The Nodal/Cripto signalling pathway in male germ cell development: relevance to testicular germ cell tumours (2011–2012)
Testicular cancer is the most common type of cancer in men aged 20-40 years, and its incidence has doubled in the last 30 years. It is sometimes fatal and often results in infertility. We have discovered new genes that regulate testicular cell behaviour in the developing fetus, and here test the concept that defects in these genes might disrupt cell behaviour to the point where cancers form. Outcomes may lead to new ways to diagnose and treat testicular cancers.