Store operated Ca2+ entry in skeletal fibres from normal and dystrophin-deficient muscle (2007–2010)
Skeletal muscle, the most abundant tissue in the body, is essential for life and movement. Muscle function is regulated in a complex manner by calcium and is severely impaired in patients with Duchenne muscular dystrophy. Changes in calcium regulation, known to occue in dystrophic muscle, will be investigated in an animal model using a novel, single cell approach. Results obtained will contribute to understanding better muscular dystrophy and help provide therapeutic targets for treatment.