The use of soluble antagonists of EphA4 in spinal cord injuries.

Abstract:: Permanent and limitied recovery of function following spinal cord injury is a direct result of the lack of nerve regrowth through the injury. Our preliminary data suggest that antagonising the effects of QphA4, a protein involved in brain development, leads to substantial functional recovery simutaneous with nerve regrowth. In addition to designing new, more effective blockers of QphA4, we will study the signalling pathways that EphA4 activates to inhibit nerve regrowth.
Grant type:: NHMRC Project Grant
Funded by:: National Health and Medical Research Council