A microfluidic array of Phylomers for rapid discovery of peptide probes and biomarkers

Abstract:: The project aims at accelerating the discovery of novel molecular probes and biomarkers using an extensive library of peptides called Phylomers, derived from uniquely diverse structures found in microorganisms, which can be screened for specific, high affinity interactions to multiple target classes. We are developing a platform for rapid screening of interactors in vitro, streamlining the biophysical validation of thousands of Phylomers against multiple targets. We will develop a novel biosensor, assembling on a single microfluidic chip a library of thousands of structures, pre-selected for folding propensity in silico and in vivo. This universal Phylomer array would allow for rapid biomarker discovery from any biological sample.
Grant type:: ARC Linkage Projects
Funded by:: Australian Research Council

The University of Queensland