How filopodia connect macrophages to the outside world (2013–2015)
This project will explore mechanisms used by cells to recognize and respond to their external surroundings. It will focus on the function of filopodia, finger-like protrusions extending from the surface of certain cells that detect environmental cues. The project aims to understand specific cellular functions controlled by a novel protein that is present on filopodia on macrophages, a type of immune cell. It also aims to characterize the exact mechanisms by which this protein controls these functions. Outcomes will include important insights into mechanisms used by cells to migrate, release cytokines and engulf microorganisms.