Honorary Professor Mark Smyth

Honorary Professor

School of Clinical Medicine
Faculty of Medicine

Overview

Qualifications

  • Elected to European Academy of Tumor Immunology, European Academy of Tumor Immunology
  • Member, Academy of Cancer Immunology
  • PhD Research Centre for Cancer & Transplantation, University of Melbourne
  • B Sc (Hons), University of Melbourne
  • BSc, University of Melbourne

Publications

  • Guillerey, Camille, Harjunpää, Heidi, Carrié, Nadège, Kassem, Sahar, Teo, Tricia, Miles, Kim, Krumeich, Sophie, Weulersse, Marianne, Cuisinier, Marine, Stannard, Kimberley, Yu, Yuan, Minnie, Simone A., Hill, Geoffrey R., Dougall, William C., Avet-Loiseau, Hervé, Teng, Michele W. L., Nakamura, Kyohei, Martinet, Ludovic and Smyth, Mark J. (2018) TIGIT immune checkpoint blockade restores CD8 T cell immunity against multiple myeloma. Blood, . doi:10.1182/blood-2018-01-825265

  • Yan, Juming, Smyth, Mark J. and Teng, Michele W. L. (2018) Interleukin (IL)-12 and IL-23 and their conflicting roles in cancer. Cold Spring Harbor Perspectives in Biology, 10 7: . doi:10.1101/cshperspect.a028530

  • Yan, Juming, Allen, Stacey, Vijayan, Dipti, Li, Xian-Yang, Harjunpää, Heidi, Takeda, Kazuyoshi, Liu, Jing, Cua, Daniel J., Smyth, Mark J. and Teng, Michele W. L. (2018) Experimental lung metastases in mice are more effectively inhibited by blockade of IL23R than IL23. Cancer Immunology Research, . doi:10.1158/2326-6066.CIR-18-0011

View all Publications

Supervision

View all Supervision

Publications

Book Chapter

  • Guillerey, Camille and Smyth, Mark J. (2016). NK cells and cancer immunoediting. In Eric Vivier, James Di Santo and Alessandro Moretta (Ed.), Natural killer cells (pp. 115-145) Switzerland: Springer. doi:10.1007/82_2015_446

  • Martinet, Ludovic and Smyth, Mark J. (2016). Regulation of Immune Cell Functions through Nectin and Nectin-Like Receptors. In Encyclopedia of Immunobiology (pp. 404-414) Kidlington, Oxford United Kingdom: Elsevier. doi:10.1016/B978-0-12-374279-7.02010-5

  • Guillerey, Camille and Smyth, Mark J. (2015). NK cells and cancer immunoediting. In Natural Killer Cells (pp. 115-145) New York, NY United States: Springer. doi:10.1007/82_2015_446

  • Mattarollo, Stephen R. and Smyth, Mark J. (2012). Therapeutic approaches utilising NKT cells. In Masaki Terabe and Jay A. A. Berzofsky (Ed.), Natural killer T cells: balancing the regulation of tumor immunity (pp. 111-128) New York, United States: Springer. doi:10.1007/978-1-4614-0613-6_7

Journal Article

  • Guillerey, Camille, Harjunpää, Heidi, Carrié, Nadège, Kassem, Sahar, Teo, Tricia, Miles, Kim, Krumeich, Sophie, Weulersse, Marianne, Cuisinier, Marine, Stannard, Kimberley, Yu, Yuan, Minnie, Simone A., Hill, Geoffrey R., Dougall, William C., Avet-Loiseau, Hervé, Teng, Michele W. L., Nakamura, Kyohei, Martinet, Ludovic and Smyth, Mark J. (2018) TIGIT immune checkpoint blockade restores CD8 T cell immunity against multiple myeloma. Blood, . doi:10.1182/blood-2018-01-825265

  • Yan, Juming, Smyth, Mark J. and Teng, Michele W. L. (2018) Interleukin (IL)-12 and IL-23 and their conflicting roles in cancer. Cold Spring Harbor Perspectives in Biology, 10 7: . doi:10.1101/cshperspect.a028530

  • Yan, Juming, Allen, Stacey, Vijayan, Dipti, Li, Xian-Yang, Harjunpää, Heidi, Takeda, Kazuyoshi, Liu, Jing, Cua, Daniel J., Smyth, Mark J. and Teng, Michele W. L. (2018) Experimental lung metastases in mice are more effectively inhibited by blockade of IL23R than IL23. Cancer Immunology Research, . doi:10.1158/2326-6066.CIR-18-0011

  • Nakamura, Kyohei and Smyth, Mark J. (2018) Aberrant erythropoiesis fuels tumor growth. Cell Research, 28 6: 611-612. doi:10.1038/s41422-018-0047-1

  • Li, Xian-Yang, Das, Indrajit, Lepletier, Ailin, Addala, Venkateswar, Bald, Tobias, Stannard, Kimberley, Barkauskas, Deborah, Liu, Jing, Aguilera, Amelia Roman, Takeda, Kazuyoshi, Braun, Matthias, Nakamura, Kyohei, Jacquelin, Sebastien, Lane, Steven W., Teng, Michele W.l., Dougall, William C. and Smyth, Mark J. (2018) CD155 loss enhances tumor suppression via combined host and tumor-intrinsic mechanisms. Journal of Clinical Investigation, 128 6: 2613-2625. doi:10.1172/JCI98769

  • Harjunpää, Heidi, Blake, Stephen J., Ahern, Elizabeth, Allen, Stacey, Liu, Jing, Yan, Juming, Lutzky, Viviana, Takeda, Kazuyoshi, Aguilera, Amy Roman, Guillerey, Camille, Mittal, Deepak, Li, Xian Yang, Dougall, William C., Smyth, Mark J. and Teng, Michele W. L. (2018) Deficiency of host CD96 and PD-1 or TIGIT enhances tumor immunity without significantly compromising immune homeostasis. OncoImmunology, 7 7: e1445949. doi:10.1080/2162402X.2018.1445949

  • Nakamura, Kyohei, Kassem, Sahar, Cleynen, Alice, Chrétien, Marie-Lorraine, Guillerey, Camille, Putz, Eva Maria, Bald, Tobias, Förster, Irmgard, Vuckovic, Slavica, Hill, Geoffrey R, Masters, Seth L, Chesi, Marta, Bergsagel, P Leif, Avet-Loiseau, Hervé, Martinet, Ludovic and Smyth, Mark J. (2018) Dysregulated IL-18 Is a Key Driver of Immunosuppression and a Possible Therapeutic Target in the Multiple Myeloma Microenvironment. Cancer Cell, 33 4: 634-648. doi:10.1016/j.ccell.2018.02.007

  • Ahern, Elizabeth, Harjunpää, Heidi, O'Donnell, Jake S., Allen, Stacey, Dougall, William C., Teng, Michele W. L. and Smyth, Mark J. (2018) RANKL blockade improves efficacy of PD1-PD-L1 blockade or dual PD1-PD-L1 and CTLA4 blockade in mouse models of cancer. OncoImmunology, 7 6: e1431088. doi:10.1080/2162402X.2018.1431088

  • Young, Arabella, Ngiow, Shin Foong, Gao, Yulong, Patch, Ann-Marie, Barkauskas, Deborah S., Messaoudene, Meriem, Lin, Gene, Coudert, Jerome D., Stannard, Kimberley A., Zitvogel, Laurence, Degli-Esposti, Mariapia A., Vivier, Eric, Waddell, Nicola, Linden, Joel, Huntington, Nicholas D., Souza-Fonseca-Guimaraes, Fernando and Smyth, Mark J. (2018) A2AR adenosine signaling suppresses natural killer cell maturation in the tumor microenvironment. Cancer Research, 78 4: 1003-1016. doi:10.1158/0008-5472.CAN-17-2826

  • Markey, Kate A., Kuns, Rachel D., Browne, Daniel J., Gartlan, Kate H., Robb, Renee J., Martins, J. Paulo, Henden, Andrea S., Minnie, Simone A., Cheong, Melody, Koyama, Motoko, Smyth, Mark J., Steptoe, Raymond J., Belz, Gabrielle, Brocker, Thomas, Degli-Esposti, Mariapia A., Lane, Steven W. and Hill, Geoffrey R. (2018) Flt-3L expansion of recipient CD8α+ dendritic cells deletes alloreactive donor T cells and represents an alternative to post-transplant cyclophosphamide for the prevention of GVHD. Clinical Cancer Research, 24 7: 1604-1616. doi:10.1158/1078-0432.CCR-17-2148

  • Jacquelot, N., Roberti, M.P., Enot, D.P., Rusakiewicz, S., Ternes, N., Jegou, S., Woods, D.M., Sodre, A.L., Hansen, M., Meirow, Y., Sade-Feldman, M., Burra, A., Kwek, S.S., Flament, C., Messaoudene, M., Duong, C.P.M., Chen, L., Kwon, B.S., Anderson, A.C., Kuchroo, V.K., Weide, B., Aubin, F., Borg, C., Dalle, S., Beatrix, O., Ayyoub, M., Balme, B., Tomasic, G., Di Giacomo, A.M., Maio, M., Schadendorf, D., Melero, I., Dreno, B., Khammari, A., Dummer, R., Levesque, M., Koguchi, Y., Fong, L., Lotem, M., Baniyash, M., Schmidt, H., Svane, I.M., Kroemer, G., Marabelle, A., Michiels, S., Cavalcanti, A., Smyth, M.J., Weber, J.S., Eggermont, A.M. and Zitvogel, L. (2017) Predictors of responses to immune checkpoint blockade in advanced melanoma. Nature Communications, 8 1: . doi:10.1038/s41467-017-00608-2

  • Guillerey, Camille and Smyth, Mark J (2017) Cytokine-driven role of Srebps in killer cell metabolism. Nature Immunology, 18 11: 1183-1184. doi:10.1038/ni.3855

  • Glodde, Nicole, Bald, Tobias, van den Boorn-Konijnenberg, Debby, Nakamura, Kyohei, O'Donnell, Jake S., Szczepanski, Sabrina, Brandes, Maria, Eickhoff, Sarah, Das, Indrajit, Shridhar, Naveen, Hinze, Daniel, Rogava, Meri, van der Sluis, Tetje C., Ruotsalainen, Janne J., Gaffal, Evelyn, Landsberg, Jennifer, Ludwig, Kerstin U., Wilhelm, Christoph, Riek-Burchardt, Monika, Müller, Andreas J., Gebhardt, Christoffer, Scolyer, Richard A., Long, Georgina V., Janzen, Viktor, Teng, Michele W. L., Kastenmüller, Wolfgang, Mazzone, Massimiliano, Smyth, Mark J., Tüting, Thomas and Hölzel, Michael (2017) Reactive Neutrophil Responses Dependent on the Receptor Tyrosine Kinase c-MET Limit Cancer Immunotherapy. Immunity, 47 4: 789-802. doi:10.1016/j.immuni.2017.09.012

  • Turcotte, Martin, Allard, David, Mittal, Deepak, Bareche, Yacine, Buisseret, Laurence, Jose, Vinu, Pommey, Sandra, Delisle, Vincent, Loi, Sherene, Joensuu, Heikki, Kellokumpu-Lehtinen, Pirkko-Liisa, Sotiriou, Christos, Smyth, Mark J. and Stagg, John (2017) CD73 promotes resistance to HER2/ErbB2 antibody therapy. Cancer Research, 77 20: 5652-5664. doi:10.1158/0008-5472.CAN-17-0707

  • Ahern, Elizabeth, Harjunpaa, Heidi, Barkauskas, Deborah, Allen, Stacey, Takeda, Kazuyoshi, Yagita, Hideo, Wyld, David, Dougall, William C., Teng, Michele W. L. and Smyth, Mark J. (2017) Co-administration of RANKL and CTLA4 Antibodies Enhances Lymphocyte-Mediated Antitumor Immunity in Mice. Clinical Cancer Research, 23 19: 5789-5801. doi:10.1158/1078-0432.CCR-17-0606

  • Reinhardt, Julia, Landsberg, Jennifer, Schmid-Burgk, Jonathan L., Ramis, Bartomeu Bibiloni, Bald, Tobias, Glodde, Nicole, Lopez-Ramos, Dorys, Young, Arabella, Ngiow, Shin Foong, Nettersheim, Daniel, Schorle, Hubert, Quast, Thomas, Kolanus, Waldemar, Schadendorf, Dirk, Long, Georgina V., Madore, Jason, Scolyer, Richard A., Ribas, Antoni, Smyth, Mark J., Tumeh, Paul C., Tueting, Thomas and Hoelzel, Michael (2017) MAPK signaling and inflammation link melanoma phenotype switching to induction of CD73 during immunotherapy. Cancer Research, 77 17: 4697-4709. doi:10.1158/0008-5472.CAN-17-0395

  • Young, Arabella, Ngiow, Shin Foong, Madore, Jason, Reinhardt, Julia, Landsberg, Jennifer, Chitsazan, Arash, Rautela, Jai, Bald, Tobias, Barkauskas, Deborah S., Ahern, Elizabeth, Huntington, Nicholas D., Schadendorf, Dirk, Long, Georgina V., Boyle, Glen M., Hoelzel, Michael, Scolyer, Richard A. and Smyth, Mark J. (2017) Targeting adenosine in BRAF-mutant melanoma reduces tumor growth and metastasis. Cancer Research, 77 17: 4684-4696. doi:10.1158/0008-5472.CAN-17-0393

  • Gao, Yulong, Souza-Fonseca-Guimaraes, Fernando, Bald, Tobias, Ng, Susanna S., Young, Arabella, Ngiow, Shin Foong, Rautela, Jai, Straube, Jasmin, Waddell, Nic, Blake, Stephen J., Yan, Juming, Bartholin, Laurent, Lee, Jason S., Vivier, Eric, Takeda, Kazuyoshi, Messaoudene, Meriem, Zitvogel-, Laurence, Teng, Michele W. L., Belz, Gabrielle T., Engwerda, Christian R., Huntington, Nicholas D., Nakamura, Kyohei, Hoelzel, Michael and Smyth, Mark J. (2017) Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cells. Nature Immunology, 18 9: 1004-1015. doi:10.1038/ni.3800

  • Casciello, Francesco, Al-Ejeh, Fares, Kelly, Greg, Brennan, Donal J., Ngiow, Shin Foong, Young, Arabella, Stoll, Thomas, Windloch, Karolina, Hill, Michelle M., Smyth, Mark J., Gannon, Frank and Lee, Jason S. (2017) G9a drives hypoxia-mediated gene repression for breast cancer cell survival and tumorigenesis. Proceedings of the National Academy of Sciences, 114 27: 7077-7082. doi:10.1073/pnas.1618706114

  • Putz, Eva M., Mayfosh, Alyce J., Kos, Kevin, Barkauskas, Deborah S., Nakamura, Kyohei, Town, Liam, Goodall, Katharine J., Yee, Dean Y., Poon, Ivan K. H., Baschuk, Nikola, Souza-Fonseca-Guimaraes, Fernando, Hulett, Mark D. and Smyth, Mark J. (2017) NK cell heparanase controls tumor invasion and immune surveillance. Journal of Clinical Investigation, 127 7: 2777-2788. doi:10.1172/JCI92958

  • Vijayan, Dipti, Barkauskas, Deborah S., Stannard, Kimberley, Sult, Erin, Buonpane, Rebecca, Takeda, Kazuyoshi, Teng, Michele W. L., Sachsenmeier, Kris, Hay, Carl and Smyth, Mark J. (2017) Selective activation of anti-CD73 mechanisms in control of primary tumors and metastases. OncoImmunology, 6 5: e1312044. doi:10.1080/2162402X.2017.1312044

  • Ambalathingal, George R., Francis, Ross S., Smyth, Mark J., Smith, Corey and Khanna, Rajiv (2017) BK polyomavirus: clinical aspects, immune regulation, and emerging therapies. Clinical Microbiology Reviews, 30 2: 503-528. doi:10.1128/CMR.00074-16

  • Smyth, Mark J. (2017) Multiple approaches to immunotherapy - the new pillar of cancer treatment. Immunology and Cell Biology, 95 4: 323-324. doi:10.1038/icb.2017.9

  • Nakamura, Kyohei and Smyth, Mark J. (2017) Targeting cancer-related inflammation in the era of immunotherapy. Immunology and Cell Biology, 95 4: 325-332. doi:10.1038/icb.2016.126

  • Dougall, William C., Kurtulus, Sema, Smyth, Mark J. and Anderson, Ana C. (2017) TIGIT and CD96: new checkpoint receptor targets for cancer immunotherapy. Immunological Reviews, 276 1: 112-120. doi:10.1111/imr.12518

  • Takeda, Kazuyoshi, Nakayama, Masafumi, Hayakawa, Yoshihiro, Kojima, Yuko, Ikeda, Hiroaki, Imai, Naoko, Ogasawara, Kouetsu, Okumura, Ko, Thomas, David M. and Smyth, Mark J. (2017) IFN-γ is required for cytotoxic T cell-dependent cancer genome immunoediting. Nature Communications, 8 14607. doi:10.1038/ncomms14607

  • Putz, Eva M., Guillerey, Camille, Kos, Kevin, Stannard, Kimberley, Miles, Kim, Delconte, Rebecca B, Takeda, Kazuyoshi, Nicholson, Sandra E., Huntington, Nicholas D. and Smyth, Mark J. (2017) Targeting cytokine signaling checkpoint CIS activates NK cells to protect from tumor initiation and metastasis. OncoImmunology, 6 2: e1267892. doi:10.1080/2162402X.2016.1267892

  • Bunting, Mark D., Varelias, Antiopi, Souza-Fonseca-Guimaraes, Fernando, Schuster, Iona S., Lineburg, Katie E., Kuns, Rachel D., Fleming, Peter, Locke, Kelly R., Huntington, Nicholas D., Blazar, Bruce R., Lane, Steven W., Tey, Siok-Keen, MacDonald, Kelli P. A., Smyth, Mark J., Degli-Esposti, Mariapia A. and Hill, Geoffrey R. (2017) GVHD prevents NK-cell-dependent leukemia and virus-specific innate immunity. Blood, 129 5: 630-642. doi:10.1182/blood-2016-08-734020

  • Overman, Jeroen, Fontaine, Frank, Moustaqil, Mehdi, Mittal, Deepak, Sierecki, Emma, Sacilotto, Natalia, Zuegg, Johannes, Robertson, Avril A. B., Holmes, Kelly, Salim, Angela A., Mamidyala, Sreeman, Butler, Mark S., Robinson, Ashley S., Lesieur, Emmanuelle, Johnston, Wayne, Alexandrov, Kirill, Black, Brian L., Hogan, Benjamin M., De Val, Sarah, Capon, Robert J., Carroll, Jason S., Bailey, Timothy L., Koopman, Peter, Jauch, Ralf, Smyth, Mark J., Cooper, Matthew A., Gambin, Yann and Francois, Mathias (2017) Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice. eLife, 6 . doi:10.7554/eLife.21221

  • O'Donnell, Jake S., Long, Georgina V., Scolyer, Richard A., Teng, Michele W. L. and Smyth, Mark J. (2017) Resistance to PD1/PDL1 checkpoint inhibition. Cancer Treatment Reviews, 52 71-81. doi:10.1016/j.ctrv.2016.11.007

  • Liu, Jing, Blake, Stephen J., Yong, Michelle C. R., Harjunpaa, Heidi, Ngiow, Shin Foong, Takeda, Kazuyoshi, Young, Arabella, O'Donnell, Jake S., Allen, Stacey, Smyth, Mark J. and Teng, Michele W. L. (2016) Improved efficacy of neoadjuvant compared to adjuvant immunotherapy to eradicate metastatic disease. Cancer Discovery, 6 12: 1382-1399. doi:10.1158/2159-8290.CD-16-0577

  • Zitvogel, Laurence, Pitt, Jonathan M., Daillere, Romain, Smyth, Mark J. and Kroemer, Guido (2016) Mouse models in oncoimmunology. Nature Reviews Cancer, 16 12: 759-773. doi:10.1038/nrc.2016.91

  • Samson, Andre L., Ho, Bosco, Au, Amanda E., Schoenwaelder, Simone M., Smyth, Mark J., Bottomley, Stephen P., Kleifeld, Oded and Medcalf, Robert L. (2016) Physicochemical properties that control protein aggregation also determine whether a protein is retained or released from necrotic cells. Open Biology, 6 11: . doi:10.1098/rsob.160098

  • Ngiow, Shin Foong, Young, Arabella, Blake, Stephen J., Hill, Geoffrey R., Yagita, Hideo, Teng, Michele W. L., Korman, Alan J. and Smyth, Mark J. (2016) Agonistic CD40 mAb-driven IL12 reverses resistance to anti-PD1 in a T-cell-rich tumor. Cancer Research, 76 21: 6266-6277. doi:10.1158/0008-5472.CAN-16-2141

  • Blake, Stephen J., Dougall, William C., Miles, John J., Teng, Michele W. L. and Smyth, Mark J. (2016) Molecular pathways: targeting CD96 and TIGIT for cancer immunotherapy. Clinical Cancer Research, 22 21: 5183-5188. doi:10.1158/1078-0432.CCR-16-0933

  • O'Donnell, Jake S., Smyth, Mark J. and Teng, Michele W. L. (2016) Acquired resistance to anti-PD1 therapy: checkmate to checkpoint blockade?. Genome Medicine, 8 1: 111. doi:10.1186/s13073-016-0365-1

  • Liu, Jing, Blake, Stephen J., Harjunpaa, Heidi, Fairfax, Kirsten A., Yong, Michelle C.R., Allen, Stacey, Kohrt, Holbrook E., Takeda, Kazuyoshi, Smyth, Mark J. and Teng, Michele W. L. (2016) Assessing immune-related adverse events of efficacious combination immunotherapies in preclinical models of cancer. Cancer Research, 76 18: 5288-5301. doi:10.1158/0008-5472.CAN-16-0194

  • Young, Arabella, Ngiow, Shin Foong, Barkauskas, Deborah S., Sult, Erin, Hay, Carl, Blake, Stephen J., Huang, Qihui, Liu, Jing, Takeda, Kazuyoshi, Teng, Michele W. L., Sachsenmeier, Kris and Smyth, Mark J. (2016) Co-inhibition of CD73 and A2AR adenosine signaling improves anti-tumor immune responses. Cancer Cell, 30 3: 391-403. doi:10.1016/j.ccell.2016.06.025

  • Guillerey, Camille, Huntington, Nicholas D. and Smyth, Mark J. (2016) Targeting natural killer cells in cancer immunotherapy. Nature Immunology, 17 9: 1025-1036. doi:10.1038/ni.3518

  • Mittal, Deepak, Sinha, Debottam, Barkauskas, Deborah, Young, Arabella, Kalimutho, Murugan, Stannard, Kimberley, Caramia, Franco, Haibe-Kains, Benjamin, Stagg, John, Khanna, Kum Kum, Loi, Sherene and Smyth, Mark J. (2016) Adenosine 2B receptor expression on cancer cells promotes metastasis. Cancer Research, 76 15: 4372-4382. doi:10.1158/0008-5472.CAN-16-0544

  • Souza-Fonseca-Guimaraes, Fernando, Blake, Stephen J., Makkouk, Amani, Chester, Cariad, Kohrt, Holbrook E. and Smyth, Mark J. (2016) Anti-CD137 enhances anti-CD20 therapy of systemic B-cell lymphoma with altered immune homeostasis but negligible toxicity. OncoImmunology, 5 7: e1192740. doi:10.1080/2162402X.2016.1192740

  • Delconte, Rebecca B., Kolesnik, Tatiana B., Dagley, Laura F., Rautela, Jai, Shi, Wei, Putz, Eva M., Stannard, Kimberley, Zhang, Jian-Guo, Teh, Charis, Firth, Matt, Ushiki, Takashi, Andoniou, Christopher E., Degli-Esposti, Mariapia A., Sharp, Phillip P., Sanvitale, Caroline E., Infusini, Giuseppe, Liau, Nicholas P. D., Linossi, Edmond M., Burns, Christopher J., Carotta, Sebastian, Gray, Daniel H. D., Seillet, Cyril, Hutchinson, Dana S., Belz, Gabrielle T., Webb, Andrew I., Alexander, Warren S., Li, Shawn S., Bullock, Alex N., Babon, Jeffery J., Smyth, Mark J., Nicholson, Sandra E. and Huntington, Nicholas D. (2016) CIS is a potent checkpoint in NK cell-mediated tumor immunity. Nature Immunology, 17 7: 816-824. doi:10.1038/ni.3470

  • Souza-Fonseca-Guimaraes, F., Krasnova, Y., Putoczki, T., Miles, K., MacDonald, K. P., Town, L., Shi, W., Gobe, G. C., McDade, L., Mielke, L. A., Tye, H., Masters, S. L., Belz, G. T., Huntington, N. D., Radford-Smith, G. and Smyth, M. J. (2016) Granzyme M has a critical role in providing innate immune protection in ulcerative colitis. Cell Death and Disease, 7 . doi:10.1038/cddis.2016.215

  • Austin, Rebecca, Smyth, Mark J. and Lane, Steven W. (2016) Harnessing the immune system in acute myeloid leukaemia. Critical Reviews in Oncology/Hematology, 103 62-77. doi:10.1016/j.critrevonc.2016.04.020

  • Smyth, Mark J., Yagita, Hideo and McArthur, Grant A. (2016) Combination Anti-CTLA-4 and Anti-RANKL in Metastatic Melanoma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 34 12: e104-e106. doi:10.1200/JCO.2013.51.3572

  • Smyth, Mark J., Yagita, Hideo and A. McArthur, Grant (2016) Combination anti-CTLA-4 and anti-RANKL in metastatic melanoma. Journal of Clinical Oncology, 34 12: e104-e106. doi:10.1200/JCO.2013.51.3572

  • Guillerey, Camille, Nakamura, Kyohei, Vuckovic, Slavica, Hill, Geoffrey R. and Smyth, Mark J. (2016) Immune responses in multiple myeloma: role of the natural immune surveillance and potential of immunotherapies. Cellular and Molecular Life Sciences, 73 8: 1569-1589. doi:10.1007/s00018-016-2135-z

  • Blake, Stephen J., Stannard, Kimberley, Liu, Jing, Allen, Stacey, Yong, Michelle C. R., Mittal, Deepak, Aguilera, Amelia Roman, Miles, John J., Lutzky, Viviana P., de Andrade, Lucas Ferrari, Martinet, Ludovic, Colonna, Marco, Takeda, Kazuyoshi, Kuhnel, Florian, Gurlevik, Engin, Bernhardt, Gunter, Teng, Michele W. L. and Smyth, Mark J. (2016) Suppression of metastases using a new lymphocyte checkpoint target for cancer immunotherapy. Cancer Discovery, 6 4: 446-459. doi:10.1158/2159-8290.CD-15-0944

  • Ngiow, Shin F., Meeth, Katrina M., Stannard, Kimberley, Barkauskas, Deborah S., Bollag, Gideon, Bosenberg, Marcus and Smyth, Mark J. (2016) Co-inhibition of colony stimulating factor-1 receptor and BRAF oncogene in mouse models of BRAFV600Emelanoma. OncoImmunology, 5 3: e1089381-1-e1089381-11. doi:10.1080/2162402X.2015.1089381

  • Dasari, Vijayendra, Schuessler, Andrea, Smith, Corey, Wong, Yide, Miles, John J., Smyth, Mark J., Ambalathingal, George, Francis, Ross, Campbell, Scott, Chambers, Daniel and Khanna, Rajiv (2016) Prophylactic and therapeutic adenoviral vector-based multivirus-specific T-cell immunotherapy for transplant patients. Molecular Therapy - Methods and Clinical Development, 3 16058: 16058. doi:10.1038/mtm.2016.58

  • Viel, Sebastien, Marcais, Antoine, Guimaraes, Fernando Souza-Fonseca, Loftus, Roisin, Rabilloud, Jessica, Grau, Morgan, Degouve, Sophie, Djebali, Sophia, Sanlaville, Amelien, Charrier, Emily, Bienvenu, Jacques, Marie, Julien C., Caux, Christophe, Marvel, Jacqueline, Town, Liam, Huntington, Nicholas D., Bartholin, Laurent, Finlay, David, Smyth, Mark J. and Walzer, Thierry (2016) TGF-beta inhibits the activation and functions of NK cells by repressing the mTOR pathway. Science Signaling, 9 415: . doi:10.1126/scisignal.aad1884

  • Restifo, Nicholas R., Smyth, Mark J. and Snyder, Alexandra (2016) Acquired resistance to immunotherapy and future challenges. Nature Reviews Cancer, 16 2: 121-126. doi:10.1038/nrc.2016.2

  • Barkauskas, Deborah S. and Smyth, Mark J. (2016) Irradiation and combination immunotherapy. Translational Cancer Research, 5 1: 75-78. doi:10.3978/j.issn.2218-676X.2016.01.12

  • Delconte, Rebecca B., Shi, Wei, Sathe, Priyanka, Ushiki, Takashi, Seillet, Cyril, Minnich, Martina, Kolesnik, Tatiana B., Rankin, Lucille C., Mielke, Lisa A., Zhang, Jian-Guo, Busslinger, Meinrad, Smyth, Mark J., Hutchinson, Dana S., Nutt, Stephen L., Nicholson, Sandra E., Alexander, Warren S., Corcoran, Lynn M., Vivier, Eric, Belz, Gabrielle, Carotta, Sebastian and Huntington, Nicholas D. (2016) The Helix-Loop-Helix Protein ID2 Governs NK Cell Fate by Tuning Their Sensitivity to Interleukin-15. Immunity, 44 1: 103-115. doi:10.1016/j.immuni.2015.12.007

  • Mittal, Deepak, Caramia, Franco, Michiels, Stefan, Joensuu, Heikki, Kellokumpu-Lehtinen, Pirkko-Liisa, Sotiriou, Christos, Loi, Sherene and Smyth, Mark J. (2016) Improved treatment of breast cancer with anti-HER2 therapy requires interleukin-21 signaling in CD8+ T cells. Cancer Research, 76 2: 264-274. doi:10.1158/0008-5472.CAN-15-1567

  • Ngiow, Shin Foong, Loi, Sherene, Thomas, David and Smyth, Mark J. (2016) Mouse models of tumor immunotherapy. Advances in Immunology, 130 1-24. doi:10.1016/bs.ai.2015.12.004

  • Kurtulus, Sema, Sakuishi, Kaori, Ngiow, Shin-Foong, Joller, Nicole, Tan, Dewar J., Teng, Michele W. L., Smyth, Mark J., Kuchroo, Vijay K. and Anderson, Ana C. (2015) TIGIT predominantly regulates the immune response via regulatory T cells. Journal of Clinical Investigation, 125 11: 4053-4062. doi:10.1172/JCI81187

  • Kara, Ervin E., McKenzie, Duncan R., Bastow, Cameron R., Gregor, Carly E., Fenix, Kevin A., Ogunniyi, Abiodim D., Paton, James C., Mack, Matthias, Pombal, Diana R., Seillet, Cyrill, Dubois, Benedocte, Liston, Adrian, Macdonald, Kelli P. A., Belz, Gabrielle T., Smyth, Mark J., Hill, Geoffrey R., Comerford, Iain and McColl, Shaun R. (2015) CCR2 defines in vivo development and homing of IL-23-driven GM-CSF-producing Th17 cells. Nature Communications, 6 . doi:10.1038/ncomms9644

  • Krasnova, Yelena, Putz, Eva Maria, Smyth, Mark J. and Souza-Fonseca-Guimaraes, Fernando (2015) Bench to bedside: NK cells and control of metastasis. Clinical Immunology, 177 50-59. doi:10.1016/j.clim.2015.10.001

  • Huntington, Nicholas D., Martinet, Ludovic and Smyth, Mark J. (2015) DNAM-1: would the real natural killer cell please stand up!. Oncotarget, 6 30: 28537-28538. doi:10.18632/oncotarget.5952

  • Gartlan, Kate H., Markey, Kate A., Varelias, Antiopi, Bunting, Mark D., Koyama, Motoko, Kuns, Rachel D., Raffelt, Neil C., Olver, Stuart D., Lineburg, Katie E., Cheong, Melody, Teal, Bianca E., Lor, Mary, Comerford, Iain, Teng, Michele W. L., Smyth, Mark J., McCluskey, James, Rossjohn, Jamie, Stockinger, Brigitta, Boyle, Glen M., Lane, Steven W., Clouston, Andrew D., McColl, Shaun R., MacDonald, Kelli P. A. and Hill, Geoffrey R. (2015) Tc17 cells are a proinflammatory, plastic lineage of pathogenic CD8<sup>+</sup> T cells that induce GVHD without antileukemic effects. Blood, 126 13: 1609-1620. doi:10.1182/blood-2015-01-622662

  • Ngiow, Shin Foong, Young, Arabella, Jacquelot, Nicolas, Yamazaki, Takahiro, Enot, David, Zitvogel, Laurence and Smyth, Mark J. (2015) A threshold level of intratumor CD8<sup>+</sup> T-cell PD1 expression dictates therapeutic response to anti-PD1. Cancer Research, 75 18: 3800-3811. doi:10.1158/0008-5472.CAN-15-1082

  • Teng, Michele W. L., Galon, Jerome, Fridman, Wolf-Herman and Smyth, Mark J. (2015) From mice to humans: Developments in cancer immunoediting. Journal of Clinical Investigation, 125 9: 3338-3346. doi:10.1172/JCI80004

  • Coquet, Jonathan M., Schuijs, Martijn J., Smyth, Mark J., Deswarte, Kim, Beyaert, Rudi, Braun, Harald, Boon, Louis, Hedestam, Gunilla B. Karlsson, Nutt, Steven L., Hammad, Hamida and Lambrecht, Bart N. (2015) Interleukin-21-producing CD4+ T cells promote type 2 immunity to house dust mites. Immunity, 43 2: 318-330. doi:10.1016/j.immuni.2015.07.015

  • Koyama, Motoko, Cheong, Melody, Markey, Kate A., Gartlan, Kate H., Kuns, Rachel D., Locke, Kelly R., Lineburg, Katie E., Teal, Bianca E., Leveque-El Mouttie, Lucie, Bunting, Mark D., Vuckovic, Slavica, Zhang, Ping, Teng, Michele W. L., Varelias, Antiopi, Tey, Siok-Keen, Wockner, Leesa F., Engwerda, Christian R., Smyth, Mark J., Belz, Gabrielle T., McColl, Shaun R., MacDonald, Kelli P. A. and Hill, Geoffrey R. (2015) Donor colonic CD103(+) dendritic cells determine the severity of acute graft-versus-host disease. Journal of Experimental Medicine, 212 8: 1303-1321. doi:10.1084/jem.20150329

  • Zitvogel, Laurence, Galluzzi, Lorenzo, Kepp, Oliver, Smyth, Mark J. and Kroemer, Guido (2015) Type I interferons in anticancer immunity. Nature Reviews Immunology, 15 7: 405-414. doi:10.1038/nri3845

  • Teng, Michele W. L., Bowman, Edward P., McElwee, Joshua J., Smyth, Mark J., Casanova, Jean-Laurent, Cooper, Andrea M. and Cua, Daniel J. (2015) IL-12 and IL-23 cytokines: from discovery to targeted therapies for immune-mediated inflammatory diseases. Nature Medicine, 21 7: 719-729. doi:10.1038/nm.3895

  • Teng, Michele W. L., Ngiow, Shin Foong, Ribas, Antoni and Smyth, Mark J. (2015) Classifying cancers based on T-cell infiltration and PD-L1. Cancer Research, 75 11: 2139-2145. doi:10.1158/0008-5472.CAN-15-0255

  • Souza-Fonseca-Guimaraes, Fernando, Young, Arabella, Mittal, Deepak, Martinet, Ludovic, Bruedigam, Claudia, Takeda, Kazuyoshi, Andoniou, Christopher E., Degli-Esposti, Mariapia A., Hill, Geoffrey R. and Smyth, Mark J. (2015) NK cells require IL-28R for optimal in vivo activity. Proceedings of the National Academy of Sciences of the United States of America, 112 18: E2376-E2384. doi:10.1073/pnas.1424241112

  • Guillerey, Camille, de Andrade, Lucas Ferrari, Vuckovic, Slavica, Miles, Kim, Ngiow, Shin Foong, Yong, Michelle C. R., Teng, Michele W. L., Colonna, Marco, Ritchie, David S., Chesi, Martha, Bergsagel, P. Leif, Hill, Geoffrey R., Smyth, Mark J. and Martinet, Ludovic (2015) Immunosurveillance and therapy of multiple myeloma are CD226 dependent. Journal of Clinical Investigation, 125 5: 2077-2089. doi:10.1172/JCI77181

  • Ngiow, Shin Foong, McArthur, Grant A. and Smyth, Mark J. (2015) Radiotherapy complements immune checkpoint blockade. Cancer Cell, 27 4: 437-438. doi:10.1016/j.ccell.2015.03.015

  • Martinet, Ludovic, FerrariDeAndrade, Lucas, Guillerey, Camille, Lee, Jason S, Liu, Jing, Souza-Fonseca-Guimaraes, Fernando, Hutchinson, Dana S, Kolesnik, Tatiana B, Nicholson, Sandra E, Huntington, Nicholas D and Smyth, Mark J (2015) DNAM-1 Expression Marks an Alternative Program of NK Cell Maturation. Cell Reports, 11 1: 85-97. doi:10.1016/j.celrep.2015.03.006

  • Martinet, Ludovic and Smyth, Mark J. (2015) Balancing natural killer cell activation through paired receptors. Nature Reviews Immunology, 15 4: 243-254. doi:10.1038/nri3799

  • Paget, C., Chow, M. T., Gherardin, N. A., Beavis, P. A., Uldrich, A. P., Duret, H., Hassane, M., Souza-Fonseca-Guimaraes, F., Mogilenko, D. A., Staumont-Salle, D., Escalante, N. K., Hill, G. R., Neeson, P., Ritchie, D. S., Dombrowicz, D., Mallevaey, T., Trottein, F., Belz, G. T., Godfrey, D. I. and Smyth, M. J. (2015) CD3 bright signals on γδ T cells identify IL-17A-producing Vγ6Vδ1+T cells. Immunology and Cell Biology, 93 2: 198-212. doi:10.1038/icb.2014.94

  • Hannani, Dalil, Vetizou, Marie, Enot, David, Rusakiewicz, Sylvie, Chaput, Nathalie, Klatzmann, David, Desbois, Melanie, Jacquelot, Nicolas, Vimond, Nadege, Chouaib, Salem, Mateus, Christine, Allison, James P., Ribas, Antoni, Wolchok, Jedd D., Yuan, Jianda, Wong, Philip, Postow, Michael, Mackiewicz, Andrzej, Mackiewicz, Jacek, Schadendorff, Dirk, Jaeger, Dirk, Korman, Alan J., Bahjat, Keith, Maio, Michele, Calabro, Luana, Teng, Michele W. L., Smyth, Mark J., Eggermont, Alexander, Robert, Caroline, Kroemer, Guido and Zitvogel, Laurence (2015) Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25. Cell Research, 25 2: 208-224. doi:10.1038/cr.2015.3

  • Li, Yi, To, Kelly, Kanellakis, Peter, Hosseini, Hamid, Deswaerte, Virginie, Tipping, Peter, Smyth, Mark J., Toh, Ban-Hock, Bobik, Alexander and Kyaw, Tin (2015) CD4+ natural killer T cells potently augment aortic root atherosclerosis by perforin-and granzyme B-dependent cytotoxicity. Circulation Research, 116 2: 245-254. doi:10.1161/CIRCRESAHA.116.304734

  • Ullah, Md Ashik, Revez, Joana A., Loh, Zhixuan, Simpson, Jennifer, Zhang, Vivian, Bain, Lisa, Varelias, Antiopi, Rose-John, Stefan, Blumenthal, Antje, Smyth, Mark J., Hill, Geoffrey R., Sukkar, Manuel A. R, Ferreira M. A. R. and Phipps, Simon (2015) Allergen-induced IL-6 trans-signaling activates γδ T cells to promote type 2 and type 17 airway inflammation. Journal of Allergy and Clinical Immunology, 136 4: 1065-1073. doi:10.1016/j.jaci.2015.02.032

  • Neeson, Paul J., Hsu, Andy K., Chen, Yin R., Halse, Heloise M., Loh, Joanna, Cordy, Reece, Fielding, Kate, Davis, Joanne, Noske, Josh, Davenport, Alex J., Lindqvist-Gigg, Camilla A., Humphreys, Robin, Tai, Tsin, Prince, H. Miles, Trapani, Joseph A., Smyth, Mark J. and Ritchie, David S. (2015) Induction of potent NK cell-dependent anti-myeloma cytotoxic T cells in response to combined mapatumumab and bortezomib. Oncoimmunology, 4 9: 1-16. doi:10.1080/2162402X.2015.1038011

  • de Andrade, Lucas Ferrari, Ngiow, Shin Foong, Martinet, Ludovic and Smyth, Mark J. (2015) Natural Killer cell control of BRAFV600E mutant melanoma during targeted therapy. Oncoimmunology, 4 4: 1-3. doi:10.1080/2162402X.2014.998119

  • Guillerey, Camille, Chow, Melvyn T., Miles, Kim, Olver, Stuart, Sceneay, Jaclyn, Takeda, Kazuyoshi, Möller, Andreas and Smyth, Mark J. (2015) Toll-like receptor 3 regulates NK cell responses to cytokines and controls experimental metastasis. Oncoimmunology, 4 9: 1-11. doi:10.1080/2162402X.2015.1027468

  • de Andrade, Lucas Ferrari, Ngiow, Shin F., Stannard, Kimberly, Rusakiewicz, Sylvie, Kalimutho, Murugan, Khanna, Kum Kum, Tey, Siok-Keen, Takeda, Kazyuoshi, Zitvogel, Laurence, Martinet, Ludovic and Smyth, Mark J. (2014) Natural killer cells are essential for the ability of BRAF inhibitors to control BRAFV600E-mutant metastatic melanoma. Cancer Research, 74 24: 7298-7308. doi:10.1158/0008-5472.CAN-14-1339

  • Galluzzi, Lorenzo, Vacchelli, Erika, Bravo-San Pedro, Jose-Manuel, Buque, Aitziber, Senovilla, Laura, Baracco, Elisa Elena, Bloy, Norma, Castoldi, Francesca, Abastado, Jean-Pierre, Agostinis, Patrizia, Apte, Ron N., Aranda, Fernando, Ayyoub, Maha, Beckhove, Philipp, Blay, Jean-Yves, Bracci, Laura, Caignard, Anne, Castelli, Chiara, Cavallo, Federica, Celis, Estaban, Cerundolo, Vincenzo, Clayton, Aled, Colombo, Mario P., Coussens, Lisa, Dhodapkar, Madhav V., Eggermont, Alexander M., Fearon, Douglas T., Fridman, Wolf H., Fucikova, Jitka, Gabrilovich, Dmitry I., Galon, Jerome, Garg, Abhishek, Ghiringhelli, Francois, Giaccone, Giuseppe, Gilboa, Eli, Gnjatic, Sacha, Hoos, Axel, Hosmalin, Anne, Jaeger, Dirk, Kalinski, Pawel, Kaerre, Klas, Kepp, Oliver, Kiessling, Rolf, Kirkwood, John M., Klein, Eva, Knuth, Alexander, Lewis, Claire E., Liblau, Roland, Lotze, Michael T., Lugli, Enrico, Mach, Jean-Pierre, Mattei, Fabrizio, Mavilio, Domenico, Melero, Ignacio, Melief, Cornelis J., Mittendorf, Elizabeth A., Moretta, Lorenzo, Odunsi, Adekunke, Okada, Hideho, Palucka, Anna Karolina, Peter, Marcus E., Pienta, Kenneth J., Porgador, Angel, Prendergast, George C., Rabinovich, Gabriel A., Restifo, Nicholas P., Rizvi, Naiyer, Sautes-Fridman, Catherine, Schreiber, Hans, Seliger, Barbara, Shiku, Hiroshi, Silva-Santos, Bruno, Smyth, Mark J., Speiser, Daniel E., Spisek, Radek, Srivastava, Pramod K., Talmadge, James E., Tartour, Eric, Van der Burg, Sjoerd H., Van den Eynde, Benoit J., Vile, Richard, Wagner, Hermann, Weber, Jeffrey S., Whiteside, Theresa L., Wolchok, Jedd D., Zitvogel, Laurence, Zou, Weiping and Kroemer, Guido (2014) Classification of current anticancer immunotherapies. Oncotarget, 5 24: 12472-12508. doi:10.18632/oncotarget.2998

  • Holmes, Melissa L., Huntington, Nicholas D., Thong, Rebecca P. L., Brady, Jason, Hayakawa, Yoshihiro, Andoniou, Christopher E., Fleming, Peter, Shi, Wei, Smyth, Gordon K., Degli-Esposti, Mariapia A., Belz, Gabrielle T., Kallies, Axel, Carotta, Sebastian, Smyth, Mark J. and Nutt, Stephen L. (2014) Peripheral natural killer cell maturation depends on the transcription factor Aiolos. EMBO Journal, 33 22: 2721-2734. doi:10.15252/embj.201487900

  • Sistigu, Antonella, Yamazaki, Takahiro, Vacchelli, Erika, Chaba, Kariman, Enot, David P., Adam, Julien, Vitale, Ilio, Goubar, Aicha, Baracco, Elisa E., Remedios, Catarina, Fend, Laetitia, Hannani, Dalil, Aymeric, Laetitia, Ma, Yuting, Niso-Santano, Mireia, Kepp, Oliver, Schultze, Joachim L., Tueting, Thomas, Belardelli, Filippo, Bracci, Laura, La Sorsa, Valentina, Ziccheddu, Giovanna, Sestili, Paola, Urbani, Francesca, Delorenzi, Mauro, Lacroix-Triki, Magali, Quidville, Virginie, Conforti, Rosa, Spano, Jean-Philippe, Pusztai, Lajos, Poirier-Colame, Vichnou, Delaloge, Suzette, Penault-Llorca, Frederique, Ladoire, Sylvain, Arnould, Laurent, Cyrta, Joanna, Dessoliers, Marie-Charlotte, Eggermont, Alexander, Bianchi, Marco E., Pittet, Mikael, Engblom, Camilla, Pfirschke, Christina, Preville, Xavier, Uze, Gilles, Schreiber, Robert D., Chow, Melvyn T., Smyth, Mark J., Proietti, Enrico, Andre, Fabrice, Kroemer, Guido and Zitvogel, Laurence (2014) Cancer cell-autonomous contribution of type I interferon signaling to the efficacy of chemotherapy. Nature Medicine, 20 11: 1301-1309. doi:10.1038/nm.3708

  • Young, Arabella, Mittal, Deepak, Stannard, Kimberley, Yong, Michelle, Teng, Michele W. L., Allard, Bertrand, Stagg, John and Smyth, Mark J. (2014) Co-blockade of immune checkpoints and adenosine A(2A) receptor suppresses metastasis. Oncoimmunology, 3 10: e958952-1-e958952-3. doi:10.4161/21624011.2014.958952

  • Harata-Lee, Yuka, Turvey, Michelle E., Brazzatti, Julie A., Gregor, Carly E., Brown, Michael P., Smyth, Mark J., Comerford, Iain and McColl, Shaun R. (2014) The atypical chemokine receptor CCX-CKR regulates metastasis of mammary carcinoma via an effect on EMT. Immunology and Cell Biology, 92 10: 815-824. doi:10.1038/icb.2014.58

  • Kansara, Maya, Teng, Michele W., Smyth, Mark J. and Thomas, David M. (2014) Translational biology of osteosarcoma. Nature Reviews Cancer, 14 11: 722-735. doi:10.1038/nrc3838

  • Schuster, Iona S., Wikstrom, Matthew E., Brizard, Geraldine, Coudert, Jerome D., Estcourt, Marie J., Manzur, Mitali, O'Reilly, Lorraine A., Smyth, Mark J., Trapani, Joseph A., Hill, Geoffrey R., Andoniou, Christopher E. and Degli-Esposti, Mariapia A. (2014) TRAIL+ NK Cells Control CD4+ T Cell Responses during Chronic Viral Infection to Limit Autoimmunity. Immunity, 41 4: 646-656. doi:10.1016/j.immuni.2014.09.013

  • Kepp, Oliver., Senovilla, Laura., Vitale, Ilio., Vacchelli, Erika., Adjemian, Sandy., Agostinis, Patrizia., Apetoh, Lionel., Aranda, Fernando., Barnaba, Vincenzo., Bloy, Norma., Bracci, Laura., Breckpot, Karine., Brough, David., Buque, Aitziber., Castro, Maria G., Cirone, Mara., Colombo, Maria I., Cremer, Isabelle., Demaria, Sandra., Dini, Luciana., Eliopoulos, Aristides G., Faggioni, Alberto., Formenti, Silvia C., Fucikova, Jitka., Gabriele, Lucia., Gaipl, Udo S., Galon, Jerome., Garg, Abhishek., Ghiringhelli, Francois., Giese, Nathalia A., Guo, Zong Sheng, Hemminki, Akseli., Herrmann, Martin., Hodge, James W., Holdenrieder, Stefan., Honeychurch, Jamie., Hu, Hong-Min., Huang, Xing., Illidge, Tim M., Kono, Koji., Korbelik, Mladen., Krysko, Dmitri C., Loi, Sherene., Lowenstein, Pedro R., Lugli. Enrico., Ma, Yuting., Madeo, Frank., Manfredi, Angelo A., Martins, Isabelle., Mavilio, Domenico., Menger, Laurie., Merendino, Nicolo., Michaud, Michael., Mignot, Gregoire., Mossman, Karen L., Multhoff, Gabriele., Oehler, Rudolf., Palombo, Fabio., Panaretakis, Theocharis., Pol, Jonathan., Proietti, Enrico., Ricci, Jean-Ehrland., Riganti, Chiara., Rovere-Querini, Patrizia., Rubartelli, Anna., Sistigu, Antonella., Smyth, Mark J., Sonnemann, Juergen., Spisek, Radek., Stagg, John., Sukkurwala, Abdul Qader., Tartour, Eric., Thorburn, Andrew., Thorne, Stephen H., Vandenabeele, Peter., Velotti, Francesca., Workenhe, Samuel T., Yang, Haining., Zong, Wei-Xing., Zitvogel, Laurence., Kroemer, Guido. and Galluzzi, Lorenzo. (2014) Consensus guidelines for the detection of immunogenic cell death. OncoImmunology, 3 9: e955691. doi:10.4161/21624011.2014.955691

  • Sathe, Priyanka, Delconte, Rebecca B., Souza-Fonseca-Guimaraes, Fernando, Seillet, Cyril, Chopin, Michael, Vandenberg, Cassandra J., Rankin, Lucille C., Mielke, Lisa A., Vikstrom, Ingela, Kolesnik, Tatiana B., Nicholson, Sandra E., Vivier, Eric, Smyth, Mark J., Nutt, Stephen L., Glaser, Stefan P., Strasser, Andreas, Belz, Gabrielle T., Carotta, Sebastian and Huntington, Nicholas D. (2014) Innate immunodeficiency following genetic ablation of Mcl1 in natural killer cells. Nature Communications, 5 1: 1-10. doi:10.1038/ncomms5539

  • Liu, Jing, Blake, Stephen J, Smyth, Mark J. and Teng, Michele Wl (2014) Improved mouse models to assess tumour immunity and irAEs after combination cancer immunotherapies. Clinical and Translational Immunology , 3 8: . doi:10.1038/cti.2014.18

  • Young, Arabella, Mittal, Deepak, Stagg, John and Smyth, Mark J. (2014) Targeting cancer-derived adenosine: new therapeutic approaches. Cancer Discovery, 4 8: 879-888. doi:10.1158/2159-8290.CD-14-0341

  • Loi, S., Michiels, S., Salgado, R., Sirtaine, N., Jose, V., Fumagalli, D., Kellokumpu-Lehtinen, P.-L., Bono, P., Kataja, V., Desmedt, C., Piccart, M. J., Loibl, S., Denkert, C., Smyth, M. J., Joensuu, H. and Sotiriou, C. (2014) Tumor infiltrating lymphocytes are prognostic in triple negative breast cancer and predictive for trastuzumab benefit in early breast cancer: results from the FinHER trial. Annals of Oncology, 25 8: 1544-1550. doi:10.1093/annonc/mdu112

  • Mittal, Deepak, Young, Arabella, Stannard, Kimberley, Yong, Michelle, Teng, Michele W. L., Allard, Bertrand, Stagg, John and Smyth, Mark J. (2014) Antimetastatic effects of blocking PD-1 and the adenosine A2A receptor. Cancer Research, 74 14: 3652-3658. doi:10.1158/0008-5472.CAN-14-0957

  • Chow, Melvyn T., Duret, Helene, Andrews, Daniel M., Faveeuw, Christelle, Moller, Andreas, Smyth, Mark J. and Paget, Christophe (2014) Type I NKT-cell-mediated TNF-α is a positive regulator of NLRP3 inflammasome priming. European Journal of Immunology, 44 7: 2111-2120. doi:10.1002/eji.201344329

  • Macagno, Marco, Bandini, Silvio, Stramucci, Lorenzo, Quaglino, Elena, Conti, Laura, Balmas, Elisa, Smyth, Mark J., Lollini, Pier-Luigi, Musiani, Piero, Forni, Guido, Iezzi, Manuela and Cavallo, Federica (2014) Multiple roles of perforin in hampering ERBB-2 (Her-2/neu) carcinogenesis in transgenic male mice. Journal of Immunology, 192 11: 5434-5441. doi:10.4049/jimmunol.1301248

  • Von Scheidt, Bianca, Leung, Patrick S.K., Yong, Michelle C.R., Zhang, Yu, Towne, Jennifer E., Smyth, Mark J. and Teng, Michele W.L. (2014) Combined anti-CD40 and anti-IL-23 monoclonal antibody therapy effectively suppresses tumor growth and metastases. Cancer Research, 74 9: 2412-2421. doi:10.1158/0008-5472.CAN-13-1646

  • Smyth, Mark J. and Teng, Michele W. L. (2014) Targeting the IL-12/IL-23 axis: an alternative approach to removing tumor induced immune suppression. Oncoimmunology, 3 e28964.1-e28964.2. doi:10.4161/onci.28964

  • Poon, Ivan K. H., Goodall, Katharine J., Phipps, Simon, Chow, Jenny D. Y., Pagler, Eloisa B., Andrews, Daniel M., Conlan, Carly L., Ryan, Gemma F., White, Julie A., Wong, Michael K. L., Horan, Catherine, Matthaei, Klaus I., Smyth, Mark J. and Hulett, Mark D. (2014) Mice deficient in heparanase exhibit impaired dendritic cell migration and reduced airway inflammation. European Journal of Immunology, 44 4: 1016-1030. doi:10.1002/eji.201343645

  • Mittal, Deepak, Gubin, Matthew M., Schreiber, Robert D. and Smyth, M. J. (2014) New insights into cancer immunoediting and its three component phases-elimination, equilibrium and escape. Current Opinion in Immunology, 27 1: 16-25. doi:10.1016/j.coi.2014.01.004

  • Seillet C., Huntington N.D., Gangatirkar P., Axelsson E., Minnich M., Brady H.J.M., Busslinger M., Smyth M.J., Belz G.T. and Carotta S. (2014) Differential requirement for Nfil3 during NK cell development. Journal of Immunology, 192 6: 2667-2676. doi:10.4049/jimmunol.1302605

  • Baschuk, N., Wang, N., Watt, S. V., Halse, H., House, C., Bird, P. I., Strugnell, R., Trapani, J. A., Smyth, M. J. and Andrews, D. M. (2014) NK cell intrinsic regulation of MIP-1α by granzyme M. Cell Death and Disease, 5 3: . doi:10.1038/cddis.2014.74

  • de Andrade, Lucas Ferrari, Smyth, Mark J and Martinet, Ludovic (2014) DNAM-1 control of natural killer cells functions through nectin and nectin-like proteins. Immunology and Cell Biology, 92 3: 237-244. doi:10.1038/icb.2013.95

  • Afshar-Sterle, Shoukat, Zotos, Dimitra, Bernard, Nicholas J., Scherger, Anna K., Roedling, Lisa, Alsop, Amber E., Walker, Jennifer, Masson, Frederick, Belz, Gabrielle T., Corcoran, Lynn M., O'Reilly, Lorraine A., Strasser, Andreas, Smyth, Mark J., Johnstone, Ricky, Tarlinton, David M., Nutt, Stephen L. and Kallies, Axel (2014) Fas ligand-mediated immune surveillance by T cells is essential for the control of spontaneous B cell lymphomas. Nature Medicine, 20 3: 283-290. doi:10.1038/nm.3442

  • Ma, Yuting, Mattarollo, Stephen R., Adjemian, Sandy, Yang, Heng, Aymeric, Laetitia, Hannani, Dalil, Portela Catani, Joao Paulo, Duret, Helene, Teng, Michele W. L., Kepp, Oliver, Wang, Yidan, Sistigu, Antonella, Schultze, Joachim L., Stoll, Gautier, Galluzzi, Lorenzo, Zitvogel, Laurence, Smyth, Mark J. and Kroemer, Guido (2014) CCL2/CCR2-dependent recruitment of functional antigen-presenting cells into tumors upon chemotherapy. Cancer Research, 74 2: 436-445. doi:10.1158/0008-5472.CAN-13-1265

  • Ramsbottom, Kelly M., Hawkins, Edwin D., Shimoni, Raz, McGrath, Mairi, Chan, Christopher J., Russell, Sarah M., Smyth, Mark J. and Oliaro, Jane (2014) Cutting edge: DNAX accessory molecule 1-deficient CD8+ T cells display immunological synapse defects that impair antitumor immunity. Journal of Immunology, 192 2: 553-557. doi:10.4049/jimmunol.1302197

  • Teng, Michele W. L. and Smyth, Mark J. (2014) Can cancer trigger autoimmunity?. Science, 343 6167: 147-148. doi:10.1126/science.1249486

  • Hannani, D., Locher, C., Yamazaki, T., Colin-Minard, V., Vetizou, M., Aymeric, L., Viaud, S., Sanchez, D., Smyth, M. J., Bruhns, P., Kroemer, G. and Zitvogel, L. (2014) Contribution of humoral immune responses to the antitumor effects mediated by anthracyclines. Cell Death and Differentiation, 21 1: 50-58. doi:10.1038/cdd.2013.60

  • Chan, C. J., Smyth, M. J. and Martinet, L. (2014) Molecular mechanisms of natural killer cell activation in response to cellular stress. Cell Death and Differentiation, 21 1: 5-14. doi:10.1038/cdd.2013.26

  • West, Alison C., Smyth, Mark J. and Johnstone, Ricky W. (2014) The anticancer effects of HDAC inhibitors require the immune system. OncoImmunology, 3 1: 1-3. doi:10.4161/onci.27414

  • Bird, C. H., Christensen, M. E., Mangan, M. S. J., Prakash, M. D., Sedelies, K. A., Smyth, M. J., Harper, I., Waterhouse, N. J. and Bird, P. I. (2014) The granzyme B-Serpinb9 axis controls the fate of lymphocytes after lysosomal stress. Cell Death and Differentiation, 21 6: 876-887. doi:10.1038/cdd.2014.7

  • Chan, Christopher J., Martinet, Ludovic, Gilfillan, Susan, Souza-Fonseca-Guimaraes, Fernando, Chow, Melvyn T., Town, Liam, Ritchie, David S., Colonna, Marco, Andrews, Daniel M. and Smyth, Mark J. (2014) The receptors CD96 and CD226 oppose each other in the regulation of natural killer cell functions. Nature Immunology, 15 5: 431-438. doi:10.1038/ni.2850

  • Devaud, Christel, Westwood, Jennifer A., John, Liza B., Flynn, Jacqueline K., Paquet-Fifield, Sophie, Duong, Connie P. M., Yong, Carmen S. M., Pegram, Hollie J., Stacker, Steven A., Achen, Marc G., Stewart, Trina J., Snyder, Linda A., Teng, Michele W. L., Smyth, Mark J., Darcy, Phillip K. and Kershaw, Michael H. (2014) Tissues in different anatomical sites can sculpt and vary the tumor microenvironment to affect responses to therapy. Molecular Therapy, 22 1: 18-27. doi:10.1038/mt.2013.219

  • West, Alison C., Mattarollo, Stephen R., Shortt, Jake, Cluse, Leonie A., Christiansen, Ailsa J., Smyth, Mark J. and Johnstone, Ricky W. (2013) An intact immune system is required for the anticancer activities of histone deacetylase inhibitors. Cancer Research, 73 24: 7265-7276. doi:10.1158/0008-5472.CAN-13-0890

  • Beavis, Paul A., Milenkovski, Nicole, Stagg, John, Smyth, Mark J. and Darcy, Phillip K. (2013) A(2A) blockade enhances anti-metastatic immune responses. Oncoimmunology, 2 12: 1-3. doi:10.4161/onci.26705

  • John, Liza B., Devaud, Christel, Duong, Connie P. M., Yong, Carmen S., Beavis, Paul A., Haynes, Nicole M., Chow, Melvyn T., Smyth, Mark J., Kershaw, Michael H. and Darcy, Phillip K. (2013) Anti-PD-1 antibody therapy potently enhances the eradication of established tumors by gene-modified T cells. Clinical Cancer Research, 19 20: 5636-5646. doi:10.1158/1078-0432.CCR-13-0458

  • Coquet, Jonathan M., Skak, Kresten, Davis, Ian D., Smyth, Mark J. and Godfrey, Dale I. (2013) IL-21 Modulates Activation of NKT Cells in Patients with Stage IV Malignant Melanoma. Clinical and Translational Immunology, 2 10: e6. doi:10.1038/cti.2013.7

  • Messina, Nicole L., Banks, Kellie M., Vidacs, Eva, Martin, Ben P., Long, Fennella, Christiansen, Ailsa J., Smyth, Mark J., Clarke, Christopher J. P. and Johnstone, Ricky W. (2013) Modulation of antitumour immune responses by intratumoural Stat1 expression. Immunology and Cell Biology, 91 9: 556-567. doi:10.1038/icb.2013.41

  • Allard, Bertrand, Pommey, Sandra, Smyth, Mark J. and Stagg, John (2013) Targeting CD73 enhances the antitumor activity of anti-PD-1 and anti-CTLA-4 mAbs. Clinical Cancer Research, 19 20: 5626-5635. doi:10.1158/1078-0432.CCR-13-0545

  • Beavis, Paul A., Divisekera, Upulie, Paget, Christophe, Chow, Melvyn T., John, Liza B., Devaud, Christel, Dwyer, Karen, Stagg, John, Smyth, Mark J. and Darcy, Phillip K. (2013) Blockade of A(2A) receptors potently suppresses the metastasis of CD73(+) tumors. Proceedings of the National Academy of Sciences of the United States of America, 110 36: 14711-14716. doi:10.1073/pnas.1308209110

  • Souza-Fonseca-Guimaraes, Fernando and Smyth, Mark J. (2013) In the spotlight: myeloid TGF-beta responsiveness promotes metastases. Cancer Discovery, 3 8: 846-848. doi:10.1158/2159-8290.CD-13-0271

  • Kershaw, Michael H. and Smyth, Mark J. (2013) Making macrophages eat cancer. Science, 341 6141: 41-42. doi:10.1126/science.1241716

  • Loi, Sherene, Pommey, Sandra, Haibe-Kains, Benjamin, Beavis, Paul A., Darcy, Phillip K., Smyth, Mark J. and Stagg, John (2013) CD73 promotes anthracycline resistance and poor prognosis in triple negative breast cancer. Proceedings of the National Academy of Sciences of the United States of America, 110 27: 11091-11096. doi:10.1073/pnas.1222251110

  • Zitvogel, Laurence, Galluzzi, Lorenzo, Smyth, Mark J. and Kroemer, Guido (2013) Mechanism of Action of Conventional and Targeted Anticancer Therapies: Reinstating Immunosurveillance. Immunity, 39 1: 74-88. doi:10.1016/j.immuni.2013.06.014

  • Ngiow, Shin Foong, Knight, Deborah A., Ribas, Antoni, McArthur, Grant A. and Smyth, Mark J. (2013) BRAF-targeted therapy and immune responses to melanoma. Oncoimmunology, 2 6: e24462.1-e24462.3. doi:10.4161/onci.24462

  • Ma, Yuting, Yamazaki, Takahiro, Yang, Heng, Kepp, Oliver, Galluzzi, Lorenzo, Zitvogel, Laurence, Smyth, Mark J. and Kroemer, Guido (2013) Tumor necrosis factor is dispensable for the success of immunogenic anticancer chemotherapy. Oncoimmunology, 2 6: e24786.1-e24786.7. doi:10.4161/onci.24786

  • Ma, Yuting, Adjemian, Sandy, Mattarollo, Stephen R., Yamazaki, Takahiro, Aymeric, Laetitia, Yang, Heng, Portela Catani, Joao P., Hannani, Dalil, Duret, Helene, Steegh, Kim, Martins, Isabelle, Schlemmer, Frederic, Michaud, Michael, Kepp, Oliver, Sukkurwala, Abdul Qader, Menger, Laurie, Vacchelli, Erika, Droin, Nathalie, Galluzzi, Lorenzo, Krzysiek, Roman, Gordon, Siamon, Taylor, Philip R., Van Endert, Peter, Solary, Eric, Smyth, Mark J., Zitvogel, Laurence and Kroemer, Guido (2013) Anticancer chemotherapy-induced intratumoral recruitment and differentiation of antigen-presenting cells. Immunity, 38 4: 729-741. doi:10.1016/j.immuni.2013.03.003

  • Ngiow, Shin Foong, Teng, Michele W. L. and Smyth, Mark J. (2013) A balance of interleukin-12 and -23 in cancer. Trends in Immunology, 34 11: 548-555. doi:10.1016/j.it.2013.07.004

  • Mattarollo, Stephen R., Steegh, Kim, Li, Ming, Duret, Helene, Ngiow, Shin Foong and Smyth, Mark J. (2013) Transient Foxp(3+) regulatory T-cell depletion enhances therapeutic anticancer vaccination targeting the immune-stimulatory properties of NKT cells. Immunology and Cell Biology, 91 1: 105-114. doi:10.1038/icb.2012.58

Conference Publication

  • Ullah, Ashik M., Pharm, M., Revez, J., Loh, Z., Simpson, J., Zhang, V, Bain, L., Varelias, A., Rose-John, S., Blumenthal, A., Smyth, M., Hill, G., Sukkar, M., Ferreira, M. and Phipps, S. (2015). Il-6R Blockade Attenuates Experimental Allergic Asthma Associated with Activation of the Il-6 Trans-Signalling Pathway. In: Abstracts of the Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science, Annual Scientific Meeting 2015. Annual Scientific Meeting 2015 of the Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science, Gold Coast, QLD Australia, (32-32). 27 March - 1 April 2015. doi:10.1111/resp.12494_9

PhD and MPhil Supervision

Current Supervision

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Associate Advisor

  • Doctor Philosophy — Associate Advisor

  • Doctor Philosophy — Associate Advisor

  • Doctor Philosophy — Associate Advisor

    Other advisors:

Completed Supervision