The University of Queensland

Double adjuvanting strategy for peptide-based vaccines: trimethyl chitosan nanoparticles for lipopeptide delivery

Marasini, Nirmal, Giddam, Ashwini K., Khalil, Zeinab G., Hussein, Waleed M., Capon, Robert J., Batzloff, Michael R., Good, Michael F., Toth, Istvan and Skwarczynski, Mariusz (2016) Double adjuvanting strategy for peptide-based vaccines: trimethyl chitosan nanoparticles for lipopeptide delivery. Nanomedicine, 11 24: 3223-3235. doi:10.2217/nnm-2016-0291

Lipid core peptide/poly(lactic-co-glycolic acid) as a highly potent intranasal vaccine delivery system against Group A streptococcus

Marasini, Nirmal, Khalil, Zeinab G., Giddam, Ashwini K., Abdul Ghaffar, Khairunnisa, Hussein, Waleed M., Capon, Robert J., Batzloff, Michael R., Good, Michael F., Skwarczynski, Mariusz and Toth, Istvan (2016) Lipid core peptide/poly(lactic-co-glycolic acid) as a highly potent intranasal vaccine delivery system against Group A streptococcus. International Journal of Pharmaceutics, 513 1-2: 410-420. doi:10.1016/j.ijpharm.2016.09.057

Roseopurpurins: chemical diversity enhanced by convergent biosynthesis and forward and reverse Michael additions

Shang, Zhuo, Khalil, Zeinab, Li, Li, Salim, Angela A., Quezada, Michelle, Kalansuriya, Pabasara and Capon, Robert J. (2016) Roseopurpurins: chemical diversity enhanced by convergent biosynthesis and forward and reverse Michael additions. Organic Letters, 18 17: 4340-4343. doi:10.1021/acs.orglett.6b02099

Linear and branched polyacrylates as a delivery platform for peptide-based vaccines

Chandrudu, Saranya, Bartlett, Stacey, Khalil, Zeinab G., Jia, Zhongfan, Hussein, Waleed M., Capon, Robert J., Batzloff, Michael R., Good, Michael F., Monteiro, Michael J., Skwarczynski, Mariusz and Toth, Istvan (2016) Linear and branched polyacrylates as a delivery platform for peptide-based vaccines. Therapeutic Delivery, 7 9: 601-609. doi:10.4155/tde-2016-0037

Fungal biotransformation of tetracycline antibiotics

Shang, Zhuo, Salim, Angela A., Khalil, Zeinab, Bernhardt, Paul V. and Capon, Robert J. (2016) Fungal biotransformation of tetracycline antibiotics. Journal of Organic Chemistry, 81 15: 6186-6194. doi:10.1021/acs.joc.6b01272

C3 and 2D C3 Marfey’s methods for amino acid analysis in natural products

Vijayasarathy, Soumini, Prasad, Pritesh, Fremlin, Leith J., Ratnayake, Ranjala, Salim, Angela A., Khalil, Zeinab and Capon, Robert J. (2016) C3 and 2D C3 Marfey’s methods for amino acid analysis in natural products. Journal of Natural Products, 79 2: 421-427. doi:10.1021/acs.jnatprod.5b01125

Viridicatumtoxins: Expanding on a Rare Tetracycline Antibiotic Scaffold

Shang, Zhuo, Salim, Angela A., Khalil, Zeinab, Quezada, Michelle, Bernhardt, Paul V. and Capon, Robert J. (2015) Viridicatumtoxins: Expanding on a Rare Tetracycline Antibiotic Scaffold. Journal of Organic Chemistry, 80 24: 12501-12508. doi:10.1021/acs.joc.5b02367

New PKS-NRPS tetramic acids and pyridinone from an Australian marine-derived fungus, Chaunopycnis sp.

Shang, Zhuo, Li, Li, Esposito, Breno P., Salim, Angela A., Khalil, Zeinab G., Quezada, Michelle, Bernhardt, Paul V. and Capon, Robert J. (2015) New PKS-NRPS tetramic acids and pyridinone from an Australian marine-derived fungus, Chaunopycnis sp.. Organic and Biomolecular Chemistry, 13 28: 7795-7802. doi:10.1039/c5ob01058f

Aranciamycins I and J, Antimycobacterial Anthracyclines from an Australian marine-derived Streptomyces sp.

Khalil, Zeinab G., Raju, Ritesh, Piggott, Andrew M., Salim, Angela A., Blumenthal, Antje and Capon, Robert J. (2015) Aranciamycins I and J, Antimycobacterial Anthracyclines from an Australian marine-derived Streptomyces sp.. Journal of Natural Products, 78 4: 949-952. doi:10.1021/acs.jnatprod.5b00095

Atropselective syntheses of (-) and (+) rugulotrosin A utilizing point-to-axial chirality transfer

Qin, Tian, Skraba-Joiner, Sarah L., Khalil, Zeinab G., Johnson, Richard P., Capon, Robert J. and Porco, John A. Jr (2015) Atropselective syntheses of (-) and (+) rugulotrosin A utilizing point-to-axial chirality transfer. Nature Chemistry, 7 3: 234-240. doi:10.1038/nchem.2173

Levofloxacin and indolicidin for combination antimicrobial therapy

Ghaffar, Khairunnisa Abdul, Hussein, Waleed M., Khalil, Zeinab G., Capon, Robert J., Skwarczynski, Mariusz and Toth, Istvan (2015) Levofloxacin and indolicidin for combination antimicrobial therapy. Current Drug Delivery, 12 1: 108-114-108-114. doi:10.2174/1567201811666140910094050

Self-assembling lipopeptides with a potent activity against Gram-positive bacteria, including multidrug resistant strains

Azmi, Fazren, Elliott, Alysha G., Khalil, Zeinab G., Hussein, Waleed M., Kavanagh, Angela, Huang, Johnny X., Quezada, Michelle, Blaskovich, Mark A. T., Capon, Robert J., Cooper, Matthew A., Skwarczynski, Mariusz and Toth, Istvan (2015) Self-assembling lipopeptides with a potent activity against Gram-positive bacteria, including multidrug resistant strains. Nanomedicine, 10 22: 3359-3371. doi:10.2217/nnm.15.137

Isolation and synthesis of N-acyladenine and adenosine alkaloids from a southern Australian marine sponge, Phoriospongia sp.

Farrugia, Michelle, Trotter, Nicholas, Vijayasarathy, Soumini, Salim, Angele A., Khalil, Zeinab G., Lacey, Ernest and Capon, Robert J. (2014) Isolation and synthesis of N-acyladenine and adenosine alkaloids from a southern Australian marine sponge, Phoriospongia sp.. Tetrahedron Letters, 55 43: 5902-5904. doi:10.1016/j.tetlet.2014.08.116

Wollamides: antimycobacterial cyclic hexapeptides from an Australian soil Streptomyces

Khalil, Zeinab G., Salim, Angela A., Lacey, Ernest, Blumenthal, Antje and Capon, Robert J. (2014) Wollamides: antimycobacterial cyclic hexapeptides from an Australian soil Streptomyces. Organic Letters, 16 19: 5120-5123. doi:10.1021/ol502472c

Shornephine A: structure, chemical stability, and P-Glycoprotein inhibitory properties of a rare Diketomorpholine from an Australian marine-derived Aspergillus sp.

Khalil, Zeinab G., Huang, Xiao-cong, Raju, Ritesh, Piggott, Andrew M. and Capon, Robert J. (2014) Shornephine A: structure, chemical stability, and P-Glycoprotein inhibitory properties of a rare Diketomorpholine from an Australian marine-derived Aspergillus sp.. Journal of Organic Chemistry, 79 18: 8700-8705. doi:10.1021/jo501501z

Heronapyrrole D: a case of co-inspiration of natural product biosynthesis, total synthesis and biodiscovery

Schmidt, Jens, Khalil, Zeinab, Capon, Robert J. and Stark, Christian B. W. (2014) Heronapyrrole D: a case of co-inspiration of natural product biosynthesis, total synthesis and biodiscovery. Beilstein Journal of Organic Chemistry, 10 1228-1232. doi:10.3762/bjoc.10.121

Mollemycin A: an antimalarial and antibacterial glyco-hexadepsipeptide-polyketide from an Australian marine-derived Streptomyces sp. (CMB-M0244)

Raju, Ritesh, Khalil, Zeinab G., Piggott, Andrew M., Blumenthal, Antje, Gardiner, Donald L., Skinner-Adams, Tina S. and Capon, Robert J. (2014) Mollemycin A: an antimalarial and antibacterial glyco-hexadepsipeptide-polyketide from an Australian marine-derived Streptomyces sp. (CMB-M0244). Organic Letters, 16 6: 1716-1719. doi:10.1021/ol5003913

Callyspongisines A-D: Bromopyrrole alkaloids from an Australian marine sponge, Callyspongia sp.

Plisson,Fabien, Prasad, Pritesh, Xiao, Xue, Piggott, Andrew M., Huang, Xiao-cong, Khalil, Zeinab and Capon, Robert J. (2014) Callyspongisines A-D: Bromopyrrole alkaloids from an Australian marine sponge, Callyspongia sp.. Organic and Biomolecular Chemistry, 12 10: 1579-1584. doi:10.1039/c4ob00091a

Lipopolysaccharide (LPS) stimulation of fungal secondary metabolism

Khalil, Zeinab G., Kalansuriya, Pabasara and Capon, Robert J. (2014) Lipopolysaccharide (LPS) stimulation of fungal secondary metabolism. Mycology, 5 3: 168-178. doi:10.1080/21501203.2014.930530

Structural and stereochemical investigations into bromotyrosine-derived metabolites from southern Australian marine sponges, Pseudoceratina spp.

Salim, Angela A., Khalil, Zeinab G. and Capon, Robert J. (2012) Structural and stereochemical investigations into bromotyrosine-derived metabolites from southern Australian marine sponges, Pseudoceratina spp.. Tetrahedron, 68 47: 9802-9807. doi:10.1016/j.tet.2012.09.008

A search for kinase inhibitors and antibacterial agents: bromopyrrolo-2-aminoimidazoles from a deep-water Great Australian Bight sponge, Axinella sp.

Zhang, Hua, Khalil, Zeinab, Conte, Melissa M., Plisson, Fabien and Capon, Robert J. (2012) A search for kinase inhibitors and antibacterial agents: bromopyrrolo-2-aminoimidazoles from a deep-water Great Australian Bight sponge, Axinella sp.. Tetrahedron Letters, 53 29: 3784-3787. doi:10.1016/j.tetlet.2012.05.051

Kinase inhibitor scaffolds against neurodegenerative diseases from a southern Australian Ascidian, Didemnum sp.

Plisson, Fabien, Conte, Melissa, Khalil, Zeinab, Huang, Xiao-Cong, Piggott, Andrew M. and Capon, Robert J. (2012) Kinase inhibitor scaffolds against neurodegenerative diseases from a southern Australian Ascidian, Didemnum sp.. ChemMedChem, 7 6: 983-990. doi:10.1002/cmdc.201200169

Lamellarins as inhibitors of P-glycoprotein-mediated multidrug resistance in a human colon cancer cell line

Plisson, Fabien, Huang, Xiao-Cong, Zhang, Hua, Khalil, Zeinab and Capon, Robert J. (2012) Lamellarins as inhibitors of P-glycoprotein-mediated multidrug resistance in a human colon cancer cell line. Chemistry - An Asian Journal, 7 7: 1616-1623. doi:10.1002/asia.201101049

New dictyodendrins as BACE inhibitors from a southern Australian marine sponge, Ianthella sp.

Zhang, Hua, Conte, Melissa M., Khalil, Zeinab, Huang, Xiao-Cong and Capon, Robert J. (2012) New dictyodendrins as BACE inhibitors from a southern Australian marine sponge, Ianthella sp.. Rsc Advances, 2 10: 4209-4214. doi:10.1039/c2ra20322g

A search for BACE inhibitors reveals new biosynthetically related pyrrolidones, furanones and pyrroles from a southern Australian marine sponge, Ianthella sp.

Zhang, Hua, Conte, Melissa M., Huang, Xiao-Cong, Khalil, Zeinab and Capon, Robert J. (2012) A search for BACE inhibitors reveals new biosynthetically related pyrrolidones, furanones and pyrroles from a southern Australian marine sponge, Ianthella sp.. Organic and Biomolecular Chemistry, 10 13: 2656-2663. doi:10.1039/c2ob06747a

Heronamycin A: A new benzothiazine ansamycin from an Australian marine-derived Streptomyces sp.

Raju, Ritesh, Piggott, Andrew M., Khalil, Zeinab, Bernhardt, Paul V. and Capon, Robert J. (2012) Heronamycin A: A new benzothiazine ansamycin from an Australian marine-derived Streptomyces sp.. Tetrahedron Letters, 53 9: 1063-1065. doi:10.1016/j.tetlet.2011.12.064

Spiralisones A-D: acylphloroglucinol hemiketals from an Australian marine brown alga, Zonaria spiralis

Zhang, Hua, Xiao, Xue, Conte, Melissa M., Khalil, Zeinab and Capon, Robert J. (2012) Spiralisones A-D: acylphloroglucinol hemiketals from an Australian marine brown alga, Zonaria spiralis. Organic and Biomolecular Chemistry, 10 48: 9671-9676. doi:10.1039/c2ob26988k

Ikirydinium A: A new indole alkaloid from the seeds of Hunteria umbellata (K. Schum)

Ajala, Olusegun S., Piggott, Andrew M., Plisson, Fabien, Zeinab, Zeinab, Huang, Xiao-cong, Adesegun, Sunday A., Coker, Herbert A. B. and Capon, Robert J. (2011) Ikirydinium A: A new indole alkaloid from the seeds of Hunteria umbellata (K. Schum). Tetrahedron Letters, 52 52: 7125-7127. doi:10.1016/j.tetlet.2011.10.106

Fascioquinols A-F: Bioactive meroterpenes from a deep-water southern Australian marine sponge, Fasciospongia sp

Zhang, Hua, Khalil, Zeinab G. and Capon, Robert J. (2011) Fascioquinols A-F: Bioactive meroterpenes from a deep-water southern Australian marine sponge, Fasciospongia sp. Tetrahedron, 67 14: 2591-2595. doi:10.1016/j.tet.2011.02.015

Reveromycins revealed: New polyketide spiroketals from Australian marine-derived and terrestrial Streptomyces spp. A case of natural products vs artifacts

Fremlin, Leith, Farrugia, Michelle, Piggott, Andrew M., Khalil, Zeinab, Lacey, Ernest and Capon, Robert J. (2011) Reveromycins revealed: New polyketide spiroketals from Australian marine-derived and terrestrial Streptomyces spp. A case of natural products vs artifacts. Organic & Biomolecular Chemistry, 9 4: 1201-1211. doi:10.1039/c0ob00654h

Heronapyrroles A-C: Farnesylated 2-nitropyrroles from an Australian marine-derived Streptomyces sp.

Raju, Ritesh, Piggott, Andrew M., Barrientos Diaz, Leticia X., Khalil, Zeinab and Capon, Robert J. (2010) Heronapyrroles A-C: Farnesylated 2-nitropyrroles from an Australian marine-derived Streptomyces sp.. Organic Letters, 12 22: 5158-5161. doi:10.1021/ol102162d

Heterofibrins: Inhibitors of lipid droplet formation from a deep-water southern Australian marine sponge, Spongia (Heterofibria) sp.

Salim, Angela A., Rae, James, Fontaine, Frank, Conte, Melissa M., Khalil, Zeinab, Martin, Sally, Parton, Robert G. and Capon, Robert J. (2010) Heterofibrins: Inhibitors of lipid droplet formation from a deep-water southern Australian marine sponge, Spongia (Heterofibria) sp.. Organic and Biomolecular Chemistry, 8 14: 3188-3194. doi:10.1039/c003840g

9-(5‘-Deoxy-5’-thio-β-d-xylofuranosyl)adenine disulfide from the Southern Australian marine sponge trachycladus laevispirulifer: The first natural occurrence of a nucleoside disulfide

Peng, Chongsheng, Gunaherath, G. M. Kamal B., Piggott, Andrew M., Khalil, Zeinab, Conte, Melissa and Capon, Robert J. (2010) 9-(5‘-Deoxy-5’-thio-β-d-xylofuranosyl)adenine disulfide from the Southern Australian marine sponge trachycladus laevispirulifer: The first natural occurrence of a nucleoside disulfide. Australian Journal of Chemistry, 63 6: 873-876. doi:10.1071/CH09645

Innovations in Microbial Biodiscovery, Targeting Silent Metabolism and New Chemical Diversity

Khalil, Zeinab (2013). Innovations in Microbial Biodiscovery, Targeting Silent Metabolism and New Chemical Diversity PhD Thesis, Institute for Molecular Bioscience, The University of Queensland. doi:10.14264/uql.2017.734