Professor Brian Gabrielli

Honorary Professor

Mater Research Institute-UQ
Faculty of Medicine

Overview

Professor Gabrielli completed his undergraduate education at James Cook University in Townsville and PhD at La Trobe University in Melbourne. After two postdoctoral positions in the USA in the emerging field of cell cycle regulation, he was recruited to establish his own independent research at the Queensland Institute of Medical Research, and then recruited to the Diamantina Institute in 2002, and Mater Research Institute in 2016. He is head of the Smiling for Smiddy Cell Cycle Group.

Research Interests

Mechanisms that regulate cell division, particularly progression into mitosis. These mechanisms are often mutated in cancers and are likely to be major contributors to cancer development. Identifying the genetic mutations that disrupt normal progression and particularly mechanisms, known as checkpoints, provides diagnostic and prognostic opportunities. It also provides potential new targets for chemotherapeutics as drugs targeting defective checkpoints have tumour selective cytotoxic potential.

Research Projects

  • Identifying the molecular basis for defective checkpoints in melanoma.
  • Targeting defective cell cycle responses to ultraviolet radiation, replication stress and TopoII inhibitors in melanoma, and investigating whether the same defects in other cancer types respond to similar targeting.
  • Investigating means of identify very early changes in moles that drive progression to melanoma
  • Targeting Aurora kinases in HPV-driven cancers

Research Interests

  • Ultraviolet radiaiton and its contribution to melanoma
  • Targeting defective cell cycle checkpoints in cancers, particularly melanoma
  • Functional genomics; using high throughout screening combined with increased or decreased gene dosage to identify novel regulatory mechanisms and drug targets
  • Mechanism of action studies for novel anti-caner therapeutics

Qualifications

  • PhD, James Cook University
  • Bachelor of Science (Honours), James Cook University

Publications

  • Shaikh, Mushfiq H., Idris, Adi, Johnson, Newell W., Fallaha, Sora, Clarke, Daniel T.W., Martin, David, Morgan, Iain M., Gabrielli, Brian and McMillan, Nigel A. J. (2018) Aurora kinases are a novel therapeutic target for HPV-positive head and neck cancers. Oral Oncology, 86 105-112. doi:10.1016/j.oraloncology.2018.09.006

  • D’Arcy, Nicholas, Matigian, Nicholas, Lê Cao, Kim-Anh and Gabrielli, Brian (2018) Pathway dysregulation analysis of the nucleotide excision repair mechanisms reveals it is not a common feature of melanomas. Pigment Cell & Melanoma Research, . doi:10.1111/pcmr.12740

  • Kalimutho, Murugan, Sinha, Debottam, Jeffery, Jessie, Nones, Katia, Srihari, Sriganesh, Fernando, Winnie C., Duijf, Pascal H. G., Vennin, Claire, Raninga, Prahlad, Nanayakkara, Devathri, Mittal, Deepak, Saunus, Jodi M., Lakhani, Sunil R., López, J Alejandro, Spring, Kevin J., Timpson, Paul, Gabrielli, Brian, Waddell, Nicola and Khanna, Kum Kum (2018) CEP55 is a determinant of cell fate during perturbed mitosis in breast cancer. EMBO Molecular Medicine, 10 9: e8566. doi:10.15252/emmm.201708566

View all Publications

Supervision

View all Supervision

Available Projects

View all Available Projects

Publications

Book Chapter

Journal Article

Conference Publication

  • Emran, A., Marzese, D. M., Menon, D. R., Stark, M., Torrano, J., Hammerlindl, H., Zhang, G., Brafford, P., Hammerlindl, S., Gupta, D., Mills, G. B., Lu, Y., Flaherty, K., Sturm, R., Hoon, D. S. B., Gabrielli, B., Herlyn, M. and Schaider, H. (2018). Distinct epigenetic remodelling defines early stress-induced drug tolerance in melanoma. In: Australasian College of Dermatologists, 51st Annual Scientific Meeting, Gold Coast, QLD, Australia , (31-32). 19–22 May 2018. doi:10.1111/ajd.16_12815

  • Duijf, Pascal H. G., Vaidyanathan, Srividya, Cato, Kathleen, Thangavelu, Pulari U., Lin, Cheng-Yu, Tang, Lu, Pavey, Sandra, Haass, Nikolas K. and Gabrielli, Brian G. (2018). Overexpression of the cell cycle regulator Emi1 promotes chromosome instability and tumorigenesis. In: 76th Annual Meeting of the Japanese Cancer Association, Yokohama, Japan, (418-418). 28-30 September 2017. doi:10.1111/cas.13499

  • Beaumont, K., Hill, D., Daignault, S., Sharp, D., Gabrielli, B., Weninger, W. and Haass, N. (2016). Cell cycle phase-specific drug resistance as an escape mechanism of melanoma cells. In: Annual Meeting of the Society-for-Investigative-Dermatology (SID), Scottsdale Az, (S116-S116). May 11-14, 2016. doi:10.1016/j.jid.2016.02.695

  • Al Emran, Abdullah, Menon, Dinoop Ravindran, Soyer, Peter, Gabrielli, Brian, Sturm, Rick, Herlyn, Meenhard and Schaider, Helmut (2016). Global histone modifications define early stress induced drug tolerance in cancer. In: American-Association-for-Cancer-Research (AACR) Special Conference on Chromatin and Epigenetics in Cancer, Atlanta, GA, United States, (). 24-27 September 2015. doi:10.1158/1538-7445.CHROMEPI15-B34

  • McMillan, N., Fallaha, S., Martin, D., Leggatt, G. and Gabrielli, B. (2016). Inhibition of Aurora Kinases is curative for HPV-driven tumours. In: 16th Biennial Meeting of the International Gynecologic Cancer Society, Lisbon, Portugal, (114-114). 28-31 October 2016. doi:10.1097/01.IGC.0000503327.50238.5c

  • Gabrielli, Brian G., Bokhari, Fawzi, Ranall, Max, Oo, Zay Yar, Stevenson, Alex, Wang, Weili, McKee, Sara, Leggatt, Graham, Leo, Paul, Gonda, Thomas J. and McMillan, Nigel A. J. (2015). Abstract 945: synthetic lethal screen identifies Aurora A as a selective target in HPV driven cervical cancer. In: 106th Annual Meeting of the American-Association-for-Cancer-Research (AACR), Philadelphia, PA United States, (97-97). 18-22 April 2015. doi:10.1158/1538-7445.AM2015-945

  • Hill, D. S., Beaumont, K. A., Daignault, S. M., Anfosso, A., Sharp, D. M., Gabrielli, B., Lovat, P. E., Weninger, W. and Haass, N. K. (2015). Melanoma cells in G1 phase escape proteasome inhibitor cytotoxicity. In: 42nd Annual Meeting of the Arbeitsgemeinschaft-Dermatologische-Forschung (ADF), Ulm, Germany, (E34-E35). Mar 05-07, 2015. doi:10.1111/exd.12623

  • Gabrielli, B., Bokhari, F., Ranall, M., Stevenson, A., Murell, M., Kelly, M., McKee, S., Leggatt, G., Gonda, T. and McMillan, N. (2014). Synthetic lethal screen identifies Aurora A as a selective target in HPV driven cervical cancer. In: 26th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, Barcelona Spain, (97). 18-21 November 2014. doi:10.1016/S0959-8049(14)70420-4

  • Gabrielli, Brian G., Brooks, Kelly, Edwards, Brooke, Chen, James and Pavey, Sandra (2013). Chk1 inhibitor targets replicative stress in melanomas. In: 104th Annual Meeting of the American-Association-for-Cancer-Research (AACR), Washington Dc, (). Apr 06-10, 2013. doi:10.1158/1538-7445.AM2013-3425

  • Lee, W. J., Skalamera, D., Dahmer, M., Shakhbazov, K., Purdon, A., Wilson, B., Ranall, M, Pinder, A., Pavey, S., Gonda, T. and Gabrielli, B. (2012). A Genome-wide Human ORF Gain-of-function Screen to Identify Genes that can Bypass p16INK4a-mediated Cellular Senescence. In: 6th Australian High Content Screening Group Meeting, Melbourne, Australia, (). 13th July 2012.

  • Gabrielli, B., Brooks, K., Oakes, V., Edwards, B., Chen, J. and Mukhopadhyay, P. (2012). Chk1 inhibitor targets replicative stress in melanomas. In: Abstracts of 24 EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics. 24th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, Dublin Ireland, (163-163). 6-9 November 2012. doi:10.1158/1538-7445.AM2013-3425

  • Lee, W. J., Skalamera, D., Dahmer, M., Shakhbazov, K., Ranall, M., Purdon, A., Wilson, B., Pinder, A., Pavey, S., Gonda, T. and Gabrielli, B. (2011). A functional genomics approach to identify genes and pathways that can bypass p16INK4a-mediated cellular senescence. In: 14th Annual Australian Cell Cycle Workshop, Noosa, Australia, (). 24 October 2011.

  • Lee, W. J., Skalamera, D. and Gabrielli, B. (2011). A high-coverage and high-content human ORF overexpression screen to identify pathways that can bypass p16INK4a-mediated cellular senescence. In: 5th Australian High Content Screening Group Meeting, Melbourme, Australia, (). 15 July 2011.

  • Skoien, R., Powell, E. E., Melino, M., Clouston, A. D., Gabrielli, B. G. and Jonsson, J. R. (2010). Fatty acids induce hepatocyte senescence in vitro: implications for pathogenesis in non-alcoholic steatohepatitis. In: Australian Gastroenterology Week 2010. Australian Gastroenterology Week 2010, Gold Coast, QLD, Australia, (A13-A14). 20-23 October 2010. doi:10.1111/j.1440-1746.2010.06450.x

  • Wigan, M., Giles, N., Pavey, S. and Gabrielli, B. (2009). Suberythemal UV G2 phase checkpoint in response to post replication repair is defective in a majority of melanoma cell lines. In: ASDR Abstracts. 5th Annual Scientific Meeting of the Australasian Society for Dermatology Research, Sydney, Australia, (2918-2918). 21-22 May 2008. doi:10.1038/jid.2009.333

  • Giles, N., Pavey, S. and Gabrielli, B (2009). UVR induced ERK signaling pathway regulates p16 expression in skin. In: ASDR Abstracts. 5th Annual Scientific Meeting of the Australasian-Society-for-Dermatology-Research, Sydney, Australia, (2919-2919). 21-22 May 2008. doi:10.1038/jid.2009.333

Grants (Administered at UQ)

PhD and MPhil Supervision

Current Supervision

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Principal Advisor

Completed Supervision

Possible Research Projects

Note for students: The possible research projects listed on this page may not be comprehensive or up to date. Always feel free to contact the staff for more information, and also with your own research ideas.