The immunogenetics of ankylosing spondylitis: a genetic and functional investigation of IL23R and related genes (2009–2011)

Abstract:
Ankylosing spondylitis (AS) is a common inflammatory arthritis which causes primarily back pain and stiffness, and affects 1/250 individuals. Our group identified association between tagging genetic markers in the gene IL23R and AS, and our preliminary data suggests some related genes are involved as well. This study aims to identify the key genetic variants involved and determine the mechanism by which they cause AS.
Grant type:
NHMRC Project Grant
Researchers:
  • Professor
    Faculty of Medicine
    Affiliate Professor
    The University of Queensland Diamantina Institute
    Faculty of Medicine
    Affil Professorial Research Fellow
    Institute for Molecular Bioscience
  • Arthritis Qld Chair of Rheumatology
    The University of Queensland Diamantina Institute
    Faculty of Medicine
  • Professorial Research Fellow - GL
    Institute for Molecular Bioscience
    Affiliate Professor
    School of Public Health
    Faculty of Medicine
    Affiliate Professorial Research Fe
    Queensland Brain Institute
    Affiliate Professorial Research Fel
    Office of the Pro-Vice-Chancellor (Research Infrastructure)
Funded by:
National Health and Medical Research Council