Dr Stefan Blum

Academic Title-Senior Lecturer

Princess Alexandra Hospital Southside Clinical Unit
Faculty of Medicine

Overview

Stefan is a Staff Specialist in Neurology at the Princess Alexandra Hospital (PAH) and the Mater Centre for Neuroscience, as well as an honourary staff specialist in Neurology at the Royal Brisbane Hospital (RBWH). He finished his training as neurologist in 2012.

He runs dedicated multiple sclerosis (MS) clinics at the PAH and Mater Hospital, leading in modern MS therapies. Moreover, he has been at the forefront of advancing the field of neuroimmunology in Queensland, with establishment of dedicated neuroimmunology outpatient clinics at the RBWH and PAH, combining expertise from neurologists and immunologists in the care of this very complex group of disorders.

In addition to his busy, full-time clinical workload, Stefan has been involved as PI or CI in a range of clinical trials in the fields of MS, botulinum toxin, CIDP and Pompe’s disease. Additionally, he has performed and is involved in ongoing research projects of neuroimmunological disorders such as neuromyelitis optica, myasthenia gravis and autoimmune limbic encephalitis. He has been a member of the New Horizons study to assess prevalence of anti-neuronal antibodies in patients with new onset psychosis.

Prior to this, Stefan finished a PhD in the field of ‘Immunogenetics of Guillain-Barre Syndrome and Chronic inflammatory polyneuropathy’ at the University of Queensland in 2014. He also completed a doctoral thesis at the University of Heidelberg, Germany in 2002 in the field of T cell immunology. During this time, he has developed solid skills in bench-side immunological research.

Currently, he is neurological lead in a diverse group of clinicians and scientists investigating the role of antineuronal antibodies in neurological and psychiatric disease. He supervises a PhD student in the field of advanced imaging in autoimmune encephalitis. He is currently building up a laboratory to test antineuronal antibodies using live cell assays.

Research Interests

  • Neuronal cell surface antibodies in neurological and psychiatric disease
  • Social cognition in Multiple Sclerosis
  • The role of low dose Rituximab in autoimmune neurological disease

Research Impacts

Stefan has been medical advisor and organiser of conferences of the national myasthenia gravis association. He is neurological advisor of the state-wide blood product services regarding use of immunoglobulins in neuroimmunological disorders. He is involved in the organisation of the International Society of Neuroimmunology Conference in Brisbane 2018. He is secretary of Neuroimmunology Australia, a national group of clinicians and researchers in the field of neuroimmunology. He was lead clinician in the development of referral guidelines for state-wide referral guidelines to Queensland Health Neurology services (CPC). He has been involved for many years in the education of medical student and young doctors, winning several teaching awards.

Publications

  • Chan, Fiona, Swayne, Andrew, Gillis, David, Walsh, Michael, Henderson, Robert D, McCombe, Pamela A, Wong, Richard C and Blum, Stefan (2018) Long-term follow-up of patients with myasthenia gravis treated with low-dose rituximab. Journal of Neurology, Neurosurgery & Psychiatry, jnnp-2018. doi:10.1136/jnnp-2018-319410

  • Pender, Michael P., Csurhes, Peter A., Smith, Corey, Douglas, Nanette L., Neller, Michelle A., Matthews, Katherine K., Beagley, Leone, Rehan, Sweera, Crooks, Pauline, Hopkins, Tracey J., Blum, Stefan, Green, Kerryn A., Ioannides, Zara A., Swayne, Andrew, Aftab, Blake T., Hooper, Kaye D., Burrows, Scott R., Thompson, Kate M., Coulthard, Alan and Khanna, Rajiv (2018) Epstein-Barr virus–specific T cell therapy for progressive multiple sclerosis. JCI Insight, 3 22: . doi:10.1172/jci.insight.124714

  • Devlin, Michael, Swayne, Andrew, Newman, Martin, O'Gorman, Cullen, Brown, Helen, Ong, Benjamin, Robertson, Thomas, Airey, Caroline and Blum, Stefan (2018) A case of immune-mediated encephalitis related to daclizumab therapy. Multiple Sclerosis Journal, . doi:10.1177/1352458518792403

View all Publications

Supervision

  • Doctor Philosophy

  • Doctor Philosophy

View all Supervision

Publications

Journal Article

Conference Publication

  • Devlin, M., Swayne, A., O'Gorman, C., Newman, M., Brown, H., Robertson, T., Airey, C. and Blum, S. (2018). A case of immune-mediated encephalitis related to daclizumab therapy. In: 34th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS), Berlin, Germany, (945-945). 10-12 October 2018.

  • Scott, James, Gillis, David, Ryan, Alex, Hargovan, Hethal and Blum, Stefan (2018). Prevalence of anti-neuronal antibodies in patients admitted with first episode of psychosis and their clinical outcomes. In: 6th Biennial Schizophrenia International Research Society Conference, Florence, Italy, (61-61). Apr 04 - 08, 2018. doi:10.1093/schbul/sby014.157

  • Scott, James, Gillis, David, Ryan, Alex, Hargovan, Hethal and Blum, Stefan (2018). Prevalence of anti-neuronal antibodies in patients admitted with first episode of psychosis and their clinical outcomes. In: 6th Biennial Conference of the Schizophrenia-International-Research-Society (SIRS), Florence, Italy, (S61-S61). 04-08 April 2018. doi:10.1093/schbul/sby014

  • Warren, N., Swayne, A. and Blum, S. (2018). Psychiatric presentations of autoimmune encephalitis. In: RANZCP 2018: Book of Abstracts. RANZCP 2018 Congress, Auckland, New Zealand, (121-122). 13 – 17 May 2018.

  • Pender, M. P., Csurhes, P. A., Smith, C., Douglas, N. L., Neller, M. A., Beagley, L., Rehan, S., Hopkins, T. J., Thompson, K. M., Blum, S., Green, K. A., Ioannides, Z. A., Coulthard, A., Hooper, K. D., Burrows, S. R. and Khanna, R. (2017). Safety and clinical improvement in a phase I trial of autologous Epstein-Barr virus-specific T-cell therapy in patients with progressive multiple sclerosis. In: 7th Joint European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) Americas Committee for Treatment and Research in Multiple Sclerosis (ACTRIMS), Paris, France, (401-401). 25-28 October 2017.

  • Pender, Michael, Csurhes, Peter, Smith, Corey, Douglas, Nanette, Neller, Michelle, Beagley, Leone, Rehan, Sweera, Hopkins, Tracey, Thompson, Kate, Blum, Stefan, Green, Kerryn, Ioannides, Zara, Coulthard, Alan, Hooper, Kaye, Burrows, Scott and Khanna, Rajiv (2017). Symptomatic and objective clinical improvement in progressive multiple sclerosis patients treated with autologous Epstein-Barr virus-specific T cell therapy: interim results of a phase I trial. In: 69th Annual Meeting of the American Academy of Neurology (AAN), Boston, Massachusetts, (E103-E103). 22-28 April 2017 .

  • Scott, J. G., Gillis, D., Hargovan, H., Gundarpi, N., Ryan, A., Prain, K., Newman, M., Wong R, R., Parry, P. and Blum, S. (2016). The Prevalence of Autoimmune Encephalitis in Patients Presenting with First-Episode Psychosis. In: RANZCP Abstract book 2016. RANZCP 2016 Congress, Hong Kong, (128-128). 8-12 May 2016.

  • Sheikh, Nabeel, McCombe, Pamela and Blum, Stefan (2014). Cardiac effects of high-dose fingolimod ingestion. In: ANZAN Annual Scientific Meeting Abstracts 2014. ANZAN Annual Scientific Meeting 2014, Adelaide, South Australia, Australia, (2058-2058). May 2014. doi:10.1016/j.jocn.2014.06.094

  • Blum, Stefan, Prain, Kerri, Swayne, Andrew, Chong, Victor, Wong, Richard, Gillis, David and Wilson, Bob (2014). Characteristics of aquaporin 4 antibodies associated with lesions of the area postrema. In: ANZAN Annual Scientific Meeting Abstracts 2014 . ANZAN Annual Scientific Meeting 2014, Adelaide, South Australia, Australia, (2036-2036). May 2014. doi:10.1016/j.jocn.2014.06.023

  • Blum, Stefan, Csurhes, Peter, Reddel, Stephen, Spies, Judy and McCombe, Pamela (2014). Killer immunoglobulin-like receptors and their HLA ligands in Guillain-Barré syndrome. In: ANZAN Annual Scientific Meeting Abstracts 2014. ANZAN Annual Scientific Meeting 2014, Adelaide, South Australia, Australia, (2038-2039). May 2014. doi:10.1016/j.jocn.2014.06.032

  • Sheikh, N., Wong, A., O'Sullivan, J., Blum, S., Airey, C., Dionisio, S., Mitchell, K., Coulthard, A., Cloustan, J., Groundwater, A., Rajah, T., Jhamb, A. and Henderson, R. (2012). CT perfusion and bilateral paramedian thalamic stroke due to Artery of Percheron occlusion. In: Special Issue: Abstracts of STROKE 2012 CONFERENCE - A combined event of the Stroke Society of Australasia 2012 Annual Scientific Meeting and the 8th Smart Strokes Australasian Nursing and Allied Health Stroke Conference. Annual Scientific Meeting and the 8th Smart Strokes Australasian Nursing and Allied Health Stroke Conference, Sydney, NSW, Australia, (56-57). 29-31 August 2012. doi:10.1111/j.1747-4930.2012.00907.x

  • Blum, Stefan, Wong, Richard, Gillis, David, Wilson, Bob, Prain, Kerryn and McCombe, Pamela (2010). Clinical characteristics of Aquaporin 4 auto-antibody positive patients – A case series. In: ANZAN Annual Scientific Meeting Abstracts 2014. ANZAN Annual Scientific Meeting 2014, Adelaide, South Australia, Australia, (1629-1630). May 2014. doi:10.1016/j.jocn.2010.07.067

  • Blum, Stefan, Robertson, Thomas, Klingberg, Sandra, Henderson, Robert and McCombe, Pamela (2010). Unusual clinical presentations associated with the A3243G mutation. In: ANZAN Annual Scientific Meeting 2010, -, (1629-1629). 2010. doi:10.1016/j.jocn.2010.07.066

Other Outputs

Grants (Administered at UQ)

PhD and MPhil Supervision

Current Supervision