A pan-genome reverse vaccinology approach to disease prevention in farmed fish (2014–2017)

Abstract:
Streptococcal pathogens cause serious diseases in humans and animals including fish. They are difficult to prevent by vaccination because new variants or serotypes rapidly evolve. This project will use Illumina sequencing to create pan-genomes for two fish pathogenic streptococcus species. Then, using our established bioinformatics pipeline, we will take a reverse-vaccinology approach by identifying and evaluating conserved vaccine targets that are critical to virulence across all strain variants for each species. This will allow development of broadly cross-protective vaccines for use in farmed fish.
Grant type:
ARC Linkage Projects
Researchers:
  • Associate Professor
    School of Biological Sciences
    Faculty of Science
  • Associate Professor
    School of Chemistry and Molecular Biosciences
    Faculty of Science
    Affiliate Associate Professor
    UQ Centre for Clinical Research
    Faculty of Medicine
  • Professor
    School of Chemistry and Molecular Biosciences
    Faculty of Science
    Affiliate Professor
    Institute for Molecular Bioscience
Funded by:
Australian Research Council