Recycling endosomes governing cell polarity and cytokine secretion (2009–2014)

Abstract:
Cytokines are chemical messengers released by cells to mount inflammatory responses to fight infections. The timing and direction of cytokine release must be tightly regulated. We investigate the cellular compartments and molecules that control cytokine secretion using sophisticated live cell imaging. Uncontrolled cytokine release is the main cause of ongoing inflammation in arthritis and inflammatory bowel disease and our studies aim to identify cellular targets for new drug development.
Grant type:
NHMRC Project Grant
Researchers:
  • Professorial Research Fellow - GL
    Institute for Molecular Bioscience
    Affiliated Professor
    School of Biomedical Sciences
    Faculty of Medicine
Funded by:
National Health and Medical Research Council