Inhibitors of Secretory Phospholipases in Diet Induced Obese Rats (2010–2012)

Abstract:
A new drug given to rats fed a high fat/carbohydrate diet shows very promising effects in preventing and treating abdominal obesity, insulin resistance, glucose intolerance, and other risk factors for diabetes and cardiovascular disease. This project will profile biochemical and pharmacological properties of the drug in more detail in order to track down molecular mechanisms of its action and potential therapeutic benefits, guided by studies on rats, biochemical markets, rat and human fat cells.
Grant type:
NHMRC Project Grant
Researchers:
  • NHMRC Snr Principal Research Fellow
    Institute for Molecular Bioscience
    Affiliated Professor
    School of Chemistry and Molecular Biosciences
    Faculty of Science
  • Senior Research Fellow
    Institute for Molecular Bioscience
Funded by:
National Health and Medical Research Council