Dr Benjamin Schulz

NHMRC Career Development Fellow

School of Chemistry and Molecular Biosciences
Faculty of Science
b.schulz@uq.edu.au
+61 7 336 54875

Overview

I graduated with a degree in Chemical Engineering and Science in 2000 from The University of Queensland, after which I joined Proteome Systems, an Australian biotechnology company. In 2004 I moved to the ETH Zurich in Switzerland for my doctoral studies. I joined the School of Chemistry & Molecular Biosciences as a University of Queensland Postdoctoral Research Fellow in 2008 and NHMRC Career Development Fellow in 2012. I am now an NHMRC Career Development Fellow and Senior Lecturer.

Research Interests

  • Glycosylation in health and disease
    Altered glycosylation is associated with cancer and infection. We aim to understand the mechanisms controlling this process using in vitro protein biochemistry, a yeast model system and human cells, to determine how it affects glycoprotein function.
  • Mass Spectrometry Glycoproteomics
    Most proteins are modified with complex sugar groups that affect their function. We develop new mass spectrometry approaches to systematically and globally identify and quantify proteins and their sugar modifications in fundamental biology and disease.
  • Beer
    Beer brewing is perhaps the most ancient biotechnology. We use modern analytical techniques to investigate and improve this complex and important process.

Research Impacts

My research focuses on the mechanisms, biological roles and applications in biotechnology of glycosylation, the most abundant and complex post-translational modification of proteins. Glycosylation is important in biological processes such as human development, cancer and microbial infection. This is because glycosylation is essential in biological activities as diverse as protein folding, fine-tuning protein enzymatic activity and determining protein-protein interactions. Half of all proteins are glycosylated, and a single protein can be modified by hundreds of different sugar moieties. The diversity of glycoproteins therefore requires that we take a systems biology approach in our research. All of our projects use a core set of methods in molecular biology, genetic manipulation, protein biochemistry, glycoprotein analysis and mass spectrometry. I aim to understand the mechanisms controlling glycosylation in these various systems to develop diagnostics, therapies, vaccines and applications in biotechnology.

Qualifications

  • Bachelor of Engineering, The University of Queensland
  • Bachelor of Science, The University of Queensland
  • Doctor of Philosophy, Zurich

Publications

View all Publications

Grants

View all Grants

Supervision

  • Doctor Philosophy

  • Doctor Philosophy

  • Doctor Philosophy

View all Supervision

Publications

Book Chapter

  • Schulz, Benjamin Luke (2012). Beyond the sequon: sites of N-Glycosylation. In Stefana Petrescu (Ed.), Glycosylation (pp. 21-40) Rijeka, Croatia: InTech. doi:10.5772/50260

Journal Article

Conference Publication

  • Tan, Xinle, Deng, Bin, Jiang, Xiaoyin, Zhang, Peng, Hu, Zhenxia, Li, Enpeng, Sullivan, Mitchell A., Schulz, Benjamin L. and Gilbert, Robert G. (2016). Glycogen: Higher -Level Molecular Structure and Diabetes. In: Proceedings of the 12Th International Conference On Polysaccharides-Glycoscience, 2016. 12th International Conferencre on Polysaccharides-Glycoscience, Prague Czech Republic, (7-8). Oct 19-21, 2016.

  • Zhuang, A., Sourris, K. C, Harcourt, B. E, Penfold, S. A., Fotheringham, A. K., McCarthy, D., Schulz, B. and Forbes, J. M. (2014). Ager1 overexpression in glomerular podocytes results in renal disease which is exacerbated by diabetes. In: Special Issue: 50th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology. 50th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology, Melbourne VIC, Australia, (56-56). 25 - 27 August 2014. doi:10.1111/nep.12301

  • Tan, Nikki, Bailey, Ulla-Maja, Jamaluddin, Fairuz, Mahmud, Siti, Raman, Suresh and Schulz, Benjamin (2014). Give up sugar with this one weird trick!. In: Program and abstracts for 2014 Joint meeting of the Society for Glycobiology (SFG) and the Japanese Society of Carbohdrate Research (JSCR). Joint Meeting of the Society for Glycobiology (SFG) and the Japanese Society of Carbohydrate Research (JSCR), Honolulu, HI United States, (1183-1184). 16-19 November 2014. doi:10.1093/glycob/cwu107

  • Karlsson, NG, Schulz, BL, Wilson, NL and Packer, NH (2004). Exploring the role of the glycosylation of mucins in the defence against pathogens in the respiratory and gastrointestinal systems. In: Glycobiology. Joint Meeting of the Society-for-Glycobiology/Japanese-Society-for-Carbohydrate-Research, Honolulu Hi, (1167-1167). Nov 17-20, 2004.

Grants (Administered at UQ)

PhD and MPhil Supervision

Current Supervision

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Associate Advisor

    Other advisors:

  • Doctor Philosophy — Associate Advisor

    Other advisors:

  • Doctor Philosophy — Associate Advisor

  • Doctor Philosophy — Associate Advisor

  • Doctor Philosophy — Associate Advisor

Completed Supervision