Associate Professor Jane Nikles

Principal Research Fellow

RECOVER Injury Research Centre
Faculty of Health and Behavioural Sciences

Principal Research Fellow

UQ Centre for Clinical Research
Faculty of Medicine
+61 7 334 65025


Dr Jane Nikles is a registered medical practitioner who has conducted research at The University of Queensland in the field of N-of-1 trials for over 19 years. In 2006, she completed a PhD at The University of Queensland; her doctoral work focussed on the use of the N-of-1 trial methodology in clinical practice. She has regular interaction with hospitals and GP practices, both staff and patients. Her research interests lie in advancing the science of N-of-1 trials and exploring the many applications of N-of-1 trials to maximise patient health outcomes. Dr Nikles’ findings have changed practice in regard to more targeted prescribing of chronic pain medications. She was involved in developing the CONSORT Extension for Reporting N-of-1 Trials (CENT), and SCRIBE (The Single-Case Reporting Guideline In BEhavioural Interventions) which are important developments in the field of N-of-1 trials that will improve the reporting of N-of-1 trials. She is currently conducting an international multi-site N-of-1 trial which also compares aggregated N-of-1 trials with parallel arm randomised controlled trials, a world first. This trial, which compares mealtonin and placebo for sleep difficulties in children with ADHD on stimulants medication, is actively recruiting particpants all over Australia at present. Dr Nikles has published 36 peer-reviewed journal articles in the field and has recently edited a book on N-of-1 trials. Her work has been highly influential, and she is the top author in the N-of-1 trial field. She has published articles in high-ranking journals including European Journal of Clinical Pharmacology, Journal of Clinical Epidemiology, Medical Journal of Australia and British Medical Journal.

Research Interests

  • Clinical trials, n-of-1 trials, research methodology, personalised medicine, individual treatments
  • Melatonin
  • ADHD, children, sleep
  • Skin cancer prevention, improving children's sun protection practices
  • dementia care in indigenous peoples


  • Doctor of Philosophy, The University of Queensland
  • MBBS, The University of Queensland


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  • Doctor Philosophy

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Available Projects

  • Please contact me on to discuss several available projects.

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Featured Publications


Book Chapter

  • Nikles, Jane and Mitchell, Geoffrey (2015). Introduction. In Jane Nikles and Geoffrey Mitchell (Ed.), The essential guide to N-of-1 trials in health (pp. 1-8) Dordrecht, The Netherlands: Springer. doi:10.1007/978-94-017-7200-6_1

  • Nikles, Jane (2015). What are N-of-1 Trials?. In Jane Nikles and Geoffrey Mitchell (Ed.), The essential guide to N-of-1 trials in health (pp. 9-17) Dordecht, Netherlands: Springer. doi:10.1007/978-94-017-7200-6_2

  • Nikles, Jane (2015). Where Are N-of-1 Trials Headed?. In Jane Nikles and Geoffrey Mitchell (Ed.), The essential guide to N-of-1 trials in health (pp. 233-241) Dordrecht, The Netherlands: Springer. doi:10.1007/978-94-017-7200-6_17

  • Nikles, C. J., Mitchell, G. K., Del Mar, C. B. and Clavarino, A. (2005). Individualised medication effectiveness tests as a means of targeting stimulants to responders in attention deficit hyperactivity disorder. In M. P. Larimer (Ed.), Attention Deficit Hyperactivity Disorder Research Developments 1 ed. (pp. 169-187) New York, U.S.A.: Nova Science.

Journal Article

Conference Publication

Other Outputs

Grants (Administered at UQ)

PhD and MPhil Supervision

Current Supervision

Possible Research Projects

Note for students: The possible research projects listed on this page may not be comprehensive or up to date. Always feel free to contact the staff for more information, and also with your own research ideas.

  • Please contact me on to discuss several available projects.