Dr Kate Markey

Academic Title-Lecturer

Royal Brisbane Clinical Unit
Faculty of Medicine

Overview

Dr. Kate Markey is Hematology Advanced Trainee at the RBWH and a Senior Research Officer at the QIMR Berghofer Medical Research Institute. She completed her undergraduate training in Chemical Engineering (UQ) then completed the combined MBBS/PhD program (UQ/QIMR). Her current research is a mixture of basic science (pre-clinical models of GVHD and GVL effects, with a focus on antigen presentation), and clinical research, aiming to better understand mechanisms underlying post-transplant mortality (which is primarily due to relapse, infection and GVHD).

Research Impacts

Within the subspecialised field of antigen presentation, Dr Markey's work has confirmed that donor DC are the key APC capable of presenting alloantigen after BMT (Markey et al, Blood 2009), and more recently established that semi-direct antigen presentation maximizes indirect antigen presentation by increasing DC:T cell immune synapse engagement (Markey et al, JI 2014).

Her contributions to the field with regard to dendritic cell function include examination of the role of RelB in DC post-BMT (Blood 2007), studies of pDC post-BMT (JI 2009, Blood 2009), and establishing that DC dysfunction after transplantation is a key contributor to immune suppression and is driven by the cytokine environment in GVHD (Markey et al, Blood 2012).

Dr Markey has extensively published in the area of cytokine biology; particularly on the role of lymphotoxin, the type 1 interferons (Blood 2011), IL-17 (Blood 2010, JCI 2014, Blood 2015, and a manuscript currently in revision) and the CSF’s (Nat Med 2009, BBMT 2009). This expertise has been used to contribute a book chapter (2012) and a review paper on the role of cytokine polymorphisms in GVHD (Markey et al, Tissue Antigens 2008).

Publications

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Publications

Featured Publications

  • Koyama, Motoko, Cheong, Melody, Markey, Kate A., Gartlan, Kate H., Kuns, Rachel D., Locke, Kelly R., Lineburg, Katie E., Teal, Bianca E., Leveque-El Mouttie, Lucie, Bunting, Mark D., Vuckovic, Slavica, Zhang, Ping, Teng, Michele W. L., Varelias, Antiopi, Tey, Siok-Keen, Wockner, Leesa F., Engwerda, Christian R., Smyth, Mark J., Belz, Gabrielle T., McColl, Shaun R., MacDonald, Kelli P. A. and Hill, Geoffrey R. (2015) Donor colonic CD103(+) dendritic cells determine the severity of acute graft-versus-host disease. Journal of Experimental Medicine, 212 8: 1303-1321. doi:10.1084/jem.20150329

  • Markey, KA, Burman, AC, Banovic, T, Kuns, RD, Raffelt, NC, Rowe, V, Olver, SD, Don, ALJ, Morris, ES, Pettit, AR, Wilson, YA, Robb, RJ, Randall, LM, Korner, H, Engwerda, CR, Clouston, AD, MacDonald, KPA and Hill, GR (2010) Soluble lymphotoxin is an important effector molecule in GVHD and GVL. Blood, 115 1: 122-132. doi:10.1182/blood-2009-01-199927

Book Chapter

  • Markey, K.A., MacDonald, K.P.A. and Hill, G.R. (2013). Cytokines in Graft-versus-host Disease and Graft-versus-leukemia. In Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation (pp. 357-391) New York, NY, U.S.A.: Elsevier Inc.. doi:10.1016/B978-0-12-416004-0.00016-1

Journal Article

Conference Publication

  • Alexander, K., Flynn, R., Lineburg, K., Kuns, R., Janela, B., Teal, B., Olver, S., Lor, M., Raffelt, N., Koyama, M., Leveque, L., Le Texier, L., Melino, M., Markey, K., Varelias, A., Ginhoux, F., Engwerda, C., Clouston, A., Blazer, B., Hill, G. and MacDonald, K. (2014). CSF-1-Dependant M2 Macrophages Mediate Chronic Graft-Versus-Host Disease. In: World Transplant Congress, San Francisco United States, (390-391). Jul 26-31, 2014. doi:10.1097/01.tp.0000452130.27963.71

  • Varelias, Antiopi, Gartlan, Kate H., Olver, Stuart D., Lineburg, Katie E., Kuns, Rachel D., Lor, Mary, Teal, Bianca E., Cheong, Melody, Koyama, Motoko, Markey, Kate A., Alexander, Kylie, Budelsky, Alison, Sturgeon, Elise, Leach, Justine, Avery, Judy, Kennedy, Glen A., Siok-Tey, Clouston, Andrew D., MacDonald, Kelli P. A. and Hill, Geoff R. (2013). Lung Parenchyma-Derived IL-6 Induces Alloantigen Specific Th17 Differentiation Within The Lung and Idiopathic Pneumonia Syndrome After Allogeneic Stem Cell Transplantation. In: Blood. 55th Annual Meeting of the American-Society-of-Hematology, New Orleans La, (). Dec 07-10, 2013.

  • Koyama, M., Kuns, R. D., Olver, S. D., Raffelt, N. C., Wilson, YA, Don, A. L. J., Lineburg, K. E., Robb, R. J., Markey, K. A., Varelias, A., Malissen, B., Hammerling, G. J., Bhat, P., Clouston, A. D., Engwerda, C. R., MacDonald, K. P. A. and Hill, G. R. (2012). Alloantigen presentation by recipient non-professional antigen presenting cells induces lethal acute Gvhd. In: Abstracts from the 2012 BMT Tandem Meetings. BMT Tandem Meeting, San Diego, CA, United States, (S362-S363). 01-05 Feburary 2012.

  • Markey, K. A., Koyama, M., Kuns, R. D., Lineburg, K. E., Wilson, Y. A., Olver, S. D., Dan, A. L. J., Varelias, A., Robb, R. J., Cheong, M., Engwerda, C. R., Steptoe, R. J., Ramshaw, H. S., Lopez, A. F., Lew, A. M., Villadangos, J. A., Hill, G. R. and MacDonald, K. P. A. (2012). Immune insufficiency after experimental transplantation is d.Due to defective antigen presentation within Dendritic Cell Subsets. In: Abstracts from the 2012 BMT Tandem Meetings. BMT Tandem Meeting, San Diego, CA, United States, (S225-S225). 01-05 Feburary 2012.

  • Markey, K, Banovic, T, Kuns, R, Raffelt, N, Olver, S, Don, A, Wilson, Y, Pettit, A, Bromberg, J, Hill, G and MacDonald, K (2009). Conventional dendritic cells are the critical donor APC presenting alloantigen after BMT. In: Bone Marrow Transplantation. 35th Annual Meeting of the European-Group-for-Blood-and-Marrow-Transplantation, Goteborg Sweden, (S83-S83). Mar 29-Apr 01, 2009.

Other Outputs

Grants (Administered at UQ)