Associate Professor Allison Pettit

ARC Future Fellow

Mater Research Institute-UQ
Faculty of Medicine

Honorary Associate Professor

Mater Research Institute-UQ
Faculty of Medicine

Overview

Dr Pettit holds a current ANZBMS Gap Fellowship and is a Senior Research Fellow leading the Bones and Immunology Research Group at Mater Research Institute-UQ. Since late 2007 she has led independent research programs focused on osteoimmunological mechanisms including characterisation of osteal tissue macrophages and haematopoietic stem cell niche macrophages. She has translated these basic biological discoveries to understanding macrophage contributions to bone repair, bone disease, including prostate cancer metastasis, and haematopoietic stem cell transplantation. Dr Pettit has published over 55 original scientific publications spanning areas of immunology, arthritis, bone biology, osteoporosis, transplantation, cancer and stem cell biology, including publications ranked in the top 1% for their field. She has successfully supervised numerous postgraduate students including 2 conferred PhDs who were both awarded Dean’s commendations for their theses.

Qualifications

  • PhD, The University of Queensland
  • BSc(Hons), Griffith University

Publications

View all Publications

Supervision

View all Supervision

Publications

Book Chapter

  • Pettit, Allison R., Cavanagh, Lois, Boyce, Amanda, Padmanabha, Jagadish, Peng, Judy and Thomas, Ranjeny. (2007). Identification and isolation of synovial dendritic cells. In Andrew P. Cope (Ed.), Arthritis Research Methods and Protocols (pp. 165-181) Totowa, N.J., U.S.A.: Humana Press Inc.

  • Pettit , Allison R. and Gravallese, E. M. (2007). Osteoprotegerin. In Peter E. Lipsky and Josef S. Smolen (Ed.), Contemporary Targeted Therapies in Rheumatology (pp. 251-264) London: Informa Healthcare.

  • Pettit, Allison R. and Gravellese, Ellen M. (2005). Pathogenesis of focal bone loss in inflammatory arthritis. In Maricic, Michael and Gluck, Oscar S. (Ed.), Bone Disease in Rheumatology (pp. 15-22) Arizona, USA: Lippincott Williams & Wilkins.

  • Pettit, A. R. and Gravellese, E. M. (2003). Osteoprotegerin. In Josef S. Smolen and Peter E. Lipsky (Ed.), Targeted therapies in rheumatology (pp. 359-377) London & New York: Martin Dunitz / Taylor & Francis.

  • Pettit, A. R., Cavanagh, L. L. and Thomas, R. (2001). Identification and isolation of synovial dendritic cells. In S. P. Robinson and A. J. Stagg (Ed.), Dendritic Cell Protocols (pp. 175-187) Totowa USA: Humana Press.

Journal Article

Conference Publication

  • Levesque, Jean-Pierre, Kaur, Simranpreet, Jacobsen, Rebecca, Millard, Susan, Batoon, Lena, Winkler, Ingrid, Macdonald, Kelli, Perkins, Andrew, Hume, David, Raggatt, Liza and Pettit, Allison (2016). Radio-resistant recipient bone marrow (BM) macrophages (Macs) are necessary for hematopoietic stem cell (HSC) engraftment post transplantation. In: 45th Annual Scientific Meeting of the ISEH – International Society for Experimental Hematology. 45th Annual Scientific Meeting of the ISEH – International Society for Experimental Hematology, San Diego, CA, United States, (S43-S44). 25-28 August, 2016. doi:10.1016/j.exphem.2016.06.049

  • Kaur, S., Raggatt, L. J., Jacobsen, R. N., Millard, S., Batoon, L., Winkler, I. G., Macdonald, K. P. A., Perkins, A. C., Hume, D. A., Levesque, J. P. and Pettit, A. R. (2016). Recipient bone marrow (BM) macrophages (Macs) are vital for haematopoietic stem cell (HSC) engraftment post autologous transplantation. In: International Congress of Immunology (ICI), Melbourne, VIC, Australia, (762-762). 21-26 August 2016. doi:10.1002/eji.201670200

  • Kaur, Simranpreet, Raggatt, Liza J., Jacobsen, Rebecca, Millard, Susan, Barbier, Valerie, Nowlan, Bianca, Winkler, Ingrid G., MacDonald, Kelli P., Perkins, Andrew C., Hume, David A., Levesque, Jean P. and Pettit, Allison R. (2015). Autologous Haematopotetic Stem Cell Transplantation Requires Recipient Bm Macrophages. In: 44th Annual Scientific Meeting of the International-Society-for-Experimental-Hematology (ISEH), Kyoto Japan, (S71-S71). 17-19 September 2015. doi:10.1016/j.exphem.2015.06.157

  • Tesch, G. H., Sourris, K. C., Summers, S. A., Mccarthy, D., Ward, M. S., Borg, D. J., Gallo, L. A., Fotheringham, A. K., Pettit, A., Yap, F. Y. T., Harcourt, B. E., Tan, A. L. Y., Kausman, J. Y., Nikolic-Paterson, D. J., Kitching, A. R. and Forbes, J. M. (2014). Deficiency of rage in bone marrow cells reduces renal injury in diabetic mice. In: 50th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology, Melbourne Australia, (41-41). 25–27 August 2014. doi:10.1111/nep.12301

  • Thomas, Gethin P., Tseng, Hsu-Wen, Pettit, Allison, Glant, Tibor T., McRae, Allan and Brown, Matthew A. (2013). Endochondral Bone Formation and Advanced Enthesitis Are Key Features Of Proteoglycan Induced Spondylitis Mouse Model Of Ankylosing Spondylitis. In: Abstract Supplement 2013 Annual Meeting. 77th Annual Meeting of the American College of Rheumatology / 48th Annual Meeting of the Association of Rheumatology Health Professionals, San Diego CA, United States, (S231-S231). 25-30 October 2013. doi:10.1002/art.38216

  • Tseng, H., Pettit, A., Glant, T., Brown, M. and Thomas, G. (2013). Endochondral bone formation and advanced enthesitis are key features of PGISp mouse model of ankylosing spondylitis. In: Special Issue: Australian Rheumatology Association in conjunction with the Rheumatology Health Professionals Association 54th Annual Scientific Meeting: Conference Abstracts. 54th Annual Scientific Meeting of the Australian Rheumatology Association in conjunction with the Rheumatology Health Professionals Association, Perth, WA Australia, (5-5). 18 -22 May 2013. doi:10.1111/imj.12139

  • Pettit, A, Raggatt, L, Wullschleger, M, Alexander, K, Steck, R, Kaur, S and Wu, A (2013). Fracture Healing Via Periosteal Callus Formation Requires Macrophages for Both Initiation and Progression of Endochondral Ossification. In: Annual Meeting of the American-Society-for-Bone-and-Mineral-Research, Baltimore MD, (). OCT 04-07, 2013.

  • Jacobsen, Rebecca, Pettit, Allison, Barbier, Valerie, Nowlan, Bianca, Raggatt, Liza, Winkler, Ingrid and Levesque, Jean-Pierre (2013). Mobilising Doses of G-Csf Stop Medullary Erythropoiesis by Depleting Cd169+Macrophages. In: 42nd Annual Scientific Meeting of ISEH - Society for Hematology and Stem Cells — Abstracts. 42nd Annual Scientific Meeting of ISEH - Society for Hematology and Stem Cells, Vienna, Austria, (S59-S59). 22-25 August 2013. doi:10.1016/j.exphem.2013.05.230

  • Jacobsen, Rebecca, Pettit, Allison R., Raggatt, Liza J., Nowlan, Bianca, Barbier, Valerie, Forristal, Catherine E., Winkler, Ingrid G. and Levesque, Jean-Pierre (2013). Mobilizing Doses Of G-CSF Stop Medullary Erythropoiesis By Depleting F4/8o+VCAM1+ER-HR3+CD169+Erythroid-Island Macrophages. In: Blood. 55th Annual Meeting of the American-Society-of-Hematology, New Orleans, LA, United States, (). 7-10 December 2013.

  • Thomas, G., Duan, R., Weedon, H., Maylin, E., Pettit, A., Smith, M. and Brown, M. (2012). Expression profiling in spondylarthropy synovial biopsies highlights inflammatory gene changes in conjunction with altered Wnt signalling. In: Australian Rheumatology Association in conjunction with Rheumatology Health Professionals 53rd Annual Scientific Meeting, Canberra, Australia, (1b-1b). 12-15 May 2012. doi:10.1111/j.1445-5994.2012.02760.x

  • Haynes, K. H., Pettit, A. P., Duan, R., Tseng, H., Kniessel, M., Glant, T. T., Brown, M. A. and Thomas, G. P. (2012). Wnt signalling inhibition as a potential therapeutic in ankylosing spondylitis. In: Eighth International Congress on Spondyloarthritis, Meeting abstracts. 8th International Congress on Spondyloarthritis, Granada, Spain, (610-610). 9-13 May 2012.

  • Pettit, A. R., Kaur, S., Alexander, K. A., MacDonald, K. P. A. and Raggatt, L. J. (2011). B Cells Do Not Influence Intramembranous Bone Modelling in Vivo. In: Osteoporosis International. IOF Regionals 2nd Asia-Pacific Osteoporosis and Bone Meeting / ANZBMS Annual Scientific Meeting held with the JSBMR, Gold Coast Australia, (S537-S538). Sep 04-08, 2011.

  • Thomas, G, Duan, R, Pettit, A, Glant, T and Brown, M (2011). Altered Wnt-Signalling Links Inflammation and Bony Ankylosis in a Mouse Model of Ankylosing Spondylitis. In: Internal Medicine Journal. Unknown, unknown, (3-3). unknown.

  • Levesque, Jean-Pierre, Bendall, Linda J., Pettit, Allison R., Raggatt, Liza, Jacobsen, Rebecca, Barbier, Valarie, Nowlan, Bianca, Shen, Yi Shen, Sims, Natalie A. and Winkler, Ingrid G. (2011). Mobilizing agents G-CSF, cyclophosphamide or AMD3100 (Plerixafor) Have distinct effects on osteoblasts, hematopoietic stem cell niches, and B-Lymphopoiesis. In: Abstracts of the American Society of Hematology 53rd Annual Meeting. 53rd Annual Meeting and Exposition of the American Society of Hematology (ASH), San Diego CA, United States, (1713-1713). 10-13 December 2011.

  • Thomas, G., Duan, R., Pettit, A., Glant, T. and Brown, M. (2010). Both DKK-1 and sost are suppressed during late stage disease development in a mouse model of ankylosing spondylitis. In: Seventh International Congress on Spondyloarthropathies, Gent, Belgium, (608-608). 7 - 9 October 2010.

  • Jacobsen, RN, Levesque, JP, Barbier, V, Raggatt, LJ and Pettit, AR (2010). DEPLETION OF BONE MARROW PHAGOCYTES CAUSES THE MOBILIZATION OF LONG-TERM RECONSTITUTING HEMATOPOIETIC STEM CELLS. In: EXPERIMENTAL HEMATOLOGY. 39th Annual Scientific Meeting of the ISEH - Society-for-Hematology-and-Stem-Cells, Melbourne AUSTRALIA, (S93-S94). SEP 15-18, 2010.

  • Markey, K, Banovic, T, Kuns, R, Raffelt, N, Olver, S, Don, A, Wilson, Y, Pettit, A, Bromberg, J, Hill, G and MacDonald, K (2009). Conventional dendritic cells are the critical donor APC presenting alloantigen after BMT. In: Bone Marrow Transplantation. 35th Annual Meeting of the European-Group-for-Blood-and-Marrow-Transplantation, Goteborg Sweden, (S83-S83). Mar 29-Apr 01, 2009.

  • Levesque, J. P., Raggatt, L. J., Pettit, A. R., Sims, N. A., Bendall, L. J. and Helwani, F. (2009). Endosteal Macrophages Maintain the Hematopoietic Stem Cell (Hsc) Niche and Participate in Hsc Mobilization Induced by G-Csf or Chemotherapy. In: Experimental Hematology. 38th Annual Scientific Meeting of the ISEH Society for Hematology and Stem Cells, Athens, Greece, (S31-S31). 9-12 September 2009.

  • Alexander, K. A., Raggatt, L., Chang, M., Maylin, E., Muller, R., Kohler, T., Wu, A., Hume, D. and Pettit, A. (2009). Osteomacs are Critical for Optimal Intramembranous Bone Formation in a Tibial Defect Model of Bone Healing. In: Journal of Bone and Mineral Research. Australian Society of Bone and Mineral Research (ASBMR) 31st Annual Meeting, Denver, Colorado, USA, (). 11-15 September, 2009.

  • Alexander, K. A., Raggatt, L. J., Chang, M. K., Maylin, E. R., Muller, R., Kohler, T., Wu, A. C. K., Hume, D. A. and Pettit, A. R. (2009). Osteomacs are critical for optimal intramembranous bone formation in a tibial defect model of bone healing. In: Bone. Abstracts from the 2nd Joint Meeting of the International Bone & Mineral Society and the Australian & New Zealand Bone & Mineral Society. 2nd Joint Meeting of the International Bone & Mineral Society and the Australian & New Zealand Bone & Mineral Society, Sydney, NSW, Australia, (S30-S30). 21-25 March 2009. doi:10.1016/j.bone.2009.01.076

  • Pettit, A. R., Sims, N. A., Winkler, I. G., Alexander, K. A., Helwani, F., Raggatt, L. J. and Levesque, J. P. (2009). Osteomacs maintain the endosteal hematopoietic stem cell niche and participate in mobilization. In: Bone. Abstracts from the 2nd Joint Meeting of the International Bone & Mineral Society and the Australian & New Zealand Bone & Mineral Society. 2nd Joint Meeting of the International Bone and Mineral Society/Australian New Zealand Bone and Mineral Society, Sydney, Australia, (S32-S33). 21-25 March, 2009. doi:10.1016/j.bone.2009.01.082

  • Raggatt, L., Chang, M., Alexander, K., Maylin, E., Walsh, N., Gravallese, E., Hume, D. and Pettit, A. (2009). Osteomacs: Osteoclast Precursors During Inflammatory Bone Disease but Regulators of Physiologic Bone Remodeling. In: Journal of Bone and Mineral Research. Australian Society of Bone and Mineral Research (ASBMR) 31st Annual Meeting, Denver, Colorado, USA, (). 11-15 September, 2009.

  • Raggatt, L. J., Chang, M. K., Alexander, K. A., Maylin, E. R., Walsh, N. C., Gravallese, E. M., Hume, D. A. and Pettit, A. R. (2009). Osteomacs: osteoclast precursors during inflammatory bone disease but regulators of physiologic bone remodelling. In: Bone. Abstracts from the 2nd Joint Meeting of the International Bone & Mineral Society and the Australian & New Zealand Bone & Mineral Society. 2nd Joint Meeting of the International Bone & Mineral Society and the Australian & New Zealand Bone & Mineral Society, Sydney, Australia, (S136-S137). 21-25 March, 2009. doi:10.1016/j.bone.2009.01.300

  • Chang, M. K., Pettit, A. R., Schroder, K., Ripoll, V. M., Alexander, K. A., Hume, D. A. and Raggatt, L. (2008). Primary murine osteoblast cultures contain macrophages that enhance osteoblast mineralisation. In: Abstracts of the 35th European Symposium on Calcified Tissues. ECTS 35th European Symposium on Calcified Tissues, Barcelona, Spain, (S98-S99). 24-28 May 2008. doi:10.1007/s00223-008-9118-5

  • Alexander, K. A., Chang, M. K., Hume, D. A., Pettit, A. R., Raggatt, L., Ripoli, V. M. and Schroder, K. (2008). Primary murine osteoblast cultures contain macrophages that enhance osteoblast mineralization. In: Calcified Tissue International. 35th European Symposium on Calcified Tissues, Barcelona, Spain, (S98-S99). 24-28 May 2008. doi:10.1007/s00223-008-9118-5

  • Wu, A. C. K., Toulson, S., Pettit, A., Grondahl, L., Mackie, E. J. and Cassady, A. I. (2007). Analysis of in vivo responses to hydrogen peroxide purified PHBV biomaterial implanted in a murine tibial defect. In: Journal of Bone and Mineral Research. Proceedings of: 29th Annual Meeting of the American Society for Bone and Mineral Research. 29th Annual Meeting of the American Society for Bone and Mineral Research, Honolulu, HI, U.S.A, (S265-S265). 16-19 Sep 2007.

  • Raggatt, L. J., Chang, M. K., Alexander, K. A., Kuiliwaba, J. S., Fazzalari, N. L., Hume, D. A. and Pettit, A. R. (2007). Osteal Macrophages: Novel regulators of Bone Formation. In: Journal of Bone and Mineral Research: 29th Annual Meeting of the American Society for Bone and Mineral Research. 29th Annual Meeting of the American Society for Bone and Mineral Research, Honolulu, HI, (s53-s53). 16th -19th September, 2007.

  • Raggatt, L. J., Alexander, K. A., Kuliwaba, J. S., Fazzalari, N. L., Hume, D. A. and Pettit, A. R. (2007). Osteal macrophages: Novel regulators of bone formation. In: Journal of Bone and Mineral Research. 29th Annual Meeting of the American Society for Bone and Mineral Research, Honolulu, HI, United States, (S53-S53). 16-19 September 2007.

  • Chang, M., Hume, D. A., Pettit, A. R., Raggatt, L., Ripoll, V. M. and Schroder, K. (2007). Primary Murine Osteoblast Cultures Contain Macrophages that Enhance Osteoblast Mineralisation. In: Journal of Bone and Mineral Research. 29th Annual Meeting of the American Society for Bone and Mineral Research (ASBMR), Honolulu, Hawaii, USA, (S139-S139). 16th - 19th September, 2007.

  • Pettit, A. R., Chang, M. K., Alexander, K. A., Wu, A. C., Hume, D. A. and Raggatt, L. J. (2007). The endosteal bone niche contains macrophages that regulate osteoblast function. In: Bone. 17th Scientific Meeting of the International Bone & Mineral Society, Montreal, Canada, (S127-S127). 24-29 June 2007. doi:10.1016/j.bone.2007.04.166

  • Pettit, A. R., Walsh, N. C., Goldring, S. R. and Gravallese, E. M. (2005). RANKL protein is expressed at the pannus-bone interface at sites of erosion in rheumatoid arthritis. In: Journal of Bone and Mineral Research. 27th Annual Meeting of the American Society for Bone and Mineral Research, Nashville, TN, United States, (S304-S304). 23-27 September 2005.

  • Gravallese E. M., Walsh N. C., Manning C. A., Goldring S. R. and Pettit A. R. (2005). RANKL protein is expressed at the pannus-bone interface at sites of erosion in rheumatoid arthritis. In: Arthritis and Rheumatism. 69th Annual Scientific Meeting of the American College of Rheumatology/40th Annual Scientific Meeting of the Association of Rheumatology Health Professionals, San Diego, Ca, USA, (S497-S497). 12-17 November 2005.

  • Pettit, A. R., Walsh, N. C., Manning, C., Goldring, S. R. and Gravallese, E. M. (2005). RANKL protein is expressed at the pannus-bone interface at sites of erosion in rheumatoid arthritis. In: Journal of Bone and Mineral Research. Abstracts of the 27th Annual Meeting of the American Society for Bone and Mineral Research. 27th Annual Meeting of the American Society for Bone and Mineral Research, Nashville, Tennessee, U.S.A., (S304-S304). 23-27 September 2005.

  • Walsh, N. C., Pettit, A. R., Manning, C., Wang, J., McHugh, K. P. and Gravallese, E. M. (2005). The expression of novel human RANKL mRNAs in cell types associated with inflammatory bone loss. In: Arthritis and Rheumatism. 69th Annual Scientific Meeting of the American College of Rheumatology/40th Annual Scientific Meeting of the Association of Rheumatology Health Professionals, San Diego, Ca, USA, (S495-S495). 12-17 November 2005.

  • Walsh, N. C., Pettit, A. R., Manning, C., Wang, J., McHugh, K. P. and Gravallese, E. M. (2005). The expression of novel human RANKL mRNAs in cell types associated with inflammatory bone loss. In: Journal of Bone and Mineral Research.. The American Society for Bone and Mineral Research 27th Annual Meeting, Nashville, Tennessee, USA, (S370-S370). 22 - 27 September 2005.

  • Walsh, N. C., Pettit, A. R., Manning, C. A., Wang, J. F., McHugh, K. P. and Gravallese, E. M. (2005). The expression of novel human RANKL mRNAs in cell types associated with inflammatory bone loss. In: Arthritis and Rheumatism. 69th Annual Scientific Meeting of the American College of Rheumatology/40th Annual Scientific Meeting of the Association of Rheumatology Health Professionals, San Diego, CA, United States, (S495-S495). 12-17 November 2005.

  • Pettit, A. R., Manning, C., Goldring, S. R., Libermann, T., Peng, S. I. and Gravallese, E. M. (2003). The NFAT family of transcription factors may be key regulators of the RANKL gene in T cells. In: Abstracts of the American Society for Bone and Mineral Research 25th Annual Meeting: Anniversary Celebration. 25th Annual Meeting of the American Society for Bone and Mineral Research, Minneapolis Minnesota, (S17-S17). 19-23 September 2003.

  • Pettit, A. R., Manning, C., Goldring, S. R., Libermann, T., Peng, S. L. and Gravallese, E. M. (2003). The NFAT family of transcription factors may be key regulators of the RANKL gene in T cells. In: ASBMR Online Abstracts. 25th Annual Meeting of the American Society for Bone and Mineral Research, Minneapolis, USA, (). 19-23 September 2003.

  • Pettit, A. R., Gravallese, E. M., Manning, C., Tsay, A., Madore, R., Gaspar, J., Goldring, S. R. and Oettgen, P. (2001). Angiopoietin-1 is expressed in RA synovium and is induced by TNF-alpha in cultured synovial fibroblasts. In: ACR/ARHP Annual Scientific Meeting, San Francisco CA, United States, (S360-S360). 10-15 November 2001.

  • Lubberts, E., Oppers, B., Pettit, A., van den Bersselaar, L., Smits, D., Joosten, L., Goldring, S., Gravellese, E. and van den Berg, W. (2001). Kinetic study of RANK and RANKL expression during collagen-induced arthritis. In: ACR/ARHP Annual Scientific Meeting, San Francisco CA, United States, (S243-S243). 10-15 November 2001.

  • Pettit, A. R., Ji, H., von Stechow, D., Mueller, R., Choi, Y., Goldring, S. R., Benoist, C. and Gravallese, E. M. (2001). TRANCE/RANKL knockout mice are protected from bone erosion in the K/BxN serum transfer model of arthritis. In: ACR/ARHP Annual Scientific Meeting, San Francisco CA, United States, (S326-S326). 10-15 November 2001.

  • Pettit, A. R., Weedon, H., Ahern, M., Zehntner, S., Slavotinek, J., Au, V., Smith, M. D. and Thomas, R. (2000). Rheumatoid arthritis clinical activity and radiological progression are related to synovial dendritic cell, lymphocyte and macrophage infiltration and TNF alpha expression. In: American College of Rheumatology Annual Scientific Meeting, Philadelphia, PA, USA, (S156-S156). 28 October - 2 November 2000.

  • Thomas, R., Pettit, A., Quinn, Christopher, MacDonald, K. and Cavanagh, L. (1997). Nuclear localisation of relB is associated with potent antigen presenting cell function. In: AAAAI/AAI/CIS Joint Meeting, -, (s450-s450). 21st – 26th February, 1997. doi:10.1016/S0091-6749(97)81067-6

  • Pettit, A. R., Quinn, C., Cavanagh, L. L., Thomas, G., Townsend, W., Handel, M. and Thomas, R. (1997). Rheumatoid arthritis synovial tissue and not synovial fluid, DC express high levels of active nuclear RelB. In: -, -, (610-610). -.

  • Thomas, R., Macdonald, K., Moore, K., Pettit, A., Quinn, C., Thomas, G. and OSullivan, B. (1997). Rheumatoid synovial fluid dendritic cells are resistant to the inhibitory effects of IL-10. In: Arthritis and Rheumatism. 61st National Scientific Meeting of the American College of Rheumatology and the 32nd National Scientific Meeting of the Association of Rheumatology Health Professionals, Washington D.C., U.S., (536-536). 8-12 November 1997.

Grants (Administered at UQ)

PhD and MPhil Supervision

Current Supervision

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Associate Advisor

  • Doctor Philosophy — Associate Advisor

Completed Supervision