The University of Queensland

The role of Crim1 in growth factor activity and cell motility/adhesion. (2007–2009)

Abstract:

Crim1 is a novel protein which appears to regulate the activity of growth factors and therefore affects the normal development of a number of organs. It is particulrly involved in normal development of blood vessels. A greater understanding of how growth factor activity is modulated by Crim1 will have significance to almost every developmental and disease state involving such growth factors. The potential for Crim1 to link the activity of several distinct growth factor pathways may explain tissue specific differences in growth factor responses. These basic advances in understanding will have implications for many disease states, including renal disease, vascular disease and cancer.

Grant type:

NHMRC Project Grant

Researchers:

• 

  Professor Alpha Yap

  Professor and ARC Laureate Fellow
  

  Institute for Molecular Bioscience

Funded by:

National Health and Medical Research Council