Professor Trent Munro

Professor

Australian Institute for Bioengineering and Nanotechnology
t.munro@uq.edu.au
+61 7 334 64100

Overview

Professor Trent Munro is a Biotechnology and Biopharmaceutical professional with extensive experience in the CMC development of a wide array of biological and synthetic therapeutic modalities.

He is currently a Senior Group Leader at the Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland where he is Director of the NCRIS Funded National Biologics Facility and Program Director for the CEPI funded Vaccine Rapid Response pipeline.

Professor Munro’s research is focussed on the development, engineering and production of complex therapeutics using biological system. This includes engineering mammalian cells in order to improve their efficiency and utility in the production of complex proteins, with a focus on biopharmaceuticals.

Prior to this, he was Executive Director of Process Development at Amgen Inc., based in California. In this role, Trent was involved in the translation of molecules from research, through clinical trials and multiple commercial product launches.

Prof. Munro has a PhD in Protein Biochemistry from UQ and completed postdoctoral studies in cell biology and developmental genetics at the Department of Cell Biology, Harvard Medical School and the Wellcome Trust and Cancer Research UK Gurdon Institute, University of Cambridge. From 2006-2013 he was an Associate Group Leader and Queensland Smart Futures fellow at the Australian Institute for Bioengineering and Nanotechnology (AIBN) at the University of Queensland.

Research Interests

  • Biopharmaceuticals
    Professor Munro’s research is focussed on the development, engineering and production of complex therapeutics using biological system. This includes engineering mammalian cells in order to improve their efficiency and utility in the production of complex proteins, with a focus on biopharmaceuticals.

Qualifications

  • Bachelor of Science, James Cook University
  • Doctor of Philosophy, The University of Queensland

Publications

  • Munro, Trent P., Pilbrough, Warren, Hughes, Benjamin S. and Gray, Peter P. (2019). Cell line isolation and design. In Comprehensive Biotechnology (pp. 144-153) : Elsevier. doi:10.1016/B978-0-444-64046-8.00013-6

  • Jorgolli, Marsela, Nevill, Tanner, Winters, Aaron, Chen, Irwin, Chong, Su, Lin, Fen-Fen, Mock, Marissa, Chen, Ching, Le, Kim, Tan, Christopher, Jess, Philip, Xu, Han, Hamburger, Agi, Stevens, Jennitte, Munro, Trent, Wu, Ming, Tagari, Philip and Miranda, Les P. (2019) Nanoscale integration of single cell biologics discovery processes using optofluidic manipulation and monitoring. Biotechnology and Bioengineering, 116 9: 2393-2411. doi:10.1002/bit.27024

  • Le, Kim, Tan, Christopher, Gupta, Shivani, Guhan, Trupti, Barkhordarian, Hedieh, Lull, Jonathan, Stevens, Jennitte and Munro, Trent (2018) A novel mammalian cell line development platform utilizing nanofluidics and optoelectro positioning technology. Biotechnology Progress, 34 6: 1438-1446. doi:10.1002/btpr.2690

View all Publications

Available Projects

  • Developing high throughput approaches which allow the rapid selection of clones which stably express high levels of the desired biopharmaceutical.

  • Developing transient protein expression systems which will allow researchers to rapidly produce larger amounts of protein needed for pre-clinical characterisation and testing.

  • Current approaches and treatments for venomous bites and stings use outdated technologies due to the complexity of the toxins. We are interested in the creation of novel recombinant approaches as treatments. We have several projects in this space and are currently seeking PhD studdents

View all Available Projects

Publications

Book Chapter

  • Munro, Trent P., Pilbrough, Warren, Hughes, Benjamin S. and Gray, Peter P. (2019). Cell line isolation and design. In Comprehensive Biotechnology (pp. 144-153) : Elsevier. doi:10.1016/B978-0-444-64046-8.00013-6

  • Codamo, Joe, Munro, Trent P., Hughes, Benjamin S., Song, Michael and Gray, Peter P. (2012). An optimised transfection platform for the Epi-CHO transient expression system in serum-free media. In Nigel Jenkins, Niall Barron and Paula Alves (Ed.), Proceedings of the 21st Annual Meeting of the European Society for Animal Cell Technology (ESACT), Dublin, Ireland, June 7-10, 2009 (pp. 19-23) Dordrecht, Netherlands: Springer. doi:10.1007/978-94-007-0884-6_3

  • Hou, Jeff Jia Cheng, Song, Michael, Munro, Trent P. and Gray, Peter P. (2012). Analysis of protein expression via alternate 3’ Untranslated Region (UTR) signals through the use of site specific recombination. In Nigel Jenkins, Niall Barron and Paula Alves (Ed.), Proceedings of the 21st Annual Meeting of the European Society for Animal Cell Technology (ESACT), Dublin, Ireland, June 7-10, 2009 (pp. 47-51) Dordrecht, Netherlands: Springer.

  • Munro, Trent P., Pilbrough, Warren, Hughes, Benjamin S. and Gray, Peter P. (2011). Cell line isolation and design. In Murray Moo-Young, Michael Butler, Colin Webb, Antonio Moreira,, Bernard Grodzinski, Z. F. Cui and Spiros Agathos (Ed.), Scientific Fundamentals of Biotechnology 2nd ed. (pp. 169-178) Amsterdam, Netherlands: Elsevier. doi:10.1016/B978-0-08-088504-9.00024-6

Journal Article

Conference Publication

  • Hart, D. N. J., Elgundi, Z., Ju Xinsheng, Verma, N. D., Silveira, P. A., Fromm, P. D., Alingcastre, R., Munster, D. J., Seldon, T. A., Sheng, Y., Jones, M. L., Munro, T. P., Mahler, S., Barnard, R. T., Vu, P. A., Lo, K., Shahin, K., Larsen, S., Bradstock, K. and Clark, G. J. (2015). CD83 Expression On Human Immune Cells as a Target for Immunosuppression. In: Abstracts from the 33rd Annual Scientific Meeting of the Transplantation Society of Australia and new Zealand. 33rd Annual Scientific Meeting of the Transplantation Society of Australia and new Zealand, Canberra, ACT Australia, (A8-A8). 21-23 June 2015. doi:10.1038/icb.2015.75

  • Hart, Derek N. J., Ju, Xinsheng, Elgundi, Zehra, Verma, Nirupama, Silveira, Pablo, Fromm, Phillip, Alingcastre, Renz, Hsu, Blake, Munster, David J., Seldon, Therese, Sheng, Yonghua, Jones, Martina, Munro, Trent, Mahler, Stephen, Barnard, Ross, Vu, Al, Lo, Tsun Ho, Shahin, Kifah, Larsen, Stephen Robert, Bradstock, Kenneth and Clark, Georgina (2015). Characterisation of human CD83 expression on immune cells and their targeting with CD83 antibodies to prevent graft versus host disease in allogeneic haematopoietic cell transplantation. In: 57th Annual Meeting of the American Society of Hematology, Orlando, FL, United States, (). 5-8 Dec 2015.

  • Ju, Xinsheng, Elgundi, Zehra, Verma, Nirupama, Silveira, Pablo, Fromm, Phillip, Alingcastre, Renz, Munster, David, Seldon, Therese, Sheng, Yonghua, Jones, Martina, Munro, Trent, Mahler, Stephen, Barnard, Ross, Vu, Ai, Lo, Tsun Ho, Shahin, Kifah, Clark, Georgina, Larsen, Stephen, Bradstock, Kenneth and Hart, Derek (2015). Human Cd83 Expression On Immune Cells Validates Anti-Cd83 Prophylaxis to Prevent Graft Versus Host Disease in Allogeneic Haematopoietic Cell Transplantation.. In: 14th Transplantation Science Symposium of the Transplantation-Society (TSS), Lorne, Australia, (S8-S9). 11-13 November 2015.

  • Orellana, Camila A., Marcellin, Esteban, Munro, Trent, Gary, Peter P. and Nielsen, Lars K. (2015). Multi-omics approach for comparative studies of monoclonal antibody producing CHO cells. In: European Society for Animal Cell Technology (ESACT) Meeting, Barcelona, Spain, (). 31 May - 3 June 2015. doi:10.1186/1753-6561-9-S9-O8

  • Verma, Nirupama D., Munster, David, Seldon, Therese, Sheng, Yong Hua, Jones, Martina, Munro, Trent, Mahler, Stephen, Barnard, Ross, Vu, Phi Ai, Lo, Kevin, Shahin, Kifah, Elgundi, Zehra, Silveira, Pablo, Fromm, Phillip D., Clark, Georgina J., Larsen, Stephen, Bradstock, Kenneth and Hart, Derek N. J. (2015). The Human Monoclonal Antibody 3C12C, Targeting Activated Dendritic Cells Is a Potential New Immunosuppressive Agent. In: Abstracts from the 2015 BMT Tandem Meetings. BMT Tandem Meetings, San Diego, CA United States, (S330-S331). 11-15 February 2015.

  • Hart, D, Verma, N., Seldon, T, Sheng, Y., Pryor, R., Palkova, A., Findova, M., Jones, M., Munro, T., Mahler, S., Braet, K., Barnard, R., Marks, J., Coley, A., Fan, F., Zhou, Y., Vu, P, Lo, K., Shahin, K., Elgundi, Z., Silveira, P., Fromm, P., Clark, G., Larsen, S., Bradstock, K. and Munster, D. (2014). The Monoclonal Antibody 3C12C, Targeting CD83 Is a T Cell Sparing, Potential New Immunosuppressive Agent. In: The World Transplant Congress 2014 Abstract Supplement. 2014 World Transplant Congress, San Francicso Ca, (390-390). 26 - 31 July 2014. doi:10.1111/ajt.12888

  • Hart, D, Seldon, T, Jones, M, Sheng, Y, Palkova, A, Cullup, H, Munro, T, Sinfield, L, Rice, AM, Wilson, J, Gray, P, Barnard, R, Mahler, S and Munster, D (2009). Developing a Therapeutic Anti - Dendritic Cell Antibody to Prevent Graft Versus Host Disease. In: Blood. 51st Annual Meeting of the American Society of Hematology, New Orleans LA, (1378-1378). 5-8 December 2009.

  • Smith, R. W., Shan, J., Munro, T., Barbarese, E. and Carson, J. H. (2002). A molecular mechanism for messenger RNA trafficking in neuronal dendrites. In: ComBio 2002. ComBio 2002, Sydney, ((Abstract)). 29 September - 3 October, 2002.

  • Ma, A. S. W., Snee, M. J., Moran-Jones, K., Munro, T., Kidd, G. J. and Smith, R. W. (2001). hnRNP A3, A novel RNA cytoplasmic trafficking response element binding protein. In: Proceedings of the Australian Society of Biochemistry & Molecular Biology Conference. ASBMB, Canberra, ACT, Australia, (). 31 September - 4 October, 2001.

  • Munro, T. P., Ma, A. S. W., Snee, M., Carson, J. H. and Smith, R. W. (2000). Identification and subcellular localization of hnRNP A3: A protein that binds to the A2RE RNA trafficking sequence. In: 2000 FASEB Summer Research Conference. 2000 FASEB Summer Research Conference, Snowmass, Colorado, ((Abstract)). 2-11 June, 2000.

  • Shan, J., Moran, K., Munro, T. P., Kidd, G., Winzor, D. J., Hoek, K. S. and Smith, R. W. (2000). Trafficking of myelin basic protein RNA: Assciation of hnRNPs A1, A2 and A3 with the hnRNP A2 response element. In: 2000 FASEB Summer Research Conference. 2000 FASEB Summer Research Conf, Snowmass, Colorado, ((Abstract)). 2-11 June, 2000.

  • Shan, J., Hoek, K. S., Kidd, G. J., Munro, T. P., Hall, D., Schindeler, A. J., Winzor, D. J. and Smith, R. W. (1999). Biosensor evidence for the existence of sequence-specific and nonspecific RNA binding sites on HNRNP A2. In: Combined Conference Abstracts: 43rd Annual ASBMB, 18th Annual ANZSCDB and 39th Annual ASPP. ComBio 99, Conrad Jupiters, Gold Coast, (Pos-Wed-49). 27-30 September, 1999.

  • Mouland, A. J., Xu, H., Mercier, J., Cui, H., Munro, T., Prasol, M., Smith, R. W., Barbarese, E., Cohen, E. and Carson, J. H. (1999). Co-trafficking of HIV-1 VPR and Gag RNA in Oligodendrocytes. In: AIDS Conference. AIDS Conference, New York, (). June, 1999.

  • Munro, T., Magee, R. J., Kidd, G. J., Carson, J. H., Barbarese, E., Smith, L. M. and Smith, R. W. (1999). Mutational analysis of an hnRNP A2 response element for RNA trafficking. In: Combined Conference Abstracts: 43rd Annual ASBMB, 18th Annual ANZSCDB and 39th Annual ASPP. ComBio 99, Conrad Jupiters, Gold Coast, (Pos-Wed-55). 27-30 September, 1999.

Other Outputs

  • Seldon, T. A., Munster, D. J., Hart, D. N., Jones, M. L., Munro, T. P., Mahler, S. M., Zhou, Y. and Marks, D. (2013). Anti-CD83 antibodies and use thereof. .

  • Munro, T. (2001). A2RE-mediated RNA transport PhD Thesis, School of Molecular and Microbial Sciences, The University of Queensland.

PhD and MPhil Supervision

Completed Supervision

Possible Research Projects

Note for students: The possible research projects listed on this page may not be comprehensive or up to date. Always feel free to contact the staff for more information, and also with your own research ideas.

  • Developing high throughput approaches which allow the rapid selection of clones which stably express high levels of the desired biopharmaceutical.

  • Developing transient protein expression systems which will allow researchers to rapidly produce larger amounts of protein needed for pre-clinical characterisation and testing.

  • Current approaches and treatments for venomous bites and stings use outdated technologies due to the complexity of the toxins. We are interested in the creation of novel recombinant approaches as treatments. We have several projects in this space and are currently seeking PhD studdents

  • Using modern ‘omics’ approaches to gain better understanding of cellular metabolism which will allow maximal protein expression by mammalian cell cultures.