Cell-free immune reactions and suppression (2011–2012)
A fundamental question in innate immunity is how a broad range of cues can be recognised with a limited number of recognition proteins. We propose a dual role of lipid carriers as sensor particles involved in the recognition and detoxification of bacteria and toxic substances. We will use lipid-anchored hemolin, an immunoglobulin-like recognition and adhesion protein in insects to explore a functional association with lipid particles in sensing bacterial cell wall components and sequestering potentially damaging objects and substances by aggregation reactions. Elucidation of this process will provide novel resistance management strategies to delay tolerance to pesticides in insect pests.