Stem cell-based interface tissue engineering (2009)

Abstract:
A functional, mechanically robust ligament-cartilage-bone and muscle-tendon-bone interface is vital to the successful integration and utilisation of prosthetic implants and engineered grafts and tissues. Mesenchymal stem cells (MSCs) represent the most ideal cell source for targeted generation of these tissue interfaces. This project will develop tailored, biofunctional and scalable biomaterial platforms, capable of controlling the differentiation of MSCs into bone, cartilage and ligament, and thereafter, generating a graded bone-cartilage-ligament tissue for regeneration of the anterior cruciate ligament-bone tissue interface.
Grant type:
ARC Discovery Projects
Researchers:
  • Head of School
    School of Chemical Engineering
    Faculty of Engineering, Architecture and Information Technology
    Affiliate Professor
    Australian Institute for Bioengineering and Nanotechnology
  • Senior Group Leader
    Australian Institute for Bioengineering and Nanotechnology
Funded by:
Australian Research Council