Understanding Novel Genetic Factors Underlying Circulating Cystatin C and Kidney Function

Fotheringham, A., Balmer, L., Morahan, G. and Forbes, J. (2016). Understanding Novel Genetic Factors Underlying Circulating Cystatin C and Kidney Function. HOBOKEN: WILEY-BLACKWELL.

IL-22-mediated suppression of islet inflammation

McGuckin, Mike, Hasnain, Sumaira Z., Borg, Danielle J., Loudovaris, Thomas, Kay, Thomas W., Thomas, Helen E., Whitehead, Jonathon P., Forbes, Josephine M. and Prins, John B. (2015). IL-22-mediated suppression of islet inflammation. IPITA/IXA/CTS Joint Congress, Melbourne Australia, Nov 15-19, 2015. HOBOKEN: LIPPINCOTT WILLIAMS & WILKINS.

Human soluble receptor for advanced glycation end products therapy reduces autoimmune diabetes in the non-obese diabetic mouse

Leung, S. S.-Y., Borg, D. J., McCarthy, D., Zhuang, A., Fotheringham, A., Di Trapani, G., Groop, P.-H., Knip, M. and Forbes, J. (2015). Human soluble receptor for advanced glycation end products therapy reduces autoimmune diabetes in the non-obese diabetic mouse. Joint Annual Conference of the International Society for Pediatric and Adolescent Diabetes and Australasian Paediatric Endocrine Group (ISPAD+APEG 2015), Brisbane, QLD Australia, 7-10 October 2015. Hoboken, NJ USA: Wiley-Blackwell Publishing. doi: 10.1111/pedi.12309

Gene Therapy Using Recombinant Adeno-Associated Virus Serotype 2/8 Liver-Directed Expression of Srage in Experimental Type 1 Diabetes

Leung, Sherman S., Borg, Danielle J., Paul, Moumita, Sharland, Alexandra F. and Forbes, Josephine M. (2015). Gene Therapy Using Recombinant Adeno-Associated Virus Serotype 2/8 Liver-Directed Expression of Srage in Experimental Type 1 Diabetes. 9th Biennial Meeting of the Australasian-Gene-and-Cell-Therapy-Society (AGCTS), Parkville, VIC Australia, 29 April - 1 May 2015. Hoboken, NJ United States: Wiley-Blackwell.

Recombinant human soluble receptor for advanced glycation end product therapy reduces autoimmune diabetes in the NOD mouse model

Leung, Sherman, Borg, Danielle J., McCarthy, Domenica, Zhuang, Aowen, Forbes, Josephine and Ward, Micheal (2015). Recombinant human soluble receptor for advanced glycation end product therapy reduces autoimmune diabetes in the NOD mouse model. 75th Scientific Sessions of the American-Diabetes-Association, Boston, MA USA, 5-9 June 2015. Alexandria, VA USA: American Diabetes Association.

Delivery of recombinant human soluble receptor for advanced glycation end products delays autoimmune diabetes in the NOD mouse model

Borg, D. J., Leung, S., Zhuang, A., Fotheringham, A., McCarthy, D., Di Trapani, J., Groop, P. -H., Knip, M. and Forbes, J. (2015). Delivery of recombinant human soluble receptor for advanced glycation end products delays autoimmune diabetes in the NOD mouse model. 51st Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Stockholm, Sweden, 14-18 September 2015. Heidelberg, Germany: Springer. doi: 10.1007/s00125-015-3687-4

IL-22-MEDIATED SUPPRESSION OF ISLET INFLAMMATION

McGuckin, Mike, Hasnain, Sumaira Z., Borg, Danielle J., Loudovaris, Thomas, Kay, Thomas W., Thomas, Helen E., Whitehead, Jonathon P., Forbes, Josephine M. and Prins, John B. (2015). IL-22-MEDIATED SUPPRESSION OF ISLET INFLAMMATION. Joint Congress of the International-Pancreas-and-Islet-Transplantation-Association, International-Xenotransplantation-Association and Cell-Transplant-Society, Melbourne Australia, Nov 15-19, 2015. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS.

In Db/db mice, Sglt2 inhibition does not improve diabetic nephropathy despite glycaemic improvements

Gallo, L. A., Ward, M. S., Fotheringham, A. K., Pollock, C., Panchapakesan, U. and Forbes, J. M. (2015). In Db/db mice, Sglt2 inhibition does not improve diabetic nephropathy despite glycaemic improvements. 51st Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology, Canberra, Australia, 7-9 September 2015. Richmond, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/nep.12543

Short-term alagebrium chloride (ALT-711) therapy pre-diabetes for the treatment of Type I Diabetes

Borg, D. J., McCarthy, D., Reeves, P., Ward, M. S., Fotheringham, A. K., Gallo, L. A., Harcourt, B. E., Agrawal, N., Steptoe, R. and Forbes, J. M. (2015). Short-term alagebrium chloride (ALT-711) therapy pre-diabetes for the treatment of Type I Diabetes. Immunology of Diabetes Society 14th International Congress, Munich, Germany, 12-16 April 2015.

Synbiotic Therapy in Pre-Dialysis: a Randomised Controlled Trial

Rossi, Megan, Johnson, David, Pascoe, Elaine, Coombes, Jeff, Forbes, Josephine, Szeto, Cheuk-Chun, McWhinney, Brett, Ungerer, Jacobus and Campbell, Katrina (2015). Synbiotic Therapy in Pre-Dialysis: a Randomised Controlled Trial. 52nd Congress of the European-Renal-Association-European-Dialysis-and-Transplant-Assocation, London England, 28-31 May 2015. United Kingdom: Oxford University Press. doi: 10.1093/ndt/gfv152.2

Manipulation of dietary advanced glycation end-product content influences the progression of non-alcoholic fatty liver disease (NAFLD)

Leung, C., Herath, C. B., Zhiyuan, J., Leong, T., Forbes, J. M. and Angus, P. W. (2014). Manipulation of dietary advanced glycation end-product content influences the progression of non-alcoholic fatty liver disease (NAFLD). HOBOKEN: WILEY-BLACKWELL. doi: 10.1111/jgh.12794

Ager1 overexpression in glomerular podocytes results in renal disease which is exacerbated by diabetes

Zhuang, A., Sourris, K. C, Harcourt, B. E, Penfold, S. A., Fotheringham, A. K., McCarthy, D., Schulz, B. and Forbes, J. M. (2014). Ager1 overexpression in glomerular podocytes results in renal disease which is exacerbated by diabetes. 50th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology, Melbourne VIC, Australia, 25 - 27 August 2014. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/nep.12301

Deficiency of rage in bone marrow cells reduces renal injury in diabetic mice

Tesch, G. H., Sourris, K. C., Summers, S. A., Mccarthy, D., Ward, M. S., Borg, D. J., Gallo, L. A., Fotheringham, A. K., Pettit, A., Yap, F. Y. T., Harcourt, B. E., Tan, A. L. Y., Kausman, J. Y., Nikolic-Paterson, D. J., Kitching, A. R. and Forbes, J. M. (2014). Deficiency of rage in bone marrow cells reduces renal injury in diabetic mice. 50th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology, Melbourne Australia, 25–27 August 2014. Richmond Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/nep.12301

Flux of advanced glycation end products across the kidney as a contributor to renal disease in diabetes

Leung, C., Fotheringham, A. K., Zhuang, A., Borg, D. J., Ward, M. S., Coughlan, M. T., Mccarthy, D. A., Gallo, L. A., Harcourt, B. E. and Forbes, J. M. (2014). Flux of advanced glycation end products across the kidney as a contributor to renal disease in diabetes. 50th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology, Melbourne, Australia, 25–27 August 2014. Richmond Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/nep.12302

Glyoxalase-1 Inhibition Leads to Podocyte Insulin Resistance and Features Resembling Diabetic Kidney Disease

Gallo, Linda A., Ward, Micheal S., Harcourt, Brooke E., Fotheringham, Amelia K., McCarthy, Domenica A., Penfold, Sally A. and Forbes, Josephine M. (2014). Glyoxalase-1 Inhibition Leads to Podocyte Insulin Resistance and Features Resembling Diabetic Kidney Disease. 14th Asian Pacific Congress of Nephrology, Tokyo, Japan, 14-17 May 2014. Richmond, VIC, Australia: Wiley-Blackwell. doi: 10.1111/nep.12236

Mitochondrial targeting of superoxide by Mitoq improves metabolic renal dysfunction

Ward, M. S., Flemming, N. B., Gallo, L. A., Fotheringham, A., Gobe, G., Vesey, D. and Forbes, J. M. (2014). Mitochondrial targeting of superoxide by Mitoq improves metabolic renal dysfunction. 50th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology, Melbourne Australia, 25–27 August 2014. Richmond Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/nep.12301

Report on ISN Forefronts, Melbourne, Australia, 4-7 October 2012: tubulointerstitial disease in diabetic nephropathy

Forbes, Josephine M., Harris, David C. H. and Cooper, Mark E. (2013). Report on ISN Forefronts, Melbourne, Australia, 4-7 October 2012: tubulointerstitial disease in diabetic nephropathy. New York, NY, United States: Elsevier. doi: 10.1038/ki.2013.89

Type 2 diabetes mellitus and brain atrophy - the role of advanced glycation end-products

Moran, C., Muench, G., Beare, R., Blizzard, L., Venn, A., Phan, T., Forbes, J. and Srikanth, V (2013). Type 2 diabetes mellitus and brain atrophy - the role of advanced glycation end-products. HOBOKEN: WILEY-BLACKWELL.

Methylglyoxal induced insulin resistance in podocytes contributes to diabetic kidney disease

Gallo, L. A., Harcourt, B. E., Fotheringham, A. K., McCarthy, D., Penfold, S. A. and Forbes, J. M. (2013). Methylglyoxal induced insulin resistance in podocytes contributes to diabetic kidney disease. 49th Annual Meeting of the European Association for the Study of Diabetes (EASD), Barcelona, Spain, 23 -27 September 2013. Heidelberg, Germany: Springer. doi: 10.1007/s00125-013-3012-z

Oligosaccharyltransferase-48 as a Novel Mediator of Chronic Kidney Disease in Diabetes

Zhuang, A., Harcourt, B., Sourris, K., Penfold, S., Ward, M., Fotheringham, A., Thorn, P. and Forbes, J. (2013). Oligosaccharyltransferase-48 as a Novel Mediator of Chronic Kidney Disease in Diabetes. WILEY-BLACKWELL.

Therapies which lower advanced glycation end products influence experimental autoimmune diabetes in a time dependent manner

Borg, D. J., Yap, F. Y. T., Fotheringham, A. K., Harcourt, B. E., McCarthy, D., Ward, M., Slattery, R., Coughlan, M. T., Kantharidis, P. and Forbes, J. M. (2013). Therapies which lower advanced glycation end products influence experimental autoimmune diabetes in a time dependent manner. 49th Annual Meeting of the European Association for the Study of Diabetes (EASD), Barcelona, Spain, 23 -27 September 2013. Heidelberg, Germany: Springer. doi: 10.1007/s00125-013-3012-z

Regulation of Renal Receptor for Advanced Glycation End Products (Rage) Via Paracrine Estrogens

Harcourt, B. E., Coughlan, M. T., Andrikopoulos, S., Thomas, M. C., Bruce, C., Febbraio, M. A., Nawroth, P., Bierhaus, A., Kantharidis, P., Cooper, M. E. and Forbes, J. M. (2011). Regulation of Renal Receptor for Advanced Glycation End Products (Rage) Via Paracrine Estrogens. WILEY-BLACKWELL.

Ubiquinone Is Renoprotective in An Experimental Model of Type 2 Diabetes

Sourris, K. C., Morley, A. L., Harcourt, B. E., Penfold, S. A., Coughlan, M. T., Nugyen, T-V, Cooper, M. E., Ritchie, R. H. and Forbes, J. M. (2011). Ubiquinone Is Renoprotective in An Experimental Model of Type 2 Diabetes. WILEY-BLACKWELL.

The pathogenic potential of different sized age modified molecules via rage signalling pathways

Penfold, S. A., Sourris, K. C., Coughlan, M. T., Tan, A. L., Kaye, D. M., Cooper, M. E. and Forbes, J. M. (2010). The pathogenic potential of different sized age modified molecules via rage signalling pathways. International Symposium on the The Maillard Reaction, Palm Cove, QLD, Australia, 29-31 August 2009. Cambridge, United Kingdom: Royal Society of Chemistry.

The renin-angiotensin system and advanced glycation end-products in diabetic nephropathy how important are these pathways as therapeutic targets?

Sourris, K. C. and Forbes, J. M. (2010). The renin-angiotensin system and advanced glycation end-products in diabetic nephropathy how important are these pathways as therapeutic targets?. Royal Society of Chemistry.

High Density Lipoprotein Modulates Glucose Metabolism by Multiple Mechanisms

Drew, Brian G., Duffy, Stephen J., Forbes, Josephine M., Chin-Dusting, Jaye, Kaye, David M., Kemp, Bruce E., Sviridov, Dmitri, Steinberg, Gregory R. and Kingwell, Bronwyn A. (2009). High Density Lipoprotein Modulates Glucose Metabolism by Multiple Mechanisms. 82nd Scientific Session of the American-Heart-Association, Orlando Fl, Nov 14-18, 2009. LIPPINCOTT WILLIAMS & WILKINS.

Plasma Hepatocyte Growth Factor (HGF) Is Inversely Associated with Insulin Sensitivity in Healthy Humans

De Courten, Barbora, De Courten, Maximilian P. J., Dougherty, Sonia, Woollard, Kevin J., Cooper, Mark E., Kingwell, Bronwyn A., Forbes, Josephine M., Potts, Jenna R. and Considine, Robert V. (2009). Plasma Hepatocyte Growth Factor (HGF) Is Inversely Associated with Insulin Sensitivity in Healthy Humans. 69th Annual Meeting of the American-Diabetes-Association, New Orleans La, Jun 05-09, 2009. AMER DIABETES ASSOC.

Interaction between the renin-angiotensin system (RAS) and advanced glycation end products (AGES) in the development of diabetic nephropathy

Sourris, K. C., Mibus, A. L., Koitka, A., Harcourt, B. E., Tan, A. L. Y., Cooper, M. E. and Forbes, J. M. (2008). Interaction between the renin-angiotensin system (RAS) and advanced glycation end products (AGES) in the development of diabetic nephropathy. SPRINGER.

The renal pathogenicity of dietary glycotoxins is mediated via the receptor for advanced glycation end products (RAGE)

Coughlan, Melinda T., Mibus, Amy L., Tan, Adeline L., Harcourt, Brooke E., Sourris, Karly C., Penfold, Sally A., Thallas-Bonke, Vicki, Yap, Felicia Y., Gasser, Anna, Thomas, Merlin, Su, Qing, Bierhaus, Angelika, Cooper, Mark E. and Forbes, Josephine M. (2008). The renal pathogenicity of dietary glycotoxins is mediated via the receptor for advanced glycation end products (RAGE). 67th Annual Meeting of the American-Diabetes-Association, San Francicso Ca, Jun 06-10, 2008. AMER DIABETES ASSOC.

Urinary, but not serum levels of the AGE, n-carboxymethyl-lysine are associated with progressive nephropathy in patients with type 1 and type 2 diabetes

Coughlan, Melinda T., Penfold, Sally A., Cooper, Mark E., Panagiotopoulos, Sianna, Macisaac, Richard J., Jerums, George and Forbes, Josephine M. (2008). Urinary, but not serum levels of the AGE, n-carboxymethyl-lysine are associated with progressive nephropathy in patients with type 1 and type 2 diabetes. 67th Annual Meeting of the American-Diabetes-Association, San Francicso Ca, Jun 06-10, 2008. AMER DIABETES ASSOC.

Oxidative stress and advanced glycation in diabetic nephropathy

Coughlan, Melinda T., Mibus, Amy L. and Forbes, Josephine M. (2008). Oxidative stress and advanced glycation in diabetic nephropathy. The 9th International Symposium on the Maillard Reaction, Munich, Germany, 1-5 September 2007. Malden, MA, United States: Wiley-Blackwell Publishing. doi: 10.1196/annals.1433.018

Therapeutic interruption of advanced glycation in diabetic nephropathy: do all roads lead to Rome?

Sourris, Karly C., Forbes, Josephine M. and Cooper, Mark E. (2008). Therapeutic interruption of advanced glycation in diabetic nephropathy: do all roads lead to Rome?. The 9th International Symposium on the Maillard Reaction, Munich, Germany, 1-5 September 2007. Malden, MA, United States: Wiley-Blackwell Publishing. doi: 10.1196/annals.1433.048

Interaction between the receptor for advanced glycation end products (RAGE) and estrone (E1) in the development of type 2 diabetic nephropathy

Harcourt, B. E., Mibus, A., Gasser, A., Andikopoulos, S., Thomas, M., Coughlan, M. T., Sourris, K., Rice, G., Bierhaus, A., Cooper, M. E. and Forbes, J. M. (2007). Interaction between the receptor for advanced glycation end products (RAGE) and estrone (E1) in the development of type 2 diabetic nephropathy. 43rd Annual Meeting of the European-Association-for-the-Study-of-Diabetes, Amsterdam Netherlands, Sep 18-21, 2007. SPRINGER.

Role of the AGE crosslink breaker, alagebrium, as a renoprotective agent in diabetes

Coughlan, M. T., Forbes, J. M. and Cooper, M. E. (2007). Role of the AGE crosslink breaker, alagebrium, as a renoprotective agent in diabetes. 5th Hyonam-Kidney-Laboratory-International-Diabetes Symposium, Seoul South Korea, Feb 02-03, 2007. Nature Publishing Group. doi: 10.1038/sj.ki.5002387

Diabetes-induced effects on endothelial function and the actions of nitric oxide

Soro-Paavonen, A., Zhang, W. -Z., Venardos, K., Jones, E., Chin-Dusting, J., Thomas, M. T., Coughlan, M. T., Brasacchio, D., Cooper, M. E., Kaye, D. and Forbes, J. M. (2006). Diabetes-induced effects on endothelial function and the actions of nitric oxide. 42nd Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Copenhagen Denmark, Sep 14-17, 2006. SPRINGER.

Advanced glycation end products and diabetic nephropathy

Thomas, Merlin C., Forbes, Josephine M. and Cooper, Mark E. (2005). Advanced glycation end products and diabetic nephropathy. doi: 10.1097/01.mjt.0000178769.52610.69

Can advanced glycation end product inhibitors modulate more than one pathway to enhance renoprotection in diabetes?

Coughlan, Melinda T., Cooper, Mark E. and Forbes, Josephine M. (2005). Can advanced glycation end product inhibitors modulate more than one pathway to enhance renoprotection in diabetes?. New York Academy of Sciences. doi: 10.1196/annals.1333.087

Direct anti-atherogenic properties of PPAR alpha and PPAR gamma agonists

Cooper, ME, Forbes, JM, Smith, CM, Lassila, M, Jandeleit-Dahm, KA, Allen, TJ and Calkin, AC (2005). Direct anti-atherogenic properties of PPAR alpha and PPAR gamma agonists. 41st Annual Meeting of the European-Association-for-the-Study-of-Diabetes, Athens Greece, Sep 10-15, 2005. SPRINGER.

Do extracellular (circulating or dietary) advanced glycation end products mediate mitochondrial dysfunction in the kidney?

Forbes, JM, Coughlan, MT, Fukami, K, Laskowski, A, Thallas-Bonke, V, Dinh, D, Long, DM, Brownlee, M, Cooper, ME and Thorburn, DR (2005). Do extracellular (circulating or dietary) advanced glycation end products mediate mitochondrial dysfunction in the kidney?. 41st Annual Meeting of the European-Association-for-the-Study-of-Diabetes, Athens Greece, Sep 10-15, 2005. SPRINGER.

Low-molecular weight advanced glycation end products: Markers of tissue AGE accumulation and more?

Thomas, Merlin C., Forbes, Josephine M., MacIsaac, Richard, Jerums, George and Cooper, Mark E. (2005). Low-molecular weight advanced glycation end products: Markers of tissue AGE accumulation and more?. New York Academy of Sciences. doi: 10.1196/annals.1333.073

Renal intra-mitochondrial glycation drives deficiencies in the activity of manganese superoxide dismutase and complex I of the mitochondrial respiratory chain in diabetes

Coughlan, MT, Thorburn, DR, Fukami, K, Laskowski, A, Thallas-Bonke, V, Long, DM, Brownlee, M, Cooper, ME and Forbes, JM (2005). Renal intra-mitochondrial glycation drives deficiencies in the activity of manganese superoxide dismutase and complex I of the mitochondrial respiratory chain in diabetes. 41st Annual Meeting of the European-Association-for-the-Study-of-Diabetes, Athens Greece, Sep 10-15, 2005. SPRINGER.

Inhibitors of advanced glycation end product accumulation ameliorate renal injury in the diabetic apoE knockout mouse

Jandeleit-Dahm, KAM, Lassila, M, Seah, KK, Allen, TJ, Thallas, V, Thomas, MC, Candido, R, Burns, WC, Forbes, JM, Calkin, AC and Cooper, ME (2004). Inhibitors of advanced glycation end product accumulation ameliorate renal injury in the diabetic apoE knockout mouse. 40th Annual Meeting of the European-Association-for-the-Study-of-Diabetes, Munich Germany, Sep 05-09, 2004. SPRINGER.

Interference with advanced glycation end-products (AGEs) attenuates extracellular matrix (ECM) accumulation in diabetic nephropathy via protein kinase C (PKC) dependent pathways.

Boner, G, Thallas, V, Cooper, ME, Rizkalla, B, Qui, ML and Forbes, JM (2003). Interference with advanced glycation end-products (AGEs) attenuates extracellular matrix (ECM) accumulation in diabetic nephropathy via protein kinase C (PKC) dependent pathways.. 36th Annual Meeting of the American-Society-of-Nephrology, San Diego California, Nov 12-17, 2003. LIPPINCOTT WILLIAMS & WILKINS.

Attenuation of diabetes associated atherosclerosis with the advanced glycation end product cross-link breaker, ALT-711

Allen, TJ, Forbes, JM, Yee, LT, Thallas, V, Thomas, MC, Candido, R, Jandeleit-Dahm, KA and Cooper, ME (2003). Attenuation of diabetes associated atherosclerosis with the advanced glycation end product cross-link breaker, ALT-711. 76th Annual Scientific Session of the American-Heart-Association, Orlando Florida, Nov 07-12, 2003. LIPPINCOTT WILLIAMS & WILKINS.

Pivotal role of the AT2 receptor subtype in mediating angiotensin II indiced renal VEGF expression.

Rizkalla, BM, Cao, ZM, Forbes, JM and Cooper, ME (2002). Pivotal role of the AT2 receptor subtype in mediating angiotensin II indiced renal VEGF expression.. LIPPINCOTT WILLIAMS & WILKINS.

Renoprotection is afforded by the advanced glycation end product (AGE) cross-link breaker, ALT-711.

Forbes, JM, Thallas, V, Jerums, G, Thomas, MC and Cooper, ME (2002). Renoprotection is afforded by the advanced glycation end product (AGE) cross-link breaker, ALT-711.. LIPPINCOTT WILLIAMS & WILKINS.

Expression of connective tissue growth factor in the diabetic kidney: association with renal collagen synthesis.

Cooper, ME, Cao, Z, Candido, R, Forbes, JM, Osicka, TM, Twigg, S and Bonnet, F (2002). Expression of connective tissue growth factor in the diabetic kidney: association with renal collagen synthesis.. 38th EASD Annual Meeting of the European-Association-for-the-Study-of-Diabetes, Budapest Hungary, Sep 01-05, 2002. SPRINGER-VERLAG.

Does combined blockade of RAS and advanced glycation end-product formation confer superior renoprotection in a hypertensive model of diabetic nephropathy?

Davis, BJ, Forbes, JM, Jerums, G, Cooper, ME and Allen, TJ (2002). Does combined blockade of RAS and advanced glycation end-product formation confer superior renoprotection in a hypertensive model of diabetic nephropathy?. 19th Meeting of the International-Society-for-Hypertension/12th European-Society-of-Hypertension Meeting, Prague Czech Republic, Jun 23-27, 2002. LIPPINCOTT WILLIAMS & WILKINS.

Renal connective tissue growth factor induction in experimental diabetes is prevented by aminoguanidine

Twigg, SM, Cao, Z, Burns, WC, Brammar, G, Forbes, JM and Cooper, ME (2002). Renal connective tissue growth factor induction in experimental diabetes is prevented by aminoguanidine. AMER DIABETES ASSOC.

Artificial activation of matrix metalloproteinases.

Jones, CI, Forbes, JM, Walker, RG and Becker, GJ (1997). Artificial activation of matrix metalloproteinases.. BLACKWELL SCIENCE INC.

Activation of renal type IV collagenases.

Jones, CL, Forbes, JM, Walker, RG and Becker, GJ (1996). Activation of renal type IV collagenases.. AMER SOC NEPHROLOGY.