Professor Theo Sloots

Academic Title-Professor

Child Health Research Centre
Faculty of Medicine

Overview

Professor Theo Sloots is a PhD graduate in Microbiology, with a special interest in molecular microbiology and medical virology. He is the Director of Research at the Queensland Paediatric Infectious Diseases (QPID) laboratory at the Queensland Children’s Medical Research Institute, Brisbane. His laboratory conducts basic and applied research in infectious diseases, particularly respiratory and gastrointestinal infections, applies molecular technology to the diagnosis and characterisation of microorganisms, and investigates undiagnosed infectious disease in children. The QPID laboratory is considered a Centre of Excellence in diagnostic microbiology. Over the last 10 years Prof Sloots has attracted research funding in excess of $14 million from external granting bodies such as the NHMRC, ARC, NIH and the Children’s Health Foundation. He has published extensively with 205 scientific articles in peer-reviewed journals and books.He is a Fellow of the Australian Society for Microbiology and a Foundation Fellow, Faculty of Science (RCPA).

Research Impacts

Research conducted by Professor Sloots has significant clinical impact on health care within the State and nationally. It has resulted in a major paradigm shift in the diagnosis of infectious disease in Queensland Health which has directly benefited the Queensland population. It has underpinned the establishment and maintenance of a novel molecular diagnostic service at the Pathology Queensland Central laboratory, which is unique in Australia. This research has resulted in the award of two international patents which are currently undergoing commercial development.

Together with international collaborators, Prof Sloots has been responsible for the discovery of new viruses, or virus species, associated with the human respiratory tract which has enhanced our understanding of respiratory disease, and has initiated further research into the biology and pathogenesis of these new viral agents.

In addition, the laboratory supervised by Prof Sloots has made an international contribution to the understanding of molecular drug resistance mechanisms of human pathogens, particularly the pathogenic Neisseria.

Qualifications

  • Postgraduate Certificate in Management, Queensland University of Technology
  • Doctor of Philosophy, The University of Queensland
  • Master of Science, The University of Queensland
  • Bachelor of Science, The University of Queensland

Publications

  • O'Grady, Kerry-Ann F., Grimwood, Keith, Sloots, Theo P. , Whiley, David M. , Acworth, Jason P. , Phillips, Natalie, Marchant, Julie, Goyal, Vikas and Chang, Anne B. (2017) Upper airway viruses and bacteria and clinical outcomes in children with cough. Pediatric Pulmonology, 52 3: 373-381. doi:10.1002/ppul.23527

  • Li-Kim-Moy, Jean P. , Yin, Jiehui K. , Heron, Leon, Leask, Julie, Lambert, Stephen B. , Nissen, Michael, Sloots, Theo and Booy, Robert (2017) Influenza vaccine efficacy in young children attending childcare: a randomised controlled trial. Journal of Paediatrics and Child Health, 53 1: 47-54. doi:10.1111/jpc.13313

  • Sarna, Mohinder, Alsaleh, Asma, Lambert, Stephen B., Ware, Robert S., Mhango, Lebogang P., Mackay, Ian M., Whiley, David M., Sloots, Theo P. and Grimwood, Keith (2016) Respiratory viruses in neonates: a prospective, community-based birth cohort study. Pediatric Infectious Disease Journal, 35 12: 1355-1357. doi:10.1097/INF.0000000000001316

View all Publications

Publications

Book Chapter

  • Liang, Fang, Arora, Neetika, Zhang, Kang Liang, Yeh, David Che Cheng, Lai, Richard, Pearson, Darnley, Barnett, Graeme, Whiley, David, Sloots, Theo, Corrie, Simon R. and Barnard, Ross T. (2013). A new, multiplex, quantitative real-time polymerase chain reaction system for nucleic acid detection and quantification. In Dmitry M. Kolpashchikov and Yulia V. Gerasimova (Ed.), Nucleic acid detection: methods and protocols (pp. 51-68) New York, NY, United States: Humana Press. doi:10.1007/978-1-62703-535-4_4

  • Goire, Namraj, Sloots, Theo P., Whiley, David M. and Nissen, Michael D. (2012). Protocol for the molecular detection of antibiotic resistance mechanisms in Neisseria gonorrhoeae. In Colin R. MacKenzie and Birgit Henrich (Ed.), Diagnosis of sexually transmitted diseases (pp. 319-328) Heidelberg, Germany: Springer. doi:10.1007/978-1-61779-937-2_22

  • Bialasiewicz, Seweryn, Mackay, Ian M., Whiley, David M. and Sloots, Theo P. (2012). Protocol for the use of enzyme-linked hybridization assays for genital ulcer disease. In Colin R. MacKenzie and Birgit Henrich (Ed.), Diagnosis of sexually transmitted diseases (pp. 225-233) New York, NY, United States: Humana Press. doi:10.1007/978-1-61779-937-2_14

  • Bialasiewicz, Seweryn, Whiley, David M. and Sloots, Theo P. (2010). Malaria (P. falciparum, P. vivax, P. malariae, P. ovale). In Margaret Schuller, Theo P. Sloots, Gregory S. James, Catriona L. Halliday and Ian W.J. Carter (Ed.), PCR for clinical microbiology : An Australian and international perspective (pp. 373-377) Dordrecht ; London: Springer Publishing. doi:10.1007/978-90-481-9039-3_64

  • Mackay, I. M., Arden, K. E., Nissen, M. D. and Sloots, T. P. (2007). Challenges Facing Real-time PCR Characterization of Acute Respiratory Tract Infections.. In Mackay, I.M. (Ed.), Real-Time PCR in Microbiology from Diagnosis to Characterization. 1 ed. (pp. 269-318) United Kingdom: Horizon Press - Calister Academic Press.

  • Beld, M. G. H. M., Mackay, I. M., Sloots, T. P. and et. al. (2007). Experts' roundtable: Real time PCR and microbiology. In Ian M. Mackay (Ed.), Real-Time PCR in Microbiology From diagnosis to characterization (pp. 357-444) Norfolk, United Kingdom: Caister Academic.

  • Mackay I M, Bustin, S. A., Andrade, J. M., Kubista, M and Sloots, T P (2007). Quantification of Microorganisms: not Human, not Simple, not Quick.. In Mackay, I. M. (Ed.), Real-Time PCR in Microbiology From Diagnosis to Characterization. 1 ed. (pp. 133-182) United Kingdom: Horizon Press - Calister Academic Press.

  • Mackay, I. M., Mackay, J. F., Nissen, M. D. and Sloots, T. P. (2007). Real-time PCR; History and Fluorgenic Chemistries. In Mackay, I. M. (Ed.), Real-Time PCR in Microbiology From diagnosis to characterization 1 ed. (pp. 1-40) United Kingdom: Horizon Press - Calister Academic Press.

  • Whiley, D. M. and Sloots, T. P. (2006). Clinical Virology. In M. Tevfik Dorak (Ed.), Real-Time PCR 1 ed. (pp. 231-276) UK: Taylor & Francis.

  • Ratcliff, M., Chang, G., Kok, T. W. and Sloots, T. P. (2006). Molecular diagnosis of medical viruses. In Juluri R. Rao, Colin C. Fleming and John E. Moore (Ed.), Current Technology and Applicantions (pp. 269-298) Norfold, United Kingdom: Horizon Bioscience.

Journal Article

Conference Publication

  • Mccallum, G., Morris, P., Grimwood, K., Maclennan, C., White, A., Sloots, T., Mackay, I, Smith-Vaughan, H., Byrnes, C. and Chang, A. (2015). Improving the Management of Indigenous Children Hospitalised with Bronchiolitis: a Multicenter Rct. In: Abstracts of the Thoracic Society of Australia and New Zealand and the Australian and New Zealand Society of Respiratory Science, Annual Scientific Meeting. The Annual Scientific Meeting for Leaders in Lung Health and Respiratory Science (TSANZSRS), Gold Coast, QLD Australia, (30-30). 27 March - 1 April 2015. doi:10.1111/resp.12494_9

  • Kumar, A., Czovek, D., Shackleton, C., Hantos, Z., Grimwood, K., Sarna, M., Whiley, D., Sloot, T., Alsaleh, A., Lambert, S. and Sly, P. (2015). Wheezy episodes during the first year of life decrease airway distensibility. In: Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science, Annual Scientific Meeting 2015, Gold Coast, Australia, (27-27). 27 March – 1 April, 2015. doi:10.1111/resp.12494_7

  • Teoh, L., Van Asperen, P., Acworth, J., Hurwitz, M., Upham, J., Wang, C., Mackay, I, Sloots, T., Neeman, T. and Chang, A. (2014). Recovery From Acute Asthma Exacerbations in Children: Influence of Viruses, Eczema and Atopy. In: Abstracts of the Thoracic Society of Australia and New Zealand and the Australian and New Zealand Society of Respiratory Science 2014 Annual Scientific Meeting. Annual Scientific Meeting of the Thoracic Society of Australia and New Zealand and the Australian and New Zealand Society of Respiratory Science 2014, Adelaide, SA Australia, (75-75). 4-9 April 2014. doi:10.1111/resp.12263_4

  • Drescher, B. J., Chang, A. B., Phillips, N., Acworth, J., Marchant, J. M., Sloots, T. and O'Grady, K. F. (2013). Chronic cough following acute respiratory illness in children. In: Abstracts of the Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science 2013 Annual Scientific Meetings. Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science 2013 Annual Scientific Meetings, Darwin, NT, Australia, (76-76). 22-27 March 2013. doi:10.1111/resp.12046

  • Wurzel, D. F., Marchant, J. M., Mackay, I. M., Wang, C. Y. T., Sloots, T., Upham, J., Yerkovich, S., Clark, J., Masters, I. B. and Chang, A. B. (2013). Protracted bacterial bronchitis in children: results of a large prospective cohort study. In: Abstracts of the Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science 2013 Annual Scientific Meetings. Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science 2013 Annual Scientific Meetings, Darwin, NT, Australia, (77-77). 22-27 March 2013. doi:10.1111/resp.12046

  • Rockett, Rebecca, Bialasiewicz, Seweryn, Lambert, Stephen B., Ware, Robert, Whiley, David M., Nissen, Michael D., Grimwood, Keith and Sloots, Theo P. (2013). WU, KI, MW and MCV polyomavirus infection in the first 2 years of life. In: Abstracts of the 5th International Conference on Polyomaviruses and Human Diseases: Basic and Clinical Perspectives. 5th International Conference on Polyomaviruses and Human Diseases: Basic and Clinical Perspectives, Stresa Italy, (304-305). 09-11 May 2013.

  • Lambert, Stephen B., Peterson KV, Selvey CE, Sloots, Theodorus P., Nissen, Michael D. and Keith Grimwood (2011). The changing epidemiology of rotavirus in Queensland, Australia, three years after the introduction of pentavalent rotavirus vaccine. In: The 7th World Congress of the World Society of Pediatric Infectious Diseases, Melbourne , Australia, (). 16 - 19th, 2011.

  • Lambert, Stephen B., Peterson, K., Selvey, C., Sloots, Theodorus P., Nissen, Michael D. and Grimwood, Keith (2011). The continuing decline: rotavirus in Queensland following the introduction of multivalent vaccine. In: Public Health Association Communicable Disease Control Conference, Canberra, ACT, Australia, (). 4-6 April 2011.

  • Barnard, R., Lai, R., Pearson, D., Phua, Z. Y., Whiley, D., Sloots, T. and Barnett, G. (2009). A new multiplexable, quantitative, real-time system for detection of nucleic acids. In: Mike L. Taussig, New Biotechnology. Abstracts of the 14th European Congress on Biotechnology. 14th European Congress on Biotechnology, Barcelona, Spain, (S17-S18). 13-16 September 2009. doi:10.1016/j.nbt.2009.06.044

  • Lambert, Stephen B., Faux, Cassandra E., Hall, L., Birrell, F. E., Peterson, K. V., Selvey, C., Sloots, T. P., Nissen, M. D. and Grimwood, K. (2009). Early evidence for direct and indirect effects of the infant rotavirus vaccine program in Queensland, Australia. In: European Society for Paediatric Infectious Diseases, 27th Annual Scientic Meeting, Brussels, Belgium, (A400-A400). 9-13 June 2009.

  • Bialasiewicz S., Whiley D., Nissen, M. D. and Sloots, T. P. (2007). The impact of oligonucleotide design on PCR sensitivity. Abstract M-54. In: Clinical Virology Symposium. Clinical Virology Symposium, Clearwater, FL, USA, (). 2007.

  • Mackay, I. M., McErlean, P., Nissen, M. D. and Sloots, T. P. (2007). The impact of quasispecies on respiratory virus PCR.. In: IX International Symposium on Respiratory Viral Infections. IX International Symposium on Respiratory Viral Infections Abstract P20., Hong Kong, (). March 2007.

  • Sloots, T. P., Mackay, I. M., Jacob, K.C., Bialasiewicz, S. and Nissen, M. D. (2006). A four year study of human metapneumovirus in Australia. In: Australian Society for Microbiology Annual Scientific Meeting, Gold Coast, Australia,, (). 2-6 July 2006.

  • McErlean P., Shackelton L., Nissen, M. D., Sloots, T. P. and Mackay, Ian M. (2006). A newly identified human rhinovirus present in young children with bronchiolitis. In: Proceedings : IX International Symposium on Respiratory Viral Infections. IX International Symposium on Respiratory Viral Infections, Causeway Bay, Hong Kong, (). 3-6 March 2007.

  • Sloots, T. P., McErlean, P., Speicher D. J., Arden, K., Nissen, M. D. and Mackay, I.M. (2006). Evidence of human coronavirus NL63, HKU1 and human bocavirus in Australian children with acute respiratory infection. In: Australian Society for Microbiology Annual Scientific Meeting, Gold Coast, Australia, (). 2006.

  • Bialasiewicz S., Whiley D., Nissen, M. D. and Sloots, T. P. (2006). Factors influencing the sensitivity of the malarial PCR assay.. In: ASM SVM Special Interest Group Meeting, Brisbane, (). 2006.

  • Bialasiewicz S., Whiley D. and Sloots, Theodorus P. (2006). The impact of competitive inhibition and sequence variation upon the sensitivity of malaria PCR. In: Australian Society for Microbiology Annual Scientific Meeting. Australian Society for Microbiology Annual Scientific Meeting, Gold Coast, Australia, (). 2006.

  • Bialasiewicz S., Whiley D. and Sloots, Theodorus P. (2006). The impact of competitive inhibition and sequence variation upon the sensitivity of malaria PCR.. In: Annual Health and Medical Research Conference of Queensland. Annual Health and Medical Research Conference of Queensland, Brisbane, Australia., (). 2006.

  • Syrmis, M., O'Carroll, M., Iredell, J., Wainwright, C., Coulter, C., Sloots, T., Bell, S. and Nissen, M. (2005). Detection of an integron associated aadB resistance gene in Pseudomonas aeruginosa isolates from patients with CF. In: P. J. Thompson, Respirology. 2005 Annual Scientific Meeting The Thoracic Society of Australia and New Zealand, Perth, Australia, (A16-A16). 18-23 March, 2005. doi:10.1111/j.1440-1843.2005.00663.x-i1

  • Syrmis, M., O'Carroll, M., Iredell, J., Wainwright, C. E., Coulter, C., Sloots, T., Bell, S. C. and Nissen, M. (2005). Detection of an integron associated aadb-resistance gene in Pseudomonas aeruginosa isolates from patients with CF. In: H. G. M. Heijerman, 28th European Cystic Fibrosis Conference. 28th European Cystic Fibrosis Conference, Crete, Greece, (S57-S57). 22-25 Jun, 2005.

  • Spence, L., Nissen, M. D., Sloots, T. P., McCormack, J. G., Locke, S., Pyne, D. B., Fricker, P. A. and Brown, W. J. (2005). Upper respiratory illness aetiology and symptomatology in elite and recreationally competitive athletes. In: J. A. Woods, Brain, Behavior, and Immunity: 7th ISEI Symposium Abstracts. 7th ISEI Symposium, Monte Carlo, (469-470). 15-17 September, 2005. doi:10.1016/j.bbi.2005.06.001

  • Spence, L., Nissen, M. D., Sloots, T. P., McCormack, J. G., Locke, S., Pyne, D., Fricker, P. and Brown, W. J. (2004). Identifying the aetiology of upper respiratory illness in elite and recreational athletes. In: C. Finch, Journal of Science and Medicine in Sport: 2004 Australian Conference Program and Abstracts. Hot Topics from the Red Centre, Alice Springs, NT, Australia, (48-48). 6-9 October 2004. doi:10.1016/S1440-2440(04)80138-5

  • O'Carroll, M. R., Bell, S. C., Coulter, C., Wainwright, C. E., Nissen, M., Sloots, T. and Syrmis, M. (2003). Presence of epidemic Pseudomonas aeruginosa shared between paediatric and adult cystic fibrosis. In: P. J. Thompson, Respirology. TSANZ 2003 Annual Scientific Meeting, Adelaide, Australia, (A12-A12). 4-9 April, 2003. doi:10.1111/j.1440-1843.2003.supp_1.x

  • O'Carroll, M. R., Coulter, C., Bell, S. C., Syrmis, M., Wainwright, C. E., Nissen, M. and Sloots, T. (2003). Presence of epidemic Pseudomonas aeruginosa shared between paediatric and adult cystic fibrosis. In: Journal of Cystic Fibrosis: Proceedings of the 26th European CF Conference. 26th European CF Conference, Belfast, Ireland, (S38-S38). 5–7 June , 2003. doi:10.1016/S1569-1993(03)00027-4

  • O'Carroll, M. R., Coulter, C., Bell, S. C., Syrmis, M., Wainwright, C. E., Nissen, M. and Sloots, T. (2003). Rapid genotyping of Pseudomonas aeruginosa using repetitive element based PCR assays. In: Journal of Cystic Fibrosis: Proceedings of the 26th European CF Conference. 26th European CF Conference, Belfast, Ireland, (S38-S38). 5–7 June , 2003. doi:10.1016/S1569-1993(03)00027-4

  • O'Carroll, M. R., Bell, S. C., Coulter, C., Wainwright, C. E., Nissen, M., Sloots, T. and Syrmis, M. (2003). Rapid genotyping of Pseudomonas aeruginosa using repetitive element based PCr assays. In: P. J. Thompson, Respirology. TSANZ 2003 Annual Scientific Meeting, Adelaide, Australia, (A47-A47). 4-9 April, 2003. doi:10.1111/j.1440-1843.2003.supp_1.x

  • Hamlet, S., Whiley, D., Sloots, T., Cullinan, M., Westerman, B., Palmer, J., West, M. and Seymour, G. (2002). Prevalence of Bacteroides forsythus in a cardiovascular diseased population: A case controlled analysis using real-time PCR. In: Journal of Dental Research. 80th General Session of the International Association of Dental Research, San Diego, (A115-A115). 6-9th March, 2002.

  • Whiting, P.W., Gowans, E.J., Sloots, T.P., Mackay, I.M., Tillack, S., Harrison, M., Beller, E.M. and Crawford, D.H.G. (2002). The effects of vitamin B12 on hepatitis C virus replication. In: Abstracts of the 103rd Annual Meeting of the American Gastroenterological Association. Digestive Disease Week and the 103rd Annual Meeting of the American Gastroenterological Association. Digestive Disease Week and the 103rd Annual Meeting of the American Gastroenterological Association, San Francisco, CA, United States, (74-74). 19-22 May 2002.

  • Irving, I, Williamson, J, Mollee, P, Morton, AJ, Sloots, T, Siebert, D and Durrant, S (2001). Low dose valaciclovir for the prevention of CMV disease post allogeneic bone marrow transplantation. In: Bone Marrow Transplantation. , , (S154-S155). .

  • Crawford, D.H., Lott, W.B., Cooksley, G., HArrison, M., McDonald, G., Sloots, T. and Gowans, E.J. (2000). Effects of cobalamin on hepatitis C virus translation and replication. In: Abstracts of the 51st Annual Meeting of the American Association for the Study of Liver Disease. 51st Annual Meeting American Association for the Study of Liver Disease, Dallas, TX, United States, (359A-359A). 27 - 31 October 2000.

  • Cooksley, W. G. E., Crawford, D., Gowans, E. J., Harrison, M., Lott, W. B., Macdonald, G. and Sloots, T. (2000). Effects of cobalamin on hepatitis C virus translation and replication. In: Annual Mtg of the American Association for the Study of Liver Disease. Ann Mtg of American Assn for the Study of Liver Disease, Dallas, Texas, ((abstract)). 27-31 Oct, 2000.

Grants (Administered at UQ)

PhD and MPhil Supervision

Completed Supervision