Investigating the mechanisms by which immune cells (particularly T cells and NKT cells) target and eliminate cells expressing tumour antigens (2011–2012)
Abstract:
We wish to develop immune treatment for skin cancers, particularly in those where a virus, human papillomavirus (HPV), is involved. We study how the immune system recognizes cancers using an animal model in which viral cancer protein is expressed by skin cells. When we transfer this skin onto another animal we find that, as in humans, the cancer protein is not rejected by the immune system. We will study how the immune cells interact with these abnormal skin cells using a microscope that can see into living skin.
