Non-viral vectors for targeted delivery of RNAi nucleotides to cervical cancers (2007–2009)

Abstract:
RNA interference (or gene silencing) is a new technique whereby we are able to turn off the expression of a particular gene either temporarily or permanently. Cancer is basically a genetic disease where certain protective genes are lost or cancer-causing genes expressed. Gene silencing holds great promise in the treatment of genetic disorders, infectious diseases and cancer. Cervical cancer is caused by infection with the human papillomavirus and the expression of two cancer-causing genes. Using RNA interference we can turn off the expression of these two genes which results in the death of the cancer cell. We are also able to cure mice of tumours derived from human cervical cancer. The major issue with gene silencing is how to deliver it effectively to patients. Here we are investigating novel nanoparticulate systems to deliver this new gene-inhibiting drugs preferentially to the tumour site.
Grant type:
NHMRC Project Grant
Researchers:
  • Senior Lecturer
    School of Pharmacy
    Faculty of Health and Behavioural Sciences
  • Professor
    Faculty of Medicine
    Affiliate Professor
    The University of Queensland Diamantina Institute
    Faculty of Medicine
    Affil Professorial Research Fellow
    Institute for Molecular Bioscience
Funded by:
National Health and Medical Research Council