The first integrated multimodal assay for the ultrasensitive detection of dengue contamination of blood (2012–2015)

For the first time we will develop an ultrasensitive system that will simultaneously detect validated nucleic acid, protein & serological biomarkers of dengue in a single assay format suitable for the screening of blood. Isothermally-amplified viral nucleic acid, NS1 antigen & IgM antibodies will be captured & concentrated using magnetic nanoparticles functionalised with state-of-the-art polymer chemistry which reduces non-specific binding. The captured dengue markers will then be probed with individually-tagged fluorescent beads in a format amenable to automation & therefore suitable for blood bank application.
Grant type:
ARC Linkage Projects
  • Professorial Research Fellow - GL
    Institute for Molecular Bioscience
  • Head of School
    School of Chemistry and Molecular Biosciences
    Faculty of Science
    Affiliated Professor
    Institute for Molecular Bioscience
    Affiliate Professor
    Australian Institute for Bioengineering and Nanotechnology
  • Senior Group Leader
    Australian Institute for Bioengineering and Nanotechnology
Funded by:
Australian Research Council