Disulfide Bonds and Protein Folding (2005–2007)

Protein folding is a major unsolved problem in biology. Here we focus on how proteins fold in the cell by studying the Dsb family of proteins that catalyse protein folding through disulfide bond oxidation reduction or isomerisation. Our international research team will use structural biology biochemistry and biophysics to investigate the function of Dsb proteins. A major aim is the crystallisation of the membrane protein DsbD. Our research will provide new insights into the process of protein folding in vivo and ultimately could lead to the development of more efficient biotechnology approaches for heterologous protein expression for research and medical applications
Grant type:
ARC Discovery Projects
Funded by:
Australian Research Council