Professor John Upham

Affiliate Professor

The University of Queensland Diamantina Institute
Faculty of Medicine

Professor of Respitatory Med (Sec)

Princess Alexandra Hospital Southside Clinical Unit
Faculty of Medicine
j.upham@uq.edu.au
+61 7 344 38024

Overview

John Upham is a clinical scientist and physician with longstanding research interests in the immunological basis of asthma and other chronic lung diseases, the role of dendritic cells in allergy and virus infections of the lung, and the development of novel approaches to treatment. He has published over 100 peer-reviewed journal articles and book chapters, has 1690 citations and an ‘H score’ of 24. The majority of these are in the higher impact journals in the field including Journal of Allergy & Clinical Immunology, American Journal of Respiratory & Critical Care Medicine, Journal of Immunology, Thorax, Infection & Immunity, and Clinical & Experimental Allergy.

He is a previous recipient of an NHMRC Neil Hamilton Fairley Fellowship, and the Young Investigator Award, Thoracic Society of Australia & New Zealand (TSANZ). He has held NHMRC Practitioner Fellowships and multiple Program and Project Grants from the NHMRC.

After completing his medical and specialty training in Brisbane, he moved to Perth to complete a PhD, followed by post-doctoral studies at McMaster University in Canada. In 2007 moved to Brisbane to take up a Chair of Respiratory Medicine with the University of Queensland and Princess Alexandra Hospital.

Research Interests

  • Immune function and susceptibility to virus infections in asthma and COPD
  • Plasmacytoid dendritic cells
    Type I interferon production Immune regulation
  • Severe asthma: towards evidence-based assessment and management
  • Innate immunity and bacterial infections of the lungs
    Bronchiectasis and chronic suppurative lung disease in children Lung health in Indigenous children
  • Allergy and immune tolerance

Publications

View all Publications

Supervision

  • Doctor Philosophy

  • Master Philosophy

  • Doctor Philosophy

View all Supervision

Publications

Book Chapter

  • Upham, John W. and Yerkovich, Stephanie T. (2011). Interactions between allergens and dendritic cells: Pattern recognition receptors and their function in the pathogenesis of allergic respiratory diseases. In Marc A. Williams (Ed.), Allergens and respiratory pollutants : the role of innate immunity (pp. 245-275) Oxford, England: Biohealthcare Publishing.

  • Upham, John W., Stick, Stephen M. and Moodley, Yuben (2008). Lung cell biology. In Lynn M. Taussig and Louis I. Landau (Ed.), Pediatric respiratory medicine 2nd ed. (pp. 35-43) Philadelphia, USA: Mosby/Elsevier. doi:10.1016/B978-032304048-8.50008-6

  • Rate, A. and Upham, J. (2008). The Epithelium and Immunoregulation. In Proud, D. (Ed.), The Pulmonary Epithelium in Health and Disease (pp. 201-214) UK: John Wiley & Sons Ltd.

  • Hughes, T. and Upham, J. W. (2006). Dendritic cells. In Geoffrey J. Laurent and Steven D. Shapiro (Ed.), Encyclopedia of Respiratory Medicine (pp. 10-15) Oxford: Elsevier Academic Press.

Journal Article

Conference Publication

  • Upham, J., Landgraf, M., Xi, Y. and Carroll, M. (2016). Il-33 Augments Rhinovirus-Induced Type 2 Immune Responses in Subjects with Asthma, But Not in Healthy Individuals. In: Respirology. Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science, Annual Scientific Meeting, Perth, WA Australia, (131-131). 1-6 April 2016.

  • Upham, J., Xi, Y., Pena, O. and Bosco, A. (2016). Plasmacytoid Dendritic Cells Play a Critical Role in Regulating Rhinovirus Induced Gene Expression Pathways. In: Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science, Annual Scientific Meeting, Perth, WA Australia, (131-131). 1-6 April 2016.

  • Scott, H., Latham, J., Callister, R., Pretto, J., Saltos, N., Upham, J. and Wood, L. (2015). A Single Bout of Exercise Is Associated with a Transient Reduction to Exhaled Nitric Oxide in Physically Inactive Adults with Asthma. In: Abstracts of the Thoracic Society of Australia and New Zealand and the Australian and New Zealand Society of Respiratory Science, Annual Scientific Meeting. The Annual Scientific Meeting for Leaders in Lung Health and Respiratory Science (TSANZSRS), Gold Coast, QLD Australia, (68-68). 27 March - 1 April 2015. doi:10.1111/resp.12495_2

  • Loh, Z., Ullah, A., Zhang, V., Lynch, J., Werder, R., Simpson, J., Upham, J., Mazzone, S., Spann, K. and Phipps, S. (2015). Interferon Regulatory Factor 7 Protects Against Pneumovirus-Induced Airway Smooth Muscle Growth in Early Life. In: Abstracts of the Thoracic Society of Australia and New Zealand and the Australian & New Zealand Society of Respiratory Science, Annual Scientific Meeting 2015. TSANZ 2015 Annual Scientific Meeting, Gold Coast, QLD Australia, (25-25). 28 March - 1 April 2015. doi:10.1111/resp.12494_7

  • Teoh, L., Van Asperen, P., Acworth, J., Hurwitz, M., Upham, J., Wang, C., Mackay, I, Sloots, T., Neeman, T. and Chang, A. (2014). Recovery From Acute Asthma Exacerbations in Children: Influence of Viruses, Eczema and Atopy. In: Abstracts of the Thoracic Society of Australia and New Zealand and the Australian and New Zealand Society of Respiratory Science 2014 Annual Scientific Meeting. Annual Scientific Meeting of the Thoracic Society of Australia and New Zealand and the Australian and New Zealand Society of Respiratory Science 2014, Adelaide, SA Australia, (75-75). 4-9 April 2014. doi:10.1111/resp.12263_4

  • Gupta, Deepali, Upham, John, Winckel, Karl, Burrows, Judith and Ross, Judy (2014). Utilisation of nicotine replacement therapy (NRT) with a hospital pharmacist initiated smoking-cessation intervention. In: Broaden Your Horizons: Medicines Management 2014. The 40th SHPA Conference. Abstracts. Medicines Management 2014: 40th SHPA Conference, Darwin, Australia, (110-110). 11-14 September 2014.

  • Gupta, D., Upham, J., Winckel, K., Burrows, J. and Ross, J. (2014). Utilisation of nicotine replacement therapy with hospital pharmacist initiated smoking cessation intervention. In: Metro South Heath: Allied Health Showcase 2014, Annerley, QLD, Australia, (). 17 October, 2014.

  • Towers, M. A., Collins, T., Green, M. F., Oakland, N. C. and Upham, J. W. (2013). A Nurse-Led Omalizumab Clinic: the Princess Alexandra Hospital Experience. In: Special Issue: Abstracts of the Thoracic Society of Australia and New Zealand and the Australian and New Zealand Society of Respiratory Science 2013 Annual Scientific Meetings. 2013 Annual Scientific Meetings of The Thoracic Society of Australia and New Zealand and the Australian and New Zealand Society of Respiratory Science, Darwin, NT Australia, (45-45). 22 - 27 March 2013. doi:10.1111/resp.12046

  • Simpson, J. L., Yang, I. A., Reynolds, P. N., Hodge, S. J., James, A. L., Upham, J., Jenkins, C., Peters, M. and Gibson, P. G. (2013). Alternatives to Induced Sputum for Identifying Patients with Eosinophilic Asthma. In: Special Issue: Abstracts of the Thoracic Society of Australia and New Zealand and the Australian and New Zealand Society of Respiratory Science 2013 Annual Scientific Meetings. 2013 Annual Scientific Meetings of The Thoracic Society of Australia and New Zealand and the Australian and New Zealand Society of Respiratory Science, Darwin, NT Australia, (43-43). 22 - 27 March 2013. doi:10.1111/resp.12046

  • Powell, H., Garside, C. G., Simpson, J. L., Yang, I. A., Reynolds, P. N., Hodge, S. J., James, A. L., Upham, J., Jenkins, C. R., Peters, M. J. and Gibson, P. G. (2013). Characteristics of Uncontrolled Asthma in Australia. In: Special Issue: Abstracts of the Thoracic Society of Australia and New Zealand and the Australian and New Zealand Society of Respiratory Science 2013 Annual Scientific Meetings. 2013 Annual Scientific Meetings of The Thoracic Society of Australia and New Zealand and the Australian and New Zealand Society of Respiratory Science, Darwin, NT Australia, (42-42). 22 - 27 March 2013. doi:10.1111/resp.12046

  • Pizzutto, S., Yerkovich, S., Hales, B., Thomas, W., Upham, J. and Chang, A. (2013). H. influenzae-specific antibody responses in children with chronic suppurative lung disease. In: Abstracts of the Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science 2013 Annual Scientific Meetings. Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science 2013 Annual Scientific Meetings, Darwin, NT, Australia, (76-76). 22-27 March 2013. doi:10.1111/resp.12046

  • Upham, J. W., Carroll, M. L., Burel, J. G., White, O. J. and Pritchard, A. L. (2012). Asthma is associated with multiple deficiencies in anti-viral type I interferon signalling pathways. In: Special Issue: Abstracts of the Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science 2012 Annual Scientific Meetings. Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science 2012 Annual Scientific Meetings, Canberra, ACT, Australia, (27-27). 30 March-4 April 2012. doi:10.1111/j.1440-1843.2012.02142.x

  • Upham, J. W., Nath, K., Pritchard, A. L., Towers, M., Looke, D., Davies, J. E. and Burel, J. G. (2012). Impaired immune response to influenza vaccination in chronic obstructive pulmonary disease. In: Special Issue: Abstracts of the Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science 2012 Annual Scientific Meetings. Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science 2012 Annual Scientific Meetings, Canberra, ACT, (16-16). 30 March - 4 April 2012. doi:10.1111/j.1440-1843.2012.02142.x

  • Garside, C. G., Simpson, J. L., Yang, I. A., Reynolds, P. N., Hodge, S. J., James, A. L., Upham, J., Gibson, P. G. and Amazes Study Research Group (2012). Inflammatory subtypes of uncontrolled asthma in Australia. In: Special Issue: Abstracts of the Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science 2012 Annual Scientific Meetings. Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science 2012 Annual Scientific Meetings, Canberra, ACT, (40-40). 30 March - 4 April 2012. doi:10.1111/j.1440-1843.2012.02142.x

  • Upham, J. W., Carroll, M. L., Phipps, S., Burel, J. G. and Pritchard, A. L. (2012). Innate interferons and plasmacytoid dendritic cells constrain T(h)2 cytokine responses to rhinovirus: A regulatory mechanism with relevance to asthma. In: Special Issue: Abstracts of the Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science 2012 Annual Scientific Meetings. Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science 2012 Annual Scientific Meetings, Canberra ACT, Australia, (51-51). 30 March-4 April 2012. doi:10.1111/j.1440-1843.2012.02143.x

  • Upham, John W., Carroll, Melanie L., Burel, Julie G. and Pritchard, Antonia L. (2012). Innate interferons and plasmacytoid dendritic cells constrain Th2 cytokine responses to rhinoviruses: A regulatory mechanism with relevance to asthma. In: Program and Abstracts of Papers to be Presented During Scientific Sessions: 2012 AAAAI Annual Meeting. Annual Meeting of the American-Academy-of-Allergy-Asthma-and-Immunology (AAAAI), Orlando Fl, (AB162-AB162). 2-6 March March 2012. doi:10.1016/j.jaci.2011.12.367

  • Wurzel, D. F., Marchant, J. M., Masters, I. B., Yerkovich, S. T., Upham, J. W. and Chang, A. B. (2012). Wet cough in children: infective and inflammatory characteristics in broncho-alveolar lavage fluid. In: 17th Congress of the Asian Pacific Society of Respirology, Hong Kong, (102-102). 14-16 December 2012. doi:10.1111/j.1440-1843.2012.02297.x

  • Burel, Julie, Li, Hongzhuo, Wong, Kelly, Towers, Michelle, Upham, John and Davies, Janet (2011). B cell responses to areoalllergens in patient with allergic disease. In: Special Issue: 22nd Australasian Society of Clinical Immunology and Allergy (ASCIA) Annual Scientific Meeting. Australasian Society of Clinical Immunology and Allergy Annual Scientific Meeting (22nd, ASCIA, 2011), Darling Harbour, NSW, Australia, (5-6). 7-9 September 2011. doi:10.1111/j.1445-5994.2011.02570.x

  • Pizzutto, S. J., Grimwood, Keith, Bauert, P., Schultz, K. I., Yerkovich, Stephanie, Upham, John and Chang, Anne B. (2011). Bronchososcopy with lavage contributes to the clinical management of children with non-CF bronchiectasis. In: Thoracic Society of Australia and New Zealand Annual Scientific Meeting, Perth, Australia, (). 2-6 April 2011.

  • Davies, Janet M., Carroll, Melanie L., Li, Hongzhuo, Poh, Alisa M., Kirkegard, Darren, Towers, Michelle and Upham, John W. (2011). Budesonide and formoterol reduce early innate anti-viral immune responses in vitro. In: Special Issue: 22nd Australasian Society of Clinical Immunology and Allergy (ASCIA) Annual Scientific Meeting. Australasian Society of Clinical Immunology and Allergy Annual Scientific Meeting (22nd, ASCIA, 2011), Darling Harbour, NSW, Australia, (5-5). 7-9 September 2011.

  • Nath, Karthik, Burel, Julie, Pritchard, Antonia L., Towers, Michelle, Looke, David, Davies, Janet E. and Upham, John W. (2011). Impaired immune response to influenza vaccination in chronic obstructive pulmonary disease. In: Abstracts of the 22nd Australasian Society of Clinical Immunology and Allergy (ASCIA) Annual Scientific Meeting. 22nd Australasian Society of Clinical Immunology and Allergy (ASCIA) Annual Scientific Meeting, Darling Harbour, NSW, Australia, (13-13). 7-9 September 2011. doi:10.1111/j.1445-5994.2011.02570.x

  • Pritchard, Antonia L., Carroll, Melanie L., Burel, Julie and Upham, John W. (2011). Type I interferons and plasmacytoid dendritic cells selectively constrain T(h)2 cytokine responses to rhinoviruses. In: Abstracts of the 22nd Australasian Society of Clinical Immunology and Allergy (ASCIA) Annual Scientific Meeting. 22nd Australasian Society of Clinical Immunology and Allergy (ASCIA) Annual Scientific Meeting, Darling Harbour, NSW, Australia, (20-21). 7-9 September 2011. doi:10.1111/j.1445-5994.2011.02570.x

  • Davies, Janet, Li, HonZhuo, Green, Melissa, Towers, Michelle and Upham, John (2010). Grass pollen allergy in Queensland: How important are the subtropical grass pollens for triggering allergic rhinitis and asthma?. In: Internal Medicine Journal. Special Issue: Abstracts of the ASCIA 2010 - 21st Annual Scientific Meeting, Australian Society of Clinical Immunology and Allergy. 21st Meeting of the Australian Society for Clinical Immunology and Allergy, Gold Coast , QLD, Australia, (1-26). 1-3 September 2010. doi:10.1111/j.1445-5994.2010.02324.x

  • Thompson, B. R., Cowin, G., Friese, M. E. J., Maillet, D., Wang, D., Eckert, J., Upham, J., Harris, G., King, G. and Thien, F. (2009). Analysis of ventilation heterogeneity (VH) with hyperpolarized helium magnetic resonance imaging (HPHeMRI) following inhaled methacholine (MCH) and mannitol (MNT) challenges in asthmatic subjects. In: Philip J. Thompson, Respirology. Special Issue: The Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science 2009 Annual Scientific Meetings. Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science 2009 Annual Scientific Meetings, Darwin, Australia, (A4-A4). 3–8 April 2009. doi:10.1111/j.1440-1843.2009.01500_3.x

  • Upham, J. W., Yerkovich, S.T., Poh, A., Sly, P. D., Holt, P. G. and Roponen, M. (2009). Reduced expression of anti-viral molecules by blood mononuclear cells is associated With asthma, but not with atopy per se. In: Program and Abstracts of Papers to be Presented During Scientific Sessions. 65th Annual Meeting of the American Academy of Allergy Asthma and Immunology, Washington, DC, U.S.A., (S221-S221). 13-17 March 2009. doi:10.1016/j.jaci.2008.12.849

  • Rate, A., Kicic, A., Stick, S. M. and Upham, J. W. (2005). Airway epithelial cells from healthy children inhibit dendritic cell activation and cytokine synthesis. In: Tissue Antigens. 35th Annual SCientific Meeting of the Australasian Society for Immunology/14th International HLA and Immunogenetics Workshops, Melbourne, Australia, (524-524). 29 November -2 December 2005.

  • Yerkovich, ST, Mus, A and Upham, JW (2005). Influence of APC maturity on the expression of allergen specific T cell memory. In: TISSUE ANTIGENS. 35th Annual SCientific Meeting of the Australasian-Society-for-Immunology/14th International HLA and Immunogenetics Workshops, Melbourne AUSTRALIA, (597-597). NOV 29-DEC 02, 2005.

  • Upham, J. W., Rate, A., Kusel, M., Sly, P. D. and Holt, P. G. (2005). Numbers of circulating plasmacytoid and myeloid dendritic cell subsets in infancy are differentially associated with risk for respiratory viral infections and allergic sensitisation. In: 35th Annual Scientific Meeting of the Australasian Society for Immunology and 14th International HLA & Immunogenetics Workshop, Melbourne, Australia, (573-573). 29 November-2 December 2005.

  • Taylor, R. C., Richmond, P. and Upham, J. W. (2005). Toll-like receptor 2 ligands inhibit Th2 responses to mite allergen. In: Tissue Antigens. 35th Annual Scientific Meeting of the Australasian Society for Immunology/14th International HLA and Immunogenetics Workshops, Melbourne, Australia, (559-560). 29 November - 2 December 2005.

  • Fogel, M., Long, J. A., Thompson, P. J. and Upham, J. W. (2002). The synthetic immune response modifier R-848 induces dendritic cells to mature and synthesize a diverse range of cytokines via a pathway distinct from lipopolysaccharide. In: Annual Meeting of the American Academy of Allergy, Asthma and Immunology, New York City, NY United States, (S67-S67). 1-6 March 2002. doi:10.1016/S0091-6749(02)81297-0

  • Denburg, Judah A., Sehmi, Roma and Upham, John (2001). Regulation of IL-5 receptor on eosinophil progenitors in allergic inflammation: role of retinoic acid. In: Takeru Ishikawa, Terumasa Miyamoto, Hirokazu Okudaira, Hisao Tomioka, Rudolf Valenta and Dietrich Kraft, Allergy in the 21st century: new answers to old questions - 23rd Symposium of the Collegium Internationale Allergologicum. 23rd Symposium of the Collegium Internationale Allergologicum (CIA 2000), Hakone, Japan, (246-248). 18-23 May 2000. doi:10.1159/000053724

  • Lacosta, S., Sehmi, R., Upham, J., Hayes, L., Tavernier, J. and Denburg, J. A. (2000). Modulation of eosinophil progenitor growth and IL5R alpha expression on CD34+cells by retinoic acid. In: Annual Meeting of the American Academy of Allergy, Asthma and Immunology, San Diego California USA, (S258-S258). 3-8 March 2000. doi:10.1016/S0091-6749(00)91195-3

  • Upham, J. W., Denburg, J. A. and O'Byrne, P. M. (1999). Circulating dendritic cells and asthma: Rapid response to inhaled allergen. In: -, -, (A854-A854). -.

  • Narita, S., Upham, J., Lundahl, J., Watson, R., Croitru, K. and O'Byrne, P. M. (1999). Intracellular cytokines in T-cells from patients with allergic asthma and the effects of inhaled corticosteroids. In: -, -, (A103-A103). -.

  • Denburg, Judah A., Sehmi, Roma, Upham, John, Wood, Lorna, Gauvreau, Gail and O'Byrne, Paul (1999). Regulation of IL-5 and IL-5 receptor expression in the bone marrow of allergic asthmatics. In: A. Togias and K. Kontou-Fili, From molecular science to the treatment of allergy: 22nd Symposium of the Collegium Internationale Allergologicum, Proceedings. 22nd Symposium of the Collegium Internationale Allergologicum, Corfu, Greece, (101-103). 12-16 September 1998. doi:10.1159/000024040

  • Lundahl, J., Sehmi, R., Hayes, L., Upham, J., Howie, K. and Denburg, J. A. (1998). Induction of eosinophilic differentiation involves selective up-regulation of beta-7 integrin. In: Unknown, Unknown, (S219-S219). Unknown.

  • Upham, J. W., Hayes, L. M., Sehmi, R. and Denburg, J. A. (1998). Retinoic acid selectively inhibits IL-5 receptor expression during differentiation of hemopoietic progenitor cells. In: Annual Meeting of the American Academy of Allergy, Asthma and Immunology, Washington DC, United States, (S214-S214). 13-18 March 1998.

  • Holt, P. G., Nelson, D. J., McWilliam, A. S., Cooper, D., Strickland, D. and Upham, J. W. (1996). Role of dendritic cells, macrophages, and gamma delta T cells in antigen processing and presentation in the respiratory mucosa. In: Essentials of Mucosal Immunology. 8th International Congress of Mucosal Immunology, San Diego CA, United States, (47-53). 4 June 1995. doi:10.1016/B978-012394330-9/50006-5

  • Robinson, B. W. S., Manning, L. S., Bowman, R. V., Christmas, T. I., Musk, A. W., Davis, M. R., Bielefeldt-Ohmann, H., Upham, J. and Garlepp, M. J. (1993). The scientific basis for the immunotherapy of human malignant mesothelioma. In: Proceedings of the International Conference on Mesothelial Cell and Mesothelioma: Past, Present and Future. International Conference on Mesothelial Cell and Mesothelioma: Past, Present and Future, Paris, France, (195-198). 20 September - 2 October 1991.

Grants (Administered at UQ)

PhD and MPhil Supervision

Current Supervision

  • Doctor Philosophy — Principal Advisor

  • Master Philosophy — Principal Advisor

  • Doctor Philosophy — Associate Advisor

    Other advisors:

  • Doctor Philosophy — Associate Advisor

  • Doctor Philosophy — Associate Advisor

  • Doctor Philosophy — Associate Advisor

Completed Supervision