High Speed Fluorescence Imaging coupled with Total Internal Reflection Microscopy and Fluorescence Recovery After Photobleaching System (2008–2009)

Abstract:
This proposal is for a Total Internal Reflection Flueorescence imaging system that will allow direct visualisation of intramolecular events and transient protein-protein interactions occurring on a millisecond time scale in living cells. The equipment will include a photo-ablation system allowing the powerful combination of imaging techniques, which will provide unprecedented insight into the dynamics of plasma membrane proteins and their mobility. This will enable researchers in cellular and neuronal biology to access sophisticated technology to pioneer their research. Understanding of the dynamics of protein and organelles and the molecular interactions underlying organelle fusion will have wide-ranging ramifications in disease treatment.
Grant type:
ARC Linkage Infrastructure, Equipment and Facilities
Researchers:
  • Professor
    Queensland Brain Institute
    Affiliate Professorial Res Fellow
    Institute for Molecular Bioscience
  • Professorial Research Fellow
    Institute for Molecular Bioscience
  • Professorial Research Fellow
    Institute for Molecular Bioscience
    Affiliate Professor
    School of Biomedical Sciences
    Faculty of Medicine
  • Associate Professor
    School of Biomedical Sciences
    Faculty of Medicine
    Director (Research Training)
    Research Strategy and Support (Medicine)
    Faculty of Medicine
    Affiliate Associate Professor
    Queensland Brain Institute
  • Professor
    School of Biomedical Sciences
    Faculty of Medicine
Funded by:
Australian Research Council