Professor Melissa Brown

Executive Dean

Faculty of Science

Affiliate Professor

Mater Research Institute-UQ
Faculty of Medicine
melissa.brown@uq.edu.au
+61 7 336 51609

Overview

Regulation and function of cancer susceptibility genes

Melissa Brown completed her PhD at the Walter and Eliza Hall Institute in Melbourne in 1993, on the structure and regulation of genes encoding colony-stimulating factor receptors in human leukaemia.

She then undertook postdoctoral training at the Imperial Cancer Research Fund (now Cancer Research UK) in London, funded firstly by an EMBO and then by an ICRF postdoctoral fellowship, working on the isolation and characterization of the first breast cancer susceptibility gene, BRCA1.

She joined The University of Queensland in 2000 as a Lecturer and is now an Associate Professor and Research Group Leader. In 2005 she undertook a six-month sabbatical at the Sir William Dunn School of Pathology at The University of Oxford. The focus of her research continues to be cancer genetics, in particular understanding the transcriptional and post-transcriptional regulation of several breast cancer associated genes, including BRCA1, and examining their role in mammary development and early breast tumourigenesis.

Melissa’s lab currently consists of four postdocs, three PhD students , one Masters student, and one RA and is currently funded by grants from the NHMRC, the National Breast Cancer Foundation and the Australian Research Council.

Research Interests

  • Regulation and function of cancer susceptibility genes
    Breast cancer is the most common cancer in women and results from abnormal expression or function of multiple tumour suppressor genes and oncogenes. Our laboratory is interested in the regulation and function of a number of breast cancer- associated genes including those encoding BRCA1, BRCA2, and a range of miRNAs. We use a wide variety of molecular and cellular techniques to study how the expression of these genes is regulated and to examine the molecular and cellular consequences of disrupting their function in breast epithelial cell-lines and the mammary gland of mouse models. Project 1: Regulation of the breast cancer susceptibility gene BRCA1 This project will involve identifying novel regulatory elements controlling the expression of the BRCA1 gene. We are especially interested in the 3�UTR of BRCA1 and miRNAs that target this region. This project will involve elucidating the structure, function and clinical relevance of functional elements in the BRCA1 3�UTR. These elements have the potential to form the basis of improved pre-symptomatic diagnostics for breast cancer. Project 2: Regulation of microRNA genes in advanced breast cancer The aim of this project is to identify and functionally characterize miRNA promoters and their downstream target genes. Particular interest will be given to miRNAs that may be susceptible to aberrant epigenetic regulation. These miRNA have the potential to be novel biomarkers for the identification and management of patients that are susceptible to advanced breast cancer. Project 3: Molecular & cellular consequences of disrupting breast cancer genes The aim of this project is to understand how changes in the regulation or function of breast cancer genes results in the development of breast cancer. This project will involve examining the effect of increasing and decreasing the expression of normal, variant and mutant forms of breast cancer genes on the expression of genes, including miRNAs, in breast epithelial cells. These molecules have the potential to be targets of novel therapeutic agents to treat breast cancer. Techniques: Bioinformatics, gene cloning and mutagenesis, mammalian cell culture and gene transfer, reporter gene assays, real-time PCR, Northern blotting, chromatin conformation assays, methylation specific DNA analysis, cell culture assays including cell proliferation and differentiation.

Qualifications

  • PhD, University of Melbourne
  • Bachelor of Science (Honours), University of Melbourne
  • Bachelor of Science, University of Melbourne

Publications

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Supervision

View all Supervision

Publications

Book Chapter

  • Sandhu, Gurveen K., Milevskiy, Michael J.G., Wilson, Wesley, Shewan, Annette M. and Brown, Melissa A. (2016). Non-coding RNAs in Mammary Gland Development and Disease. In Non-coding RNA and the Reproductive System (pp. 121-153) New York NY United States: Springer New York. doi:10.1007/978-94-017-7417-8_7

Journal Article

  • Milevskiy, Michael J. G., Al-Ejeh, Fares, Saunus, Jodi M., Northwood, Korinne S., Bailey, Peter J., Betts, Joshua A., McCart Reed, Amy E., Nephew, Kenneth P., Stone, Andrew, Gee, Julia M. W., Dowhan, Dennis H., Dray, Eloise, Shewan, Annette M., French, Juliet D., Edwards, Stacey L., Clark, Susan J., Lakhani, Sunil R. and Brown, Melissa A. (2016) Long-range regulators of the lncRNA HOTAIR enhance its prognostic potential in breast cancer. Human Molecular Genetics, 25 15: 3269-3283. doi:10.1093/hmg/ddw177

  • Peters, Amelia A., Milevskiy, Michael J. G., Lee, WeiC., Curry, Merril C., Smart, Chanel E., Saunus, Jodi M., Reid, Lynne, da Silva, Leonard, Marcial, Daneth L., Dray, Eloise, Brown, Melissa A., Lakhani, Sunil R., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2016) The calcium pump plasma membrane Ca(2+)-ATPase 2 (PMCA2) regulates breast cancer cell proliferation and sensitivity to doxorubicin. Scientific Reports, 6 . doi:10.1038/srep25505

  • Wronski, A., Sandhu, G. K., Milevskiy, M. J., Brewster, B. L., Bridge, J. A., Shewan, A. M., Edwards, S. L., French, J. D. and Brown, M. A. (2016) MicroRNA-206 is differentially expressed in Brca1-deficient mice and regulates epithelial and stromal cell compartments of the mouse mammary gland. Oncogenesis, 5 e218.1-e218.9. doi:10.1038/oncsis.2016.27

  • Pera, Elena, Kaemmerer, Elke, Milevskiy, Michael J. G., Yapa, Kunsala T. D. S., O'Donnell, Jake S., Brown, Melissa A., Simpson, Fiona, Peters, Amelia A., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2016) The voltage gated Ca2+-channel Cav3.2 and therapeutic responses in breast cancer. Cancer Cell International, 16 24: . doi:10.1186/s12935-016-0299-0

  • Gannon, Orla M., Antonsson, Annika, Milevskiy, Michael, Brown, Melissa A., Saunders, Nicholas A. and Bennett, Ian C. (2015) No association between HPV positive breast cancer and expression of human papilloma viral transcripts. Scientific Reports, 5 18081: . doi:10.1038/srep18081

  • Stirzaker, Clare, Zotenko, Elena, Song, Jenny Z., Qu, Wenja, Nair, Shalima, Locke, Warwick J., Stone, Andrew Stone, Armstrong, Nicola J., Robinson, Mark D., Dobrovic, Alexander, Avery-Kiejda, Kelly A., Peters, Kate M., French, Juliet D., Stein, Sandra, Korbie, Darren J., Trau, Matt, Forbes, John F., Scott, Rodney J., Brown, Melissa A., Francis, Glenn D. and Clark, Susan J. (2015) Methylome sequencing in triple negative breast cancer reveals distinct methylation clusters with prognostic value. Nature Communications, 6 5899: 1-11. doi:10.1038/ncomms6899

  • Glubb, Dylan, Maranian, Mel J., Michailidou, Kyriaki, Pooley, Karen A., Meyer, Kerstin, Kar, Siddhartha, Carlebur, Saskia, O'Reilly, Martin, Betts, Joshua A., Hillman, Kristine M., Kaufmann, Susanne, Beesley, Jonathan, Canisius, Sander, Hopper, John L., Southey, Melissa C., Tsimiklis, Helen, Apicella, Carmel, Schmidt, Marjanka K., Broeks, Annegien, Hogervorst, Frans B., van der Schoot, C. Ellen, Muir, Kenneth, Lophatananon, Artitaya, Stewart-Brown, Sarah, Siriwanarangsan, Pornthep, Fasching, Peter, Ruebner, Matthias, Ekici, Arif B., Beckmann, Matthias W., Peto, Julian, dos-Santos-Silva, Isabel, Fletcher, Olivia, Johnson, Nichola, Pharoah, Paul D. P., Bolla, Manjeet K., Wang, Qin, Dennis, Joe, Sawyer, Elinor J., Tomlinson, Ian, Kerin, Michael J., Miller, Nicola, Burwinkel, Barbara, Marme, Frederik, Yang, Ronxi, Surowy, Harald, Guenel, Pascal, Truong, Therese, Menegaux, Florence, Sanchez, Marie, Bojesen, Stig E., Nordestgaard, Borge, Nielsen, Sune, Flyger, Henrik, Gonzalez-Neira, Anna, Benitez, Javier, Zamora, M. Pilar, Arias Perez, Jose Ignacio, Anton-Culver, Hoda, Neuhausen, Susan L., Brenner, Hermann, Dieffenbach, Aida Karina, Arndt, Volker, Stegmaier, Christa, Meindl, Alfons, Schmutzler, Rita K., Brauch, Hiltrud, Ko, Yon-Dschun, Bruning, Thomas, Nevanlinna, Heli, Muranen, Taru A., Aittomaki, Kristiina, Blomqvist, Carl, Matsuo, Keitaro, Ito, Hidemi, Iwata, Hiroji, Tanaka, Hideo, Dork, Thilo, Bogdanova, Natalia V., Helbig, Sonja, Lindblom, Annika, Margolin, Sara, Mannermaa, Arto, Kataja, Vesa, Kosma, Veli-Matti, Hartikainen, Jaana M., Wu, Anna H., Tseng, Chiu-chen, Van Den Berg, David, Stram, Daniel O., Lambrechts, Diether, Zhao, Hui, Weltens, Caroline, van Limbergen, Erik, Chang-Claude, Jenny, Flesch-Janys, Dieter, Rudolph, Anja, Seibold, Petra, Radice, Paolo, Peterlongo, Paolo, Barile, Monica, Capra, Fabio, Couch, Fergus J., Olson, Janet E., Hallberg, Emily, Vachon, Celine, Giles, Graham G., Milne, Roger L., McLean, Catriona McLean, Haiman, Christopher A., Henderson, Brian E., Schumacher, Fredrick, LeMarchand, Loic Le, Simard, Jacques, Goldberg, Mark S., Labreche, France, Dumont, Martine, Teo, Soo Hwang, Yip, Cheng Har, See, Mee-Hoong, Cornes, Belinda, Cheng, Ching-Yu, Ikram, M. Kamram, Kristensen, Vessela, Zheng, Wei, Halverson, Sandra L., Shrubsole, Martha, Long, Jirong, Winqvist, Robert, Pylkas, Katri, Jukkola-Vuorinen, Arja, Kauppila, Saila, Andrulis, Irene L., Knight, Julia A., Glendon, Gord, Tchatchou, Sandrine, Devilee, Peter, Tollenaar, Robert A. E. M., Seynaeve, Caroline, Van Asperen, Christi J., Garcia-Closas, Montserrat, Figueroa, Jonine, Chanock, Stephen J., Lissowska, Jolanta, Czene, Kamila, Klevebring, Daniel, Darabi, Hatef, Eriksson, Mikael, Hooning, Maartje J., Hollestelle, Antoinette, Martens, John W. M., Collee, J. Margriet, Hall, Per, Li, Jingmei, Humphreys, Keith, Shu, Xiao-Ou, Lu, Wei, Gao, Yu-Tang, Cai, Hui, Cox, Angela, Cross, Simon S., Reed, Malcolm W. R., Blot, William, Signorello, Lisa B., Cai, Qiuyin, Shah, Mitul, Ghoussaini, Maya, Kang, Daehee, Choi, Ji-Yeob, Park, Sue K., Noh, Dong-Young, Hartman, Mikael, Miao, Hui, Lim, Wei Yen, Tang, Anthony, Hamann, Ute, Torres, Diana, Jakubowska, Anna, Lubinski, Jan, Jaworska, Katarzyna, Durda, Katarzyna, Sangrajrang, Suleeporn, Gaborieau, Valerie, Brennan, Paul, McKay, James, Olswold, Curtis, Slager, Susan, Toland, Amanda E., Yannoukakos, Drakoulis, Shen, Chen-Yang, Wu, Pei-Ei, Yu, Jyh-Cherng, Hou, Ming-Feng, Swerdlow, Anthony, Ashworth, Alan, Orr, Nick, Jones, Michael, Pita, Guillermo, Alonso, M. Rosario, Alvarez, Nuria, Herrero, Daniel, Tessier, Daniel C., Vincent, Daniel, Bacot, Francois, Luccarini, Craig, Baynes, Caroline, Ahmed, Shahana, Healey, Catherine S., Brown, Melissa A., Ponder, Bruce A. J., Chenevix-Trench, Georgia, Thompson, Deborah J., Edwards, Stacey L., Easton, Douglas F., Dunning, Alison M. and French, Juliet D. (2015) Fine-scale mapping of the 5q11.2 breast cancer locus reveals at least three independent risk variants regulating MAP3K1. American Journal of Human Genetics, 96 1: 5-20. doi:10.1016/j.ajhg.2014.11.009

  • Ghoussaini, Maya, Edwards, Stacey L., Michailidou, Kyriaki, Nord, Silje, Lari, Richard Cowper-Sal, Desai, Kinjal, Kar, Siddhartha, Hillman, Kristine M., Kaufmann, Susanne, Glubb, Dylan M., Beesley, Jonathan, Dennis, Joe, Bolla, Manjeet K., Wang, Qin, Dicks, Ed, Guo, Qi, Schmidt, Marjanka K., Shah, Mitul, Luben, Robert, Brown, Judith, Czene, Kamila, Darabi, Hatef, Eriksson, Mikael, Klevebring, Daniel, Bojesen, Stig E., Nordestgaard, Borge G., Nielsen, Sune F., Flyger, Henrik, Lambrechts, Diether, Thienpont, Bernard, Neven, Patrick, Wildiers, Hans, Broeks, Annegien, Van't Veer, Laura J., Rutgers, Emiel J. Th, Couch, Fergus J., Olson, Janet E., Hallberg, Emily, Vachon, Celine, Chang-Claude, Jenny, Rudolph, Anja, Seibold, Petra, Flesch-Janys, Dieter, Peto, Julian, dos-Santos-Silva, Isabel, Gibson, Lorna, Nevanlinna, Heli, Muranen, Taru A., Aittomaki, Kristiina, Blomqvist, Carl, Hall, Per, Li, Jingmei, Liu, Jianjun, Humphreys, Keith, Kang, Daehee, Choi, Ji-Yeob, Park, Sue K., Noh, Dong-Young, Matsuo, Keitaro, Ito, Hidemi, Iwata, Hiroji, Yatabe, Yasushi, Guenel, Pascal, Truong, Therese, Menegaux, Florence, Sanchez, Marie, Burwinkel, Barbara, Marme, Frederik, Schneeweiss, Andreas, Sohn, Christof, Wu, Anna H., Tseng, Chiu-Chen, Van Den Berg, David, Stram, Daniel O., Benitez, Javier, Pilar Zamora, M., Arias Perez, Jose Ignacio, Menendez, Primitiva, Shu, Xiao-Ou, Lu, Wei, Gao, Yu-Tang, Cai, Qiuyin, Cox, Angela, Cross, Simon S., Reed, Malcolm W. R., Andrulis, Irene L., Knight, Julia A., Glendon, Gord, Tchatchou, Sandrine, Sawyer, Elinor J., Tomlinson, Ian, Kerin, Michael J., Miller, Nicola, Haiman, Christopher A., Henderson, Brian E., Schumacher, Fredrick, Le Marchand, Loic, Lindblom, Annika, Margolin, Sara, Teo, Soo Hwang, Yip, Cheng Har, Lee, Daphne S. C., Wong, Tien Y., Hooning, Maartje J., Martens, John W. M., Collee, J. Margriet, van Deurzen, Carolien H. M., Hopper, John L., Southey, Melissa C., Tsimiklis, Helen, Kapuscinski, Miroslav K., Shen, Chen-Yang, Wu, Pei-Ei, Yu, Jyh-Cherng, Chen, Shou-Tung, Alnaes, Grethe Grenaker, Borresen-Dale, Anne-Lise, Giles, Graham G., Milne, Roger L., McLean, Catriona, Muir, Kenneth, Lophatananon, Artitaya, Stewart-Brown, Sarah, Siriwanarangsan, Pornthep, Hartman, Mikael, Miao, Hui, Buhari, Shaik Ahmad Bin Syed, Teo, Yik Ying, Fasching, Peter A., Haeberle, Lothar, Ekici, Arif B., Beckmann, Matthias W., Brenner, Hermann, Dieffenbach, Aida Karina, Arndt, Volker, Stegmaier, Christa, Swerdlow, Anthony, Ashworth, Alan, Orr, Nick, Schoemaker, Minouk J., Garcia-Closas, Montserrat, Figueroa, Jonine, Chanock, Stephen J., Lissowska, Jolanta, Simard, Jacques, Goldberg, Mark S., Labreche, France, Dumont, Martine, Winqvist, Robert, Pylkas, Katri, Jukkola-Vuorinen, Arja, Brauch, Hiltrud, Bruening, Thomas, Koto, Yon-Dschun, Radice, Paolo, Peterlongo, Paolo, Bonanni, Bernardo, Volorio, Sara, Doerk, Thilo, Bogdanova, Natalia V., Helbig, Sonja, Mannermaa, Arto, Kataja, Vesa, Kosma, Veli-Matti, Hartikainen, Jaana M., Devilee, Peter, Tollenaar, Robert A. E. M., Seynaeve, Caroline, Van Asperen, Christi J., Jakubowska, Anna, Lubinski, Jan, Jaworska-Bieniek, Katarzyna, Durda, Katarzyna, Slager, Susan, Toland, Amanda E., Ambrosone, Christine B., Yannoukakos, Drakoulis, Sangrajrang, Suleeporn, Gaborieau, Valerie, Brennan, Paul, Mckay, James, Hamann, Ute, Torres, Diana, Zheng, Wei, Long, Jirong, Anton-Culver, Hoda, Neuhausen, Susan L., Luccarini, Craig, Baynes, Caroline, Ahmed, Shahana, Maranian, Mel, Healey, Catherine S., Gonzalez-Neira, Anna, Pita, Guillermo, Alonso, M. Rosario, Alvarez, Nuria, Herrero, Daniel, Tessier, Daniel C., Vincent, Daniel, Bacot, Francois, de Santiago, Ines, Carroll, Jason, Caldas, Carlos, Brown, Melissa A., Lupien, Mathieu, Kristensen, Vessela N., Pharoah, Paul D. P., Chenevix-Trench, Georgia, French, Juliet D., Easton, Douglas F. and Dunning, Alison M. (2014) Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation. Nature Communications, 4 4999.1-4999.12. doi:10.1038/ncomms5999

  • Colombo, Mara, Blok, Marinus J., Whiley, Phillip, Santamarina, Marta, Gutierrez-Enriquez, Sara, Romero, Atocha, Garre, Pilar, Becker, Alexandra, Smith, Lindsay Denise, Vecchi, Giovanna De, Brandao, Rita D., Tserpelis, Demis, Brown, Melissa, Blanco, Ana, Bonache, Sandra, Menendez, Mireia, Houdayer, Claude, Foglia, Claudia, Fackenthal, James D., Baralle, Diana, Wappenschmidt, Barbara, Diaz-Rubio, Eduardo, Caldes, Trinidad, Walker, Logan, Diez, Orland, Vega, Ana, Spurdle, Amanda B., Radice, Paolo and de la Hoya, Miguel (2014) Comprehensive annotation of splice junctions supports pervasive alternative splicing at the BRCA1 locus: a report from the ENIGMA consortium. Human Molecular Genetics, 23 14: 3666-3680. doi:10.1093/hmg/ddu075

  • Whiley, Phillip J., De La Hoya, Miguel, Thomassen, Mads, Becker, Alexandra, Brandão, Rita, Sokilde Pedersen, Inge, Montagna, Marco, Menéndez, Mireia, Quiles, Francisco, Gutiérrez-Enríquez, Sara, De Leeneer, Kim, Tenés, Anna, Montalban, Gemma, Tserpelis, Demis, Yoshimatsu, Toshio, Tirapo, Carole, Raponi, Michela, Caldes, Trinidad, Blanco, Ana, Santamariña, Marta, Guidugli, Lucia, Ruiz de Garibay, Gorka, Wong, Ming, Tancredi, Mariella, Fachal, Laura, Chun Ding, Yuan, Kruse, Torben, Lattimore, Vanessa, Kwong, Ava, Leung Chan, Tsun, Colombo, Mara, De Vecchi, Giovanni, Caligo, Maria, Baralle, Diana, Lázaro, Conxi, Couch, Fergus, Radice, Paolo, Southey, Melissa C., Neuhausen, Susan, Houdayer, Claude, Fackenthal, Jim, Van Overeem Hansen, Thomas, Vega, Ana, Diez, Orland, Blok, Rien, Claes, Kathleen, Wappenschmidt, Barbara, Walker, Logan, Spurdle, Amanda B. and Brown, Melissa A. (2014) Comparison of mRNA splicing assay protocols across multiple laboratories: recommendations for best practice in standardized clinical testing. Clinical Chemistry, 60 2: 341-352. doi:10.1373/clinchem.2013.210658

  • Whiley, Phillip J., Parsons, Michael T., Leary, Jennifer, Tucker, Kathy, Warwick, Linda, Dopita, Belinda, Thorne, Heather, Lakhani, Sunil R., Goldgar, David E., Brown, Melissa A. and Spurdle, Amanda B. (2014) Multifactorial likelihood assessment of BRCA1 and BRCA2 missense variants confirms that BRCA1:c.122A>G(p.His41Arg) is a pathogenic mutation. PloS One, 9 1: 1-10. doi:10.1371/journal.pone.0086836

  • French, Juliet D., Ghoussaini, Maya, Edwards, Stacey L., Meyer, Kerstin B., Michailidou, Kyriaki, Ahmed, Shahana, Khan, Sofia, Maranian, Mel J., O'Reilly, Martin, Hillman, Kristine M., Betts, Joshua A., Carro, Thomas, Bailey, Peter J., Dicks, Ed, Beesley, Jonathan, Tyrer, Jonathan, Maia, Ana-Teresa, Beck, Andrew, Knoblauch, Nicholas W., Chen, Constance, Kraft, Peter, Barnes, Daniel, Gonzalez-Neira, Anna, Rosario Alonso, M., Herrero, Daniel, Tessier, Daniel C., Vincent, Daniel, Bacot, Francois, Luccarini, Craig, Baynes, Caroline, Conroy, Don, Dennis, Joe, Bolla, Manjeet K., Wang, Qin, Hopper, John L., Southey, Melissa C., Schmidt, Marjanka K., Broeks, Annegien, Verhoef, Senno, Cornelissen, Sten, Muir, Kenneth, Lophatananon, Artitaya, Stewart-Brown, Sarah, Siriwanarangsan, Pomthep, Fasching, Peter A., Loehberg, Christian R., Ekici, Arif B., Beckmann, Matthias W., Peto, Julian, Silva, Isabel dos Santos, Johnson, Nichola, Aitken, Zoe, Sawyer, Elinor J., Tomlinson, Ian, Kerin, Michael J., Miller, Nicola, Marme, Frederik, Schneeweiss, Andreas, Sohn, Christof, Burwinkel, Barbara, Guenel, Pascal, Therese Truong, Laurent-Puig, Pierre, Menegaux, Florence, Bojesen, Stig E., Nordestgaard, Norge G., Nielsen, Sune F., Flyger, Henrik, Milne, Roger L., Pilar Zamora, M., Arias Perez, Jose Ignacio, Benitez, Javier, Anton-Culver, Hoda, Brenner, Hermann, Mueller, Heiko, Arndt, Volker, Stegmaier, Christa, Meind, Alfons, Lichtner, Peter, Schmutzler, Rita K., Engel, Christoph, Brauch, Hiltrud, Hamann, Ute, Justenhoven, Christina, The GENICA Network, Aaltonen, Kirsimari, Heikkila, Paivi, Aittomaki, Kristiina, Blomqvist, Carl, Matsuo, Keitaro, Ito, Hidemi, Iwata, Hiroji, Sueta, Aiko, Bogdanova, Natalia V., Antonenkova, Natalia N., Dork, Thilo, Lindblom, Annika, Margolin, Sara, Mannermaa, Arto, Kataja, Vesa, Kosma, Veli-Matti, Hartikainen, Jaana M., Wu, Anna H., Tseng, Chiu-chen, Van Den Berg, David, Stram, Daniel O., Lambrechts, Diether, Peeters, Stephanie, Smeets, Ann, Floris, Giuseppe, Chang-Claude, Jenny, Rudolph, Anja, Nickels, Stefan, Flesch-Janys, Dieter, Radice, Paolo, Peterlongo, Paolo, Bonanni, Bernardo, Sardella, Domenico, Couch, Fergus J., Wang, Xianshu, Pankratz, Vernon S., Lee, Adam, Giles, Graham G., Severi, Gianluca, Baglietto, Laura, Haiman, Christopher A., Henderson, Brian E., Schumacher, Fredrick, Le Marchand, Loic, Simard, Jacques, Goldberg, Mark S., Labreche, France, Dumont, Martine, Teo, Soo Hwang, Yip, Cheng Har, Ng, Char-Hong, Vithana, Eranga Nishanthie, Kristensen, Vessela, Zheng, Wei, Deming-Halverson, Sandra, Shrubsole, Martha, Long, Jirong, Winqvist, Robert, Pylkas, Katri, Jukkola-Vuorinen, Arja, Grip, Mervi, Andrulis, Irene L., Knight, Julia A., Glendon, Gord, Mulligan, Anna Marie, Devilee, Peter, Seynaeve, Caroline, Garcia-Closas, Montserrat, Figueroa, Jonine, Chanock, Stephen J., Lissowska, Jolanta, Czene, Kamila, Klevebring, Daniel, Schoof, Nils, Hooning, Maartje J., Martens, John W. M., Collee, J. Margriet, Tilanus-Linthorst, Madeleine, Hall, Per, Li, Jingmei, Liu, Jianjun, Humphreys, Keith, Shu, Xiao-Ou, Lu, Wei, Gao, Yu-Tang, Cai, Hui, Cox, Angela, Balasubramanian, Sabapathy P., Blot, William, Signorello, Lisa B., Cai, Qiuyin, Pharoah, Paul D. P., Healey, Catherine S., Shah, Mitul, Pooley, Karen A., Kang, Daehee, Yoo, Keun-Young, Noh, Dong-Young, Hartman, Mikael, Miao, Hui, Sng, Jen-Hwei, Sim, Xueling, Jakubowska, Anna, Lubinski, Jan, Jaworska-Bieniek, Katarzyna, Durda, Katarzyna, Sangrajrang, Suleeporn, Gaborieau, Valerie, McKay, James, Toland, Amanda E., Ambrosone, Christine B., Yannoukakos, Drakoulis, Godwin, Andrew K., Shen, Chen-Yang, Hsiung, Chia-Ni, Wu, Pei-Ei, Chen, Shou-Tung, Swerdlow, Anthony, Ashworth, Alan, Orr, Nick, Schoemaker, Minouk J., Ponder, Bruce A. J., Nevanlinna, Heli, Brown, Melissa A., Chenevix-Trench, Georgia, Easton, Douglas F. and Dunning, Alison M. (2013) Functional variants at the 11q13 risk locus for breast cancer regulate cyclin D1 expression through long-range enhancers. American Journal of Human Genetics, 92 4: 489-503. doi:10.1016/j.ajhg.2013.01.002

  • Parsons, Michael T., Whiley, Phillip J., Beesley, Jonathan, Drost, Mark, de Wind, Neils, Thompson, Bryony A., Marquart, Lousie, Hopper, John L., Jenkins, Mark A., Brown, Melissa A., Tucker, Kathy, Warwick, Linda, Buchanan, Daniel D., Spurdle, Amanda B. and Australasian Colorectal Cancer Family Registry (2013) Consequences of germline variation disrupting the constitutional translational initiation codon start sites of MLH1 and BRCA2: Use of potential alternative start sites and implications for predicting variant pathogenicity. Molecular Carcinogenesis, 54 7: 513-522. doi:10.1002/mc.22116

  • Wee, Eugene J. H., Shiddiky, Muhammad J. A., Brown, Melissa A. and Trau, Matt (2012) eLCR: electrochemical detection of single DNA base changes via ligase chain reaction. Chemical Communications, 48 98: 1214-1216. doi:10.1039/C2CC35841G

  • Betts, Joshua A., French, Juliet D., Brown, Melissa A. and Edwards, Stacey L. (2012) Long-range transcriptional regulation of breast cancer genes. Genes, Chromosomes and Cancer, 52 2: 113-125. doi:10.1002/gcc.22020

  • Spurdle, Amanda B., Whiley, Phillip J., Thompson, Bryony, Feng, Bingjian, Healey, Sue, Brown, Melissa A., Pettigrew, Christopher, kConFab, Van Asperen, Christi J., Ausems, Margreet G. E. M., Kattentidt-Mouravieva, Anna A., Pigg, Maritta H., Schmutzler, Rita K., Engel, Christoph, Meindl, Alfons, German Consortium of Hereditary Breast and Ovarian Cancer, Caputo, Sandrine, Sinilnikova, Olga M., Lidereau, Rosette, French COVAR group collaborators, Couch, Fergus J., Guidugli, Lucia, van Overeem Hansen, Thomas, Thomassen, Mads, Eccles, Diana M., Tucker, Kathy, Benitez, Javier, Domchek, Susan M., Toland, Amanda E., Van Rensburg, Elizabeth J., Wappenschmidt, Barbara, Borg, Åke, Vreeswijk, Maaike P. G ., Goldgar, David E. and ENIGMA Consortium (2012) BRCA1 R1699Q variant displaying ambiguous functional abrogation confers intermediate breast and ovarian cancer risk. Journal of Medical Genetics, 49 8: 525-532. doi:10.1136/jmedgenet-2012-101037

  • Waddell, N., Stein, S. R., Wagner, S. A., Bennett, I., Djougarian, A., Melana, S., Jaffer, S., Holland, J. F., Pogo, B. G. T., Gonda, T. J., Brown, M. A., Leo, P., Saunders, N. A., McMillan, N. A., Cocciardi, S., Vargas, A. C., Lakhani, S. R., Chenevix-Trench, G., Newman, B. and Francis, G. D. (2012) Morphological and molecular analysis of a breast cancer cluster at the ABC Studio in Toowong. Pathology, 44 5: 469-472. doi:10.1097/PAT.0b013e3283559e67

  • Dowhan, Dennis H., Harrison, Matthew J., Eriksson, Natalie A., Bailey, Peter, Pearen, Michael A, Fuller, Peter J., Funder, John W., Simpson, Evan R., Leedman, Peter J., Tilley, Wayne D., Brown, Melissa A., Clarke, Christine L. and Muscat, George E. O. (2012) Protein arginine methyltransferase 6-dependent gene expression and splicing: Association with breast cancer outcomes. Endocrine-Related Cancer, 19 4: 509-526. doi:10.1530/ERC-12-0100

  • Brewster, Brooke L., Rossiello, Francesca, French, Juliet D., Edwards, Stacey L., Wong, Ming, Wronski, Ania, Whiley, Phillip, Waddell, Nic, Chen, Xiaowei, Bove, Betsy, kConFab, Hopper, John L., John, Esther M., Andrulis, Irene, Daly, Mary, Volorio, Sara, Bernard, Loris, Peissel, Bernard, Manoukian, Siranoush, Barile, Monica, Pizzamiglio, Sara, Verderio, Paolo, Spurdle, Amanda B., Radice, Paolo, Godwin, Andrew K., Southey, Melissa C., Brown, Melissa A. and Peterlongo, Paolo (2012) Identification of fifteen novel germline variants in the BRCA1 3′UTR reveals a variant in a breast cancer case that introduces a functional miR-103 target site. Human Mutation, 33 12: 1665-1675. doi:10.1002/humu.22159

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  • Saunus, Jodi M., Edwards, Stacey L., French, Juliet D., Smart, Chanel E. and Brown, Melissa A. (2007) Regulation of BRCA1 messenger RNA stability in human epithelial cell lines and during cell cycle progression. FEBS Letters, 581 18: 3435-3442. doi:10.1016/j.febslet.2007.06.046

  • Lovelock P. K., Healey, S., Au, W., Sum, E, Y. M., Tesoriero, A., Wong, E. M., Hinson, S., Brinkworth, R., Bekessy, A., Diez, O., Izatt, L., Solomon, E., Jenkins, M., Renard, H., Hopper, J., Waring, P., kConFab Investigators, Tavtigian, S. V., Goldgar, D., Lindeman, G J ., Visvader, J. E., Couch, F. J., Henderson, B. R., Southey, M., Chenevix-Trench, G., Spurdle, A. B. and Brown, M. A. (2006) Genetic, functional, and histopathological evaluation of two C-terminal BRCA1 missense variants. Journal of Medical Genetics, 43 1: 74-83. doi:10.1136/jmg.2005.033258

  • French, Juliet D., Dunn, Jasmyn, Smart, Chanel E., Manning, Nathan and Brown, Melissa A. (2006) Disruption of BRCA I function results in telomere lengthening and increased anaphase bridge formation in immortalized cell lines. Genes Chromosomes and Cancer, 45 3: 277-289. doi:10.1002/gcc.20290

  • Chenevix-Trench, Georgia, Healey, Sue, Lakhani, Sunil, Waring, Paul, Cummings, Margaret, Brinkworth, Ross, Deffenbaugh, Amie M., Burbidge, Lynn Anne, Pruss, Dmitry, Judkins, Thad, Scholl, Tom, Bekessy, Anna, Marsh, Anna, Lovelock, Paul, Wong, Ming, Tesoriero, Andrea, Renard, Helene, Southey, Melissa, Hopper, John L., Yannoukakos, Koulis, Brown, Melissa, kConFab Investigators, Easton, Douglas, Tavtigian, Sean V., Goldgar, David and Spurdle, Amanda B. (2006) Genetic and Histopathologic Evaluation of BRCA1 and BRCA2 DNA Sequence Variance of Unknown Clinical Significance. Cancer Research, 66 4: 2019-2027. doi:10.1158/0008-5472.CAN-05-3546

  • Lewis, Aaron G., Flanagan, James, Marsh, Anna, Pupo, Gulietta M., Mann, Graham, Spurdle, Amanda B., Lindeman, Geoffrey J., Visvader, Jane E., Brown, Melissa A., Chenevix-Trench, Georgia and KConFab, Kathleen Cuningham Foundation (2005) Mutation analysis of FANCD2, BRIP1/BACH1, LMO4 and SFN in familial breast cancer. Breast Cancer Research, 7 6: R1005-R1016. doi:10.1186/bcr1336

  • Pettigrew, Christopher, Wayte, Nicola, Lovelock, Paul K., Tavtigian, Sean V, Chenevix-Trench, Georgia, Spurdle, Amanda B. and Brown, Melissa A. (2005) Evolutionary conservation analysis increases the colocalization of predicted exonic splicing enhancers in the BRCA1 gene with missense sequence changes and in-frame deletions, but not polymorphisms. Breast Cancer Research, 7 6: R929-R939. doi:10.1186/bcr1324

  • Wardrop, Stacey L., Brown, Melissa A. and kConFab Investigators (2005) Identification of two evolutionarily conserved and functional regulatory elements in intron 2 of the human BRCA1 gene. Genomics, 86 3: 316-328. doi:10.1016/j.ygeno.2005.05.006

  • He, Y. W., Brown, M. A., Rothnagel, J. A., Saunders, N. A. and Smith, R. (2005) Roles of heterogeneous nuclear ribonucleoproteins A and B in cell proliferation. Journal of Cell Science, 118 14: 3173-3183. doi:10.1242/jcs.02448

  • Timmins, N. E., Harding, F. J., Smart, C. E., Brown, M. A. and Nielsen, L. K. (2005) Method for the generation and cultivation of functional three-dimensional mammary constructs without exogenous extracellular matrix. Cell And Tissue Research, 320 1: 207-210. doi:10.1007/s00441-004-1064-6

  • Tesoriero, A. A., Wong, E. M., Jenkins, M. A., Hopper, J. L., KConFab, K. C. F., Brown, M. A., Chenevix-Trench, G., Spurdle, A. B. and Southey, M. C. (2005) Molecular characterization and cancer risk associated with BRCA1 and BRCA2 splice site variants identified in multiple-case breast cancer families. Human Mutation, 26 5: 495-495. doi:10.1002/humu.9379

  • Simpson, K. J., Wati, M. R., Deans, A. J., Lindeman, G. J. and Brown, M. A. (2004) MMTV-trBrca 1 mice display strain-dependent abnormalities in vaginal development. International Journal of Developmental Biology, 48 7: 675-678. doi:10.1387/ijdb.041849ks

  • Deans, Andrew J., Simpson, Kaylene J., Trivett, Melanie K., Brown, Melissa A. and McArthur, Grant (2004) Brca1 inactivation induces p27Kip1-dependent cell cycle arrest and delayed development in the mouse mammary gland. Oncogene, 23 36: 6136-6145. doi:10.1038/sj.onc.1207805

  • He, Y., Brown, M. A., Rothnagel, J. A., Saunders, N. A. and Smith, R. (2004) Roles of heterogeneous nuclear ribonucleoproteins A/B in cell growth. Molecular Biology of The Cell, 15 252A-253A.

  • Brown, M. A., Nicolai, H., Howe, K., Katagiri, T., Lalani, E., Simpson, K. J., Manning, N. W., Deans, A., Chen, P., Khanna, K. K., Wati, M. R., Griffiths, B. L., Xu, C. F., Stamp, G. W. H. and Solomon, E. (2002) Expression of a truncated Brca1 protein delays lactational mammary development in transgenic mice. Transgenic Research, 11 5: 467-478. doi:10.1023/A:1020348025139

  • Brown, M. A., Lo, L. J., Catteau, A., Xu, C. F., Lindeman, G. J., Hodgson, S. and Solomon, E. (2002) Germline BRCA1 promoter deletions in UK and Australian familial breast cancer patients: Identification of a novel deletion consistent with BRCA1 :psi VBRCA1 recombination. Human Mutation, 19 4: 435-442. doi:10.1002/humu.10055

  • Lane, T. F., Lin, C. W., Brown, M. A., Solomon, E. and Leder, P. (2000) Gene replacement with the human BRCA1 locus: tissue specific expression and rescue of embryonic lethality in mice. Oncogene, 19 36: 4085-4090. doi:10.1038/sj.onc.1203760

  • Catteau, A., Xu, C. F., Brown, M. A., Hodgson, S., Greenman, J., Mathew, C. G., Dunning, A. M. and Solomon, E. (1999) Identification of a C/G polymorphism in the promoter region of the BRCA1 gene and its use as a marker for rapid detection of promoter deletions. British Journal of Cancer, 79 5-6: 759-763. doi:10.1038/sj.bjc.6690122

  • Xu, CF, Brown, MA, Nicolai, H, Chambers, JA, Griffiths, BL and Solomon, E (1997) Isolation and characterisation of the NBR2 gene which lies head to head with the human BRCA1 gene. Human Molecular Genetics, 6 7: 1057-1062. doi:10.1093/hmg/6.7.1057

  • Brown, MA and Solomon, E (1997) Studies on inherited cancers: Outcomes and challenges of 25 years. Trends in Genetics, 13 5: 202-206. doi:10.1016/S0168-9525(97)01132-3

  • Xu, CF, Chambers, JA, Nicolai, H, Brown, MA, Hujeirat, Y, Mohammed, S, Hodgson, S, Kelsell, DP, Spurr, NK, Bishop, DT and Solomon, E (1997) Mutations and alternative splicing of the BRCAI gene in UK breast/ovarian cancer families. Genes Chromosomes & Cancer, 18 2: 102-110. doi:10.1002/(SICI)1098-2264(199702)18:2<102::AID-GCC4>3.0.CO;2-6

  • Brown, MA (1997) Tumor suppressor genes and human cancer. Advances in Genetics, Vol 36, 36 C: 45-135. doi:10.1016/S0065-2660(08)60307-7

  • Brown, MA, Xu, CF, Nicolai, H, Griffiths, B, Chambers, JA, Black, D and Solomon, E (1996) The 5' end of the BRCA1 gene lies within a duplicated region of human chromosome 17q21. Oncogene, 12 12: 2507-2513.

  • Xu, CF, Brown, MA, Chambers, JA, Griffiths, B, Nicolai, H and Solomon, E (1995) Distinct Transcription Start Sites Generate 2 Forms of Brca1 Messenger-Rna. Human Molecular Genetics, 4 12: 2259-2264. doi:10.1093/hmg/4.12.2259

  • Brown, MA, Jones, KA, Nicolai, H, Bonjardim, M, Black, D, McFarlane, R, Dejong, P, Quirk, JP, Lehrach, H and Solomon, E (1995) Physical Mapping, Cloning, and Identification of Genes Within a 500-Kb Region Containing Brca1. Proceedings of the National Academy of Sciences of the United States of America, 92 10: 4362-4366. doi:10.1073/pnas.92.10.4362

  • Jones, KA, Brown, MA and Solomon, E (1995) Molecular genetics of sporadic and familial breast cancer. Cancer Surveys, 25 315-334.

  • Brown, MA, Nicolai, H, Xu, CF, Griffiths, BL, Jones, KA, Solomon, E, Hosking, L, Trowsdale, J, Black, DM and McFarlane, R (1994) Regulation of Brca1. Nature, 372 6508: 733-733. doi:10.1038/372733a0

  • Jones, KA, Black, DM, Brown, MA, Griffiths, BL, Nicolai, HM, Chambers, JA, Bonjardim, M, Xu, CF, Boyd, M, McFarlane, R, Korn, B, Poustka, A, North, MA, Schalkwyk, L, Lehrach, H and Solomon, E (1994) The Detailed Characterization of a 400-Kb Cosmid Walk in the Brca1 Region - Identification and Localization of 10 Genes Including a Dual-Specificity Phosphatase. Human Molecular Genetics, 3 11: 1927-1934.

  • Brown, MA, Harrisonsmith, M, Deluca, E, Begley, CG and Gough, NM (1994) No Evidence for Gm-Csf Receptor a Chain Gene Mutation in Aml-M2 Leukemias Which Have Lost a Sex-Chromosome. Leukemia, 8 10: 1774-1779.

  • Barnard, W, Bower, J, Brown, MA, Murphy, M and Austin, L (1994) Leukemia Inhibitory Factor (lif) Infusion Stimulates Skeletal-Muscle Regeneration After Injury - Injured Muscle Expresses Lif Messenger-Rna. Journal of the Neurological Sciences, 123 1-2: 108-113. doi:10.1016/0022-510X(94)90211-9

  • Brown, MA, Metcalf, D and Gough, NM (1994) Leukemia Inhibitory Factor and Interleukin-6 Are Expressed At Very-Low Levels in the Normal Adult-Mouse and Are Induced by Inflammation. Cytokine, 6 3: 300-309. doi:10.1016/1043-4666(94)90027-2

  • Murphy, M, Reid, K, Brown, MA and Bartlett, PF (1993) Involvement of Leukemia Inhibitory Factor and Nerve Growth-Factor in the Development of Dorsal-Root Ganglion Neurons. Development, 117 3: 1173-1182.

  • Brown, MA, Gough, NM, Willson, TA, Rockman, S and Begley, CG (1993) Structure and Expression of the Gm-Csf Receptor Alpha-Chain and Beta-Chain Genes in Human Leukemia. Leukemia, 7 1: 63-74.

  • Purcell, Dfj, Russell, SM, Deacon, NJ, Brown, MA, Hooker, DJ and McKenzie, Ifc (1991) Alternatively Spliced Rnas Encode Several Isoforms of Cd46 (mcp), a Regulator of Complement Activation. Immunogenetics, 33 5-6: 335-344. doi:10.1007/BF00216692

  • Fahey, KJ, McWaters, P, Brown, MA, Erny, K, Murphy, VJ and Hewish, DR (1991) Virus-Neutralizing and Passively Protective Monoclonal-Antibodies to Infectious Bursal Disease Virus of Chickens. Avian Diseases, 35 2: 365-373. doi:10.2307/1591191

  • Croy, BA, Guilbert, LJ, Browne, MA, Gough, NM, Stinchcomb, DT, Reed, N and Wegmann, TG (1991) Characterization of Cytokine Production by the Metrial Gland and Granulated Metrial Gland-Cells. Journal of Reproductive Immunology, 19 2: 149-166.

  • Allan, EH, Hilton, DJ, Brown, MA, Evely, RS, Yumita, S, Metcalf, D, Gough, NM, Ng, KW, Nicola, NA and Martin, TJ (1990) Osteoblasts Display Receptors for and Responses to Leukemia-Inhibitory Factor. Journal of Cellular Physiology, 145 1: 110-119. doi:10.1002/jcp.1041450116

  • Stahl, Juergen, Gearing, David P., Willson, Tracy A., Brown, Melissa A., King, Julie A. and Gough, Nicholas M. (1990) Structural organization of the genes for murine and human leukemia inhibitory factor: evolutionary conservation of coding and non-coding regions. Journal of Biological Chemistry, 265 15: 8833-8841.

  • Azad, AA, Jagadish, MN, Brown, MA and Hudson, PJ (1987) Deletion Mapping and Expression in Escherichia-Coli of the Large Genomic Segment of a Birnavirus. Virology, 161 1: 145-152. doi:10.1016/0042-6822(87)90180-2

Conference Publication

Grants (Administered at UQ)

PhD and MPhil Supervision

Current Supervision

  • Doctor Philosophy — Principal Advisor

Completed Supervision