The contribution of upstream open reading frames to the eukaryotic proteome (2010–2012)
This project will investigate the novel idea that genomes of complex organisms (including human) 'double-dip' with many genes containing information for more than one protein. It will also examine if these small supernumary proteins have cell regulatory functions. If proved, it would significantly alter current view on the information content of higher vertebrate genomes. An understanding of the roles of these novel protein sequences may result in the development of new drugs.