Genetic dissection of cardiac morphogenesis (2012–2016)
The heart is essential for our survival and defects affecting cardiac function can result in death or debilitation. The creation of the heart involves finely regulated and rapidly executed steps, which we are still unraveling. The project will study a collection of novel mutants with cardiac defects and aims to identify the genes responsible for the defects. A novel cardiac regulator will also be studied. Finally, a suite of new tools will be created, permitting detailed cellular analysis at a precision not previously possible. Outcomes of this project will illuminate how organs develop, suggest novel modes of stem cell programming and inform congenital and acquired heart disease with a view to improve diagnostics and therapeutics.