The University of Queensland

Matriptase-2

Ramsay, Andrew J., Kwarciak, Agnieszka, Hooper, John D., Lopez-Otin, Carlos and Velasco, Gloria (2013). Matriptase-2. Handbook of proteolytic enzymes. (pp. 2975-2983) edited by Neil D. Rawlings and Guy Salvensen. London, United Kingdom: Academic Press. doi: 10.1016/B978-0-12-382219-2.00650-5

The Human Tissue Kallikrein and Kallikrein-related Peptidase Family

Clements, Judith A., Hooper, John D. and Dong, Ying (2013). The Human Tissue Kallikrein and Kallikrein-related Peptidase Family. Handbook of Proteolytic Enzymes. (pp. 2747-2756) edited by Neil D. Rawlings and Guy Salvesen. London, United Kingdom: Elsevier. doi: 10.1016/B978-0-12-382219-2.00606-2

Endogenous strategies for steroidogenesis and androgen signalling in prostate cancer cells

Bennett, Nigel C., Hooper, John and Gobe, Glenda C. (2012). Endogenous strategies for steroidogenesis and androgen signalling in prostate cancer cells. Androgens: production, functions and disorders. (pp. 99-114) edited by Berkley F. Thompson and Devon J. Robinson. New York, NY, United States: Nova Science Publishers.

Kallikrein-related peptidases (KLKs), Proteinase-mediated Signalling and Proteinase-activated receptors (PARs)

Hollenberg, M.D. and Hooper, John David (2012). Kallikrein-related peptidases (KLKs), Proteinase-mediated Signalling and Proteinase-activated receptors (PARs). Kallikrein-related peptidases Volume 1, Characterization, regulation, and interactions within the protease web. (pp. 373-398) edited by Viktor Magdolen, Christian Sommerhoff, Hans Fritz and Manfred Schmitt. Berlin Germany: DeGruyter.

Kallikrein-related peptidases (KLKs), Proteinase-mediated signaling and proteinase-activated receptors (PARs)

Hollenberg, Morley D., Hooper, John D., Darmoul, Dalila and Oikonomopoulou, Katerina (2012). Kallikrein-related peptidases (KLKs), Proteinase-mediated signaling and proteinase-activated receptors (PARs). Characterization, regulation, and interactions within the protease web. (pp. 373-398) Berlin, Germany: De Gruyter Mouton.

The tissue kallikrein gene cluster

Clements, J. A., Hooper, John David, Odorico, D. M. and Dong, Y. (2004). The tissue kallikrein gene cluster. Handbook of Proteolytic Enzymes / 1. Aspartic and metallo peptidases. (pp. 478-478) edited by Barrett, A. J., Rawlings, N. D. and Woessner, J. F.. Amsterdam, The Netherlands: Elsevier Academic Press.

Inhibition of Aurora B kinase (AURKB) enhances the effectiveness of 5-fluorouracil chemotherapy against colorectal cancer cells

Shah, Esha T., Molloy, Christopher, Gough, Madeline, Kryza, Thomas, Samuel, Selwin G., Tucker, Amos, Bhatia, Maneet, Ferguson, Genevieve, Heyman, Rebecca, Vora, Shivam, Monkman, James, Bolderson, Emma, Kulasinghe, Arutha, He, Yaowu, Gabrielli, Brian, Hooper, John D., Richard, Derek J., O’Byrne, Kenneth J. and Adams, Mark N. (2024). Inhibition of Aurora B kinase (AURKB) enhances the effectiveness of 5-fluorouracil chemotherapy against colorectal cancer cells. British Journal of Cancer. doi: 10.1038/s41416-024-02584-z

UGDH promotes tumor-initiating cells and a fibroinflammatory tumor microenvironment in ovarian cancer

Harrington, Brittney S., Kamdar, Rahul, Ning, Franklin, Korrapati, Soumya, Caminear, Michael W., Hernandez, Lidia F., Butcher, Donna, Edmondson, Elijah F., Traficante, Nadia, Hendley, Joy, Gough, Madeline, Rogers, Rebecca, Lourie, Rohan, Shetty, Jyoti, Tran, Bao, Elloumi, Fathi, Abdelmaksoud, Abdalla, Nag, Madhu Lal, Mazan-Mamczarz, Krystyna, House, Carrie D., Hooper, John D. and Annunziata, Christina M. (2023). UGDH promotes tumor-initiating cells and a fibroinflammatory tumor microenvironment in ovarian cancer. Journal of Experimental and Clinical Cancer Research, 42 (1) 270, 270. doi: 10.1186/s13046-023-02820-z

Improved concordance of challenging human epidermal growth factor receptor 2 dual in-situ hybridisation cases with the use of a digital image analysis algorithm in breast cancer

Gough, Madeline, Liu, Cheng, Srinivasan, Bhuvana, Wilkinson, Lisa, Dunk, Louisa, Yang, Yuanhao, Schreiber, Veronika, Tuffaha, Haitham, Kryza, Thomas, Hooper, John D., Lakhani, Sunil R. and Snell, Cameron E. (2023). Improved concordance of challenging human epidermal growth factor receptor 2 dual in-situ hybridisation cases with the use of a digital image analysis algorithm in breast cancer. Histopathology, 83 (4), 647-656. doi: 10.1111/his.15000

MUC13 cell surface mucin limits Salmonella Typhimurium infection by protecting the mucosal epithelial barrier

McGuckin, Michael A., Davies, Julie M., Felgner, Pascal, Wong, Kuan Yau, Giri, Rabina, He, Yaowu, Moniruzzaman, Md., Kryza, Thomas, Sajiir, Haressh, Hooper, John D., Florin, Timothy H., Begun, Jakob, Oussalah, Abderrahim, Hasnain, Sumaira Z., Hensel, Michael and Sheng, Yong H. (2023). MUC13 cell surface mucin limits Salmonella Typhimurium infection by protecting the mucosal epithelial barrier. Cellular and Molecular Gastroenterology and Hepatology, 16 (6), 985-1009. doi: 10.1016/j.jcmgh.2023.08.011

Development of a CUB domain-containing protein 1 (CDCP1)-targeting antibody-drug conjugate for triple-negative and metastatic breast cancer

Gough, Madeline, Kwah, Kayden, He, Yaowu, Snell, Cameron Edward, Hooper, John D. and Kryza, Thomas (2023). Development of a CUB domain-containing protein 1 (CDCP1)-targeting antibody-drug conjugate for triple-negative and metastatic breast cancer. Journal of Clinical Oncology, 41 (16_suppl), e15012-e15012. doi: 10.1200/jco.2023.41.16_suppl.e15012

The roles of proteases in prostate cancer

Koistinen, Hannu, Kovanen, Ruusu‐Maaria, Hollenberg, Morley D., Dufour, Antoine, Radisky, Evette S., Stenman, Ulf‐Håkan, Batra, Jyotsna, Clements, Judith, Hooper, John D., Diamandis, Eleftherios, Schilling, Oliver, Rannikko, Antti and Mirtti, Tuomas (2023). The roles of proteases in prostate cancer. IUBMB Life, 75 (6), 493-513. doi: 10.1002/iub.2700

Discovery and validation of serum glycoprotein biomarkers for high grade serous ovarian cancer

Dutt, Mriga, Hartel, Gunter, Richards, Renee S., Shah, Alok K., Mohamed, Ahmed, Apostolidou, Sophia, Gentry‐Maharaj, Aleksandra, Hooper, John D., Perrin, Lewis C., Menon, Usha, Hill, Michelle M. and Australian Ovarian Cancer Study Group (2023). Discovery and validation of serum glycoprotein biomarkers for high grade serous ovarian cancer. Proteomics - Clinical Applications, 17 (4) 2200114, 1-16. doi: 10.1002/prca.202200114

Combined thioredoxin reductase and glutaminase inhibition exerts synergistic anti-tumor activity in MYC-high high-grade serous ovarian carcinoma

Raninga, Prahlad V., He, Yaowu, Datta, Keshava K., Lu, Xue, Maheshwari, Uma R., Venkat, Pooja, Mayoh, Chelsea, Gowda, Harsha, Kalimutho, Murugan, Hooper, John D. and Khanna, Kum Kum (2023). Combined thioredoxin reductase and glutaminase inhibition exerts synergistic anti-tumor activity in MYC-high high-grade serous ovarian carcinoma. Molecular Therapy, 31 (3), 729-743. doi: 10.1016/j.ymthe.2022.12.011

Reactive oxygen species as mediators of disease progression and therapeutic response in colorectal cancer

Lyons, Nicholas, Giri, Rabina, Begun, Jakob, Clark, David A, Proud, David, He, Yaowu, Hooper, John and Kryza, Thomas (2023). Reactive oxygen species as mediators of disease progression and therapeutic response in colorectal cancer. Antioxidants and Redox Signaling, 39 (1-3), 186-205. doi: 10.1089/ars.2022.0127

In comparison with polypectomy, colorectal resection is associated with improved survival for patients diagnosed with malignant polyps

Zammit, Andrew P., Hooper, John D., Brown, Ian, Clark, David A. and Riddell, Andrew D. (2023). In comparison with polypectomy, colorectal resection is associated with improved survival for patients diagnosed with malignant polyps. Colorectal Disease, 25 (2), 261-271. doi: 10.1111/codi.16369

Missing parameters in malignant polyp histology reports: can appropriate decisions be made?

Zammit, Andrew P., Brown, Ian, Hooper, John D., Clark, David A. and Riddell, Andrew D. (2023). Missing parameters in malignant polyp histology reports: can appropriate decisions be made?. Pathology, 55 (1), 58-63. doi: 10.1016/j.pathol.2022.06.007

Malignant polyps in the COVID ‐19 era: a population‐based analysis

Zammit, Andrew P., Brown, Ian, Hooper, John D., Clark, David A. and Riddell, Andrew D. (2023). Malignant polyps in the COVID ‐19 era: a population‐based analysis. ANZ Journal of Surgery, 93 (4), 932-938. doi: 10.1111/ans.18253

Management of high and low risk malignant polyps – a population wide analysis

Zammit, Andrew P., Panahi, Seyed E., Brown, Ian, Hooper, John D., Clark, David A. and Riddell, Andrew D. (2023). Management of high and low risk malignant polyps – a population wide analysis. Colorectal Disease, 25 (1), 66-74. doi: 10.1111/codi.16328

CBL0137 impairs homologous recombination repair and sensitizes high-grade serous ovarian carcinoma to PARP inhibitors

Lu, Xue, He, Yaowu, Johnston, Rebecca L., Nanayakarra, Devathri, Sankarasubramanian, Sivanandhini, Lopez, J. Alejandro, Friedlander, Michael, Kalimutho, Murugan, Hooper, John D., Raninga, Prahlad V. and Khanna, Kum Kum (2022). CBL0137 impairs homologous recombination repair and sensitizes high-grade serous ovarian carcinoma to PARP inhibitors. Journal of Experimental and Clinical Cancer Research, 41 (1) 355, 1-17. doi: 10.1186/s13046-022-02570-4

Development of antibody-drug conjugates targeting the CDCP1 receptor for the treatment of Triple negative and metastatic breast cancer

Gough, M., Kwah, K., Khan, T., He, Y., Pyke, C., Ratnayake, G., Snell, C., Hooper, J. and Kryza, T. (2022). Development of antibody-drug conjugates targeting the CDCP1 receptor for the treatment of Triple negative and metastatic breast cancer. European Journal of Cancer, 175, S81-S82. doi: 10.1016/s0959-8049(22)01571-4

CUB Domain-Containing Protein 1 (CDCP1) is a rational target for the development of imaging tracers and antibody-drug conjugates for cancer detection and therapy

Khan, Tashbib, Lyons, Nicholas J., Gough, Madeline, Kwah, Kayden K.X., Cuda, Tahleesa J., Snell, Cameron E., Tse, Brian W., Sokolowski, Kamil A., Pearce, Lesley A., Adams, Timothy E., Rose, Stephen E., Puttick, Simon, Pajic, Marina, Adams, Mark N., He, Yaowu, Hooper, John D. and Kryza, Thomas (2022). CUB Domain-Containing Protein 1 (CDCP1) is a rational target for the development of imaging tracers and antibody-drug conjugates for cancer detection and therapy. Theranostics, 12 (16), 6915-6930. doi: 10.7150/thno.78171

Timing of surveillance colonoscopy following malignant colorectal polypectomy in Queensland

Zammit, Andrew P., Brown, Ian, Hooper, John D., Clark, David A. and Riddell, Andrew D. (2022). Timing of surveillance colonoscopy following malignant colorectal polypectomy in Queensland. ANZ Journal of Surgery, 93 (3), 606-611. doi: 10.1111/ans.18069

A population‐based study of the management of rectal malignant polyps and the use of trans‐anal surgery

Zammit, Andrew P., Brown, Ian, Hooper, John D., Clark, David A. and Riddell, Andrew D. (2022). A population‐based study of the management of rectal malignant polyps and the use of trans‐anal surgery. ANZ Journal of Surgery, 92 (11), 2949-2955. doi: 10.1111/ans.17917

Erratum: Alpha-Tomatine Attenuation of In Vivo Growth of Subcutaneous and Orthotopic Xenograft Tumors of Human Prostate Carcinoma PC-3 Cells Is Accompanied by Inactivation of Nuclear Factor-Kappa B Signaling (PLoS ONE (2013) 8:2 (e57708) DOI: 10.1371/journal.pone.0057708)

Lee, Sui-Ting, Wong, Pooi-Fong, He, Hui, Hooper, John David and Mustafa, Mohd Rais (2022). Erratum: Alpha-Tomatine Attenuation of In Vivo Growth of Subcutaneous and Orthotopic Xenograft Tumors of Human Prostate Carcinoma PC-3 Cells Is Accompanied by Inactivation of Nuclear Factor-Kappa B Signaling (PLoS ONE (2013) 8:2 (e57708) DOI: 10.1371/journal.pone.0057708). PLoS ONE, 17 (5 May) e0268234. doi: 10.1371/journal.pone.0268234

Protease‐activated receptor‐2 dependent and independent responses of bone cells to prostate cancer cell secretory products

Pagel, Charles N., Kularathna, Pamu K., Sanaei, Reza, Young, Neil D., Hooper, John D. and Mackie, Eleanor J. (2022). Protease‐activated receptor‐2 dependent and independent responses of bone cells to prostate cancer cell secretory products. The Prostate, 82 (6), 723-739. doi: 10.1002/pros.24316

Patient and pathological predictors of management strategy for malignant polyps following polypectomy: a systematic review and meta-analysis

Zammit, Andrew P., Lyons, Nicholas J., Chatfield, Mark D., Hooper, John D., Brown, Ian, Clark, David A. and Riddell, Andrew D. (2022). Patient and pathological predictors of management strategy for malignant polyps following polypectomy: a systematic review and meta-analysis. International Journal of Colorectal Disease, 37 (5), 1035-1047. doi: 10.1007/s00384-022-04142-6

Protease-activated receptor-2 promotes osteogenesis in skeletal mesenchymal stem cells at the expense of adipogenesis: involvement of interleukin-6

Sanaei, R., Kularathna, P. K., Taghavi, N., Hooper, J. D., Pagel, C. N. and Mackie, E. J. (2021). Protease-activated receptor-2 promotes osteogenesis in skeletal mesenchymal stem cells at the expense of adipogenesis: involvement of interleukin-6. Bone Reports, 15 101113, 101113. doi: 10.1016/j.bonr.2021.101113

Elevating CDCA3 levels enhances tyrosine kinase inhibitor sensitivity in TKI-resistant EGFR mutant non-small-cell lung cancer

Sahin, Katherine B., Shah, Esha T., Ferguson, Genevieve P., Molloy, Christopher, Kalita-de Croft, Priyakshi, Hayes, Sarah A., Hudson, Amanda, Colvin, Emily, Kamitakahara, Hannah, Harvie, Rozelle, Hasovits, Csilla, Khan, Tashbib, Duijf, Pascal H. G., Howell, Viive M., He, Yaowu, Bolderson, Emma, Hooper, John D., Lakhani, Sunil R., Richard, Derek J., O’Byrne, Kenneth J. and Adams, Mark N. (2021). Elevating CDCA3 levels enhances tyrosine kinase inhibitor sensitivity in TKI-resistant EGFR mutant non-small-cell lung cancer. Cancers, 13 (18) 4651, 4651. doi: 10.3390/cancers13184651

Preclinical molecular PET-CT imaging targeting CDCP1 in colorectal cancer

Cuda, Tahleesa J., He, Yaowu, Kryza, Thomas, Khan, Tashbib, Tse, Brian W., Sokolowski, Kamil A., Liu, Cheng, Lyons, Nicholas, Gough, Madeline, Snell, Cameron E., Wyld, David K., Rose, Stephen, Riddell, Andrew D., Stevenson, Andrew R. L., Thomas, Paul A., Clark, David A., Puttick, Simon and Hooper, John D. (2021). Preclinical molecular PET-CT imaging targeting CDCP1 in colorectal cancer. Contrast Media and Molecular Imaging, 2021 3153278, 3153278. doi: 10.1155/2021/3153278

Preclinical Evaluation of a Fluorescent Probe Targeting Receptor CDCP1 for Identification of Ovarian Cancer

He, Yaowu, Khan, Tashbib, Kryza, Thomas, Jones, Martina L., Goh, Justin B., Lyons, Nicholas J., Pearce, Lesley A., Lee, Michael D, Gough, Madeline, Rogers, Rebecca, Davies, Claire M,, Gilks, C. Blake, Hodgkinson, Thomas, Lourie, Rohan, Barry, Sinead C., Perrin, Lewis C., Williams, Charlotte C., Puttick, Simon, Adams, Timothy E., Munro, Trent P., Hooper, John D. and Chetty, Naven (2021). Preclinical Evaluation of a Fluorescent Probe Targeting Receptor CDCP1 for Identification of Ovarian Cancer. Molecular Pharmaceutics, 18 (9) acs.molpharmaceut.1c00401, 3464-3474. doi: 10.1021/acs.molpharmaceut.1c00401

Extracellular vesicle transmission of chemoresistance to ovarian cancer cells is associated with hypoxia-induced expression of glycolytic pathway proteins, and prediction of epithelial ovarian cancer disease recurrence

Alharbi, Mona, Lai, Andrew, Sharma, Shayna, Kalita-De Croft, Priyakshi, Godbole, Nihar, Campos, America, Guanzon, Dominic, Salas-Burgos, Alexis, Carrion, Flavio, Zuñiga, Felipe A., Perrin, Lewis, He, Yaowu, Pejovic, Tanja, Winters, Carmen, Morgan, Terry, Hooper, John D., Rice, Gregory E. and Salomon, Carlos (2021). Extracellular vesicle transmission of chemoresistance to ovarian cancer cells is associated with hypoxia-induced expression of glycolytic pathway proteins, and prediction of epithelial ovarian cancer disease recurrence. Cancers, 13 (14) 3388, 1-26. doi: 10.3390/cancers13143388

Substrate-biased activity-based probes identify proteases that cleave receptor CDCP1

Kryza, Thomas, Khan, Tashbib, Lovell, Scott, Harrington, Brittney S., Yin, Julia, Porazinski, Sean, Pajic, Marina, Koistinen, Hannu, Rantala, Juha K., Dreyer, Tobias, Magdolen, Viktor, Reuning, Ute, He, Yaowu, Tate, Edward W. and Hooper, John D. (2021). Substrate-biased activity-based probes identify proteases that cleave receptor CDCP1. Nature Chemical Biology, 17 (7), 776-783. doi: 10.1038/s41589-021-00783-w

The CDCP1 signalling hub: a target for cancer detection and therapeutic intervention

Khan, Tashbib, Kryza, Thomas, Lyons, Nicholas J., He, Yaowu and Hooper, John D. (2021). The CDCP1 signalling hub: a target for cancer detection and therapeutic intervention. Cancer Research, 81 (9) canres.2978.2020, QF1-QF11. doi: 10.1158/0008-5472.can-20-2978

Histone modifying enzymes in gynaecological cancers

Ramarao-Milne, Priya, Kondrashova, Olga, Barry, Sinead, Hooper, John D., Lee, Jason S. and Waddell, Nicola (2021). Histone modifying enzymes in gynaecological cancers. Cancers, 13 (4) 816, 1-21. doi: 10.3390/cancers13040816

A nucleotide analog prevents colitis associated cancer via Β-catenin independently of inflammation and autophagy

Sheng, Yong Hua, Giri, Rabina, Davies, Julie, Schreiber, Veronika, Alabbas, Saleh, Movva, Ramya, He, Yaowu, Wu, Andy, Hooper, John, McWhinney, Brett, Oancea, Iulia, Kijanka, Gregor, Hasnain, Sumaira, Lucke, Andrew J., Fairlie, David P., McGuckin, Michael A., Florin, Timothy H. and Begun, Jakob (2021). A nucleotide analog prevents colitis associated cancer via Β-catenin independently of inflammation and autophagy. Cellular and Molecular Gastroenterology and Hepatology, 11 (1), 33-53. doi: 10.1016/j.jcmgh.2020.05.012

PET imaging quantifying Ga-PSMA-11 uptake in metastatic colorectal cancer

Cuda, Tahleesa J., Riddell, Andrew D., Liu, Cheng, Whitehall, Vicki L., Borowsky, Jennifer, Wyld, David K., Burge, Matthew E., Ahern, Elizabeth, Griffin, Alison, Lyons, Nicholas J. R., Rose, Stephen E., Clark, David A., Stevenson, Andrew R. L., Hooper, John D., Puttick, Simon and Thomas, Paul A. (2020). PET imaging quantifying Ga-PSMA-11 uptake in metastatic colorectal cancer. The Journal of Nuclear Medicine, 61 (11), 1576-1579. doi: 10.2967/jnumed.119.233312

Revisiting Glycogen in Cancer: A Conspicuous and Targetable Enabler of Malignant Transformation

Khan, Tashbib, Sullivan, Mitchell A., Gunter, Jennifer H., Kryza, Thomas, Lyons, Nicholas, He, Yaowu and Hooper, John D. (2020). Revisiting Glycogen in Cancer: A Conspicuous and Targetable Enabler of Malignant Transformation. Frontiers in Oncology, 10 592455, 592455. doi: 10.3389/fonc.2020.592455

HBV induced hepatocellular carcinoma and related potential immunotherapy

Jia, Liyang, Gao, Yanan, He, Yaowu, Hooper, John D. and Yang, Pengyuan (2020). HBV induced hepatocellular carcinoma and related potential immunotherapy. Pharmacological Research, 159 104992, 104992. doi: 10.1016/j.phrs.2020.104992

miRNa signature in small extracellular vesicles and their association with platinum resistance and cancer recurrence in ovarian cancer

Alharbi, Mona, Sharma, Shayna, Guanzon, Dominic, Lai, Andrew, Zuñiga, Felipe, Shiddiky, Muhammad J.A., Yamauchi, Yusuke, Salas-Burgos, Alexis, He, Yaowu, Pejovic, Tanja, Winters, Carmen, Morgan, Terry, Perrin, Lewis, Hooper, John D. and Salomon, Carlos (2020). miRNa signature in small extracellular vesicles and their association with platinum resistance and cancer recurrence in ovarian cancer. Nanomedicine: Nanotechnology, Biology, and Medicine, 28 102207, 102207. doi: 10.1016/j.nano.2020.102207

Disruption of glycogen utilization markedly improves the efficacy of carboplatin against preclinical models of clear cell ovarian carcinoma

Khan, Tashbib, He, Yaowu, Kryza, Thomas, Harrington, Brittney S., Gunter, Jennifer H., Sullivan, Mitchell A., Cuda, Tahleesa, Rogers, Rebecca, Davies, Claire M., Broomfield, Amy, Gough, Madeline, Wu, Andy C., McGann, Thomas, Weroha, S. John, Haluska, Paul, Forbes, Josephine M., Armes, Jane E., Barry, Sinead C., Coward, Jermaine I., Jagasia, Nisha, Chetty, Naven, Snell, Cameron E., Lourie, Rohan, Perrin, Lewis C. and Hooper, John D. (2020). Disruption of glycogen utilization markedly improves the efficacy of carboplatin against preclinical models of clear cell ovarian carcinoma. Cancers, 12 (4) 869, 869. doi: 10.3390/cancers12040869

Anti-CDCP1 immuno-conjugates for detection and inhibition of ovarian cancer

Harrington, Brittney S., He, Yaowu, Khan, Tashbib, Puttick, Simon, Conroy, Paul J., Kryza, Thomas, Cuda, Tahleesa, Sokolowski, Kamil A., Tse, Brian W.C ., Robbins, Katherine K., Arachchige, Buddhika J., Stehbens, Samantha J., Pollock, Pamela M., Reed, Sarah, Weroha, S. John, Haluska, Paul, Salomon, Carlos, Lourie, Rohan, Perrin, Lewis C., Law, Ruby H. P., Whisstock, James C. and Hooper, John D. (2020). Anti-CDCP1 immuno-conjugates for detection and inhibition of ovarian cancer. Theranostics, 10 (5), 2095-2114. doi: 10.7150/thno.30736

Effective targeting of intact and proteolysed CDCP1 for imaging and treatment of pancreatic ductal adenocarcinoma

Kryza, Thomas, Khan, Tashbib, Puttick, Simon, Li, Chao, Sokolowski, Kamil A., Tse, Brian W.C., Cuda, Tahleesa, Lyons, Nicholas, Gough, Madeline, Yin, Julia, Parkin, Ashleigh, Deryugina, Elena I., Quigley, James P., Law, Ruby H.P., Whisstock, James C., Riddell, Andrew D., Barbour, Andrew P., Wyld, David K., Thomas, Paul A., Rose, Stephen, Snell, Cameron E., Pajic, Marina, He, Yaowu and Hooper, John D. (2020). Effective targeting of intact and proteolysed CDCP1 for imaging and treatment of pancreatic ductal adenocarcinoma. Theranostics, 10 (9), 4116-4133. doi: 10.7150/thno.43589

The molecular function of kallikrein-related peptidase 14 demonstrates a key modulatory role in advanced prostate cancer

Kryza, Thomas, Bock, Nathalie, Lovell, Scott, Rockstroh, Anja, Lehman, Melanie L., Lesner, Adam, Panchadsaram, Janaththani, Silva, Lakmali Munasinghage, Srinivasan, Srilakshmi, Snell, Cameron E., Williams, Elizabeth D., Fazli, Ladan, Gleave, Martin, Batra, Jyotsna, Nelson, Colleen, Tate, Edward W., Harris, Jonathan, Hooper, John D. and Clements, Judith A. (2019). The molecular function of kallikrein-related peptidase 14 demonstrates a key modulatory role in advanced prostate cancer. Molecular Oncology, 14 (1) 1878-0261.12587, 105-128. doi: 10.1002/1878-0261.12587

CDCP1 enhances Wnt signaling in colorectal cancer promoting nuclear localization of β-catenin and E-cadherin

He, Yaowu, Davies, Claire M., Harrington, Brittney S., Hellmers, Linh, Sheng, Yonghua, Broomfield, Amy, McGann, Thomas, Bastick, Kate, Zhong, Laurie, Wu, Andy, Maresh, Grace, McChesney, Shannon, Yau Wong, Kuan, Adams, Mark N., Sullivan, Ryan C., Palmer, James S., Burke, Lez J., Ewing, Adam D., Zhang, Xin, Margolin, David, Li, Li, Lourie, Rohan, Matsika, Admire, Srinivasan, Bhuvana, McGuckin, Michael A., Lumley, John W. and Hooper, John D. (2019). CDCP1 enhances Wnt signaling in colorectal cancer promoting nuclear localization of β-catenin and E-cadherin. Oncogene, 39 (1), 219-233. doi: 10.1038/s41388-019-0983-3

MUC13 promotes the development of colitis-associated colorectal tumors via β-catenin activity

Sheng, Yong Hua, Wong, Kuan Yau, Seim, Inge, Wang, Ran, He, Yaowu, Wu, Andy, Patrick, Maya, Lourie, Rohan, Schreiber, Veronika, Giri, Rabina, Ng, Choa Ping, Popat, Amirali, Hooper, John, Kijanka, Gregor, Florin, Timothy H., Begun, Jakob, Radford, Kristen J., Hasnain, Sumaira and McGuckin, Michael A. (2019). MUC13 promotes the development of colitis-associated colorectal tumors via β-catenin activity. Oncogene, 38 (48), 7294-7310. doi: 10.1038/s41388-019-0951-y

Ovarian cancer-derived exosomes promote tumor metastasis in vivo an effect modulated by the invasiveness capacity of their originating cells

Alharbi, Mona, Lai, Andrew, Guanzon, Dominic, Palma, Carlos, Zuñiga, Felipe, Perrin, Lewis, He, Yaowu, Hooper, John D and Salomon, Carlos (2019). Ovarian cancer-derived exosomes promote tumor metastasis in vivo an effect modulated by the invasiveness capacity of their originating cells. Clinical Science, 133 (13), CS20190082-1419. doi: 10.1042/cs20190082

The potential role of miRNAs and exosomes in chemotherapy in ovarian cancer

Alharbi, Mona, Zuñiga, Felipe, Elfeky, Omar, Guanzon, Dominic, Lai, Andrew, Rice, Gregory E., Perrin, Lewis, Hooper, John and Salomon, Carlos (2018). The potential role of miRNAs and exosomes in chemotherapy in ovarian cancer. Endocrine-Related Cancer, 25 (12), R663-R685. doi: 10.1530/erc-18-0019

Proteomic analysis of exosomes reveals an association between cell invasiveness and exosomal bioactivity on endothelial and mesenchymal cell migration

Sharma, Shayna, Alharbi, Mona, Kobayashi, Miharu, Lai, Andrew, Guanzon, Dominic, Zuñiga, Felipe, Ormazabal, Valeska, Palma, Carlos, Scholz-Romero, Katherin, Rice, Gregory E., Hooper, John D. and Salomon, Carlos (2018). Proteomic analysis of exosomes reveals an association between cell invasiveness and exosomal bioactivity on endothelial and mesenchymal cell migration. Clinical Science, 132 (18), 2029-2044. doi: 10.1042/CS20180425

Evidence that cell surface localization of serine protease activity facilitates cleavage of the protease activated receptor CDCP1

He, Yaowu, Reid, Janet C., He, Hui, Harrington, Brittney S., Finlayson, Brittney, Khan, Tashbib and Hooper, John D. (2018). Evidence that cell surface localization of serine protease activity facilitates cleavage of the protease activated receptor CDCP1. Biological Chemistry, 399 (9), 1091-1097. doi: 10.1515/hsz-2017-0308

L1 retrotransposon heterogeneity in ovarian tumor cell evolution

Nguyen, Thu H. M., Carreira, Patricia E., Sanchez-Luque, Francisco J., Schauer, Stephanie N., Fagg, Allister C., Richardson, Sandra R., Davies, Claire M., Jesuadian, J. Samuel, Kempen, Marie-Jeanne H. C., Troskie, Robin-Lee, James, Cini, Beaven, Elizabeth A., Wallis, Tristan P., Coward, Jermaine I. G., Chetty, Naven P., Crandon, Alexander J., Venter, Deon J., Armes, Jane E., Perrin, Lewis C., Hooper, John D., Ewing, Adam D., Upton, Kyle R. and Faulkner, Geoffrey J. (2018). L1 retrotransposon heterogeneity in ovarian tumor cell evolution. Cell Reports, 23 (13), 3730-3740. doi: 10.1016/j.celrep.2018.05.090

Tumor-derived exosomes in ovarian cancer - liquid biopsies for early detection and real-time monitoring of cancer progression

Sharma, Shayna, Zuñiga, Felipe, Rice, Gregory E., Perrin, Lewis C., Hooper, John D. and Salomon, Carlos (2017). Tumor-derived exosomes in ovarian cancer - liquid biopsies for early detection and real-time monitoring of cancer progression. Oncotarget, 8 (61), 104687-104703. doi: 10.18632/oncotarget.22191

Kallikrein-related peptidase 4 induces cancer-associated fibroblast features in prostate-derived stromal cells

Kryza, Thomas, Silva, Lakmali M., Bock, Nathalie, Fuhrman-Luck, Ruth, Stephens, Carson, Gao, Jin, Samaratunga, Hema, Lawrence, Mitchell, Hooper, John D., Dong, Ying, Risbridger, Gail and Clements, Judith A. (2017). Kallikrein-related peptidase 4 induces cancer-associated fibroblast features in prostate-derived stromal cells. Molecular Oncology, 11 (10), 1307-1329. doi: 10.1002/1878-0261.12075

The emerging roles of extracellular vesicles as communication vehicles within the tumor microenvironment and beyond

Sullivan, Ryan, Maresh, Grace, Zhang, Xin, Salomon, Carlos, Hooper, John, Margolin, David and Li, Li (2017). The emerging roles of extracellular vesicles as communication vehicles within the tumor microenvironment and beyond. Frontiers in Endocrinology, 8 (AUG) 194, 194. doi: 10.3389/fendo.2017.00194

Expression of CDCA3 is a prognostic biomarker and potential therapeutic target in non–small cell lung cancer

Adams, Mark N., Burgess, Joshua T., He, Yaowu, Gately, Kathy, Snell, Cameron, Zhang, Shu-Dong, Hooper, John D., Richard, Derek J. and O'Byrne, Kenneth J. (2017). Expression of CDCA3 is a prognostic biomarker and potential therapeutic target in non–small cell lung cancer. Journal of Thoracic Oncology, 12 (7), 1071-1084. doi: 10.1016/j.jtho.2017.04.018

Plasmin(ogen) serves as a favorable biomarker for prediction of survival in advanced high-grade serous ovarian cancer

Zhao, Shuo, Dorn, Julia, Napieralski, Rudolf, Walch, Axel, Diersch, Sandra, Kotzsch, Matthias, Ahmed, Nancy, Hooper, John D., Kiechle, Marion, Schmitt, Manfred and Magdolen, Viktor (2017). Plasmin(ogen) serves as a favorable biomarker for prediction of survival in advanced high-grade serous ovarian cancer. Biological Chemistry, 398 (7), 765-773. doi: 10.1515/hsz-2016-0282

Development of an enzyme-linked immunosorbent assay for detection of CDCP1 shed from the cell surface and present in colorectal cancer serum specimens

Chen, Yang, Harrington, Brittney S., Lau, Kevin C. N., Burke, Lez J., He, Yaowu, Iconomou, Mary, Palmer, James S., Meade, Brian, Lumley, John W. and Hooper, John D. (2017). Development of an enzyme-linked immunosorbent assay for detection of CDCP1 shed from the cell surface and present in colorectal cancer serum specimens. Journal of Pharmaceutical and Biomedical Analysis, 139, 65-72. doi: 10.1016/j.jpba.2017.02.047

Mapping transmembrane residues of proteinase activated recpetor 2 (PAR2) that influence ligand-modulated calcium signaling

Suen, J.Y., Adams, M. N., Lim, J., Madala, P.K., Xu, W, Cotterell, A., He, Y., Yua, Mei-Kwan, Hooper, J. D. and Fairlie, D.P. (2017). Mapping transmembrane residues of proteinase activated recpetor 2 (PAR2) that influence ligand-modulated calcium signaling. Pharmacological Research, 117, 328-342. doi: 10.1016/j.phrs.2016.12.020

MUC13 overexpression in renal cell carcinoma plays a central role in tumor progression and drug resistance

Sheng, Yonghua, Ng, Choa Ping, Lourie, Rohan, Shah, Esha T., He, Yaowu, Wong, Kuan Yua, Seim, Inge, Oancea, Iulia, Morais, Christudas, Jeffery, Penny L., Hooper, John, Gobe, Glenda C. and Mcguckin, Michael A. (2017). MUC13 overexpression in renal cell carcinoma plays a central role in tumor progression and drug resistance. International Journal of Cancer, 140 (10), 2351-2363. doi: 10.1002/ijc.30651

Osteoporosis-Related Health Behaviors in Men With Prostate Cancer and Survivors Exploring Osteoporosis Knowledge, Health Beliefs, and Self-Efficacy

Lassemillante, Annie-Claude M., Skinner, Tina L., Hooper, John D., Prins, John B. and Wright, Olivia R. L. (2017). Osteoporosis-Related Health Behaviors in Men With Prostate Cancer and Survivors Exploring Osteoporosis Knowledge, Health Beliefs, and Self-Efficacy. American Journal of Men’s Health, 11 (1), 13-23. doi: 10.1177/1557988315615956

Pericellular regulation of prostate cancer expressed kallikrein-related peptidases and matrix metalloproteinases by cell surface serine proteases

Reid, Janet C., Matsika, Admire, Davies, Claire M., He, Yaowu, Broomfield, Amy, Bennett, Nigel C., Magdolen, Viktor, Srinivasan, Bhuvana, Clements, Judith A. and Hooper, John D. (2017). Pericellular regulation of prostate cancer expressed kallikrein-related peptidases and matrix metalloproteinases by cell surface serine proteases. American Journal of Cancer Research, 7 (11), 2257-2274.

In vitro evidence that KLK14 regulates the components of the HGF/Met axis, pro-HGF and HGF-activator inhibitor 1A and 1B

Reid, Janet C., Bennett, Nigel C., Stephens, Carson R., Carroll, Melanie L., Magdolen, Viktor, Clements, Judith A. and Hooper, John D. (2016). In vitro evidence that KLK14 regulates the components of the HGF/Met axis, pro-HGF and HGF-activator inhibitor 1A and 1B. Biological Chemistry, 397 (12), 1299-1305. doi: 10.1515/hsz-2016-0163

MUC13 protects colorectal cancer cells from death by activating the NF-κB pathway and is a potential therapeutic target

Sheng, Y. H., He, Y., Hasnain, S. Z., Wang, R., Tong, H., Clarke, D. T., Lourie, R., Oancea, I., Wong, K. Y., Lumley, J. W., Florin, T. H., Sutton, P., Hooper, J. D., McMillan, N. A. and McGuckin, M. A. (2016). MUC13 protects colorectal cancer cells from death by activating the NF-κB pathway and is a potential therapeutic target. Oncogene, 36 (5), 700-713. doi: 10.1038/onc.2016.241

CD169+ macrophages mediate pathological formation of woven bone in skeletal lesions of prostate cancer

Wu, Andy C., He, Yaowu, Broomfield, Amy, Paatan, Nicoll J., Harrington, Brittney S., Tseng, Hsu-Wen, Beaven, Elizabeth A., Kiernan, Deirdre M., Swindle, Peter, Clubb, Adrian B., Levesque, Jean-Pierre, Winkler, Ingrid G., Ling, Ming-Tat, Srinivasan, Bhuvana, Hooper, John D. and Pettit, Allison R. (2016). CD169+ macrophages mediate pathological formation of woven bone in skeletal lesions of prostate cancer. Journal of Pathology, 239 (2), 218-230. doi: 10.1002/path.4718

Cell line and patient-derived xenograft models reveal elevated CDCP1 as a target in high-grade serous ovarian cancer

Harrington, Brittney S., He, Yaowu, Davies, Claire M., Wallace, Sarah J., Adams, Mark N., Beaven, Elizabeth A., Roche, Deborah K., Kennedy, Catherine, Chetty, Naven P., Crandon, Alexander J., Flatley, Christopher, Oliveira, Niara B., Shannon, Catherine M., deFazio, Anna, Tinker, Anna V., Gilks, C. Blake, Gabrielli, Brian, Brennan, Donal J., Coward, Jermaine I., Armes, Jane E., Perrin, Lewis C. and Hooper, John D. (2016). Cell line and patient-derived xenograft models reveal elevated CDCP1 as a target in high-grade serous ovarian cancer. British Journal of Cancer, 114 (4), 417-426. doi: 10.1038/bjc.2015.471

New crossroads for potential therapeutic intervention in cancer - intersections between CDCP1, EGFR family members and downstream signaling pathways

He, Yaowu, Harrington, Brittney S. and Hooper, John D. (2016). New crossroads for potential therapeutic intervention in cancer - intersections between CDCP1, EGFR family members and downstream signaling pathways. Oncoscience, 3 (1), 5-8. doi: 10.18632/oncoscience.286

Elevated CDCP1 predicts poor patient outcome and mediates ovarian clear cell carcinoma by promoting tumor spheroid formation, cell migration and chemoresistance

He, Y., Wu, A. C., Harrington, B. S., Davies, C. M., Wallace, S. J., Adams, M. N., Palmer, J. S., Roche, D. K., Hollier, B. G., Westbrook, T. F., Hamidi, H., Konecny, G. E., Winterhoff, B., Chetty, N. P., Crandon, A. J., Oliveira, N. B., Shannon, C. M., Tinker, A. V., Gilks, C. B., Coward, J. I., Lumley, J. W., Perrin, L. C., Armes, J. E. and Hooper, J. D. (2016). Elevated CDCP1 predicts poor patient outcome and mediates ovarian clear cell carcinoma by promoting tumor spheroid formation, cell migration and chemoresistance. Oncogene, 35 (4), 468-478. doi: 10.1038/onc.2015.101

Potent small agonists of protease activated receptor 2

Yau, Mei-Kwan, Suen, Jacky Y., Xu, Weijun, Lim, Junxian, Liu, Ligong, Adams, Mark N., He, Yaowu, Hooper, John D., Reid, Robert C. and Fairlie, David P. (2016). Potent small agonists of protease activated receptor 2. ACS Medicinal Chemistry Letters, 7 (1), 105-110. doi: 10.1021/acsmedchemlett.5b00429

Cancer stem cell markers in prostate cancer: An immunohistochemical study of ALDH1, SOX2 and EZH2

Matsika, Admire, Srinivasan, Bhuvana, Day, Christopher, Mader, Sabina Ann, Kiernan, Deirdre Margaret, Broomfield, Amy, Fu, Jinlin, Hooper, John D., Kench, James G. and Samaratunga, Hemamali (2015). Cancer stem cell markers in prostate cancer: An immunohistochemical study of ALDH1, SOX2 and EZH2. Pathology, 47 (7), 622-628. doi: 10.1097/PAT.0000000000000325

Tissue engineered humanized bone supports human hematopoiesis in vivo

Holzapfel, Boris M., Hutmacher, Dietmar W., Nowlan, Bianca, Barbier, Valerie, Thibaudeau, Laure, Theodoropoulos, Christina, Hooper, John D., Loessner, Daniela, Clements, Judith A., Russell, Pamela J., Pettit, Allison R., Winkler, Ingrid G. and Levesque, Jean-Pierre (2015). Tissue engineered humanized bone supports human hematopoiesis in vivo. Biomaterials, 61, 103-114. doi: 10.1016/j.biomaterials.2015.04.057

Functional analysis of matriptase-2 mutations and domains: Insights into the molecular basis of iron-refractory iron deficiency anemia

McDonald, Cameron J., Ostini, Lesa, Bennett, Nigel, Subramaniam, Nanthakumar, Hooper, John, Velasco, Gloria, Wallace, Daniel F. and Nathan Subramaniam, V. (2015). Functional analysis of matriptase-2 mutations and domains: Insights into the molecular basis of iron-refractory iron deficiency anemia. American Journal of Physiology - Cell Physiology, 308 (7), C539-C547. doi: 10.1152/ajpcell.00264.2014

A critical role for murine transferrin receptor 2 in erythropoiesis during iron restriction

Wallace, Daniel F., Secondes, Eriza S., Rishi, Gautam, Ostini, Lesa, McDonald, Cameron J., Lane, Steven W., Vu, Therese, Hooper, John D., Velasco, Gloria, Ramsay, Andrew J., Lopez-Otin, Carlos and Subramaniam, V. Nathan (2015). A critical role for murine transferrin receptor 2 in erythropoiesis during iron restriction. British Journal of Haematology, 168 (6), 891-901. doi: 10.1111/bjh.13225

Prevalence of osteoporosis in prostate cancer survivors II: a meta-analysis of men not on androgen deprivation therapy

Lassemillante, Annie-Claude M., Doi, Suhail A. R., Hooper, John D., Prins, John B. and Wright, Olivia R. L. (2015). Prevalence of osteoporosis in prostate cancer survivors II: a meta-analysis of men not on androgen deprivation therapy. Endocrine, 50 (2), 344-354. doi: 10.1007/s12020-015-0536-7

EGF inhibits constitutive internalization and palmitoylation-dependent degradation of membrane-spanning procancer CDCP1 promoting its availability on the cell surface

Adams, M. N., Harrington, B. S., He, Y., Davies, C. M., Wallace, S. J., Chetty, N. P., Crandon, A. J., Oliveira, N. B., Shannon, C. M., Coward, J. I., Lumley, J. W., Perrin, L. C., Armes, J. E. and Hooper, J. D. (2015). EGF inhibits constitutive internalization and palmitoylation-dependent degradation of membrane-spanning procancer CDCP1 promoting its availability on the cell surface. Oncogene, 34 (11), 1375-1383. doi: 10.1038/onc.2014.88

Activation of membrane-bound proteins and receptor systems: a link between tissue kallikrein and the KLK-related peptidases

Dong, Ying, Harrington, Brittney S., Adams, Mark N., Wortmann, Andreas, Stephenson, Sally-Anne, Lisle, Jessica, Herington, Adrian, Hooper, John D. and Clements, Judith A. (2014). Activation of membrane-bound proteins and receptor systems: a link between tissue kallikrein and the KLK-related peptidases. Biological Chemistry, 395 (9), 977-990. doi: 10.1515/hsz-2014-0147

Prevalence of osteoporosis in prostate cancer survivors: a meta-analysis

Lassemillante, Annie-Claude M., Doi, Suhail A. R, Hooper, John D., Prins, John B. and Wright, Olivia R. L. (2014). Prevalence of osteoporosis in prostate cancer survivors: a meta-analysis. Endocrine, 45 (3), 370-381. doi: 10.1007/s12020-013-0083-z

Expression profiles and functional associations of endogenous androgen receptor and caveolin-1 in prostate cancer cell lines

Bennett, Nigel C., Hooper, John D., Johnson, David W. and Gobe, Glenda C. (2014). Expression profiles and functional associations of endogenous androgen receptor and caveolin-1 in prostate cancer cell lines. Prostate, 74 (5), 478-487. doi: 10.1002/pros.22767

Alpha-tomatine synergises with paclitaxel to enhance apoptosis of androgen-independent human prostate cancer PC-3 cells in vitro and in vivo

Lee, Sui-Ting, Wong, Pooi-Fong, Hooper, John David and Mustafa, Mohd Rais (2013). Alpha-tomatine synergises with paclitaxel to enhance apoptosis of androgen-independent human prostate cancer PC-3 cells in vitro and in vivo. Phytomedicine, 20 (14), 1297-1305. doi: 10.1016/j.phymed.2013.07.002

Alpha-Tomatine Attenuation of In Vivo Growth of Subcutaneous and Orthotopic Xenograft Tumors of Human Prostate Carcinoma PC-3 Cells Is Accompanied by Inactivation of Nuclear Factor-Kappa B Signaling

Lee, Sui-Ting, Wong, Pooi-Fong, He, Hui, Hooper, John David and Mustafa, Mohd Rais (2013). Alpha-Tomatine Attenuation of In Vivo Growth of Subcutaneous and Orthotopic Xenograft Tumors of Human Prostate Carcinoma PC-3 Cells Is Accompanied by Inactivation of Nuclear Factor-Kappa B Signaling. PLoS One, 8 (2), e57708-e57708. doi: 10.1371/journal.pone.0057708

Stratum basale keratinocyte expression of the cell-surface glycoprotein CDCP1 during epidermogenesis and its role in keratinocyte migration

McGovern, J. A., Heinemann, J. R., Burke, L. J., Dawson, R., Parker, T. J., Upton, Z., Hooper, J. D. and Manton, K. J. (2013). Stratum basale keratinocyte expression of the cell-surface glycoprotein CDCP1 during epidermogenesis and its role in keratinocyte migration. British Journal of Dermatology, 168 (3), 496-503. doi: 10.1111/bjd.12119

Evidence for steroidogenic potential in human prostate cell lines and tissues

Bennett, Nigel C., Hooper, John D., Lambie, Duncan, Lee, Cheok S., Yang, Tao, Vesey, David A., Samaratunga, Hemamali, Johnson, David W. and Gobe, Glenda C. (2012). Evidence for steroidogenic potential in human prostate cell lines and tissues. American Journal of Pathology, 181 (3), 1078-1087. doi: 10.1016/j.ajpath.2012.06.009

Blocking of CDCP1 cleavage in vivo prevents Akt-dependent survival and inhibits metastatic colonization through PARP1-mediated apoptosis of cancer cells

Casar, B., He, Y., Iconomou, M., Hooper, J. D., Quigley, J. P. and Deryugina, E. I. (2012). Blocking of CDCP1 cleavage in vivo prevents Akt-dependent survival and inhibits metastatic colonization through PARP1-mediated apoptosis of cancer cells. Oncogene, 31 (35), 3924-3938. doi: 10.1038/onc.2011.555

Selective cleavage of human sex hormone-binding globulin by kallikrein-related peptidases and effects on androgen action in LNCaP prostate cancer cells

Sanchez, Washington Y., de Veer, Simon J., Swedberg, Joakim E., Hong, Eui-Ju, Reid, Janet C., Walsh, Terry P., Hooper, John D., Hammond, Geoffrey L., Clements, Judith A. and Harris, Jonathan M. (2012). Selective cleavage of human sex hormone-binding globulin by kallikrein-related peptidases and effects on androgen action in LNCaP prostate cancer cells. Endocrinology, 153 (7), 3179-3189. doi: 10.1210/en.2012-1011

The cell surface glycoprotein CUB domain-containing protein 1 (CDCP1) contributes to epidermal growth factor receptor-mediated cell migration

Dong, Ying, He, Yaowu, de Boer, Leonore, Stack, M. Sharon, Lumley, John W., Clements, Judith A. and Hooper, John D. (2012). The cell surface glycoprotein CUB domain-containing protein 1 (CDCP1) contributes to epidermal growth factor receptor-mediated cell migration. Journal of Biological Chemistry, 287 (13), 9792-9803. doi: 10.1074/jbc.M111.335448

Evaluation of antibodies directed against human protease-activated receptor-2

Adams, Mark N., Pagel, Charles N., Mackie, Eleanor J. and Hooper, John D. (2012). Evaluation of antibodies directed against human protease-activated receptor-2. Naunyn-Schmiedeberg's Archives of Pharmacology, 385 (9), 861-873. doi: 10.1007/s00210-012-0783-6

Cellular settings mediating Src substrate switching between focal adhesion kinase tyrosine 861 and CUB-domain-containing protein 1 (CDCP1) tyrosine 734

Wortmann, Andreas, He, Yaowu, Christensen, Melinda E., Linn, Mayla, Lumley, John W., Pollock, Pamela M., Waterhouse, Nigel J. and Hooper, John D. (2011). Cellular settings mediating Src substrate switching between focal adhesion kinase tyrosine 861 and CUB-domain-containing protein 1 (CDCP1) tyrosine 734. Journal of Biological Chemistry, 206 (49), 42303-42315. doi: 10.1074/jbc.M111.227462

The role of palmitoylation in signalling, cellular trafficking and plasma membrane localization of protease-activated receptor-2

Adams, Mark N., Christensen, Melinda E., He, Yaowu, Waterhouse, Nigel J. and Hooper, John D. (2011). The role of palmitoylation in signalling, cellular trafficking and plasma membrane localization of protease-activated receptor-2. PLoS One, 6 (11) e28018, 1-14. doi: 10.1371/journal.pone.0028018

Structure, function and pathophysiology of protease activated receptors

Adams, Mark N., Ramachandran, Rithwik, Yau, Mei-Kwan, Suen, Jacky Y., Fairlie, David P., Hollenberg, Morley D. and Hooper, John D. (2011). Structure, function and pathophysiology of protease activated receptors. Pharmacology and Therapeutics, 120 (3), 248-282. doi: 10.1016/j.pharmthera.2011.01.003

Proteolysis-induced N-terminal ectodomain shedding of the integral membrane glycoprotein CUB domain-containing protein 1 (CDCP1) is accompanied by tyrosine phosphorylation of its C-terminal domain and recruitment of Src and PKC delta

He, Yaowu, Wortmann, Andreas, Burke, Les J., Reid, Janet C., Adams, Mark N., Abdul-Jabbar, Ibtissam, Quigley, James P., Leduc, Richard, Kirchhofer, Daniel and Hooper, John D. (2010). Proteolysis-induced N-terminal ectodomain shedding of the integral membrane glycoprotein CUB domain-containing protein 1 (CDCP1) is accompanied by tyrosine phosphorylation of its C-terminal domain and recruitment of Src and PKC delta. Journal of Biological Chemistry, 285 (34), 26162-26173. doi: 10.1074/jbc.M109.096453

The cutting edge: Membrane-anchored serine protease activities in the pericellular microenvironment

Antalis, Toni M., Buzza, Marguerite S., Hodge, Kathryn M., Hooper, John D. and Netzel-Arnett, Sarah (2010). The cutting edge: Membrane-anchored serine protease activities in the pericellular microenvironment. Biochemical Journal, 428 (3), 325-346. doi: 10.1042/BJ20100046

Molecular cell biology of androgen receptor signalling

Bennett, Nigel C., Gardiner, Robert A., Hooper, John D., Johnson, David W. and Gobe, Glenda C. (2010). Molecular cell biology of androgen receptor signalling. International Journal of Biochemistry and Cell Biology, 42 (6), 813-827. doi: 10.1016/j.biocel.2009.11.013

Androgen Receptor and Caveolin-1 in Prostate Cancer

Bennett, Nigel, Hooper, John D., Lee, C. Soon and Gobe, Glenda C. (2009). Androgen Receptor and Caveolin-1 in Prostate Cancer. IUBMB Life, 61 (10), 961-970. doi: 10.1002/IUB.244

The Glycosylphosphatidylinositol-Anchored Serine Protease PRSS21 (Testisin) Imparts Murine Epididymal Sperm Cell Maturation and Fertilizing Ability

Sarah Netzel-Arnett, Thomas H. Bugge, Rex A. Hess, Kay Carnes, Brett W. Stringer, Anthony L. Scarman, John D. Hooper, Ian D. Tonks, Graham F. Kay and Toni M. Antalis (2009). The Glycosylphosphatidylinositol-Anchored Serine Protease PRSS21 (Testisin) Imparts Murine Epididymal Sperm Cell Maturation and Fertilizing Ability. Biology of Reproduction, 81 (5), 921-932. doi: 10.1095/biolreprod.109.076273

Substrate-guided design of a potent and selective kallikrein-related peptidase inhibitor for kallikrein 4

Swedberg, Joakim E., Nigon, Laura V., Reid, Janet C., de Veer, Simon J., Walpole, Carina M., Stephens, Carson R., Walsh, Terry P., Takayama, Thomas K., Hooper, John D., Clements, Judith A., Buckle, Ashley M. and Harris, Jonathan M. (2009). Substrate-guided design of a potent and selective kallikrein-related peptidase inhibitor for kallikrein 4. Chemistry and Biology, 16 (6), 633-643. doi: 10.1016/j.chembiol.2009.05.008

Functional role of cell surface CUB domain-containing protein 1 in tumor cell dissemination

Deryugina, Elena I., Conn, Erin M., Wortmann, Andreas, Partridge, Juneth J., Kupriyanova, Tatyana A., Ardi, Veronica C., Hooper, John D. and Quigley, James P. (2009). Functional role of cell surface CUB domain-containing protein 1 in tumor cell dissemination. Molecular Cancer Research, 7 (8), 1197-1211. doi: 10.1158/1541-7786.MCR-09-0100

Matriptase-2 (TMPRSS6): A proteolytic regulator of iron homeostasis

Ramsay, Andrew J., Hooper, John D., Folgueras, Alicia R., Velasco, Gloria and Lopez-Otin, Carlos (2009). Matriptase-2 (TMPRSS6): A proteolytic regulator of iron homeostasis. Haematologica, 94 (6), 840-849. doi: 10.3324/haematol.2008.001867

The cell surface glycoprotein CDCP1 in cancer - Insights, opportunities, and challenges

Wortmann, Andreas, He, Yaowu, Deryugina, Elena I., Quigley, James P. and Hooper, John D. (2009). The cell surface glycoprotein CDCP1 in cancer - Insights, opportunities, and challenges. IUBMB Life, 61 (7), 723-730. doi: 10.1002/iub.198

The ubiquitin-protein ligase Nedd4-2 differentially interacts with and regulates members of the Tweety family of chloride ion channels

He, Yaowu, Hryciw, Deanne H., Carroll, Melanie L., Myers, Stephen A., Whitbread, Astrid K., Kumar, Sharad, Poronnik, Philip and Hooper, John D. (2008). The ubiquitin-protein ligase Nedd4-2 differentially interacts with and regulates members of the Tweety family of chloride ion channels. Journal of Biological Chemistry, 283 (35), 24000-24010. doi: 10.1074/jbc.M803361200

N-glycosylation analysis of the human Tweety family of putative chloride ion channels supports a penta-spanning membrane arrangement: impact of N-glycosylation on cellular processing of Tweety homologue 2 (TTYH2)

He, Yaowu, Ramsay, Andrew, Hunt, Melanie, Whitbread, Astrid, Myers, Stephen and Hooper, John (2008). N-glycosylation analysis of the human Tweety family of putative chloride ion channels supports a penta-spanning membrane arrangement: impact of N-glycosylation on cellular processing of Tweety homologue 2 (TTYH2). Biochemical Journal, 412 (1), 45-55. doi: 10.1042/BJ20071722

Kallikrein-related peptidase 4( KLK4)initiates intracellular signaling via protease-activated receptors(PARs):KLK4 and PAR-2 are co-expressed during prostate cancer progression

Ramsay, Andrew J., Dong, Ying, Hunt, Melanie L., Linn, MayLa, Samaratunga, Hemamali, Clements, Judith A. and Hooper, John D. (2008). Kallikrein-related peptidase 4( KLK4)initiates intracellular signaling via protease-activated receptors(PARs):KLK4 and PAR-2 are co-expressed during prostate cancer progression. The Journal of Biological Chemistry, 283 (18), 12293-12304. doi: 10.1074/jbc.M709493200

A novel transcript from the KLKP1 gene is androgen regulated, down-regulated during prostate cancer progression and encodes the first non-serine protease identified from the human kallikrein gene locus

Myers, Stephen A., Kaushal, Aneel, Dong, Ying, Lai, John, Tan, Olivia L., Bui, Loan T., Hunt, Melanie L., Digby, Matthew R., Samaratunga, Hemamali, Gardiner, Robert A., Clements, Judith A. and Hooper, John D. (2008). A novel transcript from the KLKP1 gene is androgen regulated, down-regulated during prostate cancer progression and encodes the first non-serine protease identified from the human kallikrein gene locus. Prostate, 68 (4), 381-399. doi: 10.1002/pros.20685

Tissue-specific promoter utilisation of the kallikrein-related peptidase genes, KLK5 and KLK7, and cellular localisation of the encoded proteins suggest roles in exocrine pancreatic function

Dong, Ying, Matigian, Nick, Harvey, Tracey J., Samaratunga, Hemamali, Hooper, John D. and Clements, Judith A. (2008). Tissue-specific promoter utilisation of the kallikrein-related peptidase genes, KLK5 and KLK7, and cellular localisation of the encoded proteins suggest roles in exocrine pancreatic function. Biological Chemistry, 389 (2), 99-109. doi: 10.1515/BC.2008.013

The type II transmembrane serine protease Matriptase-2 - identification, structural features, enzymology, expression pattern and potential roles

Ramsay, Andrew J., Reid, Janet C., Velasco, Gloria, Quigley, James P. and Hooper, John D. (2008). The type II transmembrane serine protease Matriptase-2 - identification, structural features, enzymology, expression pattern and potential roles. Frontiers in Bioscience, 13 (2), 569-579. doi: 10.2741/2702

Potential physiological and pathophysiological roles for protease-activated receptor-2 in the kidney

Vesey, David A., Hooper, John D., Gobe, Glenda C. and Johnson, David W. (2007). Potential physiological and pathophysiological roles for protease-activated receptor-2 in the kidney. Nephrology, 12 (1), 36-43. doi: 10.1111/j.1440-1797.2006.00746.x

The membrane-anchored serine protease, TMPRSS2, activates PAR-2 in prostate cancer cells

Wilson, S, Greer, B, Hooper, J, Zijlstra, A, Walker, B, Quigley, J and Hawthorne, S (2005). The membrane-anchored serine protease, TMPRSS2, activates PAR-2 in prostate cancer cells. Biochemical Journal, 388 (3), 967-972. doi: 10.1042/BJ20041066

Mouse matriptase-2: identification, characterization and comparative mRNA expression analysis with mouse hepsin in adult and embryonic tissues

Hooper, John D., Campagnolo, Luisa, Goodarzi, Goodarz, Truong, Tony N., Stuhlmann, Heidi and Quigley, James P. (2003). Mouse matriptase-2: identification, characterization and comparative mRNA expression analysis with mouse hepsin in adult and embryonic tissues. Biochemical Journal, 373 (3), 689-702. doi: 10.1042/BJ20030390

Membrane anchored serine proteases: A rapidly expanding group of cell surface proteolytic enzymes with potential roles in cancer

Netzel-Arnett, Sarah, Hooper, John D., Szabo, Roman, Madison, Edwin L., Quigley, James P., Bugge, Thomas H. and Antalis, Toni M. (2003). Membrane anchored serine proteases: A rapidly expanding group of cell surface proteolytic enzymes with potential roles in cancer. Cancer and Metastasis Reviews, 22 (2-3), 237-258. doi: 10.1023/A:1023003616848

Subtractive immunization using highly metastatic human tumor cells identifies SIMA135/CDCP1, a 135 kDa cell surface phosphorylated glycoprotein antigen

Hooper, John D., Zijlstra, Andries, Aimes, Ronald T., Liang, Hongyan, Claassen, Gisela F., Tarin, David, Testa, Jacqueline E. and Quigley, James P. (2003). Subtractive immunization using highly metastatic human tumor cells identifies SIMA135/CDCP1, a 135 kDa cell surface phosphorylated glycoprotein antigen. Oncogene, 22 (12), 1783-1794. doi: 10.1038/sj.onc.1206220

Endothelial cell serine proteases expressed during vascular morphogenesis and angiogenesis

Aimes, RT, Zijlstra, A, Hooper, JD, Ogbourne, SM, Sit, ML, Fuchs, S, Gotley, DC, Quigley, JP and Antalis, TM (2003). Endothelial cell serine proteases expressed during vascular morphogenesis and angiogenesis. Thrombosis And Haemostasis, 89 (3), 561-572. doi: 10.1055/s-0037-1613388

A quantitative analysis of rate-limiting steps in the metastatic cascade using human-specific real-time polymerase chain reaction

Zijlstra, A, Mellor, R, Panzarella, G, Aimes, RT, Hooper, JD, Marchenko, ND and Quigley, JP (2002). A quantitative analysis of rate-limiting steps in the metastatic cascade using human-specific real-time polymerase chain reaction. Cancer Research, 62 (23), 7083-7092.

TTYH2, a human homologue of the Drosophila melanogaster gene tweety, is located on 17q24 and upregulated in renal cell carcinoma

Rae, Fiona K., Hooper, John D., Eyre, Helen J., Sutherland, Grant R., Nicol, David L. and Clements, Judith A. (2001). TTYH2, a human homologue of the Drosophila melanogaster gene tweety, is located on 17q24 and upregulated in renal cell carcinoma. Genomics, 77 (3), 200-207. doi: 10.1006/geno.2001.6629

Identification and characterization of KLK14, a novel kallikrein serine protease gene located on human chromosome 19q13.4 and expressed in prostate and skeletal muscle

Hooper, John D., Bui, Loan T., Rae, Fiona K., Harvey, Tracey J., Myers, Stephen A., Ashworth, Linda K. and Clements, Judith A. (2001). Identification and characterization of KLK14, a novel kallikrein serine protease gene located on human chromosome 19q13.4 and expressed in prostate and skeletal muscle. Genomics, 73 (1), 117-122. doi: 10.1006/geno.2000.6490

Organization and chromosomal localization of the murine Testisin gene encoding a serine protease temporally expressed during spermatogenesis

Scarman, Anthony L., Hooper, John D., Boucaut, Kerry J., Sit, Mae-Le, Webb, Graham C., Normyle, John F. and Antalis, Toni M. (2001). Organization and chromosomal localization of the murine Testisin gene encoding a serine protease temporally expressed during spermatogenesis. European Journal of Biochemistry, 268 (5), 1250-1258. doi: 10.1046/j.1432-1327.2001.01986.x

Type II transmembrane serine proteases - Insights into an emerging class of cell surface proteolytic enzymes

Hooper, John D., Clements, Judith A., Quigley, James P. and Antalis, Toni M. (2001). Type II transmembrane serine proteases - Insights into an emerging class of cell surface proteolytic enzymes. Journal of Biological Chemistry, 276 (2), 857-860. doi: 10.1074/jbc.R000020200

The expanded human kallikrein (KLK) gene family: genomic organisation, tissue-specific expression and potential function.

Clements, Judith, Hooper, John, Dong, Ying and Harvey, Tracey (2001). The expanded human kallikrein (KLK) gene family: genomic organisation, tissue-specific expression and potential function.. Biological Chemistry, 382 (1), 5-14. doi: 10.1515/BC.2001.002

Tissue-specific expression patterns and fine mapping of the human kallikrein (KLK) locus on proximal 19q13.4

Harvey, TJ, Hooper, JD, Myers, SA, Stephenson, SA, Ashworth, LK and Clements, JA (2000). Tissue-specific expression patterns and fine mapping of the human kallikrein (KLK) locus on proximal 19q13.4. Journal of Biological Chemistry, 275 (48), 37397-37406. doi: 10.1074/jbc.M004525200

Cloning of the cDNA and localization of the gene encoding human NRBP, a ubiquitously expressed, multidomain putative adapter protein

Hooper, John D., Baker, Elizabeth, Ogbourne, Steven M., Sutherland, Grant R. and Antalis, Toni M. (2000). Cloning of the cDNA and localization of the gene encoding human NRBP, a ubiquitously expressed, multidomain putative adapter protein. Genomics, 66 (1), 113-118. doi: 10.1006/geno.2000.6167

Localization of the mosaic transmembrane serine protease corin to heart myocytes

Hooper, J. D., Scarman, A. L., Clarke, B., Normyle, J. F. and Antalis, T. M. (2000). Localization of the mosaic transmembrane serine protease corin to heart myocytes. European Journal of Biochemistry, 267 (23), 6931-6937. doi: 10.1046/j.1432-1327.2000.01806.x

Localization, expression and genomic structure of the gene encoding the human serine protease testisin

Hooper, John D., Bowen, Natalie, Marshall, Heidi, Cullen, Lara M., Sood, Raman, Daniels, Rachael, Stuttgen, Melanie A., Normyle, John F., Higgs, Douglas R., Kastner, Daniel L., Ogbourne, Steven M., Pera, Martin F., Jazwinska, Elizabeth C. and Antalis, Toni M. (2000). Localization, expression and genomic structure of the gene encoding the human serine protease testisin. Biochimica et Biophysica Acta, 1492 (1), 63-71. doi: 10.1016/S0167-4781(00)00071-3

Testisin, a new human serine proteinase expressed by premeiotic testicular germ cells and lost in testicular germ cell tumors

Hooper, J. D., Nicol, D. L., Dickinson, J. L., Eyre, H. J., Scarman, A. L., Normyle, J. F., Stuttgen, M. A., Douglas, M. L., Loveland, K. A. L., Sutherland, G. R. and Antalis, T. M. (1999). Testisin, a new human serine proteinase expressed by premeiotic testicular germ cells and lost in testicular germ cell tumors. Cancer Research, 59 (13), 3199-3205.

HER2 in situ hybridization testing in breast cancer: applying algorithm-assisted assessment to reduce interobserver variability in difficult cases

Gough, Madeline, Liu, Cheng, Srinivasan, Bhuvana, Wilkinson, Lisa, Dunk, Louisa, Yang, Yuanhao, Tuffaha, Haitham, Kryza, Thomas, Hooper, John D., Lakhani, Sunil R. and Snell, Cameron Edward (2023). HER2 in situ hybridization testing in breast cancer: applying algorithm-assisted assessment to reduce interobserver variability in difficult cases. 2023 ASCO Annual Meeting, Chicago, IL United States, 2-6 June 2023. Alexandria, VA United States: American Society of Clinical Oncology. doi: 10.1200/jco.2023.41.16_suppl.e13561

Abstract P4-07-26: Development of CDCP1-targeting antibody-drug conjugate for Triple negative and metastatic breast cancer

Gough, Madeline, Khan, Tashbib, Kwah, Kayden, He, Yaowu, Ratnayake, Gishan, Pyke, Christopher, Snell, Cameron, Hooper, John and Kryza, Thomas (2023). Abstract P4-07-26: Development of CDCP1-targeting antibody-drug conjugate for Triple negative and metastatic breast cancer. 2022 San Antonio Breast Cancer Symposium, San Antonio, TX United States, 6-10 December 2022. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.sabcs22-p4-07-26

EP-369 examining EphA2 expression in colorectal cancer

Lyons, Nicholas, Hooper, John, Kryza, Thomas, Clark, David and Riddell, Andrew (2022). EP-369 examining EphA2 expression in colorectal cancer. Association of Surgeons of Great Britain and Ireland Annual Congress, Liverpool, United Kingdom, 2022. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/bjs/znac245.094

Intraoperative identification of colorectal cancer lesions using indocyanine green labelled antibodies in preclinical murine models

Lyons, Nicholas, Hooper, John, Clark, David, Riddell, Andrew and Kryza, Thomas (2022). Intraoperative identification of colorectal cancer lesions using indocyanine green labelled antibodies in preclinical murine models. Association of Surgeons of Great Britain and Ireland, Annual Congress, Liverpool, United Kingdom, 3-5 May 2022. Oxford, United Kingdom: Oxford University Press . doi: 10.1093/bjs/znac245.093

Thioguanine inhibits colorectal tumorigenesis via β-catenin signalling in intestinal epithelial cells independently of immunosuppression or autophagy

Sheng, Yong H., Giri, Rabina, Davies, Julie, Schreiber, Veronika, Alabbas, Saleh Y., He, Yaowu, Wu, Andy, Hooper, John, Oancea, Iulia, Kijanka, Gregor, Hasnain, Sumaira Z., McGuckin, Michael, Florin, Timothy H. and Begun, Jakob (2020). Thioguanine inhibits colorectal tumorigenesis via β-catenin signalling in intestinal epithelial cells independently of immunosuppression or autophagy. DDW 2020, Online, 2-5 May 2020. Philadelphia, PA United States: Elsevier . doi: 10.1016/s0016-5085(20)30856-8

Inhibition of Aurora B kinase activity triggers senescence that can be bypassed by blocking p53 and RB function, promoting replication stress

Andrews, Ariel, Kumar, Ramyashree Prasanna, Nazareth, Deborah, Ehmann, Anna, Hooper, John, McMillan, Nigel and Gabrielli, Brian (2019). Inhibition of Aurora B kinase activity triggers senescence that can be bypassed by blocking p53 and RB function, promoting replication stress. AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, Boston, MA USA, 26-30 October 2019. Philadelphia, PA USA: American Association for Cancer Research. doi: 10.1158/1535-7163.TARG-19-A060

"Theranostics" - radioimmunodetection and radioimmunotherapy for metastatic colorectal cancer in preclinical cancer models

Cuda, T., Thomas, P., Rose, S., Puttick, S. and Hooper, J. (2019). "Theranostics" - radioimmunodetection and radioimmunotherapy for metastatic colorectal cancer in preclinical cancer models. 32nd Annual Congress of the European-Association-of-Nuclear-Medicine (EANM), Barcelona, Spain, 12-16 October 2019. Heidelberg, Germany: Springer.

GALIUM-68-PSMA-617 AS A NOVEL PET-CT MARKER FOR DISEASE STRATIFYING METASTATIC COLORECTAL CANCER: A PROSPECTIVE PILOT STUDY

Cuda, T., Riddell, A., Thomas, P., Puttick, S. and Hooper, J. (2019). GALIUM-68-PSMA-617 AS A NOVEL PET-CT MARKER FOR DISEASE STRATIFYING METASTATIC COLORECTAL CANCER: A PROSPECTIVE PILOT STUDY. HOBOKEN: WILEY.

"Theranostics": radioimmunodetection and radioimmunotherapy for metastatic colorectal cancer

Cuda, T., Hooper, J., Puttick, S., He, Y., Kryza, T. and Khan, T. (2019). "Theranostics": radioimmunodetection and radioimmunotherapy for metastatic colorectal cancer. Australian and New Zealand Society of Nuclear Medicine (ANZSNM) 49th ASM, Adelaide, Australia, 26-28 April 2019. Richmond, VIC, Australia: Wiley-Blackwell Publishing Asia.

Circulating exosomal miRNAs from women with ovarian cancer for early detection and real-time monitoring of disease progression

Sharma, Shayna, Lai, Andrew, Guanzon, Dominic, Morgan, Terry, Perrin, Lewis C., Hooper, John D. and Salomon, Carlos (2019). Circulating exosomal miRNAs from women with ovarian cancer for early detection and real-time monitoring of disease progression. 66th Annual Scientific Meeting of the Society for Reproductive Investigation (SRI), Paris, France, 12-16 March 2019. Thousand Oaks, CA, United States: Sage Publications. doi: 10.1177/1933719119834079

Ovarian cancer cell invasiveness regulates their exosomes which induces oncogenic potential and cancer progression in vivo

Alharbi, Mona G., Lai, Andrew, Zuniga, Felipe, Perrin, Lewis, He, Yaowu, Hooper, John D. and Salomon, Carlos (2019). Ovarian cancer cell invasiveness regulates their exosomes which induces oncogenic potential and cancer progression in vivo. 66th Annual Scientific Meeting of the Society for Reproductive Investigation (SRI), Paris, France, March 12-16, 2019. Thousand Oaks, CA, United States: Sage Publications. doi: 10.1177/1933719119834079

Granulocyte Colony Stimulating Factor impacts on osteomacs and bone marrow macrophages - implications for prostate cancer osteoblastic lesion formation

Millard, Susan, Wu, Andy, Kaur, Simran, He, Yaowu, Batoon, Lena, Hooper, John and Pettit, Allison (2018). Granulocyte Colony Stimulating Factor impacts on osteomacs and bone marrow macrophages - implications for prostate cancer osteoblastic lesion formation. Annual Meeting of the American Society for Bone and Mineral Research, Montréal, Quebéc, Canada, Sep 28-Oct 01, 2018. Hoboken, NJ, United States: Wiley-Blackwell Publishing. doi: 10.1002/jbmr.3621

Integrative Analysis of Multi-Omics Exosomal Data for Identifying Multi-Markers for Susceptibility to Chemotherapy in Ovarian Cancer

Alharbi, Mona, Lai, Andrew, Guanzon, Dominic, Sharma, Shayna, Palma, Carlos, Zuniga, Felipe, Rice, Gregory E., Perrin, Lewis, Hooper, John D. and Salomon, Carlos (2018). Integrative Analysis of Multi-Omics Exosomal Data for Identifying Multi-Markers for Susceptibility to Chemotherapy in Ovarian Cancer. 65th Annual Scientific Meeting of the Society-for-Reproductive-Investigation (SRI), San Diego Ca United States, 6-10 March 2018. Thousand Oaks, CA United States: Sage.

Exosomal content in the plasma of patients with ovarian cancer reflect tumor state and induce the epithelial to mesenchymal transition in target cells

Sharma, Shayna, Scholz-Romero, Katherin, Kline, Richard, Wade, Katrina, Estes, Jacob, Palma, Carlos, Guanzon, Dominic, Lai, Andrew, Hooper, John, Rice, Gregory E. and Salomon, Carlos (2017). Exosomal content in the plasma of patients with ovarian cancer reflect tumor state and induce the epithelial to mesenchymal transition in target cells. 64th Annual Scientific Meeting of the Society for Reproductive Investigation (SRI), Orlando, FL, United States, 15-18 March 2017. Thousand Oaks, CA, United States: Sage Publications. doi: 10.1177/1933719117699773

Ovarian cancer cells transfer resistance to chemotherapy to other cells via exosomes

Alharbi, Mona, Kline, Richard, Wade, Katrina, Estes, Jacob, Hooper, John, Rice, Gregory E. and Salomon, Carlos (2017). Ovarian cancer cells transfer resistance to chemotherapy to other cells via exosomes. 64th Annual Scientific Meeting of the Society for Reproductive Investigation (SRI), Orlando, FL, United States, 5-18 March 2017. Heidelberg, Germany: Springer.

MUC13 protects colorectal cancer cells from death by activating the NF-Kb pathway and is a potential therapeutic target

Sheng, Yong H., He, Yaowu, Hasnain, Sumaira Z., Wang, Ran, Tong, Hui, Clarke, Daniel T., Lourie, Rohan, Oancea, Lulia, Wong, Kuanyau, Lumley, John W., Florin, Timothy H., Sutton, Philip, Hooper, John. D., Mcmillan, Nigel A. and Mcguckin, Michael A. (2016). MUC13 protects colorectal cancer cells from death by activating the NF-Kb pathway and is a potential therapeutic target. AACR 107th Annual Meeting on Bioinformatics and Systems Biology, New Orleans, Los Angeles, 16-20 April 2016 . Philadelphia, PA, United States: American Association for Cancer Research. doi: 10.1158/1538-7445.AM2016-3564

Targeting Apoptosis as a Novel Therapy for Myc-Driven Medulloblastoma

Ji, Pengxiang, Genovesi, Laura, He, Yaowu, Hooper, John and Wainwright, Brandon (2016). Targeting Apoptosis as a Novel Therapy for Myc-Driven Medulloblastoma. 17th International Symposium on Pediatric Neuro-Oncology (ISPNO), Liverpool England, 12-15 June 2016. United States: Oxford University Press.

The role of cancer stem cells in colorectal cancer metastasis

Kemp, M. C., Pummer, J., He, Y., Hooper, J., Reuter, B., Borgovan, T., Zhang, X., Sullivan, R., Maresh, G., Green, H., Del Valle, L., Margolin, D. and Li, L. (2016). The role of cancer stem cells in colorectal cancer metastasis. Southern Regional Meeting of the American Federation for Medical Research (AFMR), New Orleans, LA, United States, Feb 18-20, 2016. London, United Kingdom: BMJ Group. doi: 10.1136/jim-2015-000035.415

EGF-induced recycling of the cancer promoting protein CDCP1

Adams, Mark N., Harrington, Brittney S., He, Yaowu, Davies, Claire M., Wallace, Sarah J., Chetty, Naven P., Crandon, Alexander J., Oliveira, Niara B., Shannon, Catherine M., Coward, Jermaine I., Lumley, John W., Perrin, Lewis C., Armes, Jane E. and Hooper, John D. (2015). EGF-induced recycling of the cancer promoting protein CDCP1. 15th International Biennial Congress of the Metastasis Research Society, Heidelberg, Germany, June 28th–July 1st, 2014. Dordrecht, Netherlands: Springer Netherlands. doi: 10.1007/s10585-015-9708-3

A New Marker of Poor Outcome and Potential Therapeutic Target in Ovarian Clear Cell Carcinoma

Hooper, J., He, Y., Wu, A., Harrington, B., Davies, C., Wallace, S., Gilks, B., Perrin, L. and Armes, J. (2014). A New Marker of Poor Outcome and Potential Therapeutic Target in Ovarian Clear Cell Carcinoma. 15th Biennial Meeting of the International Gynecologic Cancer Society, Melbourne, VIC Australia, 8-11 November 2014. London, United Kingdom: Lippincott Williams and Wilkins. doi: 10.1097/01.IGC.0000457075.08973.89

Investigation of mice deficient in matriptase-2, Hfe and transferrin receptor 2 reveals a novel non-hepatic role for Tfr2 in erythropoiesis

Wallace, D. F., Secondes, E. S., Rishi, G., Ostini, L., Mcdonald, C. J., Lane, S. W., Hooper, J. D., Lopez-Otin, C. and Subramaniam, V. N. (2014). Investigation of mice deficient in matriptase-2, Hfe and transferrin receptor 2 reveals a novel non-hepatic role for Tfr2 in erythropoiesis. Australian Gastroenterology Week 2014, Broadbeach, Australia, 22-24 October 2014. Richmond, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/jgh.12736_6

Targeting the cell surface protein Cdcp1 in a model of advanced ovarian cancer

Harrington, B., Davies, C. M., Wallace, S. J., He, Y., Armes, J. E., Perrin, L. C. and Hooper, J. D. (2014). Targeting the cell surface protein Cdcp1 in a model of advanced ovarian cancer. London, United Kingdom: B M J Group.

An Essential Role For Transferrin Receptor 2 In Erythropoiesis During Iron Restriction

Wallace, Daniel F., McDonald, Cameron J., Secondes, Eriza S., Ostini, Lesa, Rishi, Gautam, Hooper, John D., Velasco, Gloria, Ramsay, Andrew J., Lopez-Otin, Carlos and Subramaniam, V. Nathan (2013). An Essential Role For Transferrin Receptor 2 In Erythropoiesis During Iron Restriction. 55th Annual Meeting of the American-Society-of-Hematology, New Orleans La, Dec 07-10, 2013. WASHINGTON: AMER SOC HEMATOLOGY.

Clinically Identified Tmprss6 Mutations Result in Either Trafficking Defects or Inability to Cleave Hemojuvelin

Bennett, Nigel C., McDonald, Cameron J., Wallace, Daniel F., Hooper, John D., Lopez-Otin, Carlos and Subramaniam, V. Nathan (2013). Clinically Identified Tmprss6 Mutations Result in Either Trafficking Defects or Inability to Cleave Hemojuvelin. BioIron 2013: 5th Meeting of the International BioIron Society, University College London UK, April 14 – 18, 2013. Hoboken, United States: Jossey Bass, Ed. & Pub.. doi: 10.1002/ajh.23453

The prevalence of osteoporosis in men with prostate cancer on androgen deprivation therapy: a systematic review and meta-analysis

Lassemillante, Annie-Claude, Hooper, John, Prins, John, Doi, Suhail and Wright, Olivia (2013). The prevalence of osteoporosis in men with prostate cancer on androgen deprivation therapy: a systematic review and meta-analysis. Prostate Cancer World Congress & 14th Australasian Prostate Cancer Conference, Melbourne Australia, 6–10 August 2013. West Sussex United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/bju.12293

Kallikrein-related proteases as novel therapeutic targets in prostate and ovarian cancer

Clements, J. A., Dong, Y., Loessner, D., Tan, O., Sieh, S., Reichert, J., Burke, L., Stephens, C., Lawrence, M., Stansfield, S., Swedberg, J., Ramsay, A., Hooper, J., Harris, J. and Hutmacher, D. (2009). Kallikrein-related proteases as novel therapeutic targets in prostate and ovarian cancer. 40th Annual Conference of the Society for Reproductive Biology, Clayton, VIC, Australia: CSIRO Publishing. doi: 10.1071/srb09abs009

Prostatic trypsin-like kallikrein-related peptidases (KLKs) and other prostate-expressed tryptic proteinases as regulators of signalling via proteinase-activated receptors (PARs)

Ramsay, Andrew J., Reid, Janet C., Adams, Mark N., Samaratunga, Hemamali, Dong, Ying, Clements, Judith A. and Hooper, John D. (2008). Prostatic trypsin-like kallikrein-related peptidases (KLKs) and other prostate-expressed tryptic proteinases as regulators of signalling via proteinase-activated receptors (PARs). 2nd International Symposium on Kallikrein and Kallikrein-Related Peptidases (ISK 2007), Santorini, Greece, 16-18 October 2007. Berlin, Germany: Walter de Gruyter. doi: 10.1515/BC.2008.078

Identification and characterization of a novel gene STAG1 is up-regulated in renal cell carcinoma

Rae, F., Hooper, J.D., Nicol, D. L. and Clements, J.A. (2001). Identification and characterization of a novel gene STAG1 is up-regulated in renal cell carcinoma. 2001 Annual Scientific Meeting of the Urological Society of Australasia, Coolum, Australia, March 2001. Australia: Blackwell Publishing Asia.

Localization, structure and regulation of the human PRSS14 gene encoding the serine proteinase Testisin

Antalis, T. M., Boucaut, K. J., Normyle, J. F., Fitzpatrick, D. R. and Hooper, J. (2000). Localization, structure and regulation of the human PRSS14 gene encoding the serine proteinase Testisin. 91st Annual Meeting of the American Association for Cancer Research, San Francisco, 1-5 Apr, 2000. Philadelphia, U.S.A.: American Association for Cancer Research.

Substrate-biased activity-based probes identify the urokinase-plasminogen axis as a master regulator of metastatic signaling by orphan membrane receptor CDCP1

Kryza, Thomas, Khan, Tashbib, Lovell, Scott, Harrington, Brittney S., Yin, Julia, Porazinski, Sean, Pajic, Marina, Koistinen, Hannu, Rantala, Juha, Dreyer, Tobias, Magdolen, Viktor, Reuning, Ute, He, Yaowu, Tate, Edward and Hooper, John David (2020). Substrate-biased activity-based probes identify the urokinase-plasminogen axis as a master regulator of metastatic signaling by orphan membrane receptor CDCP1.

Binding proteins to CUB domain-containing protein (CDCP1)

Puttick, S., Kryza, T., Hooper, J. D., He, Y., Harrington, B., Quigley, J. and Deryugina, E. (2020). Binding proteins to CUB domain-containing protein (CDCP1). PCT/AU2020/051216.