Metals in Biocatalysis: a Powerful Combination for the Chemistry of Life (2013–2017)
Metal ions contribute greatly to the diversity of chemical reactions in biological systems. A growing number of metal ion-dependent biocatalysts (metalloenzymes) have become targets for the development of chemotherapeutics for the treatment of diseases such as osteoporosis or to combat the spread of antibiotics resistance. Other metalloenzymes are capable of degrading organophosphate pesticides and nerve agents. I will use an integrated, multi-disciplinary approach to study the mechanisms of action of such enzymes, develop potent inhibitors and utilise their potential in biotechnology. Ultimately, new drugs and bioremediators that significantly improve the quality of life and the environment in Australia will result.