The University of Queensland

The immunogenetics of ankylosing spondylitis: a genetic and functional investigation of IL23R and related genes (2009–2011)

Abstract:

Ankylosing spondylitis (AS) is a common inflammatory arthritis which causes primarily back pain and stiffness, and affects 1/250 individuals. Our group identified association between tagging genetic markers in the gene IL23R and AS, and our preliminary data suggests some related genes are involved as well. This study aims to identify the key genetic variants involved and determine the mechanism by which they cause AS.

Grant type:

NHMRC Project Grant

Researchers:

• 

  Professor Ian Frazer

  Emeritus Professor
  

  Faculty of Medicine

• 

  Professor Ranjeny Thomas

  Arthritis Qld Chair of Rheumatology
  

  Frazer Institute

  Faculty of Medicine

• 

  Professor Grant Montgomery

  NHMRC Leadership Fellow - GL
  

  Institute for Molecular Bioscience

Funded by:

National Health and Medical Research Council