Molecular regulation of angiotensin receptors (2010–2012)
The hormone angiotensin II affect our heart and blood vessels by 'switching-on' receptors that are then 'switched-off' to prevent over-stimulation. This application continues our investigations into how angiotensin II receptors are 'switched-on and -off'. We apply new technologies to identify and study receptor modulating proteins and the pairing receptors into dimers. Results will further our understanding of angiotensin receptors and cardiovascular control.