Professor Gregory Monteith

Professor

School of Pharmacy
Faculty of Health and Behavioural Sciences

Professor

Mater Research Institute-UQ
Faculty of Medicine
greg@pharmacy.uq.edu.au
+61 7 334 61855

Overview

Greg studies cellular signalling in disease and the identification of new drug targets.

Following his PhD at the University of Sydney, Greg spent two years at the University of Maryland at Baltimore (USA) in the Department of Physiology, developing novel techniques for the assessment of calcium (Ca2+) in sub-cellular organelles. Since his appointment at the University of Queensland, Greg has established a research program with research funding via NHMRC and National Heart Foundation, Queensland Cancer Fund, Society of biomolecular Screening (USA) and other grants and collaboration with Pharmaceutical companies. His interests are signal transduction in disease, calcium transporters as drug targets and biomolecular screening. In 2006 he received a UQ Foundation research excellence award and in 2016 he received the UQ Research Higher Degree Supervision Excellence Award - video link

ResearcherID - http://www.researcherid.com/rid/B-1626-2008

Selected Publications

Peters AA, Jamaludin SYN, Yapa KTDS, Chalmers S, Wiegmans AP, Lim HF, Milevskiy MJG, Azimi I, Davis FM, Northwood KS, Pera E, Marcial DL, Dray E, Waterhouse NJ, Cabot PJ, Gonda TJ, Kenny PA, Brown MA, Khanna KK, Roberts-Thomson SJ, Monteith GR. Oncosis and apoptosis induction by activation of an overexpressed ion channel in breast cancer cells. Oncogene. doi: 10.1038/onc.2017.234, 2017

Monteith GR, Prevarskaya N, Roberts-Thomson SJ. The calcium-cancer signalling nexus. Nature Reviews Cancer. Jun;17(6):367-380, 2017

Davis FM, Janoshazi A, Janardhan KS, Steinckwich N, D'Agostin DM, Petranka JG, Desai PN, Roberts-Thomson SJ, Bird GS, Tucker DK, Fenton SE, Feske S, Monteith GR, Putney JW Jr. Essential role of Orai1 store-operated calcium channels in lactation. Proc Natl Acad Sci U S A. 5;112(18):5827-32. 2015.

Davis FM, Stewart TA, Thompson EW, Monteith GR. Targeting EMT in cancer: opportunities for pharmacological intervention. Trends Pharmacol Sci. 35:479-88, 2014.

Davis FM1, Azimi I, Faville RA, Peters AA, Jalink K, Putney JW Jr, Goodhill GJ, Thompson EW, Roberts-Thomson SJ, Monteith GR. Induction of epithelial-mesenchymal transition (EMT) in breast cancer cells is calcium signal dependent. Oncogene. doi: 10.1038/onc.2013.187, 2013

Peters AA, Simpson PT, Bassett JJ, Lee JM, Da Silva L, Reid LE, Song S, Parat MO, Lakhani SR, Kenny PA, Roberts-Thomson SJ, Monteith GR. Calcium channel TRPV6 as a potential therapeutic target in estrogen receptor-negative breast cancer. Mol Cancer Ther.;11:2158-68, 2012

Feng M, Grice D, Faddy H, Nguyen N, Leitch S, Wang Y, Muend S, Kenny P, Sukumar S, Roberts-Thomson SJ, Monteith GR, Rao R. Store-Independent Activation of Orai1 by SPCA2 in Mammary Tumors. Cell. 143: 84-98. 2010


Monteith GR, McAndrew D, Faddy HM, Roberts-Thomson SJ. Calcium and cancer: targeting Ca2+ transport. Nature Reviews Cancer. 7:519-30, 2007


Monteith GR and Bird St J. High throughput measurement of calcium: back to basics. Trends in Pharmacological Sciences 26(4):218-23, 2005

Research Interests

  • calcium regulation in disease and cell signalling
    Our current projects are focussed on the study of a variety of calcium transporters in disease for the identification of novel drug targets. PhD and Post-doctoral opportunities may be available, contact - gregm@uq.edu.au and see the "available projects" link.
  • High throughput calcium assays for biomolecular screening and cancer research
    Our laboratory has the the first FLIPR-tetra system in Australia, allowing high throughput measurement of intracellular calcium in living cells.

Qualifications

  • PhD, The University of Sydney
  • Bachelor of Pharmacy (Honours), The University of Sydney

Publications

  • Davis, Felicity M., Stewart, Teneale A., Thompson, Erik W. and Monteith, Gregory R. (2014) Targeting EMT in cancer: opportunities for pharmacological intervention. Trends in Pharmacological Sciences, 35 9: 479-488. doi:10.1016/j.tips.2014.06.006

  • Davis, F. M., Azimi, I., Faville, R. A., Peters, A. A., Jalink, K., Putney Jr, J. W., Goodhill, G. J., Thompson, E. W., Roberts-Thomson, S. J. and Monteith, G. R. (2014) Induction of epithelial-mesenchymal transition (EMT) in breast cancer cells is calcium signal dependent. Oncogene, 33 18: 2307-2316. doi:10.1038/onc.2013.187

  • McAndrew, Damara, Grice, Desma M., Peters, Amelia A., Davis, Felicity M., Stewart, Teneale, Rice, Michelle, Smart, Chanel E., Brown, Melissa A., Kenny, Paraic A., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2011) ORAI1-mediated calcium influx in lactation and in breast cancer. Molecular Cancer Therapeutics, 10 3: 448-460. doi:10.1158/1535-7163.MCT-10-0923

  • Feng, Mingye, Grice, Desma, Faddy, Helen, Nguyen, Nguyen, Leitch, Sharon, Wang, Yingyu, Muend, Sabina, Kenny, Paraic A, Sukumar, Saraswati, Roberts-Thomson, Sarah J., Monteith, Gregory R. and Rao, Rajini (2010) Store-independent activation of Orai1 by SPCA2 in mammary tumors. Cell, 143 1: 84-98. doi:10.1016/j.cell.2010.08.040

  • Monteith, Gregory R., McAndrew, Damara, Faddy, Helen M. and Roberts-Thomson, Sarah J. (2007) Calcium and cancer: targeting Ca2+ transport. Nature Reviews Cancer, 7 7: 519-530. doi:10.1038/nrc2171

View all Publications

Supervision

View all Supervision

Available Projects

  • Suited to students interested in a career in biomedical research.

    How calcium transporters in the cell function and what their specific roles in biological pathways are is not fully understood. This project seeks to investigate calcium transporters using molecular biology techniques and advanced techniques for the measurement of intracellular calcium.

  • Suited to students interested in a career in biomedical research or the pharmaceutical industry.

    High throughput screening is increasingly using calcium as a measure to identify biologically active compounds. Our laboratory is developing new techniques which may help identify new drugs.

    Contact greg@pharmacy.uq.edu.au for more information.

  • Suited to a non-UQ graduate with a background in pharmacology, pharmacy, physiology, molecular biology or biochemsitry

    The project involves investigating specific transporters of calcium ions, and their possible roles in a variety of diseases.

View all Available Projects

Publications

Featured Publications

  • Davis, Felicity M., Stewart, Teneale A., Thompson, Erik W. and Monteith, Gregory R. (2014) Targeting EMT in cancer: opportunities for pharmacological intervention. Trends in Pharmacological Sciences, 35 9: 479-488. doi:10.1016/j.tips.2014.06.006

  • Davis, F. M., Azimi, I., Faville, R. A., Peters, A. A., Jalink, K., Putney Jr, J. W., Goodhill, G. J., Thompson, E. W., Roberts-Thomson, S. J. and Monteith, G. R. (2014) Induction of epithelial-mesenchymal transition (EMT) in breast cancer cells is calcium signal dependent. Oncogene, 33 18: 2307-2316. doi:10.1038/onc.2013.187

  • McAndrew, Damara, Grice, Desma M., Peters, Amelia A., Davis, Felicity M., Stewart, Teneale, Rice, Michelle, Smart, Chanel E., Brown, Melissa A., Kenny, Paraic A., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2011) ORAI1-mediated calcium influx in lactation and in breast cancer. Molecular Cancer Therapeutics, 10 3: 448-460. doi:10.1158/1535-7163.MCT-10-0923

  • Feng, Mingye, Grice, Desma, Faddy, Helen, Nguyen, Nguyen, Leitch, Sharon, Wang, Yingyu, Muend, Sabina, Kenny, Paraic A, Sukumar, Saraswati, Roberts-Thomson, Sarah J., Monteith, Gregory R. and Rao, Rajini (2010) Store-independent activation of Orai1 by SPCA2 in mammary tumors. Cell, 143 1: 84-98. doi:10.1016/j.cell.2010.08.040

  • Monteith, Gregory R., McAndrew, Damara, Faddy, Helen M. and Roberts-Thomson, Sarah J. (2007) Calcium and cancer: targeting Ca2+ transport. Nature Reviews Cancer, 7 7: 519-530. doi:10.1038/nrc2171

Book

Book Chapter

Journal Article

Conference Publication

Grants (Administered at UQ)

PhD and MPhil Supervision

Current Supervision

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Associate Advisor

    Other advisors:

Completed Supervision

Possible Research Projects

Note for students: The possible research projects listed on this page may not be comprehensive or up to date. Always feel free to contact the staff for more information, and also with your own research ideas.

  • Suited to students interested in a career in biomedical research.

    How calcium transporters in the cell function and what their specific roles in biological pathways are is not fully understood. This project seeks to investigate calcium transporters using molecular biology techniques and advanced techniques for the measurement of intracellular calcium.

  • Suited to students interested in a career in biomedical research or the pharmaceutical industry.

    High throughput screening is increasingly using calcium as a measure to identify biologically active compounds. Our laboratory is developing new techniques which may help identify new drugs.

    Contact greg@pharmacy.uq.edu.au for more information.

  • Suited to a non-UQ graduate with a background in pharmacology, pharmacy, physiology, molecular biology or biochemsitry

    The project involves investigating specific transporters of calcium ions, and their possible roles in a variety of diseases.

  • Project suited a student interested in a career in biomedical research and/or pharmaceutical industry research and development

    Our laboratory is studying the role of some calcium transporters in cancer. These studies have implications for the discovery of new drugs for cancer treatment.