NmlR-dependent thiol-based redox systems and their role in global stress responses in bacteria (2009–2011)

This proposal aims to characterize the thiol-based redox switch in proteins of the NmlR family of transcription factors. These novel transcription factors control a glutathione-based oxidative stress defense system in a wide range of bacteria. The project will characterise the molecular basis of signalling via NmlR. The role of the NmlR-dependent defenses will be defined for several different bacteria in relation to their metabolic physiology. The project will provide new insights into the physiology of bacteria of importance in infectious disease as well as biotechnology. It will also influence the general understanding of the role of glutathione-dependent defenses in biology
Grant type:
ARC Discovery Projects
Funded by:
Australian Research Council