The University of Queensland

Advanced paternal age: behavioural, neuroanatomical and genomic correlates in the offspring of older fathers (2009–2012)

Abstract:

The offspring of older fathers have an increased risk of developing disorders such as autism and schizophrenia. This is thought to be due to mutations in the developing sperm. Our group has shown in a mouse model that the offspring of older fathers have changes in brain shape and in behaviour, similar to some findings in autism. In this grant we will refine this animal model and explore the brain, behavioural and genetic correlates of advanced paternal age.

Grant type:

NHMRC Project Grant

Researchers:

• 

  Professor John McGrath

  Conjoint Professor
  

  Queensland Brain Institute

  ATH - Professor
  

  Medical School (GBCS)

  Faculty of Medicine

• 

  Professor Darryl Eyles

  Professor (Conjoint)
  

  Queensland Brain Institute

• 

  Professor Thomas Burne

  Professorial Research Fellow
  

  Queensland Brain Institute

Funded by:

National Health and Medical Research Council