Nuclear Receptor 4A3 signalling in skeletal muscle (2010–2012)
Nuclear receptors regulate hormonal control of reproduction, endocrine physiology, and metabolism, and are very important in human health. NR4A3 function in peripheral tissues remains illusive. However, it is expressed in skeletal muscle, a tissue that (i) modulates blood lipids, insulin sensitivity and evergy balance, and (ii) has an important role in diabetes and obesity. Understanding NR4A3 function in metabolism provides a potential platform for therapeutic intervention.