Dissecting the shared genetic architecture of psychiatric and psychological traits with application to prediction of genetic risk (2011–2014)
Psychiatric disorders, like other complex diseases, are caused by multiple genetic and environmental factors. The genetic component is substantial, yet few specific high risk variants have been identified. Evidence is mounting for thousands of risk loci each individually conferring a very low increase in risk to disease. Using new national and international genetic data resources, predictions of genetic risk that utilise information from thousands of genetic risk variants will be developed. The aim is to idenity sets of genetic markers that allow predictions of genetic risk.