The University of Queensland

High resolution single particle analysis of biological macromolecules (2004–2006)

Abstract:

One of the great challenges of cell biology is to increase the rate of atomic resolution structure determination particularly of membrane proteins and macromolecular assemblies. The current rate-limiting step is high quality crystal production. Our goal is to prove that protein structures can be determined to atomic resolution by single-particle analysis. 3D structures will be produced by computationally aligning high-resolution electron microscope images of individual randomly oriented molecules. The importance of this project is highlighted by the fact over

Grant type:

ARC Discovery Projects

Researchers:

• 

  Professor Ben Hankamer

  Professorial Research Fellow
  

  Institute for Molecular Bioscience

• 

  Emeritus Professor Alasdair McDowall AM

  Emeritus Professor
  

  Faculty of Science

• 

  Professor Paul Young

  Professor, Research Development
  

  Office of the Deputy Vice-Chancellor (Research and Innovation)

  Affiliate Professor
  

  Australian Institute for Bioengineering and Nanotechnology

Funded by:

Australian Research Council